LOCUS       NM_174998               4652 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus hippocalcin-like 4 (Hpcal4), mRNA.
ACCESSION   NM_174998
VERSION     NM_174998.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4652)
  AUTHORS   Alvaro,C.G., Braz,J.M., Bernstein,M., Hamel,K.A., Craik,V.,
            Yamanaka,H. and Basbaum,A.I.
  TITLE     Hippocalcin-like 4, a neural calcium sensor, has a limited
            contribution to pain and itch processing
  JOURNAL   PLoS One 15 (2), e0226289 (2020)
   PUBMED   32015563
  REMARK    GeneRIF: These results indicate that the neural calcium sensor
            Hpcal4 likely makes a limited contribution to pain and itch
            processing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4652)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   3  (bases 1 to 4652)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 4652)
  AUTHORS   Onishi,M., Yasunaga,T., Tanaka,H., Nishimune,Y. and Nozaki,M.
  TITLE     Gene structure and evolution of testicular haploid germ
            cell-specific genes, Oxct2a and Oxct2b
  JOURNAL   Genomics 83 (4), 647-657 (2004)
   PUBMED   15028287
REFERENCE   5  (bases 1 to 4652)
  AUTHORS   Ohya,S. and Horowitz,B.
  TITLE     Differential transcriptional expression of Ca2+ BP superfamilies in
            murine gastrointestinal smooth muscles
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 283 (6), G1290-G1297 (2002)
   PUBMED   12388203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL606934.12.
            
            [WARNING] On Apr 30, 2024 this sequence was replaced by
            NM_174998.5.
            
            On Oct 19, 2007 this sequence version replaced NM_174998.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032591.1, SRR1660811.187381.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AL606934.12        104819-104939
            122-225             AL606934.12        105068-105171
            226-394             AL606934.12        110030-110198
            395-610             AL606934.12        110340-110555
            611-4652            AL606934.12        111973-116014
FEATURES             Location/Qualifiers
     source          1..4652
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.4 cM"
     gene            1..4652
                     /gene="Hpcal4"
                     /gene_synonym="NVP-2"
                     /note="hippocalcin-like 4"
                     /db_xref="GeneID:170638"
                     /db_xref="MGI:MGI:2157521"
     exon            1..121
                     /gene="Hpcal4"
                     /gene_synonym="NVP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            122..225
                     /gene="Hpcal4"
                     /gene_synonym="NVP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            226..394
                     /gene="Hpcal4"
                     /gene_synonym="NVP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..808
                     /gene="Hpcal4"
                     /gene_synonym="NVP-2"
                     /note="neural visinin-like protein 2"
                     /codon_start=1
                     /product="hippocalcin-like protein 4"
                     /protein_id="NP_778163.1"
                     /db_xref="CCDS:CCDS18611.1"
                     /db_xref="GeneID:170638"
                     /db_xref="MGI:MGI:2157521"
                     /translation="MGKNNSKLAPEVLEDLVQNTEFSEQELKQWYKGFLKDCPSGILN
                     LEEFQQLYIKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSVTSRGSFEQKLN
                     WAFEMYDLDGDGRITRLEMLEIIEAIYKMVGTVIMMRMNQDGLTPQQRVDKIFKKMDQ
                     DKDDQITLEEFKEAAKSDPSIVLLLQCDMQK"
     exon            395..610
                     /gene="Hpcal4"
                     /gene_synonym="NVP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            611..4652
                     /gene="Hpcal4"
                     /gene_synonym="NVP-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagaactggg gaggcggctc cgacgcggac cctacagagc ctgtcgtccg cctgatagcc
       61 agccttgtcc ccgcggccgc ccaagctcgg agccatctag cgactcggcg agcggcctca
      121 ggtggacagc catctgggaa gcccgccttg ggccaggaac tttcacttca agccgggtct
      181 ccagttcaag aaggaggtac agctgcctcc ttacccccag ctcaggccca ccatggggaa
      241 aaacaacagc aagctggccc ccgaggtgct ggaagacctg gtccagaaca cggagttcag
      301 cgagcaggag ctaaagcagt ggtataaggg tttcctgaag gactgcccca gtggcatcct
      361 caacctggag gagtttcagc aactctatat caagttcttc ccttatggag acgcgtccaa
      421 gtttgcgcag catgctttcc gcaccttcga caagaacggc gatggcacca tcgacttccg
      481 ggagttcatc tgcgcccttt ctgtcacctc ccgtggcagc ttcgagcaga agctcaactg
      541 ggcctttgag atgtacgatc tggacggtga cggccgcatc acacggctgg agatgctgga
      601 gatcatcgag gctatctata agatggtggg caccgtgatc atgatgcgca tgaaccagga
      661 tgggctcaca ccccagcagc gtgtggacaa gatcttcaag aagatggacc aggataagga
      721 tgaccagatt acgctggagg agttcaagga ggcggccaag agtgacccgt ccatcgtgtt
      781 gctcctgcag tgtgacatgc agaagtagag gccggtgagg ggcagggccc ctggccagga
      841 aaggcatggc aaccttccaa cctgatgtcc tctctgctgg cccacccccg gggggagggg
      901 cgttccagcc tcactctcta gctcacccac tcctctgtcc aagcctttct ctcctcagtc
      961 aagttcctcg agcgaccacc acctcattct gtaaaagaga caggtcctct caagtagcct
     1021 gtcctcagat agtctgtcac tagctccacc tctagccttg gcctagaacc aacatccttt
     1081 gggcttagga gagttggctt ttgaccccag aggcgaggtt aaggaggggc tgaggacttg
     1141 ctttgcaatc ctgttgttcc caggattatg gtccaaataa acagcatggt cccacaggcc
     1201 cccagtcaaa gggccaaacc gggtctgtcc cgggctatcg ggattccccg agaggtggtc
     1261 tctgccctgc tcccttgctc tacctggccc ctctggcccc agtctttgga acgttcagtg
     1321 agtcctttct tcagctaatg cttgttgaac acttgcccca tgccaggcac ctgaaggtgc
     1381 taagaatacg gttgtttaca gaaacccatc ccatgccctc tggaagctca cagggtagcg
     1441 agacaactgc caagggttgc agtctcggac aggatggtgg aacacaatgg agatgaaggt
     1501 gtgaggtagc tggcacgctg tcagaactag tgtgtcctcc agctggtgcc acccaaagct
     1561 gcagaaagtc caactgaaaa acctgtggaa ctttaggtgc cacgtgggtg gatgttttaa
     1621 gaaaaacaaa attttatgta atatttattt ttttagtgcc ctttcaaaga cataagatca
     1681 ttttattaga ctataaaaat atactctata ttacttgatt tcttaaaaaa agatttaaat
     1741 gaatataaaa atgctgatgt tcaagggggg aaaatgttta ggcaaaagcg gtagggccac
     1801 catcaggtct ggagaacccg tactctcgcc accagcagtt cctgctgtct ctgctatgtc
     1861 cctttattac cttttctcaa ttccacaagt gacttttctg tcgcacacct tgggtgctga
     1921 catcagagta agaaacgaaa cttaccatgg gcaaacgcag ttcattccca cggcccggta
     1981 ccatgggcat gcgcagttca ttcccatagc gcagtatcat gggcaagcgc tgttcattcc
     2041 cacatctcgg taccatgggc aagcacagtg catacccaca tctcgatagc ttgtttctga
     2101 gtttgggttg gtttttcagg gatcggctta ttctttcaca gcctaagata gaaggagcta
     2161 gaagaaaggg atcttgcggc tgttcaggct tcgggggctg cgcttatcta tggaccaaat
     2221 gcttaaagaa tgtgctgggc gtactccgtg caaaaggctt ttcctaaacc cttccgtcct
     2281 agatctgcca ggtaatctac tttgtcacct tccaagctca ccagcctcgc tttctgaatt
     2341 ttaaggtcta tgagctaact agtgtgctgc atgctttcca gaaaaatcca cctgcttctt
     2401 ccagttcctc gcttcacttt cgcctacgct tccttgcgat cagaggttgg ctttgatgtg
     2461 cgatgacagt tggcttcctc ttgagctgct gtgaaaacag tctagtacag agatgctgtc
     2521 agccagggtg ggcgtagaga gagcttgaga agctggggcg tgtggtggcg gagattgccc
     2581 tgcagaagat acgctatttg ccacttactt ccgagtgctc acctcccttc tggtagaaat
     2641 gtttgtagat tctgacctgt ggtccaaagt tctgtcagac tttccttctt gtggcctttg
     2701 gagggagcaa gccaccttct tcctgacctg cctatccagg ccacgtgcta agggtgagga
     2761 attcttagcc tcaagtggta ctagcagttg tttatctggt gatgcttcgt ggggttgctc
     2821 catagctctg gcacacggcc tgctaagcat gtcttttgct atcatcagtg ccacagacac
     2881 ataaataccc aaccaccttg ctcagctggg acctggatct tctagtgaaa agcttttcct
     2941 tccccccaaa tgtttaatct agcccaaccc acaatgacac agaatttctt ggctttctaa
     3001 ggcttgtatc tgcctgcatc tcattttgtc ctcacagccc aaggagataa gggttttacc
     3061 caggcttgga agctaaagtt aagggttgag ggagagaggt ctcttgtatg agagacacac
     3121 aatgctaaga ctcgaacgca aggctctcca agagtctctt ctctgctcca tctgatttgt
     3181 ccagatgcta actgcaagac aaatcgactt ttatcctttc agaagtttcc tgccaagaac
     3241 ttgctgaggc tacagtcttc cgaaaaggag gaggagcttg aagtctctcc actttcaagc
     3301 atcctctcgt agcttctggg cagctttgca gtgctgttct tggaggctgc taatcaagtc
     3361 ctggaagcat cttgtgttgt cttctccact atcttccttc cccaaagaat tgcttttctt
     3421 tttccaagtt ggtaggcaag tcctacccat gagacagatc actctaggct tctagtcacc
     3481 cactcacggg caatatttgc tgcttaaggc caagggtttc agacagccaa caggcctcaa
     3541 actggctctg ccctcttgct catgggagaa gccacagaca ggtcgagcct tgctcccaca
     3601 ttctcctggg tgtctaaaac tcagtatgcc caggagacca tgtggtagag cgcccgtccc
     3661 tgccttggga agagagagat ctcccatctc cactccggct tgggaagcac ttagcatgaa
     3721 gcacaggtca gcagagatct gggtatgact cgcacaggca tgaaaaccta aatgcagata
     3781 aaacactggc ataccaagtt ctccttcgag gttctgtatc ctcttacaaa aagtctgtga
     3841 atctggtggt tccaaattta gccttctcat gcctgctatc ctcattcatc ctttctggct
     3901 aagtgatgag ccccttattt ctcatcccta aaaatcccca gcgtaggctg ccttgtgtgc
     3961 cgctgcgatc cgtgcagctg cgtaattact cgcgtacctt tgaaatgaag agaaagccaa
     4021 gcccattggc caaggcacca attcctctct gctctggcaa tggcagagcc tcaaaagcag
     4081 aaatccattt aacgcagaag gttatggaag caagaaaagg acacgctggt cttcccaggc
     4141 agggcagtga gcagacactg taaatatttt tacacaaaat ttattaaagc aaaagtcatt
     4201 tcctgaagat ccaccctggg tgaggctttg tgttggcttt agaaatcacc acggggctaa
     4261 gaatacattt cctacatagc tgcttcattg tgcttaaagg aagcaaagaa gtcacgtgct
     4321 aaattttaaa gtctcagaaa aacatgggtt ttgttttcta ccccctagac ttttcagggt
     4381 tttctcttct tagctttgtc ggagtatggg gtaggacagg gtctctaggg atgcatgggt
     4441 ccctctgctt ggtggaggct gcccaggtgc atggtcttct aagcagtgag gaagcctagg
     4501 tgtatcccag ttcactatgg gagccccagt gtagccctgt cccctccgga catgctgctt
     4561 ctaattgtgt tcacagcaac catcttcact gatcaaccct gtgccacgtg gtgtgtgttt
     4621 ttcccactga caatgaataa aaggtgtgac tg
//
