LOCUS       NM_001130419            1655 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus hippocalcin (Hpca), transcript variant 1, mRNA.
ACCESSION   NM_001130419
VERSION     NM_001130419.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1655)
  AUTHORS   Ye Q, Bhojwani A and Hu JK.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   2  (bases 1 to 1655)
  AUTHORS   Pal S, Dwivedi D, Pramanik T, Godbole G, Iwasato T, Jabaudon D,
            Bhalla US and Tole S.
  TITLE     An Early Cortical Progenitor-Specific Mechanism Regulates
            Thalamocortical Innervation
  JOURNAL   J Neurosci 41 (32), 6822-6835 (2021)
   PUBMED   34193558
REFERENCE   3  (bases 1 to 1655)
  AUTHORS   Ratie L, Desmaris E, Garcia-Moreno F, Hoerder-Suabedissen A, Kelman
            A, Theil T, Bellefroid EJ and Molnar Z.
  TITLE     Loss of Dmrt5 Affects the Formation of the Subplate and Early
            Corticogenesis
  JOURNAL   Cereb Cortex 30 (5), 3296-3312 (2020)
   PUBMED   31845734
REFERENCE   4  (bases 1 to 1655)
  AUTHORS   Kim JH, Liu QF, Urnuhsaikhan E, Jeong HJ, Jeon MY and Jeon S.
  TITLE     Moderate-Intensity Exercise Induces Neurogenesis and Improves
            Cognition in Old Mice by Upregulating Hippocampal Hippocalcin,
            Otub1, and Spectrin-alpha
  JOURNAL   Mol Neurobiol 56 (5), 3069-3078 (2019)
   PUBMED   30091036
  REMARK    GeneRIF: neurogenic markers, including doublecortin and the
            neuronal nuclei antigen, and hippocalcin, otub1, and spectrin-alpha
            are potential molecular links between hippocampal neurogenesis and
            exercise in the elderly.
REFERENCE   5  (bases 1 to 1655)
  AUTHORS   Ji J, Hong X, Su L and Liu Z.
  TITLE     Proteomic identification of hippocalcin and its protective role in
            heatstroke-induced hypothalamic injury in mice
  JOURNAL   J Cell Physiol 234 (4), 3775-3789 (2019)
   PUBMED   30256386
  REMARK    GeneRIF: Hippocalcin hasa protective role in heatstroke-induced
            hypothalamic injury in mice.
REFERENCE   6  (bases 1 to 1655)
  AUTHORS   Korhonen L, Hansson I, Kukkonen JP, Brannvall K, Kobayashi M,
            Takamatsu K and Lindholm D.
  TITLE     Hippocalcin protects against caspase-12-induced and age-dependent
            neuronal degeneration
  JOURNAL   Mol Cell Neurosci 28 (1), 85-95 (2005)
   PUBMED   15607944
  REMARK    GeneRIF: An age-dependent increase in neurodegeneration occurred in
            the gene-deleted mice, showing that hippocalcin contributes to
            neuronal viability during aging.
REFERENCE   7  (bases 1 to 1655)
  AUTHORS   Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai
            M, Kobayashi H, Sato K, Sasajima T and Tateno M.
  TITLE     Neuronal calcium sensor protein visinin-like protein-3 interacts
            with microsomal cytochrome b5 in a Ca2+-dependent manner
  JOURNAL   J Biol Chem 279 (15), 15142-15152 (2004)
   PUBMED   14739275
REFERENCE   8  (bases 1 to 1655)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 1655)
  AUTHORS   Fehr C, Shirley RL, Belknap JK, Crabbe JC and Buck KJ.
  TITLE     Congenic mapping of alcohol and pentobarbital withdrawal liability
            loci to a <1 centimorgan interval of murine chromosome 4:
            identification of Mpdz as a candidate gene
  JOURNAL   J Neurosci 22 (9), 3730-3738 (2002)
   PUBMED   11978849
REFERENCE   10 (bases 1 to 1655)
  AUTHORS   Masaki T, Sakai E, Furuta Y, Kobayashi M and Takamatsu K.
  TITLE     Genomic structure and chromosomal mapping of the human and mouse
            hippocalcin genes
  JOURNAL   Gene 225 (1-2), 117-124 (1998)
   PUBMED   9931466
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY769297.1, BY128037.1, CX240757.1, BC058588.1 and AI835374.1.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_001130419.3.
            
            On Oct 30, 2013 this sequence version replaced NM_001130419.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3 and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX236918.1, CX239144.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY769297.1         1-39
            40-107              BY128037.1         1-68
            108-892             CX240757.1         1-785
            893-1634            BC058588.1         711-1452
            1635-1655           AI835374.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..1655
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..1655
                     /gene="Hpca"
                     /note="hippocalcin"
                     /db_xref="GeneID:15444"
                     /db_xref="MGI:MGI:1336200"
     exon            1..178
                     /gene="Hpca"
                     /inference="alignment:Splign:2.1.0"
     exon            179..577
                     /gene="Hpca"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..781
                     /gene="Hpca"
                     /codon_start=1
                     /product="neuron-specific calcium-binding protein
                     hippocalcin"
                     /protein_id="NP_001123891.1"
                     /db_xref="CCDS:CCDS18682.1"
                     /db_xref="GeneID:15444"
                     /db_xref="MGI:MGI:1336200"
                     /translation="MGKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILN
                     VDEFKKIYANFFPYGDASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLM
                     WAFSMYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNN
                     DGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF"
     exon            578..683
                     /gene="Hpca"
                     /inference="alignment:Splign:2.1.0"
     exon            684..1639
                     /gene="Hpca"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgaggcgg aggtagcagg gggcgtgtct ggcccctgga agaccttggg actgagcaat
       61 gggtgctccc tcctccctag agagccccca gttcatctgg ctcgggagtt gaggtgcggg
      121 ggcagcgagg gtgcctatcg gattcctccc tcagagcgac aggcggccct gcgcccaggt
      181 gggacttggc tcttctgcca tgggcaagca gaacagcaag ctgcggccag agatgctgca
      241 ggacctgcga gagaacacgg agttctctga gctggagcta caggagtggt acaagggctt
      301 cctgaaggac tgccccactg gcatcctcaa cgtggatgag ttcaagaaga tctacgccaa
      361 cttcttcccc tatggcgacg cctccaagtt tgccgagcac gtcttccgca cctttgacac
      421 caacagcgac ggcaccatcg acttccggga gttcatcatt gctctgagcg tgacctcgcg
      481 tggccgcctg gagcagaagc tcatgtgggc cttcagcatg tatgacctgg atggcaatgg
      541 ctacatcagc cgggaggaga tgctagaaat tgtgcaggcc atttacaaga tggtttcgtc
      601 cgtgatgaaa atgcccgagg atgagtcgac cccggaaaag aggactgaga aaatcttccg
      661 ccaaatggac acaaacaatg acggcaagct gtcgctggag gagttcatcc gcggagccaa
      721 aagcgaccca tccatcgtgc gcctgctgca gtgtgatccc agcagcgcct cccagttctg
      781 agctgagagg agccagctcg cctccctgcc ttcaccggcc ctccggctct cagcttcctc
      841 tccctcgtgt ctatccaggc tgggggccag actggggatc cctttctggg gtctgcactg
      901 tgtgtgtgtg tgggcctctg gagaagtgaa acctgcaagg aaggggctaa gcaagacagc
      961 tgttagtctc cacggcccaa gaggcagaat ctcccttagt gggaccgaga tagccctccg
     1021 gtcaggttct gtattcttta gtgagacagc tggatcatct tacacccacc cacagtcagg
     1081 aggatcttcc acaacacggg ggcagggggg cgggtaggtc ccctttgggt ggtcctcagc
     1141 ctggagggag gtggggagtc atgccaaggt gaagagtctt tttgtttggt ggggagccac
     1201 ggatgatttc tgggctgtgg ggctttgaag aagttccctg atctacttcc ctgcagaaga
     1261 acacttcttg tcccagctct tgctggctgg aggccatggt aaaacaaaac aaaactccca
     1321 ggattccaac tgggggtccc caaactcaac ctgcctcttt gcacttagat aaccacagat
     1381 ttaccccgtc tgtactctgt atttcacctc tctctctcgt gcactcacgc aaacacacac
     1441 acacacacac acacacacac acacacacac acacacacag aggcccacag acagatgggc
     1501 agagcccctc cacagcattc tgtgtgggaa ggaagcgcag gcccccggcc aagccccatg
     1561 tccctctgca tgcagccaca cggagcatct tggttctttt taataacttc aaaataaagt
     1621 cttgtttcag tgcattgtaa aaaaaaaaaa aaaaa
//
