LOCUS       NM_001285478            4911 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus heterochromatin protein 1, binding protein 3 (Hp1bp3),
            transcript variant 4, mRNA.
ACCESSION   NM_001285478
VERSION     NM_001285478.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4911)
  AUTHORS   Tonelli Gombalova Z, Kosuth J, Alexovic Matiasova A, Zrubakova J,
            Zezula I, Giallongo T, Di Giulio AM, Carelli S, Tomaskova L,
            Daxnerova Z and Sevc J.
  TITLE     Majority of cerebrospinal fluid-contacting neurons in the spinal
            cord of C57Bl/6N mice is present in ectopic position unlike in
            other studied experimental mice strains and mammalian species
  JOURNAL   J Comp Neurol 528 (15), 2523-2550 (2020)
   PUBMED   32212159
REFERENCE   2  (bases 1 to 4911)
  AUTHORS   Neuner SM, Ding S and Kaczorowski CC.
  TITLE     Knockdown of heterochromatin protein 1 binding protein 3
            recapitulates phenotypic, cellular, and molecular features of aging
  JOURNAL   Aging Cell 18 (1), e12886 (2019)
   PUBMED   30549219
  REMARK    GeneRIF: Hp1bp3 is a critical mediator of aging-related changes at
            the phenotypic, cellular, and molecular level.
REFERENCE   3  (bases 1 to 4911)
  AUTHORS   Choo HJ, Cutler A, Rother F, Bader M and Pavlath GK.
  TITLE     Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and
            Survival by Modulating Nuclear Import
  JOURNAL   Stem Cells 34 (11), 2784-2797 (2016)
   PUBMED   27434733
REFERENCE   4  (bases 1 to 4911)
  AUTHORS   Neuner SM, Garfinkel BP, Wilmott LA, Ignatowska-Jankowska BM, Citri
            A, Orly J, Lu L, Overall RW, Mulligan MK, Kempermann G, Williams
            RW, O'Connell KM and Kaczorowski CC.
  TITLE     Systems genetics identifies Hp1bp3 as a novel modulator of
            cognitive aging
  JOURNAL   Neurobiol Aging 46, 58-67 (2016)
   PUBMED   27460150
  REMARK    GeneRIF: Hp1bp3 and associated molecular networks are modulators of
            cognitive aging.
            GeneRIF: Loss of Hp1bp3 expression is associated with cognitive
            decline in both mice and humans.
REFERENCE   5  (bases 1 to 4911)
  AUTHORS   Garfinkel BP, Arad S, Neuner SM, Netser S, Wagner S, Kaczorowski
            CC, Rosen CJ, Gal M, Soreq H and Orly J.
  TITLE     HP1BP3 expression determines maternal behavior and offspring
            survival
  JOURNAL   Genes Brain Behav 15 (7), 678-688 (2016)
   PUBMED   27470444
  REMARK    GeneRIF: Hp1bp3(-/-) females showed no deficits in behaviors often
            associated with impaired maternal care, including social behavior,
            depression, motor coordination and olfactory capability; and
            maintained unchanged anxiety-associated hallmarks such as
            cholinergic status and brain miRNA profiles. Results suggest a
            novel role for HP1BP3 in regulating maternal and anxiety-related
            behavior in mice
REFERENCE   6  (bases 1 to 4911)
  AUTHORS   Hadac JN, Miller DD, Grimes IC, Clipson L, Newton MA, Schelman WR
            and Halberg RB.
  TITLE     Heterochromatin Protein 1 Binding Protein 3 Expression as a
            Candidate Marker of Intrinsic 5-Fluorouracil Resistance
  JOURNAL   Anticancer Res 36 (3), 845-852 (2016)
   PUBMED   26976970
  REMARK    GeneRIF: Study identified Hp1bp3 overexpression as a potential
            novel marker for intrinsic 5-5-Fluorouracil resistance in colon
            cancer .
REFERENCE   7  (bases 1 to 4911)
  AUTHORS   Garfinkel BP, Arad S, Le PT, Bustin M, Rosen CJ, Gabet Y and Orly
            J.
  TITLE     Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1
            Binding Protein 3 (HP1BP3) Is Associated With Alterations in the
            Endocrine IGF-1 Pathway
  JOURNAL   Endocrinology 156 (12), 4558-4570 (2015)
   PUBMED   26402843
  REMARK    GeneRIF: HP1BP3 plays a key role in normal growth and bone
            development by regulating transcription of endocrine IGF-1
            components.
            GeneRIF: HP1BP3 regulates hepatic expression of IGF-1 and its
            binding proteins, thus regulating the endocrine IGF-1 pathway.
REFERENCE   8  (bases 1 to 4911)
  AUTHORS   Garfinkel BP, Melamed-Book N, Anuka E, Bustin M and Orly J.
  TITLE     HP1BP3 is a novel histone H1 related protein with essential roles
            in viability and growth
  JOURNAL   Nucleic Acids Res 43 (4), 2074-2090 (2015)
   PUBMED   25662603
  REMARK    GeneRIF: The results suggest that HP1BP3 is a ubiquitous histone H1
            like nuclear protein with distinct and non-redundant functions
            necessary for survival and growth.
REFERENCE   9  (bases 1 to 4911)
  AUTHORS   Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco
            G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T,
            Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T,
            Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ,
            Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A,
            Vescovi AL, Rossant J, Kunath T, Hogan BL, Curci A, D'Urso M, Kelso
            J, Hide W and Ko MS.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   10 (bases 1 to 4911)
  AUTHORS   Le Douarin B, Nielsen AL, Garnier JM, Ichinose H, Jeanmougin F,
            Losson R and Chambon P.
  TITLE     A possible involvement of TIF1 alpha and TIF1 beta in the
            epigenetic control of transcription by nuclear receptors
  JOURNAL   EMBO J 15 (23), 6701-6715 (1996)
   PUBMED   8978696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE994919.1, AK150784.1, AL807249.8, AK004938.1 and BI133236.1.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_001285478.2.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 4 all encode isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150784.1, ERR3363658.2308911.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                BE994919.1         200-296             c
            98-194              AK150784.1         84-180
            195-195             AL807249.8         6061-6061
            196-1222            AK150784.1         182-1208
            1223-1224           AL807249.8         18814-18815
            1225-3357           AK004938.1         1143-3275
            3358-4430           AL807249.8         27672-28744
            4431-4911           BI133236.1         1-481               c
FEATURES             Location/Qualifiers
     source          1..4911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..4911
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /note="heterochromatin protein 1, binding protein 3"
                     /db_xref="GeneID:15441"
                     /db_xref="MGI:MGI:109369"
     exon            1..188
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
     exon            189..386
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1955
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /codon_start=1
                     /product="heterochromatin protein 1-binding protein 3
                     isoform 1"
                     /protein_id="NP_001272407.1"
                     /db_xref="CCDS:CCDS38927.1"
                     /db_xref="GeneID:15441"
                     /db_xref="MGI:MGI:109369"
                     /translation="MATDMSQGELIHPKALPLIVGAQLIHADKLGEKAEDTTMPIRRA
                     VNSTRETPPKSKLAEGEEEKPEPDGSSEESISTVEEQENETPPATSSEAEQPKGEPES
                     GEKEENNNKSAEEPKKDEKDQSKEKEKKVKKTIPAWATLSASQLARAQRQTPMASSPR
                     PKMDAILTEAIKACFQKTGASVVAIRKYIIHKYPSLGLERRGYLLKQALKRELNRGVI
                     RQVKGKGASGSFVVVQKSKPPQKSKNRKKGSALDPEPQVKLEDVLPLAFTRLCEPKEA
                     SYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEK
                     PLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGANSNYQMHLLKKTLQKCE
                     KNGWLEQISGKGFSGTFQLSFPYYPSPGVLFPKKESGGSDDEDEDDDDDESSEDSEDE
                     EPPPKRSLQKKTPAKSQGKTASMKQRGSKPARKVPAAQRGKVRPLPKKAPPKAKTPAR
                     KARPSPSVIKKPSGSSSRKPIASARKEAKLPGKGKSAMKKSFKTKK"
     exon            387..486
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
     exon            487..646
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
     exon            647..806
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
     exon            807..950
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1028
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1180
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1271
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1431
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1543
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1660
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..4898
                     /gene="Hp1bp3"
                     /gene_synonym="Hp1bp74"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgggcagg ggggcggggc ggcagagctc ggtgcccggc ctggaggaca gcggtgtcgc
       61 gagtcggcga tcggtggtcc gcggcaacgc cgagaggccg tacgggaacg cgggcgccgg
      121 agctcagagg taacgcggga tggacccgga cccggcgcgc agggagtggg cgcgagctcc
      181 gtgcgcgagt tgactcttca ccacactgaa gccgttagga aaacaaacct tgtggttatc
      241 agcagagcct tcagagtttc accataactc aggcctagac attattctaa atggcaactg
      301 atatgtctca aggtgaactc atccatccta aggcactccc acttatagta ggagcgcagc
      361 tgatccacgc ggacaagtta ggtgagaaag cagaagatac caccatgcct atacgtcgag
      421 ccgtgaattc tacccgggaa actccaccca aaagcaaact tgctgaaggg gaggaagaaa
      481 aaccagaacc agatggaagt tcagaggaat ctatctctac tgtagaagaa caggagaatg
      541 agactccacc tgctacatcc agtgaggcag agcagcccaa gggggagcct gagagtggag
      601 agaaggaaga gaacaacaac aagtctgctg aggaacccaa aaaggatgag aaggatcagt
      661 ctaaagaaaa ggagaagaaa gtgaaaaaga cgattcctgc ctgggcgact ctctctgcca
      721 gccagctagc cagggcccag agacaaaccc ccatggcttc ctccccacgg cccaagatgg
      781 acgcaatctt aactgaggcc attaaggcat gcttccagaa gactggcgcc tcggtggttg
      841 cgattcgaaa gtacatcatt cataagtacc cgtctctggg tctggagaga aggggctatc
      901 tgctcaagca agcgctgaag agagagttaa acagaggagt catcagacag gtaaaaggaa
      961 aaggtgcatc tggcagtttt gttgtggtcc agaaatcaaa accacctcag aaatccaaaa
     1021 acagaaagaa gggctcggct ctggatccag aaccacaagt aaaactggaa gatgttctcc
     1081 cgttggcttt tactcggctc tgtgaaccta aagaagcttc ctacagtctc atcaggaaat
     1141 acgtgtctca gtattaccct aagctcagag tggacatcag gccccagttg ttgaagaatg
     1201 ctctgcagcg agcagtagag agaggccagc tcgagcagat aactggcaag ggtgcttcgg
     1261 ggacatttca gctgaagaaa tcaggggaga agcccctgct gggtggaagc ctgatggaat
     1321 atgcaatctt gtctgccatt gctgccatga acgagcctaa gacctgctcc accactgctc
     1381 tgaagaagta tgtcctggag aaccacccag gggccaactc taactatcag atgcatttgc
     1441 tgaaaaaaac cctgcagaaa tgtgagaaga acgggtggct ggagcagatc tctgggaagg
     1501 ggttcagcgg caccttccag ctgtccttcc cctactaccc tagcccagga gttctatttc
     1561 cgaagaaaga atccggtggc tctgacgatg aagatgaaga tgacgatgac gatgaatcat
     1621 cagaagactc tgaggatgag gaaccaccac ccaagaggag cttacagaag aaaacaccag
     1681 ccaagtccca agggaagaca gcctccatga agcagagagg gtcgaagcct gcgcggaaag
     1741 tcccggctgc ccagagaggg aaagtgaggc cgctgcctaa gaaagctcca cccaaggcca
     1801 agacccctgc caggaaagcc agaccctctc cctcagtcat caagaagcct agtgggagct
     1861 cctccagaaa gcccatagcc agtgcacgaa aggaagcgaa actgcccggg aagggcaaat
     1921 ctgccatgaa gaagtctttc aagacaaaaa agtaaatttt atagggaaaa gggtatcatg
     1981 attgaattca gaatcttact ttataaggtc agtgtgcatt tgttctagtt ataatgcttt
     2041 taaattgtac tttttcttcc catgtgagca ttgtgggaag gaatggacac agagcagcgt
     2101 agacatttgt gagcttcggt gctgttcagt gcctgcttct tcatcacctt aatttctgcc
     2161 ataacctgga cttcgctgac tgtgtgactg ccctgctccc tctgttcatc ttagccccag
     2221 ccctcgtcct ctttctgtga tccgattgag gattttttcc tccttcaagt taatttaaac
     2281 aactgcagag atgtgtttgt agagcactta gaggtctggg gctggaagtc cagacggcgc
     2341 aggagcagtg ttgggaaggc tttgcgtcct gcctgcagac ttgctagagc tgtggtgatt
     2401 aaccctggct gttgaatcac tccactgacc agtctccagc ttgagtcggg gacatgttaa
     2461 cttcggaaag aagcccccgt ccctgccatc ccatagattc tgaagggctc ctctcctccg
     2521 gtcacgctga ccaactgcca agctcgcttt gctgcccaga gcactgtccc ctcacagcaa
     2581 gcacaagttg tctgcaccac ttggtttctg actgaagggg aagtacagga ctacatggaa
     2641 tctgatttct ggtgttgctt attaccaaaa atgacagaat attcttgatc aaatgtctag
     2701 atatattttt aatatttggg gcatgagttg tccctgtttg agagttccca ttactaatgt
     2761 agaaatgtta aatggtaaaa cataatttgc taaaatgacc agttttcaga ttcacctgtg
     2821 cgtgtgcccc ccactcccat cccaccctgt tctttccata gaacttttga tatcaggcaa
     2881 acggtttcct ttttgagata ttttaacaga gaaggggtgg gggagaagca gatgaagctg
     2941 tactacccag ccctcttctt gtttgtattt gtttagggtt gtgaggttgt gtaaaatagt
     3001 actagcttct tacttgagaa ctacagtttc tgcttatcat ttattcttcc ttgtggcact
     3061 taatatttta attgtcttaa gctttttgat gtatatatcc tctggcccct tacatgctgc
     3121 cagaggagaa ggtgtttgtt tgagattcat tccacttgaa gtgtctcctg ggatccccac
     3181 agctgcgtat ggctgggaaa tggacttaag gcttgggctt gaattggtgg ctcctacctg
     3241 tgaggtccca tcgtgagtca ctgggatttg tgttgcatgg aaggcagtct ttcctgttgt
     3301 aaatcttcct tttttatgta caaatatttt gaaaaatatg aataaacatg aacttttaaa
     3361 agctgctgaa ctacagctta gtgaaaagtt tccagtacct gtcctgcaat ctctcctcct
     3421 gcaagggata ccatggcttc ctttttcttt tgagttctta ctttgatggt catttatttt
     3481 atatatatga gtacactgta gctgtcttca gacacaccag aagagggagt cagattccac
     3541 caaagagtca tcttaggggc tggagagatg gctcagcatt aagagcactg tctgctctaa
     3601 cagaggacct gggttcagtt cccagcatcc atatggtagc tcatatttgc ctctaacttc
     3661 agttccaggg tttctgacac tctcacacag acatacttgc agacaaagca ccaatgaaca
     3721 taaaataaaa gcaaacttgt tttttaagag agtcatcttg aggctgtggt ggcatacacc
     3781 tttagtcctg gcacttagga gtcagaagca ggctgatctc tgagttcaag gctaccctgg
     3841 tctttagagt gagtgacagc cagagaaacc ctgtctgaaa gaaagagggg gtgggggagg
     3901 gagggaggga gggaggagtc atctttattg aaaaactttt ctcaacatca taagagccta
     3961 gttttttgtt tttaattaac atacaaaatt caggttagac tggggaaaaa aatgacagca
     4021 cagttacaga cagtagccca ccacagagat ctctctctct agaaagcttg aattcctcat
     4081 atgtgtgcca gggactggtt actcataggg tattgttagc tacctgagcc aacaattctc
     4141 tgctcttatg gaatcaaaaa ttgcaggtcg gtttttctgt gttatacagt attgcttgta
     4201 cagaggtttg ctgactgctc agctggcccc tgccccatac atcagacact gtaacttgta
     4261 ctatgagaag ctggggtcat gtaaggtctc tctctctgct ctgaatgcgc cttaacaaaa
     4321 gtttagggta ggacagtctg ctttaacgtc ccaggaaagg taaagactgg atcactcagc
     4381 tccaaaggcc cagctgtcca acacatacac tttcatacct gacagagagg cttttgattt
     4441 ctgttttcat ctgtgcactc tgcagaagac atttacagac tttacttttg tgttaaatga
     4501 gaagagaaaa cgcaggaggt gggtgtctgg cctaatggtc tgtctggttt aatagtcttt
     4561 catagactct gaagtcgcct gctccaaagt ggttgaaaaa tgagtctctg aagatgctgg
     4621 aagcaaggtg gttggcttaa cttgtattct cagagactca ttattacttt attccgtagt
     4681 aatgtgataa aggcaaagtt tattagcaca ggttagacct agtccacatg agcataactg
     4741 caggaaatcg agtcctgtat acaccccaga aaggacaggc ttggtggccc atgcctgtca
     4801 aggcagcagt gggagctgtt tgcatcatgt ctgttgacaa tagtttgagt aatttatgga
     4861 aaaacaagat ctaaataaat gtaacccttg gatataaaaa aaaaaaaaaa a
//
