LOCUS       NM_017370               1365 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus haptoglobin (Hp), transcript variant 1, mRNA.
ACCESSION   NM_017370
VERSION     NM_017370.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1365)
  AUTHORS   Horakova,E., Vrbacky,M., Tesarova,M., Stribrna,E., Pilny,J.,
            Vavruskova,Z., Vancova,M., Sobotka,R., Lukes,J. and Perner,J.
  TITLE     Haptoglobin is dispensable for haemoglobin uptake by Trypanosoma
            brucei
  JOURNAL   Front Immunol 15, 1441131 (2024)
   PUBMED   39114668
  REMARK    GeneRIF: Haptoglobin is dispensable for haemoglobin uptake by
            Trypanosoma brucei.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1365)
  AUTHORS   Ramos,S., Jeney,V., Figueiredo,A., Paixao,T., Sambo,M.R.,
            Quinhentos,V., Martins,R., Gouveia,Z., Carlos,A.R., Ferreira,A.,
            Pais,T.F., Laine,H., Faisca,P., Rebelo,S., Cardoso,S., Tolosano,E.,
            Penha-Goncalves,C. and Soares,M.P.
  TITLE     Targeting circulating labile heme as a defense strategy against
            malaria
  JOURNAL   Life Sci Alliance 7 (4), e202302276 (2024)
   PUBMED   38307624
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1365)
  AUTHORS   Martinez,E.E., Lan,J., Konno,T., Miranda-Ribera,A., Fiorentino,M.,
            Mehta,N.M. and Fasano,A.
  TITLE     Novel role of zonulin in the pathophysiology of gastro-duodenal
            transit: a clinical and translational study
  JOURNAL   Sci Rep 11 (1), 22462 (2021)
   PUBMED   34789790
  REMARK    GeneRIF: Novel role of zonulin in the pathophysiology of
            gastro-duodenal transit: a clinical and translational study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1365)
  AUTHORS   Erdel,F., Rademacher,A., Vlijm,R., Tunnermann,J., Frank,L.,
            Weinmann,R., Schweigert,E., Yserentant,K., Hummert,J., Bauer,C.,
            Schumacher,S., Al Alwash,A., Normand,C., Herten,D.P., Engelhardt,J.
            and Rippe,K.
  TITLE     Mouse Heterochromatin Adopts Digital Compaction States without
            Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation
  JOURNAL   Mol Cell 78 (2), 236-249 (2020)
   PUBMED   32101700
  REMARK    GeneRIF: Mouse Heterochromatin Adopts Digital Compaction States
            without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase
            Separation.
REFERENCE   5  (bases 1 to 1365)
  AUTHORS   Kerchberger,V.E., Bastarache,J.A., Shaver,C.M., Nagata,H.,
            McNeil,J.B., Landstreet,S.R., Putz,N.D., Yu,W.K., Jesse,J.,
            Wickersham,N.E., Sidorova,T.N., Janz,D.R., Parikh,C.R., Siew,E.D.
            and Ware,L.B.
  TITLE     Haptoglobin-2 variant increases susceptibility to acute respiratory
            distress syndrome during sepsis
  JOURNAL   JCI Insight 4 (21), 131206 (2019)
   PUBMED   31573976
  REMARK    GeneRIF: Haptoglobin-2 variant increases susceptibility to acute
            respiratory distress syndrome during sepsis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1365)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   7  (bases 1 to 1365)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   8  (bases 1 to 1365)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   9  (bases 1 to 1365)
  AUTHORS   Spitkovsky,D.D., Royer-Pokora,B., Delius,H., Kisseljov,F.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Royer,H.D.
  TITLE     Tissue restricted expression and chromosomal localization of the
            YB-1 gene encoding a 42 kD nuclear CCAAT binding protein
  JOURNAL   Nucleic Acids Res 20 (4), 797-803 (1992)
   PUBMED   1542575
REFERENCE   10 (bases 1 to 1365)
  AUTHORS   Hatta,M., Miyatani,S., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Takeichi,M.
  TITLE     Genomic organization and chromosomal mapping of the mouse
            P-cadherin gene
  JOURNAL   Nucleic Acids Res 19 (16), 4437-4441 (1991)
   PUBMED   1886768
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125162.4, AK152698.1 and
            M96827.1.
            
            On Jul 30, 2009 this sequence version replaced NM_017370.1.
            
            Summary: This gene encodes a plasma glycoprotein called haptoglobin
            that binds free hemoglobin. The encoded preproprotein undergoes
            proteolytic processing to generate alpha and beta subunits that
            form a disulfide-linked tetrameric protein that plays an important
            role in the sequestration and clearance of extracorpuscular
            hemoglobin. Mice lacking the encoded protein exhibit stunted
            development of lymphoid organs associated with lower counts of
            mature T and B cells in the blood and secondary lymphoid
            compartments. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M96827.1, AK152698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC125162.4         87548-87655         c
            109-1343            AK152698.1         2-1236
            1344-1365           M96827.1           1234-1255
FEATURES             Location/Qualifiers
     source          1..1365
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.11 cM"
     gene            1..1365
                     /gene="Hp"
                     /gene_synonym="HP-1; preHP2"
                     /note="haptoglobin"
                     /db_xref="GeneID:15439"
                     /db_xref="MGI:MGI:96211"
     exon            1..163
                     /gene="Hp"
                     /gene_synonym="HP-1; preHP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1202
                     /gene="Hp"
                     /gene_synonym="HP-1; preHP2"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; zonulin"
                     /codon_start=1
                     /product="haptoglobin isoform 1 preproprotein"
                     /protein_id="NP_059066.1"
                     /db_xref="CCDS:CCDS40470.1"
                     /db_xref="GeneID:15439"
                     /db_xref="MGI:MGI:96211"
                     /translation="MRALGAVVTLLLWGQLFAVELGNDAMDFEDDSCPKPPEIANGYV
                     EHLVRYRCRQFYRLRAEGDGVYTLNDEKQWVNTVAGEKLPECEAVCGKPKHPVDQVQR
                     IIGGSMDAKGSFPWQAKMISRHGLTTGATLISDQWLLTTAKNLFLNHSETASAKDITP
                     TLTLYVGKNQLVEIEKVVLHPNHSVVDIGLIKLKQRVLVTERVMPICLPSKDYIAPGR
                     VGYVSGWGRNANFRFTDRLKYVMLPVADQDKCVVHYENSTVPEKKNLTSPVGVQPILN
                     EHTFCAGLTKYQEDTCYGDAGSAFAIHDMEEDTWYAAGILSFDKSCAVAEYGVYVRAT
                     DLKDWVQETMAKN"
     exon            164..246
                     /gene="Hp"
                     /gene_synonym="HP-1; preHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            247..348
                     /gene="Hp"
                     /gene_synonym="HP-1; preHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..423
                     /gene="Hp"
                     /gene_synonym="HP-1; preHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..1345
                     /gene="Hp"
                     /gene_synonym="HP-1; preHP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1320..1325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hp"
                     /gene_synonym="HP-1; preHP2"
                     /note="hexamer: AATAAA"
     polyA_site      1344
                     /gene="Hp"
                     /gene_synonym="HP-1; preHP2"
                     /note="major polyA site"
ORIGIN      
        1 tgcaaacaca gaaatggagg aggaggggaa ggaggaggag gaggagaagg aggaggaggt
       61 ggtggtggtg gtggtgggat aaaacccctg aggcataaag ggctcggccg gagtcagcac
      121 agcccagccc ttccagagag aggcaagaga ggtccacgat gagagccctg ggagctgttg
      181 tcactctcct gctctggggt cagctttttg ctgtggagtt gggcaatgat gccatggact
      241 ttgaagatga cagctgccca aagcccccag agattgcaaa cggctatgtg gagcacttgg
      301 ttcgctatcg ctgccgacag ttctacagac tacgggccga aggagatggg gtgtacacct
      361 taaacgacga gaagcaatgg gtgaacacag tcgctggaga gaaactcccc gaatgtgagg
      421 cagtgtgtgg gaagcccaag caccctgtgg accaggtgca gcgcatcatc ggtggctcta
      481 tggatgccaa aggcagcttt ccttggcagg ccaagatgat ctcccgccac ggactcacca
      541 ccggggccac gttgatcagt gaccagtggc tgctgaccac ggccaaaaac ctcttcctga
      601 accacagcga gacggcgtca gccaaggaca tcacccccac cctaacgctc tacgtgggga
      661 aaaaccagct ggtggagatt gagaaggtcg ttctccaccc caaccactcc gtggtggata
      721 tcgggctaat caaactcaag cagagggtgc ttgtaaccga gagagtcatg cctatctgcc
      781 tgccttccaa agactacata gcaccaggcc gtgtgggcta cgtgtctggc tgggggcgga
      841 acgccaactt tagatttacc gatcgtctca agtatgtcat gctgcctgtg gccgaccagg
      901 acaagtgtgt ggtgcactat gagaatagta cagtgcccga gaagaaaaac ttgacgagtc
      961 ccgttggggt ccagcctatc ttgaacgagc acaccttctg tgctggcctc accaagtacc
     1021 aggaagacac ctgctacggt gacgccggca gtgcctttgc cattcatgac atggaggagg
     1081 acacctggta cgcagctggg atcctgagct ttgacaagag ctgcgctgtc gctgagtatg
     1141 gtgtgtacgt gagggcgacc gacctgaagg actgggttca ggaaaccatg gccaagaact
     1201 agttcagggc tcactagaag gctgcacatg gcagggcagg ctgggagcca tggaagaggg
     1261 ggaagtggaa gggttgggct atactctgat gggttctagc cctgcactgc tcagtcaaca
     1321 ataaaaaaat gtgctttgga cccataaaaa aaaaaaaaaa aaaaa
//
