LOCUS       NM_008276               2193 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox D8 (Hoxd8), transcript variant 1, mRNA.
ACCESSION   NM_008276 XM_355338 XM_912169 XM_994637
VERSION     NM_008276.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2193)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2193)
  AUTHORS   Yang,Y., Zhang,M., Zhao,Y., Deng,T., Zhou,X., Qian,H., Wang,M.,
            Zhang,C., Huo,Z., Mao,Z., Shao,Z., Liu,M., Yang,C., Lin,C., Xu,F.,
            Tian,G. and Zhang,Y.
  TITLE     HOXD8 suppresses renal cell carcinoma growth by upregulating SHMT1
            expression
  JOURNAL   Cancer Sci 114 (12), 4583-4595 (2023)
   PUBMED   37752684
  REMARK    GeneRIF: HOXD8 suppresses renal cell carcinoma growth by
            upregulating SHMT1 expression.
REFERENCE   3  (bases 1 to 2193)
  AUTHORS   Hintermann,A., Guerreiro,I., Lopez-Delisle,L., Bolt,C.C., Gitto,S.,
            Duboule,D. and Beccari,L.
  TITLE     Developmental and evolutionary comparative analysis of a regulatory
            landscape in mouse and chicken
  JOURNAL   Development 149 (12) (2022)
   PUBMED   35770682
REFERENCE   4  (bases 1 to 2193)
  AUTHORS   Amandio,A.R., Beccari,L., Lopez-Delisle,L., Mascrez,B., Zakany,J.,
            Gitto,S. and Duboule,D.
  TITLE     Sequential in cis mutagenesis in vivo reveals various functions for
            CTCF sites at the mouse HoxD cluster
  JOURNAL   Genes Dev 35 (21-22), 1490-1509 (2021)
   PUBMED   34711654
REFERENCE   5  (bases 1 to 2193)
  AUTHORS   Higashijima,Y., Nagai,N., Yamamoto,M., Kitazawa,T., Kawamura,Y.K.,
            Taguchi,A., Nakada,N., Nangaku,M., Furukawa,T., Aburatani,H.,
            Kurihara,H., Wada,Y. and Kanki,Y.
  TITLE     Lysine demethylase 7a regulates murine anterior-posterior
            development by modulating the transcription of Hox gene cluster
  JOURNAL   Commun Biol 3 (1), 725 (2020)
   PUBMED   33257809
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2193)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2193)
  AUTHORS   Nazarali,A., Kim,Y. and Nirenberg,M.
  TITLE     Hox-1.11 and Hox-4.9 homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2883-2887 (1992)
   PUBMED   1348361
REFERENCE   8  (bases 1 to 2193)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   9  (bases 1 to 2193)
  AUTHORS   Zappavigna,V., Renucci,A., Izpisua-Belmonte,J.C., Urier,G.,
            Peschle,C. and Duboule,D.
  TITLE     HOX4 genes encode transcription factors with potential auto- and
            cross-regulatory capacities
  JOURNAL   EMBO J 10 (13), 4177-4187 (1991)
   PUBMED   1756725
REFERENCE   10 (bases 1 to 2193)
  AUTHORS   Sadoul,R. and Featherstone,M.S.
  TITLE     Sequence analysis of the homeobox-containing exon of the murine
            Hox-4.3 homeogene
  JOURNAL   Biochim Biophys Acta 1089 (2), 259-261 (1991)
   PUBMED   1675873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928644.12.
            
            On Jan 13, 2022 this sequence version replaced NM_008276.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016033.1, BY715614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-773               AL928644.12        190278-191050
            774-2193            AL928644.12        191446-192865
FEATURES             Location/Qualifiers
     source          1..2193
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 44.13 cM"
     gene            1..2193
                     /gene="Hoxd8"
                     /gene_synonym="4921540P06Rik; Hox-4.3; Hox-5.4"
                     /note="homeobox D8"
                     /db_xref="GeneID:15437"
                     /db_xref="MGI:MGI:96209"
     exon            1..773
                     /gene="Hoxd8"
                     /gene_synonym="4921540P06Rik; Hox-4.3; Hox-5.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1072
                     /gene="Hoxd8"
                     /gene_synonym="4921540P06Rik; Hox-4.3; Hox-5.4"
                     /note="isoform a is encoded by transcript variant 1;
                     homeobox protein Hox-D8; homeobox protein Hox-4.3;
                     homeobox protein Hox-5.4; homeo box D8"
                     /codon_start=1
                     /product="homeobox protein Hox-D8 isoform a"
                     /protein_id="NP_032302.2"
                     /db_xref="CCDS:CCDS16143.1"
                     /db_xref="GeneID:15437"
                     /db_xref="MGI:MGI:96209"
                     /translation="MSSYFVNPLYSKYKAAAAAAAAAAAAAAGEAINPTYYDCHFAPE
                     VSGRHAAALQLYGNSAAGFPHAHPHPHPHPSPPPGCGGGGGPGPGQDYFHAGAGSPTA
                     AYQAAPPPPHPPPPPPPPPCGGIACHGEPAKFYGYDNLQRQPIFTTQQEAELVQYPDC
                     KSSSGNIGEDPDHLNQSSSPSQMFPWMRPQAAPGRRRGRQTYSRFQTLELEKEFLFNP
                     YLTRKRRIEVSHTLALTERQVKIWFQNRRMKWKKENNKDKFPASRPEAKDGDPKKEVS
                     GLEEDGAEGCPTN"
     exon            774..2193
                     /gene="Hoxd8"
                     /gene_synonym="4921540P06Rik; Hox-4.3; Hox-5.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2170..2175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxd8"
                     /gene_synonym="4921540P06Rik; Hox-4.3; Hox-5.4"
                     /note="hexamer: AATAAA"
     polyA_site      2193
                     /gene="Hoxd8"
                     /gene_synonym="4921540P06Rik; Hox-4.3; Hox-5.4"
                     /note="major polyA site"
ORIGIN      
        1 gagacggagg cgcgagagcc aggcatgagc ggccggcggc cggacggtcg agcctgagcg
       61 gggcggggga agcgctcgcc gggcgacgag gcccggcggc ccccgcgggc tcgagtgagc
      121 cgccccagag gcccccgcgg cggcgcgacc gagctgaggc gcgcccctta ccggctccgc
      181 gccgccggcg gccgccgccc cgatgagctc gtacttcgtg aacccgctgt actccaagta
      241 caaggcggcg gccgcggcgg cggcggcggc tgcggcggcc gcggcgggcg aggccatcaa
      301 tcccacttac tacgactgtc attttgcacc cgaggtcagc ggccgccacg ccgccgccct
      361 gcagctctat ggcaacagcg ccgccggctt cccgcacgcg cacccgcacc cgcacccgca
      421 cccgtcgccg ccgcccgggt gcggcggagg gggcggcccg gggcccggcc aggactactt
      481 ccacgccggc gcgggcagcc cgaccgctgc ctaccaggcc gccccacctc ctccgcaccc
      541 tccgcctccg ccgccgcctc ccccctgcgg cgggattgcc tgtcacgggg agcccgcgaa
      601 gttttacgga tacgataact tacagagaca gccgattttt acgacccagc aagaggccga
      661 gctggtacaa tatcctgact gtaaatcgtc cagtggtaat attggcgagg acccagacca
      721 cttaaatcag agctcgtctc cttctcaaat gtttccctgg atgagaccac aagcagctcc
      781 tggtagacgg agaggaagac aaacctacag tcgcttccaa accctagagt tggaaaagga
      841 attccttttt aacccttatc tgaccaggaa gaggagaatc gaggtctccc atactctggc
      901 cctcacggag agacaggtaa aaatctggtt ccagaacagg agaatgaaat ggaaaaagga
      961 gaacaacaaa gacaagtttc ctgcgtcccg gccggaggca aaggatggag accccaaaaa
     1021 ggaagtctcg gggctggaag aagacggagc tgaaggctgc cccacaaatt aaactctacc
     1081 tttacacttc taccacagac tattaagact gatgatcagt ataagtatat actggtggac
     1141 accaccggtc ctccctcttg tgttttggaa acggacttta cctgtgtttc aagctacctt
     1201 aatgtcactg ctcttgaggt ttctgcgctt tgaaagggat ttctgtgttt ttaaagagaa
     1261 tagtttgtag tatcgcatag aagcagtcct tgagctgtcc tatagaaggg taatttgata
     1321 cggaccttgt ggctatattt ttataatggt aatttttaac gtctgagctg gtggtttgcc
     1381 tcaacaacat aaacttccta atgatcagcg ctagatgatt gaatataaaa tgctttatta
     1441 atcaaacaag tgcacttgaa cattttaaat ctttatggtg agtaaattaa aagaagttta
     1501 ttaataatgt ttttaaaaat tatgcctgca gaatatttac tttattattt gattaaatgt
     1561 attatttata tttttctttc tgcttttgta acgatggttc aggtgtcttc tggctcactt
     1621 ccaggaggtt tctttgagca tttttgtaaa tgtttgtcag ggaagagtct gggccaaata
     1681 ttggaaaagc acattagctg aagagtgcaa tgtattgtcc aggctgccga ttccttaaac
     1741 ttgggagagt gttgtccagt gacaggagtt tgaggataat gtcaaagtcg acatttagtt
     1801 gggcttctgt agtccataca aattatggcc attgaataat ctagagaatt aatacttgaa
     1861 aactaattgc aatattttca ctaactattc attctggcaa gtggccttgc tttctttttg
     1921 aaccctgctt gtaatggcct ggggtttcta ggtctcgatg ctctgtgttt ctgctttgtc
     1981 aagtaggtgc catattcatt gtatccttct tgcactgctc ctgtgctccc gtgttgtaag
     2041 ccagcttgct gtatgcatct cagatgtcgg ttggtacgtc caccctctgc tgttcttcag
     2101 gaaatccgtg gcctcacaga ttggaaatga gccctgagtg taaacagccg ctccagagca
     2161 tagctcctta ataaagagat gtacctccat aaa
//
