LOCUS       NM_010468               2902 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus homeobox D3 (Hoxd3), mRNA.
ACCESSION   NM_010468
VERSION     NM_010468.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2902)
  AUTHORS   Hintermann,A., Guerreiro,I., Lopez-Delisle,L., Bolt,C.C., Gitto,S.,
            Duboule,D. and Beccari,L.
  TITLE     Developmental and evolutionary comparative analysis of a regulatory
            landscape in mouse and chicken
  JOURNAL   Development 149 (12) (2022)
   PUBMED   35770682
REFERENCE   2  (bases 1 to 2902)
  AUTHORS   Zhang,M., Du,S., Ou,H., Cui,R., Jiang,N., Lin,Y., Ge,R., Ma,D. and
            Zhang,J.
  TITLE     Ablation of Zfhx4 results in early postnatal lethality by
            disrupting the respiratory center in mice
  JOURNAL   J Mol Cell Biol 13 (3), 210-224 (2021)
   PUBMED   33475140
REFERENCE   3  (bases 1 to 2902)
  AUTHORS   Lopez-Delgado,A.C., Delgado,I., Cadenas,V., Sanchez-Cabo,F. and
            Torres,M.
  TITLE     Axial skeleton anterior-posterior patterning is regulated through
            feedback regulation between Meis transcription factors and retinoic
            acid
  JOURNAL   Development 148 (1) (2021)
   PUBMED   33298461
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2902)
  AUTHORS   Higashijima,Y., Nagai,N., Yamamoto,M., Kitazawa,T., Kawamura,Y.K.,
            Taguchi,A., Nakada,N., Nangaku,M., Furukawa,T., Aburatani,H.,
            Kurihara,H., Wada,Y. and Kanki,Y.
  TITLE     Lysine demethylase 7a regulates murine anterior-posterior
            development by modulating the transcription of Hox gene cluster
  JOURNAL   Commun Biol 3 (1), 725 (2020)
   PUBMED   33257809
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2902)
  AUTHORS   Sato,T., Kataoka,K., Ito,Y., Yokoyama,S., Inui,M., Mori,M.,
            Takahashi,S., Akita,K., Takada,S., Ueno-Kudoh,H. and Asahara,H.
  TITLE     Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation
            during axial patterning in vertebrates
  JOURNAL   Elife 9, e53608 (2020)
   PUBMED   32479258
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2902)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2902)
  AUTHORS   Orr-Urtreger,A., Bedford,M.T., Do,M.S., Eisenbach,L. and Lonai,P.
  TITLE     Developmental expression of the alpha receptor for platelet-derived
            growth factor, which is deleted in the embryonic lethal Patch
            mutation
  JOURNAL   Development 115 (1), 289-303 (1992)
   PUBMED   1322271
REFERENCE   8  (bases 1 to 2902)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   9  (bases 1 to 2902)
  AUTHORS   Hunt,P., Gulisano,M., Cook,M., Sham,M.H., Faiella,A., Wilkinson,D.,
            Boncinelli,E. and Krumlauf,R.
  TITLE     A distinct Hox code for the branchial region of the vertebrate head
  JOURNAL   Nature 353 (6347), 861-864 (1991)
   PUBMED   1682814
REFERENCE   10 (bases 1 to 2902)
  AUTHORS   Siracusa,L.D., Alvord,W.G., Bickmore,W.A., Jenkins,N.A. and
            Copeland,N.G.
  TITLE     Interspecific backcross mice show sex-specific differences in
            allelic inheritance
  JOURNAL   Genetics 128 (4), 813-821 (1991)
   PUBMED   1916246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138525.1 and AK133705.1.
            
            On Mar 2, 2007 this sequence version replaced NM_010468.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2036              AK138525.1         2-2037
            2037-2546           AK133705.1         1905-2414
            2547-2902           AK138525.1         2548-2903
FEATURES             Location/Qualifiers
     source          1..2902
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 44.13 cM"
     gene            1..2902
                     /gene="Hoxd3"
                     /gene_synonym="Hox-4.1; Hox-5.5"
                     /note="homeobox D3"
                     /db_xref="GeneID:15434"
                     /db_xref="MGI:MGI:96207"
     exon            1..324
                     /gene="Hoxd3"
                     /gene_synonym="Hox-4.1; Hox-5.5"
                     /inference="alignment:Splign:2.1.0"
     exon            325..952
                     /gene="Hoxd3"
                     /gene_synonym="Hox-4.1; Hox-5.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..1710
                     /gene="Hoxd3"
                     /gene_synonym="Hox-4.1; Hox-5.5"
                     /note="homeo box D4; homeobox protein MH-19; homeobox
                     protein Hox-4.1; homeo box D3"
                     /codon_start=1
                     /product="homeobox protein Hox-D3"
                     /protein_id="NP_034598.2"
                     /db_xref="CCDS:CCDS38149.1"
                     /db_xref="GeneID:15434"
                     /db_xref="MGI:MGI:96207"
                     /translation="MLFEQGQLTLELPECTMQKAAYYENPGLFGGYGYSKATDTYGYS
                     TPHQPYPPPAAANSLDSDYPSSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGG
                     GGNQPPGLNSEQQPPQPPPPPPPTLPPSSPTNPGSGVPAKKTKGGLSASSSSSTISKQ
                     IFPWMKESRQNSKQKNSCATSGENCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNR
                     YLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILHSPAGQSPERSPPLGG
                     AAGHVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAYTAPLSSCLPQQKRYPAPE
                     FEPHPMASNGGGFASANLQGSPVYVGGNFVDSMAPTSGPVFNLGHLSHPSSASVDYSC
                     AAQIPGNHHHGPCDPHPTYTDLSAHHSSQGRLPEAPKLTHL"
     exon            953..2902
                     /gene="Hoxd3"
                     /gene_synonym="Hox-4.1; Hox-5.5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2525..2530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxd3"
                     /gene_synonym="Hox-4.1; Hox-5.5"
                     /note="hexamer: AATAAA"
     polyA_site      2549
                     /gene="Hoxd3"
                     /gene_synonym="Hox-4.1; Hox-5.5"
                     /note="major polyA site"
ORIGIN      
        1 ctagtcgccg gctgcgggat cgcgtggtcc gcagcggcct gggctcccgc cgcgactcca
       61 ccgcagctcg cccccggtcg cgattgcggc cgcttccaga gccggcgggg agcccggaag
      121 gagccccggg cgccgagcca ccagccgcct ctcacactcc agcagggagc cgaccgcctg
      181 cttcaaccct ggtcccgagc ttcctacccg atccctccag caacatgagc ccaaacctgc
      241 cgaggatggt gagcgcagcc gggcagcgcc ggatggattc cagccacagt ccgggccgac
      301 cgcccgcagt tcggcaccct ccgggttacc tggagcctga gagctggccc agctctctca
      361 agattcagca gacattggcc ttggaggaga aggagaccgt ggtagtcaat gttatttgag
      421 cagggtcagc tgaccctgga acttcctgag tgcaccatgc agaaggctgc atactacgag
      481 aacccaggac tctttggagg ctacggatat agcaaagcca ctgacacata tggctacagc
      541 actcctcatc agccttaccc accccctgct gctgccaact ccctggacag tgattaccca
      601 agttctgcct gctccatcca gagctctgca cctctccgag ccccagccca caaaggagct
      661 gaactcaatg gtagctgtat gagacctggc actgggaata gccagggtgg aggtggtggc
      721 aaccaacccc ctggtctgaa ctcagagcag cagccaccac aacctcctcc tccaccacca
      781 cccaccttgc ccccatcttc acctaccaat cctggaagtg gagtgcctgc caagaagacc
      841 aagggtggac tcagtgcttc tagctcttca tccaccatca gcaaacagat cttcccctgg
      901 atgaaagaat cccgacagaa ctccaagcag aagaacagct gtgccacttc aggagagaac
      961 tgtgaggaca agagcccacc cggcccagca tccaagaggg tgcgcacggc gtacacgagt
     1021 gctcagctgg tggagctgga gaaggagttc cacttcaacc gctatctgtg ccggccgcgc
     1081 cgcgtggaga tggccaacct gctgaacctc accgaacgcc agatcaagat ctggttccag
     1141 aaccgtcgca tgaagtacaa gaaggaccag aaggctaagg gcatcctgca ttctccagcc
     1201 ggtcagtccc cggagcgcag cccacctctt ggaggagcgg cgggccacgt ggcttactcc
     1261 ggccagctgc cgccggtgcc cggcctggcc tacgacgcac cctcgccgcc cgctttcgcc
     1321 aaatcgcagc ccaatatgta cggcctggcc gcctacacgg cgccgctcag cagctgcctg
     1381 cctcagcaga agcggtaccc ggcgcccgag ttcgagcctc accccatggc gagcaacggc
     1441 ggcggcttcg ccagcgccaa cctgcagggc agcccggtgt acgtgggcgg caacttcgtc
     1501 gactccatgg cgcccacgtc cgggccggtc ttcaatctgg gccacctctc gcacccgtct
     1561 tcggccagcg tggactacag ttgcgccgcg caaatccctg gcaaccatca ccacggaccc
     1621 tgcgaccctc atcccaccta cacagatctc tcggctcacc actcgtctca gggacgcctg
     1681 cccgaggccc ccaaactgac acatctgtag ctgttgccgc cggccaggcg caattacctc
     1741 tctggttttg gtggcagagg tggtggtggg gcggggcggg gcccgagggg cagtttaggg
     1801 gatccccctc cctgatctgg cctggcggat gcctcacgag tggcttccag cggccagggc
     1861 tgacgcgact gggcctccct ccaggcgcgt cctcctttgg gtgactcgcc ataaatcagc
     1921 cgcaaggatc ctccccagta aacctgacag tgccataaac tgcggaccga gggactctaa
     1981 tctggtaatg gtgtccctaa ggtaagtcct cgacccatcc gtggcgagtc ctgaagaggg
     2041 actagggcct ggagaaccct gggcctggcc cttctgtcta gcttagtttc agagacctta
     2101 atttataatg ctccgtcccc tcctgtaaag attgcatcgg actaaacaat ctgtatttat
     2161 tatttgaagc gagtaatttc gtttccctga ttatttatcc tcgtcttaat gtatttatgt
     2221 gtatatttgt agaattctga ggctgggcct aggtacacgc tcccaggcct tgggggggcc
     2281 acttttcacc tctttagtcc ccttggtctg aactagttga gaggatagtt ttgaacagtt
     2341 gtaaccatgg ctggtgtctg tagttgatgt taaaggattg agatcacaaa tggtccttca
     2401 tgggtagagt caggcagccc ggtggcagga ctcacgctag tcgtttctca acagccgaag
     2461 ccctcaccac tcgacacagc ttattgattt caaattgtct ggtactattt gaacaaacat
     2521 ttagaataaa accttttttt cagttggaag tgtatctgtg ttaatcgcac acatctgcaa
     2581 gcagatcact ctgtcttcat ccctctgtat gatcccgggt tgggggaaaa ggaccctctg
     2641 aaacatttta tttattcgga acctattgca caaaattggc gtggagaaat acttgattac
     2701 atttaagctc ttaaaactga gcggcagtaa ttggaggatg caaactcgat atcacctaag
     2761 tggggggcag tcgcaatagg attttgccag agcagcgcct gcatgctctt tctatacatg
     2821 atcgtcacat gggcgggtgt gtgttcattt tttctgcatt aaataataaa aaaataaact
     2881 ttggggaaaa accctgacaa tc
//
