LOCUS       NP_034598                433 aa            linear   ROD 02-JUN-2024
DEFINITION  homeobox protein Hox-D3 [Mus musculus].
ACCESSION   NP_034598
VERSION     NP_034598.2
DBSOURCE    REFSEQ: accession NM_010468.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 433)
  AUTHORS   Hintermann,A., Guerreiro,I., Lopez-Delisle,L., Bolt,C.C., Gitto,S.,
            Duboule,D. and Beccari,L.
  TITLE     Developmental and evolutionary comparative analysis of a regulatory
            landscape in mouse and chicken
  JOURNAL   Development 149 (12) (2022)
   PUBMED   35770682
REFERENCE   2  (residues 1 to 433)
  AUTHORS   Zhang,M., Du,S., Ou,H., Cui,R., Jiang,N., Lin,Y., Ge,R., Ma,D. and
            Zhang,J.
  TITLE     Ablation of Zfhx4 results in early postnatal lethality by
            disrupting the respiratory center in mice
  JOURNAL   J Mol Cell Biol 13 (3), 210-224 (2021)
   PUBMED   33475140
REFERENCE   3  (residues 1 to 433)
  AUTHORS   Lopez-Delgado,A.C., Delgado,I., Cadenas,V., Sanchez-Cabo,F. and
            Torres,M.
  TITLE     Axial skeleton anterior-posterior patterning is regulated through
            feedback regulation between Meis transcription factors and retinoic
            acid
  JOURNAL   Development 148 (1) (2021)
   PUBMED   33298461
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 433)
  AUTHORS   Higashijima,Y., Nagai,N., Yamamoto,M., Kitazawa,T., Kawamura,Y.K.,
            Taguchi,A., Nakada,N., Nangaku,M., Furukawa,T., Aburatani,H.,
            Kurihara,H., Wada,Y. and Kanki,Y.
  TITLE     Lysine demethylase 7a regulates murine anterior-posterior
            development by modulating the transcription of Hox gene cluster
  JOURNAL   Commun Biol 3 (1), 725 (2020)
   PUBMED   33257809
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 433)
  AUTHORS   Sato,T., Kataoka,K., Ito,Y., Yokoyama,S., Inui,M., Mori,M.,
            Takahashi,S., Akita,K., Takada,S., Ueno-Kudoh,H. and Asahara,H.
  TITLE     Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation
            during axial patterning in vertebrates
  JOURNAL   Elife 9, e53608 (2020)
   PUBMED   32479258
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 433)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (residues 1 to 433)
  AUTHORS   Orr-Urtreger,A., Bedford,M.T., Do,M.S., Eisenbach,L. and Lonai,P.
  TITLE     Developmental expression of the alpha receptor for platelet-derived
            growth factor, which is deleted in the embryonic lethal Patch
            mutation
  JOURNAL   Development 115 (1), 289-303 (1992)
   PUBMED   1322271
REFERENCE   8  (residues 1 to 433)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   9  (residues 1 to 433)
  AUTHORS   Hunt,P., Gulisano,M., Cook,M., Sham,M.H., Faiella,A., Wilkinson,D.,
            Boncinelli,E. and Krumlauf,R.
  TITLE     A distinct Hox code for the branchial region of the vertebrate head
  JOURNAL   Nature 353 (6347), 861-864 (1991)
   PUBMED   1682814
REFERENCE   10 (residues 1 to 433)
  AUTHORS   Siracusa,L.D., Alvord,W.G., Bickmore,W.A., Jenkins,N.A. and
            Copeland,N.G.
  TITLE     Interspecific backcross mice show sex-specific differences in
            allelic inheritance
  JOURNAL   Genetics 128 (4), 813-821 (1991)
   PUBMED   1916246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138525.1 and AK133705.1.
            
            On Mar 2, 2007 this sequence version replaced NP_034598.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 44.13 cM"
     Protein         1..433
                     /product="homeobox protein Hox-D3"
                     /note="homeo box D4; homeobox protein MH-19; homeobox
                     protein Hox-4.1; homeo box D3"
                     /calculated_mol_wt=45845
     Region          44..198
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P09027.4)"
     Region          161..166
                     /region_name="Antp-type hexapeptide"
                     /note="propagated from UniProtKB/Swiss-Prot (P09027.4)"
     Region          196..252
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          258..280
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P09027.4)"
     Region          370..431
                     /region_name="DUF4074"
                     /note="Domain of unknown function (DUF4074); pfam13293"
                     /db_xref="CDD:463833"
     Region          401..433
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P09027.4)"
     CDS             1..433
                     /gene="Hoxd3"
                     /gene_synonym="Hox-4.1; Hox-5.5"
                     /coded_by="NM_010468.2:409..1710"
                     /db_xref="CCDS:CCDS38149.1"
                     /db_xref="GeneID:15434"
                     /db_xref="MGI:MGI:96207"
ORIGIN      
        1 mlfeqgqltl elpectmqka ayyenpglfg gygyskatdt ygystphqpy pppaaansld
       61 sdypssacsi qssaplrapa hkgaelngsc mrpgtgnsqg ggggnqppgl nseqqppqpp
      121 ppppptlpps sptnpgsgvp akktkgglsa ssssstiskq ifpwmkesrq nskqknscat
      181 sgencedksp pgpaskrvrt aytsaqlvel ekefhfnryl crprrveman llnlterqik
      241 iwfqnrrmky kkdqkakgil hspagqsper spplggaagh vaysgqlppv pglaydapsp
      301 pafaksqpnm yglaaytapl ssclpqqkry papefephpm asngggfasa nlqgspvyvg
      361 gnfvdsmapt sgpvfnlghl shpssasvdy scaaqipgnh hhgpcdphpt ytdlsahhss
      421 qgrlpeapkl thl
//
