LOCUS       NM_008274               2534 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus homeobox D12 (Hoxd12), mRNA.
ACCESSION   NM_008274
VERSION     NM_008274.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2534)
  AUTHORS   Charng,W.L., Nikolov,M., Shrestha,I., Seeley,M.A., Josyula,N.S.,
            Justice,A.E., Dobbs,M.B. and Gurnett,C.A.
  TITLE     Exome sequencing of 1190 non-syndromic clubfoot cases reveals
            HOXD12 as a novel disease gene
  JOURNAL   J Med Genet 61 (7), 699-706 (2024)
   PUBMED   38663984
  REMARK    GeneRIF: Exome sequencing of 1190 non-syndromic clubfoot cases
            reveals HOXD12 as a novel disease gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2534)
  AUTHORS   Chen,Y., Zhou,T., Liao,Z., Gao,W., Wu,J., Zhang,S., Li,Y., Liu,H.,
            Zhou,H., Xu,C. and Su,P.
  TITLE     Hnrnpk is essential for embryonic limb bud development as a
            transcription activator and a collaborator of insulator protein
            Ctcf
  JOURNAL   Cell Death Differ 30 (10), 2293-2308 (2023)
   PUBMED   37608075
REFERENCE   3  (bases 1 to 2534)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   4  (bases 1 to 2534)
  AUTHORS   Chang,Y.C., Manent,J., Schroeder,J., Wong,S.F.L., Hauswirth,G.M.,
            Shylo,N.A., Moore,E.L., Achilleos,A., Garside,V., Polo,J.M.,
            Trainor,P. and McGlinn,E.
  TITLE     Nr6a1 controls Hox expression dynamics and is a master regulator of
            vertebrate trunk development
  JOURNAL   Nat Commun 13 (1), 7766 (2022)
   PUBMED   36522318
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2534)
  AUTHORS   Bolt,C.C., Lopez-Delisle,L., Hintermann,A., Mascrez,B., Rauseo,A.,
            Andrey,G. and Duboule,D.
  TITLE     Context-dependent enhancer function revealed by targeted inter-TAD
            relocation
  JOURNAL   Nat Commun 13 (1), 3488 (2022)
   PUBMED   35715427
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2534)
  AUTHORS   Chan,D.C., Wynshaw-Boris,A. and Leder,P.
  TITLE     Formin isoforms are differentially expressed in the mouse embryo
            and are required for normal expression of fgf-4 and shh in the limb
            bud
  JOURNAL   Development 121 (10), 3151-3162 (1995)
   PUBMED   7588050
REFERENCE   7  (bases 1 to 2534)
  AUTHORS   Dolle,P., Izpisua-Belmonte,J.C., Boncinelli,E. and Duboule,D.
  TITLE     The Hox-4.8 gene is localized at the 5' extremity of the Hox-4
            complex and is expressed in the most posterior parts of the body
            during development
  JOURNAL   Mech Dev 36 (1-2), 3-13 (1991)
   PUBMED   1685889
REFERENCE   8  (bases 1 to 2534)
  AUTHORS   Izpisua-Belmonte,J.C., Falkenstein,H., Dolle,P., Renucci,A. and
            Duboule,D.
  TITLE     Murine genes related to the Drosophila AbdB homeotic genes are
            sequentially expressed during development of the posterior part of
            the body
  JOURNAL   EMBO J 10 (8), 2279-2289 (1991)
   PUBMED   1676674
REFERENCE   9  (bases 1 to 2534)
  AUTHORS   Duboule,D., Boncinelli,E., DeRobertis,E., Featherstone,M.,
            Lonai,P., Oliver,G. and Ruddle,F.H.
  TITLE     An update of mouse and human HOX gene nomenclature
  JOURNAL   Genomics 7 (3), 458-459 (1990)
   PUBMED   1973145
REFERENCE   10 (bases 1 to 2534)
  AUTHORS   Dolle,P., Izpisua-Belmonte,J.C., Falkenstein,H., Renucci,A. and
            Duboule,D.
  TITLE     Coordinate expression of the murine Hox-5 complex
            homoeobox-containing genes during limb pattern formation
  JOURNAL   Nature 342 (6251), 767-772 (1989)
   PUBMED   2574828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928644.12 and AK031206.1.
            
            On Aug 2, 2012 this sequence version replaced NM_008274.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031206.1, BC145656.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AL928644.12        159945-160006
            63-1482             AK031206.1         2-1421
            1483-1483           AL928644.12        161586-161586
            1484-2534           AK031206.1         1423-2473
FEATURES             Location/Qualifiers
     source          1..2534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 44.13 cM"
     gene            1..2534
                     /gene="Hoxd12"
                     /gene_synonym="Hox-4.7; Hox-5.6"
                     /note="homeobox D12"
                     /db_xref="GeneID:15432"
                     /db_xref="MGI:MGI:96204"
     exon            1..642
                     /gene="Hoxd12"
                     /gene_synonym="Hox-4.7; Hox-5.6"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..881
                     /gene="Hoxd12"
                     /gene_synonym="Hox-4.7; Hox-5.6"
                     /note="homeobox protein Hox-4.7; homeobox protein Hox-5.6;
                     homeo box D12"
                     /codon_start=1
                     /product="homeobox protein Hox-D12"
                     /protein_id="NP_032300.2"
                     /db_xref="CCDS:CCDS38147.1"
                     /db_xref="GeneID:15432"
                     /db_xref="MGI:MGI:96204"
                     /translation="MCERSLYRAGYVGSLLNLQSPDSFYFSNLRANGSQLAALPPISY
                     PRSALPWATTPASCTPAQPATASAFGGFSQPYLTGSGPIGLQSPGAKDGPEDQVKFYT
                     PDAPTASEERSRTRPPFAPESSLVHSALKGTKYDYAGVGRTAPGSATLLQGAPCASSF
                     KEDTKGPLNLNMAVQVAGVASCLRSSLPDGLPWGAAPGRARKKRKPYTKQQIAELENE
                     FLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKRVVQREQALALY"
     exon            643..2534
                     /gene="Hoxd12"
                     /gene_synonym="Hox-4.7; Hox-5.6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctctgagcc cgtcctccta ttccgggttg taactaaata ctgttgcgag cacagccgag
       61 gccctttgtt ggagatgtgt gagcgcagtc tctacagagc tggctatgtg ggctcgcttc
      121 tgaatttaca gtcaccggac tctttctact tttccaacct gagagccaat ggcagccagt
      181 tggccgcgct tccccccatc tcataccctc gcagcgcgct gccctgggct actacgcccg
      241 cctcatgcac ccctgcgcag cctgccaccg cctctgcctt tggaggcttc tctcagcctt
      301 acttgaccgg ctctgggcca attggcctgc agtctccagg cgccaaggac ggacccgaag
      361 accaggtcaa gttctatacg cctgatgcgc ccaccgcatc tgaggaacgc agccggacta
      421 ggccgccctt cgcccccgag tctagtctgg ttcattcggc tctcaaaggc accaagtatg
      481 actacgcggg tgtgggccgg accgctccag gctctgcgac cctgctccag ggggccccct
      541 gtgcctccag cttcaaggaa gacaccaaag gcccgctcaa cttgaacatg gcagtgcaag
      601 tggccggggt ggcctcttgc ctgcgatctt cactgcccga cggcctgccg tggggggcgg
      661 ccccggggag ggcccgcaag aagaggaaac cctacacaaa gcagcagatt gcggagctgg
      721 agaacgaatt cctggtcaat gaattcatca accggcagaa gcgtaaggaa ttgtctaaca
      781 ggctgaacct cagcgaccag caggtcaaaa tctggttcca gaaccggcgt atgaagaaga
      841 agcgggtagt gcagcgcgag caagcactgg ccctctatta gctgcccacg ggggcctgag
      901 gccttgccaa gcctgccctt ttggaccaag gcctggctgt ggaggaggtg ttggggctgc
      961 agatttccct cccactcctc tggtcctggg cgcccttcgg ctcagtctgt agctgaggaa
     1021 ccaggaggag atttggagat gaggccagtg gagccccctt cgctttcagc tctctttggg
     1081 accctcctga gaggtgtttg ggaattgcaa tctaacactg gctttaaaca ttcagcatgg
     1141 tgtctggggg tcacctgtcc ttgtctatga tgtttacatc cggggctcac tattgaaaca
     1201 ctgtatgagg gtttgttttt tccggttttc aacgtgttct ttttcttttt ctttctctat
     1261 ccagctcttt ctgcatgaaa caggagccta gctagagctc cgggtataag tgcaggtaga
     1321 aaggccctga gaccccgctg cagtgcaagg ggctggggat aactctagcc ccttcgcagc
     1381 agaagccctt tgtgacaaag ctgggctctc cactctgcag gaaggaaagg gcctgattcc
     1441 acaaccccca tctgccctga atgatttggg aggacaaaag ctaccctaga ccttcagact
     1501 tgtggggggg gggggaggaa aggataccct ggaacctcag cgcttcaaag gttctcctgc
     1561 tgagtaaaac aggctggaag atctccttct cagagacagg gagagaaact gggactccaa
     1621 aacaaagtat ggtctctaga ctgtcataat tcccctgctc cagcctcacc tatccctgag
     1681 ccaaggccaa gcactctgta actagatccc cagaactgag ctatgggtga ggggagctgc
     1741 tggcctgttt tgaggcttgg ctgcacaggg aagaaagaag agtaagcgag gcggaggagg
     1801 atctgcactc tgtaaccacg actctcctct tgaatgaatg aagttatcca tatgtctgtc
     1861 tttcttgaat ttccttaatg tatcaccaca ggaagagacc ccccccccaa aaaaaatgcc
     1921 tccttgagga gtctgaaggg tgggagaaga aacctctcag attctcagac tgtagttgct
     1981 gctcttgaag gacagaaaac cagcacttct tccccatcct ctccaccacc caccaactcc
     2041 atcagaactt agctagggtg tctcttctca gagactggtg gtcagctctt gtaaagcttt
     2101 taaggcccca agccctgcca ggtttacctt gagaaaccta ggttttctga attgtgaatg
     2161 aagttgctct acgcctgtta tagaatctgt ccagcctcat tcccagtgaa ttcaactccg
     2221 ccttccccta caatctttgc ctcttctttt gagctttaag ccccaccccc aacctttagc
     2281 aagatgcaca acatcccaaa ggctcatgat tccttcccca agtccaatgg ctttccttta
     2341 gagaaggtct ccaggaactg gacctcgaag ggcatctcac aaggaccttt gagcctcgcc
     2401 ccaactgacc tcggttggtg tgttaaatat tatttcctgt gctaacagtt gccgtttatg
     2461 ttttgttttg attttgtaaa ataacacttc cctgtatata ttagcttcat agtgaaaata
     2521 aatatccaga tccc
//
