LOCUS       NM_013554               1850 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox D10 (Hoxd10), mRNA.
ACCESSION   NM_013554
VERSION     NM_013554.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1850)
  AUTHORS   Chen,Y., Zhou,T., Liao,Z., Gao,W., Wu,J., Zhang,S., Li,Y., Liu,H.,
            Zhou,H., Xu,C. and Su,P.
  TITLE     Hnrnpk is essential for embryonic limb bud development as a
            transcription activator and a collaborator of insulator protein
            Ctcf
  JOURNAL   Cell Death Differ 30 (10), 2293-2308 (2023)
   PUBMED   37608075
REFERENCE   3  (bases 1 to 1850)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   4  (bases 1 to 1850)
  AUTHORS   Min,K.W., Kim,N., Lee,J.H., Sung,Y., Kim,M., Lee,E.J., Kim,J.M.,
            Kim,J.H., Lee,J., Cho,W., Yang,J.M., Kim,N., Kim,J., Lee,C.J.,
            Park,Y.G., Lee,S.H., Lee,H.W. and Kim,J.W.
  TITLE     Visuomotor anomalies in achiasmatic mice expressing a
            transfer-defective Vax1 mutant
  JOURNAL   Exp Mol Med 55 (2), 385-400 (2023)
   PUBMED   36737666
REFERENCE   5  (bases 1 to 1850)
  AUTHORS   Bertol,J.W., Johnston,S., Ahmed,R., Xie,V.K., Hubka,K.M., Cruz,L.,
            Nitschke,L., Stetsiv,M., Goering,J.P., Nistor,P., Lowell,S.,
            Hoskens,H., Claes,P., Weinberg,S.M., Saadi,I., Farach-Carson,M.C.
            and Fakhouri,W.D.
  TITLE     TWIST1 interacts with beta/delta-catenins during neural tube
            development and regulates fate transition in cranial neural crest
            cells
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35781329
REFERENCE   6  (bases 1 to 1850)
  AUTHORS   Juriloff,D.M., Harris,M.J., Miller,J.E., Jacobson,D. and Martin,P.
  TITLE     Is Far a Hox mutation?
  JOURNAL   J Craniofac Genet Dev Biol 12 (3), 119-129 (1992)
   PUBMED   1355490
REFERENCE   7  (bases 1 to 1850)
  AUTHORS   Kessel,M.
  TITLE     Respecification of vertebral identities by retinoic acid
  JOURNAL   Development 115 (2), 487-501 (1992)
   PUBMED   1358593
REFERENCE   8  (bases 1 to 1850)
  AUTHORS   Peterson,R.L., Jacobs,D.F. and Awgulewitsch,A.
  TITLE     Hox-3.6: isolation and characterization of a new murine homeobox
            gene located in the 5' region of the Hox-3 cluster
  JOURNAL   Mech Dev 37 (3), 151-166 (1992)
   PUBMED   1353983
REFERENCE   9  (bases 1 to 1850)
  AUTHORS   Renucci,A., Zappavigna,V., Zakany,J., Izpisua-Belmonte,J.C.,
            Burki,K. and Duboule,D.
  TITLE     Comparison of mouse and human HOX-4 complexes defines conserved
            sequences involved in the regulation of Hox-4.4
  JOURNAL   EMBO J 11 (4), 1459-1468 (1992)
   PUBMED   1348690
REFERENCE   10 (bases 1 to 1850)
  AUTHORS   Bastian,H., Gruss,P., Duboule,D. and Izpisua-Belmonte,J.C.
  TITLE     The murine even-skipped-like gene Evx-2 is closely linked to the
            Hox-4 complex, but is transcribed in the opposite direction
  JOURNAL   Mamm Genome 3 (4), 241-243 (1992)
   PUBMED   1611218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134330.1 and AL928644.12.
            
            On Aug 2, 2012 this sequence version replaced NM_013554.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134330.1, BC048690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-709               AK134330.1         2-710
            710-1355            AK134330.1         712-1357
            1356-1850           AL928644.12        179544-180038
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 44.13 cM"
     gene            1..1850
                     /gene="Hoxd10"
                     /gene_synonym="Hox-4.5; Hox-5.3"
                     /note="homeobox D10"
                     /db_xref="GeneID:15430"
                     /db_xref="MGI:MGI:96202"
     exon            1..834
                     /gene="Hoxd10"
                     /gene_synonym="Hox-4.5; Hox-5.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1112
                     /gene="Hoxd10"
                     /gene_synonym="Hox-4.5; Hox-5.3"
                     /note="homeobox protein Hox-4.5; homeobox protein Hox-5.3;
                     homeo box D10"
                     /codon_start=1
                     /product="homeobox protein Hox-D10"
                     /protein_id="NP_038582.2"
                     /db_xref="CCDS:CCDS16141.1"
                     /db_xref="GeneID:15430"
                     /db_xref="MGI:MGI:96202"
                     /translation="MSFPNSSPAANTFLVDSLISACRSDSFYSSSASMYMPPPSADMG
                     TYGMQTCGLLPSLAKREVNHQNMGMNVHPYIPQVDSWTDPNRSCRIEQPVTQQVPTCS
                     FTANIKEESNCCMYSDKRNKLISAEVPSYQRLVPESCPVENPEVPVPGYFRLSQTYAT
                     GKTQEYNNSPEGSSTVMLQLNPRGAAKPQLSAAQLQMEKKMNESASGQEPTKVSQVES
                     PEAKGGLPEDRSCLAEVSVSSPEVQEKESKEEIKSDTPTSNWLTAKSGRKKRCPYTKH
                     QTLELEKEFLFNMYLTRERRLEISKSVNLTDRQVKIWFQNRRMKLKKMSRENRIRELT
                     ANLTFS"
     exon            835..1850
                     /gene="Hoxd10"
                     /gene_synonym="Hox-4.5; Hox-5.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxd10"
                     /gene_synonym="Hox-4.5; Hox-5.3"
                     /note="hexamer: AATAAA"
     polyA_site      1847
                     /gene="Hoxd10"
                     /gene_synonym="Hox-4.5; Hox-5.3"
                     /note="major polyA site"
ORIGIN      
        1 agaggcatcc acaattacac cgggaatgtt ttcctagcga tgtcagccta caaaggacac
       61 aatctctctt cttcaaattc ctccccaaaa tgtcctttcc caacagctct cctgctgcta
      121 atactttttt agtagattcc ttgatcagtg cctgcaggag tgacagtttt tattcgagca
      181 gcgccagcat gtacatgcca ccacctagcg cagacatggg gacctatgga atgcaaacct
      241 gtggactgct cccgtctttg gccaaaagag aagtgaacca ccaaaatatg ggtatgaatg
      301 tacatcctta tatacctcaa gtagacagtt ggacagaccc gaacagatct tgtcgaatag
      361 agcaacctgt tacacagcaa gtccccactt gctcattcac cgccaacatt aaagaagaat
      421 ccaattgctg catgtattct gataagcgca acaaactcat ttctgccgag gtcccttcgt
      481 accagaggct ggtccccgag tcttgtcctg ttgagaaccc cgaggttcct gtccctggat
      541 attttagact gagtcagacc tacgccaccg ggaaaaccca agagtacaat aacagccccg
      601 aaggcagctc cactgtcatg ctccagctca accctcgtgg cgcggccaag ccgcagctct
      661 cggctgccca gctgcagatg gaaaagaaga tgaacgaaag cgcgagcggc caggagccca
      721 ctaaagtctc ccaagtggag agccccgagg ccaaaggcgg ccttccagaa gacaggagct
      781 gcctggctga ggtttccgtg tccagtcccg aagtgcagga gaaggaaagc aaagaggaaa
      841 tcaagtctga tactccaacc agcaattggc tcactgcaaa gagtggcaga aagaagaggt
      901 gcccttacac caagcaccaa acgctggaat tggaaaaaga gttcttgttc aatatgtacc
      961 tcacccgcga gcgccgccta gagatcagta agagcgttaa cctcaccgac aggcaggtca
     1021 agatttggtt tcaaaaccgc cgaatgaaac tcaagaagat gagccgagag aatcgaatcc
     1081 gagaactgac cgccaacctc accttttctt aggtctgagg cccatgtgag gccaggatcc
     1141 gagagggggc accgagttcc aggcctgagt gctggaggac tggcaaggcg gaaacaaacc
     1201 cttcattgct ctttggtttt tttgttttgt tttgttctgt tctgttctgt tttcctgcta
     1261 gaatgtgact ttggggtcat tctgttcgtg ctgcaagtga tctgtaatcc ctatgagtat
     1321 acatatatat atatattaaa aaaacttagc acgtgtaatt tatttttttt catcgtaatg
     1381 cagggtaact attactgcgc attttcattt gggtcttaac ttattggaac tgtagaacat
     1441 ccatctaaac gtatccatcg catcccaccc atctatcccg ccagcaatgt gacttttcca
     1501 tgtttttcct aacataaaag ttctctgtgt gtggttagcc catgaactca tggcattttg
     1561 aaaacatcca gtatttaaaa aaacaaacaa cctatatcta tatatatttc aaaagattaa
     1621 gaaaacccac aagctttggg gggaggggga ctttaaaaag cacattacaa tgtatctttt
     1681 cacaaatgaa cttagcaatt gtccttggtg aaatggaata ttgatgactt atgccttgta
     1741 gcctttcctt gtggtgcatc tgtggtttgg tagaagtaca agcgcaacct gtgcttttct
     1801 gtgcatgttc tggtcgcatg tgtaatgcaa taaactctgg aaatgggttt
//
