LOCUS       NM_010466               2369 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox C8 (Hoxc8), mRNA.
ACCESSION   NM_010466
VERSION     NM_010466.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2369)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2369)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2369)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   4  (bases 1 to 2369)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2369)
  AUTHORS   Sawai,A., Pfennig,S., Bulajic,M., Miller,A., Khodadadi-Jamayran,A.,
            Mazzoni,E.O. and Dasen,J.S.
  TITLE     PRC1 sustains the integrity of neural fate in the absence of PRC2
            function
  JOURNAL   Elife 11, e72769 (2022)
   PUBMED   34994686
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2369)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2369)
  AUTHORS   Hameister,H., Schulz,W.A., Meyer,J., Thoma,S., Adolph,S., Gaa,A.
            and von Deimling,O.
  TITLE     Gene order and genetic distance of 13 loci spanning murine
            chromosome 15
  JOURNAL   Genomics 14 (2), 417-422 (1992)
   PUBMED   1358803
REFERENCE   8  (bases 1 to 2369)
  AUTHORS   Brannan,C.I., Gilbert,D.J., Ceci,J.D., Matsuda,Y., Chapman,V.M.,
            Mercer,J.A., Eisen,H., Johnston,L.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific linkage map of mouse chromosome 15 positioned with
            respect to the centromere
  JOURNAL   Genomics 13 (4), 1075-1081 (1992)
   PUBMED   1354638
REFERENCE   9  (bases 1 to 2369)
  AUTHORS   Peterson,R.L., Jacobs,D.F. and Awgulewitsch,A.
  TITLE     Hox-3.6: isolation and characterization of a new murine homeobox
            gene located in the 5' region of the Hox-3 cluster
  JOURNAL   Mech Dev 37 (3), 151-166 (1992)
   PUBMED   1353983
REFERENCE   10 (bases 1 to 2369)
  AUTHORS   Le Mouellic,H., Lallemand,Y. and Brulet,P.
  TITLE     Homeosis in the mouse induced by a null mutation in the Hox-3.1
            gene
  JOURNAL   Cell 69 (2), 251-264 (1992)
   PUBMED   1348969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021667.21.
            
            On May 15, 2009 this sequence version replaced NM_010466.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X07439.1, AK051173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-677               AC021667.21        93362-94038
            678-2369            AC021667.21        95386-97077
FEATURES             Location/Qualifiers
     source          1..2369
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.05 cM"
     gene            1..2369
                     /gene="Hoxc8"
                     /gene_synonym="D130011F21Rik; Hox-3.1"
                     /note="homeobox C8"
                     /db_xref="GeneID:15426"
                     /db_xref="MGI:MGI:96198"
     exon            1..677
                     /gene="Hoxc8"
                     /gene_synonym="D130011F21Rik; Hox-3.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..970
                     /gene="Hoxc8"
                     /gene_synonym="D130011F21Rik; Hox-3.1"
                     /note="homeobox protein M31; homeobox protein Hox-3.1;
                     homeo box C8"
                     /codon_start=1
                     /product="homeobox protein Hox-C8"
                     /protein_id="NP_034596.1"
                     /db_xref="CCDS:CCDS27894.1"
                     /db_xref="GeneID:15426"
                     /db_xref="MGI:MGI:96198"
                     /translation="MSSYFVNPLFSKYKGGESLEPAYYDCRFPQSVGRSHALVYGPGG
                     SAPGFQHASHHVQDFFHHGTSGISNSGYQQNPCSLSCHGDASKFYGYEALPRQSLYGA
                     QQEASVVQYPDCKSSANTNSSEGQGHLNQNSSPSLMFPWMRPHAPGRRSGRQTYSRYQ
                     TLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKLPGARD
                     EEKVEEEGNEEEEKEEEEKEENKD"
     exon            678..2369
                     /gene="Hoxc8"
                     /gene_synonym="D130011F21Rik; Hox-3.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgttagagga aagagctaag tgagagcgcg cgctctacct accgacagtg agcagagagc
       61 tgcagccgcc cgagcccgca gccggcaccg cgcccccacc tgcccagccc ccagcccagc
      121 agtccagccc gggggagccg gccagcttgg ggttcggtcc cggggggagg ggagtttcgg
      181 ggatacccgg cgggggagcg tgatccaagg ggagggggcc gcgggttttc atgtacccag
      241 catgagctcc tacttcgtca accccctgtt ttccaaatac aaaggcggcg agtccctgga
      301 accggcctat tacgactgcc ggttccctca gagcgtgggc agaagccatg cgctggtgta
      361 cgggcccggc ggctccgcgc ccggtttcca gcacgcctcg caccacgtcc aagacttctt
      421 ccaccacggc acctccggca tctccaactc gggctaccag cagaacccat gctcgctgag
      481 ctgccacgga gacgcctcca aattctatgg ctacgaggcg ctccccagac agtcccttta
      541 tggggctcag caagaggcga gcgtggtgca atatcccgac tgtaaatcct ccgccaacac
      601 taacagtagc gaaggacaag gccacttaaa tcagaactcg tctcccagcc tcatgtttcc
      661 atggatgaga ccccacgctc ctgggcggcg cagcggtcga caaacttaca gccggtatca
      721 gaccttggaa ctagagaagg agtttctctt taatccttat ttgaccagaa agcgccggat
      781 tgaagtctct cacgccctgg gactgacaga aagacaagtg aagatttggt tccagaatcg
      841 aaggatgaag tggaaaaagg agaacaacaa ggataaactg cctggggccc gagatgagga
      901 gaaggtggaa gaagaaggga atgaggaaga ggagaaagag gaggaggaaa aggaagaaaa
      961 taaggactaa ggaaaaaaag agagagaaaa tcagcccccc ccccagcaac tcccttgaag
     1021 tttcgtttta tggtagcaga taaattgaga agtttacgac tgtcatttgc ttttatagag
     1081 aatagaatga cactcacaac tctaactacc tgtcagatag ttgcagctct gcttttatta
     1141 cctttgggct tcccccactc tttatttgtc tgggggttgg gagggggaac ctgagacaca
     1201 gggaaaagtt ctgttctact ccatgcccag catacactct cttgttcctg ctcccacctt
     1261 ctgagccctt ccccataaag tctaaccctt cacacacaca cacacacaca cacacacaca
     1321 cacacacaca cacacacaca cacttctctc cacactccct cttcacggtg cttctctggt
     1381 atttatttta aaagggattc ccctgaagat atagaagatg attcctggct ttgcttgtat
     1441 gctgggaatt agaatactgg ataaacagtt tttttttaat gaaaagaaag aaggaaaaaa
     1501 acaggaaagg gggaaatgaa aggaaaaatt aaaaagaaat aaaagatagc aaagaagatt
     1561 cccctccccc tctgaggctc tttccttaga aaaaccccct tgactttctc caggaatctg
     1621 ctggaaatca aggagatgtg ggtttctcta cccacctcct tcctgagggg tctattagaa
     1681 ctggcaatgg tctctgaaat cctacctatc catcccatag tcacttgggt ccatgccttc
     1741 cttgccttgc ctttgctgtt tgatcttttg ggcccccggc ttcctctgag ctgtgttagt
     1801 gtttgtgctc agaagtcacc ataatcatga aaataatata ctgataataa atctttaaca
     1861 tactacctaa agggaacctg caataatctt gggggaaaaa aaaaaaagaa agaaaaattc
     1921 ctaatacagg agggagaaaa aaaaaaagaa aaaaaaagaa aaaaaagaaa aaaggaagaa
     1981 acctccagcg tattttatca ctacctatag aaagaaatcc tgctttgaga gtatttgtaa
     2041 tgcggttttg ttgttgtttg ttgctgcttc tttcactaag aaaaaaaaaa atcccaacaa
     2101 ctgagactgc ctagcccgcc ggtcttgtgc gcttttattg tgcttctaac cccagtagag
     2161 tagaactaaa ctgcactgaa tgtatagtta ctctgtcttg aattctctgt ttatgcaatg
     2221 tgctcgaaag gaaaaaaaaa cgttaaaata tatctataat aataattttg gtcatttgtc
     2281 tttatgtcca gctatgaatg tagattttgt gtcctgaaag ctctgttcct ggtccaagta
     2341 ctttgtattg tatacgtgag tcataataa
//
