LOCUS       NM_010465               1592 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox C6 (Hoxc6), mRNA.
ACCESSION   NM_010465 XM_181367
VERSION     NM_010465.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1592)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1592)
  AUTHORS   Li,J., Song,H., Chen,Z., Yang,Q., Yang,Z., Yan,C. and Zhong,C.
  TITLE     MicroRNA-574-5p targeting HOXC6 expression inhibits the hepatocyte
            lipid uptake to alleviate non-alcoholic fatty liver disease
  JOURNAL   Exp Cell Res 428 (1), 113631 (2023)
   PUBMED   37150392
  REMARK    GeneRIF: MicroRNA-574-5p targeting HOXC6 expression inhibits the
            hepatocyte lipid uptake to alleviate non-alcoholic fatty liver
            disease.
REFERENCE   3  (bases 1 to 1592)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   4  (bases 1 to 1592)
  AUTHORS   Benetti,N., Gouil,Q., Tapia Del Fierro,A., Beck,T., Breslin,K.,
            Keniry,A., McGlinn,E. and Blewitt,M.E.
  TITLE     Maternal SMCHD1 regulates Hox gene expression and patterning in the
            mouse embryo
  JOURNAL   Nat Commun 13 (1), 4295 (2022)
   PUBMED   35879318
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1592)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1592)
  AUTHORS   Jegalian,B.G., Miller,R.W., Wright,C.V., Blum,M. and De
            Robertis,E.M.
  TITLE     A Hox 3.3-lacZ transgene expressed in developing limbs
  JOURNAL   Mech Dev 39 (3), 171-180 (1992)
   PUBMED   1292571
REFERENCE   7  (bases 1 to 1592)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   8  (bases 1 to 1592)
  AUTHORS   Geada,A.M., Gaunt,S.J., Azzawi,M., Shimeld,S.M., Pearce,J. and
            Sharpe,P.T.
  TITLE     Sequence and embryonic expression of the murine Hox-3.5 gene
  JOURNAL   Development 116 (2), 497-506 (1992)
   PUBMED   1363091
REFERENCE   9  (bases 1 to 1592)
  AUTHORS   Shimeld,S.M. and Sharpe,P.T.
  TITLE     Cell-surface changes induced by ectopic expression of the murine
            homeobox gene Hox-3.3
  JOURNAL   Biochim Biophys Acta 1136 (3), 253-258 (1992)
   PUBMED   1355668
REFERENCE   10 (bases 1 to 1592)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX528590.1 and AK050798.1.
            
            On Sep 7, 2006 this sequence version replaced NM_010465.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050798.1, X16511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               BX528590.1         2-234
            234-1592            AK050798.1         2-1360
FEATURES             Location/Qualifiers
     source          1..1592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.06 cM"
     gene            1..1592
                     /gene="Hoxc6"
                     /gene_synonym="Hox-3.3; Hox-6.1"
                     /note="homeobox C6"
                     /db_xref="GeneID:15425"
                     /db_xref="MGI:MGI:96197"
     exon            1..444
                     /gene="Hoxc6"
                     /gene_synonym="Hox-3.3; Hox-6.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..752
                     /gene="Hoxc6"
                     /gene_synonym="Hox-3.3; Hox-6.1"
                     /note="homeobox protein Hox-3.3; homeobox protein Hox-6.1;
                     homeo box C6"
                     /codon_start=1
                     /product="homeobox protein Hox-C6"
                     /protein_id="NP_034595.2"
                     /db_xref="CCDS:CCDS27895.1"
                     /db_xref="GeneID:15425"
                     /db_xref="MGI:MGI:96197"
                     /translation="MNSYFTNPSLSCHLAGGQDVLPNVALNSTAYDPVRHFSTYGAAV
                     AQNRIYSTPFYSPQENVVFSSSRGPYDYGSNSFYQEKDMLSNCRQNTLGHNTQTSIAQ
                     DFSSEQGRTAPQDQKASIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEF
                     HFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGGGATADSL
                     GGKEEKREETEEEKQKE"
     exon            445..1592
                     /gene="Hoxc6"
                     /gene_synonym="Hox-3.3; Hox-6.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1566..1571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxc6"
                     /gene_synonym="Hox-3.3; Hox-6.1"
                     /note="putative"
ORIGIN      
        1 taaatattaa agaaatcata gcccgaccag gtaaaggcaa agggatgaat tcctacttca
       61 ctaacccttc cttatcctgc cacctcgccg ggggccagga cgtcctcccc aacgtcgccc
      121 tcaattccac cgcctatgat ccagtgaggc atttctcgac ctatggagca gccgtagctc
      181 agaaccggat ctactcgact cccttttatt cgccacagga gaatgtcgtg ttcagttcca
      241 gccgggggcc gtatgactat ggatctaatt ccttttacca ggagaaagac atgctctcaa
      301 actgcagaca aaacacctta ggacataaca cacagacctc aatcgctcag gattttagtt
      361 ctgagcaggg caggactgcg ccccaggacc agaaagccag tatccagatt tacccctgga
      421 tgcagcgaat gaattcgcac agtggggtcg gttacggagc ggaccggagg cgcggccgcc
      481 agatctactc tcggtaccag accctggaac tggagaagga atttcacttc aaccgctacc
      541 taactcggcg ccggcgcatc gagatcgcca atgctctgtg cctgaccgag cgacagatca
      601 aaatctggtt ccagaaccgc cgcatgaagt ggaaaaaaga atctaatctc acgtccacac
      661 tctcaggggg tggcggaggg gcaaccgccg acagcctggg aggaaaagag gaaaagcgag
      721 aagagacaga agaagagaag cagaaagagt gaccaggact gtccttgcac ccctctcttc
      781 tcccttgctc atcccagctc cccgaatcac acactctgta tttatctctg gcacaatgat
      841 gtgttgtgac ttcctaaaac aaaacaggga gtcagacgtg gacctaaaag tcagctttgg
      901 accccctccc tcactgcaca actcttcact cgtctcttcc tctagctccc tcgctagctt
      961 cttcctggct tgtctgcagg ccccttccct cgcctaggcc taggagacct gaacctcgct
     1021 tcagactcct cagatgtctc tccaagtgag ccctaggctc cctccccacc cccgacgccc
     1081 ttcacccccg ccctccggcg cagagagctg gctccagggc ctggggcctc cactcggggg
     1141 cctcagggcc cggcctgaca gccggagggc aggaggcctc aggagggcgc gccttggccc
     1201 tgcaacaacc cccagggcct ctccccagtc cctgcccggt ccctctgccc cagcaaatgc
     1261 ccagtccagg caaattgtat ttaaagattc ctgggggtca ttatggcata tttcgaactg
     1321 tgaccgtttc tgtgtgaata tttctagctg tatttgtggt ctctgtattt atatttatgt
     1381 ttagcaccgt cagtgttcct atctcattta aaaaaggatt taaaaaaaaa agagggaaaa
     1441 taacaaaaag agaaaaaaag tgaatgacgt ttgtttagcc agtaggagaa aataaataaa
     1501 gaaataaccc cctacgtgtt atcctcctgt ataaatccga cctctggatc cgttctcgaa
     1561 tatttaataa aactgatatt atttttaaaa gt
//
