LOCUS       NM_175730               2730 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox C5 (Hoxc5), mRNA.
ACCESSION   NM_175730 NM_008271
VERSION     NM_175730.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2730)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2730)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2730)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   4  (bases 1 to 2730)
  AUTHORS   Li,M.H., Kuetemeyer,J.M., Yallowitz,A.R. and Wellik,D.M.
  TITLE     Characterization of a novel Hoxa5eGFP mouse line
  JOURNAL   Dev Dyn 252 (4), 536-546 (2023)
   PUBMED   36577717
REFERENCE   5  (bases 1 to 2730)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2730)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2730)
  AUTHORS   Geada,A.M., Gaunt,S.J., Azzawi,M., Shimeld,S.M., Pearce,J. and
            Sharpe,P.T.
  TITLE     Sequence and embryonic expression of the murine Hox-3.5 gene
  JOURNAL   Development 116 (2), 497-506 (1992)
   PUBMED   1363091
REFERENCE   8  (bases 1 to 2730)
  AUTHORS   Nazarali,A., Kim,Y. and Nirenberg,M.
  TITLE     Hox-1.11 and Hox-4.9 homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2883-2887 (1992)
   PUBMED   1348361
REFERENCE   9  (bases 1 to 2730)
  AUTHORS   Gaunt,S.J., Coletta,P.L., Pravtcheva,D. and Sharpe,P.T.
  TITLE     Mouse Hox-3.4: homeobox sequence and embryonic expression patterns
            compared with other members of the Hox gene network
  JOURNAL   Development 109 (2), 329-339 (1990)
   PUBMED   1976088
REFERENCE   10 (bases 1 to 2730)
  AUTHORS   Sharpe,P.T., Miller,J.R., Evans,E.P., Burtenshaw,M.D. and
            Gaunt,S.J.
  TITLE     Isolation and expression of a new mouse homeobox gene
  JOURNAL   Development 102 (2), 397-407 (1988)
   PUBMED   2458223
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC021667.21.
            
            On Oct 19, 2007 this sequence version replaced NM_175730.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078527.1, BC115552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               AC021667.21        116831-117358
            529-2730            AC021667.21        118051-120252
FEATURES             Location/Qualifiers
     source          1..2730
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.07 cM"
     gene            1..2730
                     /gene="Hoxc5"
                     /gene_synonym="Hox-3.4; Hox-6.2"
                     /note="homeobox C5"
                     /db_xref="GeneID:15424"
                     /db_xref="MGI:MGI:96196"
     exon            1..528
                     /gene="Hoxc5"
                     /gene_synonym="Hox-3.4; Hox-6.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..743
                     /gene="Hoxc5"
                     /gene_synonym="Hox-3.4; Hox-6.2"
                     /note="homeobox protein Hox-3.4; homeobox protein Hox-6.2;
                     homeo box C5"
                     /codon_start=1
                     /product="homeobox protein Hox-C5"
                     /protein_id="NP_783857.1"
                     /db_xref="CCDS:CCDS27896.1"
                     /db_xref="GeneID:15424"
                     /db_xref="MGI:MGI:96196"
                     /translation="MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLD
                     LSITFPPPAPSNSLHGVDMAANPRAHPDRPACSAAAAPGHALGRDEAAPLNPGMYSQK
                     AARPALEERAKSSGEIKEEQAQTGQPAGLSQPPAPPQIYPWMTKLHMSHETDGKRSRT
                     SYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKMKS
                     KEAL"
     exon            529..2730
                     /gene="Hoxc5"
                     /gene_synonym="Hox-3.4; Hox-6.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1567..1572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxc5"
                     /gene_synonym="Hox-3.4; Hox-6.2"
                     /note="hexamer: AATAAA"
     polyA_site      1590
                     /gene="Hoxc5"
                     /gene_synonym="Hox-3.4; Hox-6.2"
                     /note="major polyA site"
ORIGIN      
        1 ccctcaactt caaagagtca caaatcaccc ttaatcaaaa agggtgcaga aatttttttt
       61 gggccctccc cgccatgagc tcctacgtag ccaattcatt ctataagcag agccccaata
      121 tccctgccta taacatgcaa acttgtggga actatggatc ggcctcagag gtgcaggcat
      181 ccaggtactg ctacggcgga ttggacttaa gcatcacttt cccaccgcct gcgccttcca
      241 actctctcca cggggtagac atggctgcca acccccgggc tcaccccgac cgccccgcct
      301 gcagcgccgc ggccgctccg ggacacgctc tgggcagaga cgaagcggct cctctgaacc
      361 ctgggatgta cagtcagaag gcggctcgcc cggcgctgga ggagcgagct aagagcagtg
      421 gggagatcaa agaggagcag gcgcagacag ggcagcctgc cggactgagc cagccaccgg
      481 ccccgccaca gatttacccg tggatgacca aactgcacat gagccacgag acggatggca
      541 agcggtcccg aaccagttac acgcgctacc agaccctgga actcgagaaa gaattccatt
      601 ttaaccgcta cctcactcgc cgcaggcgca tagagattgc caacaacttg tgtctcaacg
      661 agagacagat caagatctgg ttccagaacc gcaggatgaa gtggaagaaa gattccaaaa
      721 tgaagagcaa agaagctctt tagaggaagc agggagccct cagagagcac cccggtctgc
      781 tgtggtccct gcgcccttcc ttttcggttt tcctccttct agattttgag gcggaggcta
      841 gagcactggc tccgggcctc ccagacaaaa gcgcatttct ttggcattcc gaatccccat
      901 cgacccaggg ttccgcagga ccgcctgcac tgcctgtctt gcctcagctc agctgagcac
      961 cccaggcccg gggcacattc ttgtagggcg ggtactggat aagtctcagc ctgggctgcc
     1021 tctctcggct ccgagcccta gttcagctag cctgagttaa ggtgagacag actgactgta
     1081 accccttctc cccgacctcc gcctcaccct cttctttgtt cctgcctagg ctgaccagcc
     1141 tgctgaaggc tggttgtgcc aggcagaggc tatgactagc tagaatcggg gtgctttcaa
     1201 ctaacctttg taacttctaa actgtctttg ctcattaatt atttgcatat gaaagaggga
     1261 gataagtgaa agtgggcctg taaccccgga ggttgtccta tgctctctat accttccaat
     1321 ccccttccca aagcccggga acttccctag cctggcttgc tgcatgcact ctcaggttca
     1381 cagttccagc ctgctagcta gctcaactat tggggtctct tgtctttgga ccctagcaag
     1441 ttgttctttg aggctttttg ctatcctata tatcttgcca tgactttctc accttcctgc
     1501 cccattgcag ttgcccaact atttattgac tccaagccct tcctgaaact atattttgtc
     1561 atatcaaata aagccagaaa aagaacagga ctaaagattc aattacttct gtctgtttag
     1621 ggcatgcatt gaattgatgt gtctaaatag gctctgagat gtattgggag gcccagtctt
     1681 taaaccatcc cttaaaaaat atttttaaac acctttagga gcagcaagaa tagggaacaa
     1741 tggaactgag ttcttttctt gattcatggt tccaagaagg gcctctgggg tgaaggggag
     1801 tacacttgag gactcctgta ctgttgtttc cacttgctgt gtgtgtctaa gttacccaga
     1861 cttttctata tcctattctc aacgttggct aaaacaactt gagacttgaa gcttctagac
     1921 tgtagtctgt actttatgcc agagaatagt agctctgtgg ctccactgac ttagattcag
     1981 gctcttctgg gtctaggtca tccttgtagg tcctttctga catagaagaa aggttgagtc
     2041 ctctgtctag atgccagaag gattcgcagc aatagtaggt gctgcttggt aaagaggtgt
     2101 tggggaagga gaaatggcca cggtttgaga tgttcttcag ccttctaaga tatgggatgg
     2161 ggcaaggggg actaaggaga cagtgaatgc aacctgcagt gtgtgcctgc cttagagaaa
     2221 acatacagac tgctccctgt cttctagggt ctaagccaat gaaggacagt taactggaat
     2281 aagagctgta tagatcagtg tgggagccat gcctgtttgc tgtcatctat catatctctg
     2341 agattttgta tacaggggga gggtgcccta taggagaggg tatgcagcta attcaggtgg
     2401 ggctggccta ggctgatgcg ctgcttagct ccactccagg ctccaggact tgttgaagga
     2461 ggaagtactt tacaggagaa acaaacgcac ggaatgggcc cataaaacct tactgcattt
     2521 cctctccagc cttccacaat ggggtgattt cctggagcca agcctaggcc ccccacactg
     2581 gaggagtggg gaatctgaaa ctgggctaag ggctgctcta cactaggaca gaaaggaaac
     2641 agagtggctc tggggagggg cagggagatt cctttttatg attattaatg cttatgctct
     2701 ttgaatttat taaaggtctg acttcactgc
//
