LOCUS       NM_013553               1983 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox C4 (Hoxc4), mRNA.
ACCESSION   NM_013553
VERSION     NM_013553.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1983)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1983)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   3  (bases 1 to 1983)
  AUTHORS   Fernandez-Guerrero,M., Zdral,S., Castilla-Ibeas,A.,
            Lopez-Delisle,L., Duboule,D. and Ros,M.A.
  TITLE     Time-sequenced transcriptomes of developing distal mouse limb buds:
            A comparative tissue layer analysis
  JOURNAL   Dev Dyn 251 (9), 1550-1575 (2022)
   PUBMED   34254395
REFERENCE   4  (bases 1 to 1983)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1983)
  AUTHORS   Sawai,A., Pfennig,S., Bulajic,M., Miller,A., Khodadadi-Jamayran,A.,
            Mazzoni,E.O. and Dasen,J.S.
  TITLE     PRC1 sustains the integrity of neural fate in the absence of PRC2
            function
  JOURNAL   Elife 11, e72769 (2022)
   PUBMED   34994686
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1983)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 1983)
  AUTHORS   Geada,A.M., Gaunt,S.J., Azzawi,M., Shimeld,S.M., Pearce,J. and
            Sharpe,P.T.
  TITLE     Sequence and embryonic expression of the murine Hox-3.5 gene
  JOURNAL   Development 116 (2), 497-506 (1992)
   PUBMED   1363091
REFERENCE   8  (bases 1 to 1983)
  AUTHORS   Murtha,M.T., Leckman,J.F. and Ruddle,F.H.
  TITLE     Detection of homeobox genes in development and evolution
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10711-10715 (1991)
   PUBMED   1720547
REFERENCE   9  (bases 1 to 1983)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   10 (bases 1 to 1983)
  AUTHORS   Hunt,P., Gulisano,M., Cook,M., Sham,M.H., Faiella,A., Wilkinson,D.,
            Boncinelli,E. and Krumlauf,R.
  TITLE     A distinct Hox code for the branchial region of the vertebrate head
  JOURNAL   Nature 353 (6347), 861-864 (1991)
   PUBMED   1682814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124345.4 and AC021667.21.
            
            On Aug 7, 2007 this sequence version replaced NM_013553.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X69019.1, D11329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               AC124345.4         1-334               c
            335-767             AC021667.21        137546-137978
            768-1983            AC021667.21        138454-139669
FEATURES             Location/Qualifiers
     source          1..1983
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.08 cM"
     gene            1..1983
                     /gene="Hoxc4"
                     /gene_synonym="Hox-3.5"
                     /note="homeobox C4"
                     /db_xref="GeneID:15423"
                     /db_xref="MGI:MGI:96195"
     exon            1..767
                     /gene="Hoxc4"
                     /gene_synonym="Hox-3.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..1123
                     /gene="Hoxc4"
                     /gene_synonym="Hox-3.5"
                     /note="homeobox protein Hox-3.5; homeo box C4"
                     /codon_start=1
                     /product="homeobox protein Hox-C4"
                     /protein_id="NP_038581.2"
                     /db_xref="CCDS:CCDS27897.1"
                     /db_xref="GeneID:15423"
                     /db_xref="MGI:MGI:96195"
                     /translation="MIMSSYLMDSNYIDPKFPPCEEYSQNSYIPEHSPEYYGRTRESG
                     FQHHHQELYPPPPPRPSYPERQYSCTSLQGPGNSRAHGPAQAGHHHPEKSQPLCEPAP
                     LSGTSASPSPAPPACSQPAPDHPSSAASKQPIVYPWMKKIHVSTVNPNYNGGEPKRSR
                     TAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKDHRLP
                     NTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAEDITRL"
     exon            768..1983
                     /gene="Hoxc4"
                     /gene_synonym="Hox-3.5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1955..1960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxc4"
                     /gene_synonym="Hox-3.5"
                     /note="hexamer: AATAAA"
     polyA_site      1983
                     /gene="Hoxc4"
                     /gene_synonym="Hox-3.5"
                     /note="major polyA site"
ORIGIN      
        1 acattggagt cgagctggga gccacccatc tttagcaagg aaggattgtc agtctggtgg
       61 ggtgtgcaat ggtgagcacc ccagcttctg ccagccatcc cccaccccca cccccagcag
      121 cagcagcacc accaccacat acacaaaaaa ttggatacat tttgaataaa gcgattcggt
      181 tccttatccg gggactgggt tgctcggtgt gattggccgg cggagtcaca tggtgaaagt
      241 aactttacag ggtcgctagc tagtaggagg gctttatgga gcagaaaaac gacaaagcga
      301 gaaaaattat tttccactcc agaaattaat gatcatgagc tcgtatttga tggactctaa
      361 ctacatcgat ccgaaatttc ctccatgcga agaatattcg caaaatagct acatccctga
      421 acacagtccg gaatattacg gccggaccag ggaatcggga ttccagcatc accaccagga
      481 gctgtaccca ccaccgcctc cgcgccctag ctaccctgag cgtcagtata gctgcaccag
      541 tctccagggg cctggcaatt cgcgagccca cgggccggcc caggcgggcc accaccaccc
      601 tgagaaatcg cagccgctct gcgagccggc gcctctctca ggcacctctg cctccccgtc
      661 cccagccccg ccagcctgca gccagccagc ccctgaccat ccctccagcg ccgccagcaa
      721 gcaacccata gtctaccctt ggatgaaaaa aattcacgtt agcacggtga accccaatta
      781 taacggaggg gagcccaagc gctcgaggac agcctacacc cggcagcagg tcctggaatt
      841 agagaaagag tttcattaca accgctacct gacccgaagg agaaggatcg agatcgccca
      901 ctcgctgtgc ctctctgaga ggcagatcaa aatctggttc caaaaccgtc gtatgaaatg
      961 gaagaaggac caccgactcc ccaacaccaa agtgaggtca gcgcccccgg ccggcgctgc
     1021 gcccagcacc ctctcggcag ccacccccgg cacttctgaa gaccactccc agagcgccac
     1081 gccgccggag cagcaacggg cagaggacat caccaggtta taagacataa cttacacccc
     1141 tgcccccacc ctgtgctccg tgcccccctc acacacaaat tgactcttat ttatagaatt
     1201 taatatatat atatatattt tggttctttt ctctctcttc ctcttgcctc ctcccttgtc
     1261 agttccaaac agacaaaaca gataaacaaa caagcccctt gcccttttcc cttgctgtta
     1321 aagacccctt taagcatgtg gtgttgtctt agcatggtac ctgctgggtt tttgttgttg
     1381 ttgttttgtt ttgggttttt tgttttgttt tgttttgctt tgctttgctt ttaaggccat
     1441 tggggggggt atttattttt taagaaaaaa agctgcaaaa attatatatt gcaaggtgtg
     1501 atggtctggt ttgggtgaat ttcaggggaa atgaggaaaa gaaaaaggaa agggagattt
     1561 gtaagtggag tctcatcctc tctcctcctc ctttcccccc atctctttcc ttaggccttt
     1621 tgcattgaaa atgcaccagg ggaggttagt gaggggggaa gtcattttaa ggagaacaaa
     1681 gctatgaagt tcttttgtat tcttgtgggg gggtggaagg aggggggagg acagcaaaca
     1741 aagctaaatg catctggaga gcctctggga gctgttcagt ttgaggagcc aaaagaaaat
     1801 aaaaatgaac tttcagttca gagaggcagt ctgtaggtag atgctccccc taccctcatc
     1861 gtggttattg tgttttttgg actgaattta cttgattatt gtaaaacttg caataaagaa
     1921 ttttagtgtt gatgtgaaat gccccgtgat caataataaa ccagtggctg tgaattagtt
     1981 tta
//
