LOCUS       NM_010464               2433 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus homeobox C13 (Hoxc13), mRNA.
ACCESSION   NM_010464
VERSION     NM_010464.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2433)
  AUTHORS   Castilla-Ibeas,A., Zdral,S., Galan,L., Haro,E., Allou,L.,
            Campa,V.M., Icardo,J.M., Mundlos,S., Oberg,K.C. and Ros,M.A.
  TITLE     Failure of digit tip regeneration in the absence of Lmx1b suggests
            Lmx1b functions disparate from dorsoventral polarity
  JOURNAL   Cell Rep 42 (1), 111975 (2023)
   PUBMED   36641754
REFERENCE   2  (bases 1 to 2433)
  AUTHORS   Perez,C.J., Mecklenburg,L., Fernandez,A., Cantero,M., de
            Souza,T.A., Lin,K., Dent,S.Y.R., Montoliu,L., Awgulewitsch,A. and
            Benavides,F.
  TITLE     Naked (N) mutant mice carry a nonsense mutation in the homeobox of
            Hoxc13
  JOURNAL   Exp Dermatol 31 (3), 330-340 (2022)
   PUBMED   34657330
REFERENCE   3  (bases 1 to 2433)
  AUTHORS   Sawai,A., Pfennig,S., Bulajic,M., Miller,A., Khodadadi-Jamayran,A.,
            Mazzoni,E.O. and Dasen,J.S.
  TITLE     PRC1 sustains the integrity of neural fate in the absence of PRC2
            function
  JOURNAL   Elife 11, e72769 (2022)
   PUBMED   34994686
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2433)
  AUTHORS   Xie,Y., Chen,D., Jiang,K., Song,L., Qian,N., Du,Y., Yang,Y.,
            Wang,F. and Chen,T.
  TITLE     Hair shaft miniaturization causes stem cell depletion through
            mechanosensory signals mediated by a Piezo1-calcium-TNF-alpha axis
  JOURNAL   Cell Stem Cell 29 (1), 70-85 (2022)
   PUBMED   34624205
REFERENCE   5  (bases 1 to 2433)
  AUTHORS   Higashijima,Y., Nagai,N., Yamamoto,M., Kitazawa,T., Kawamura,Y.K.,
            Taguchi,A., Nakada,N., Nangaku,M., Furukawa,T., Aburatani,H.,
            Kurihara,H., Wada,Y. and Kanki,Y.
  TITLE     Lysine demethylase 7a regulates murine anterior-posterior
            development by modulating the transcription of Hox gene cluster
  JOURNAL   Commun Biol 3 (1), 725 (2020)
   PUBMED   33257809
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2433)
  AUTHORS   Nadeau,J.H., Compton,J.G., Giguere,V., Rossant,J. and Varmuza,S.
  TITLE     Close linkage of retinoic acid receptor genes with homeobox- and
            keratin-encoding genes on paralogous segments of mouse chromosomes
            11 and 15
  JOURNAL   Mamm Genome 3 (4), 202-208 (1992)
   PUBMED   1377062
REFERENCE   7  (bases 1 to 2433)
  AUTHORS   Compton,J.G., Ferrara,D.M., Yu,D.W., Recca,V., Freedberg,I.M. and
            Bertolino,A.P.
  TITLE     Chromosomal localization of mouse hair keratin genes
  JOURNAL   Ann N Y Acad Sci 642, 32-43 (1991)
   PUBMED   1725581
REFERENCE   8  (bases 1 to 2433)
  AUTHORS   Saffer,J.D., Thurston,S.J., Annarella,M.B. and Compton,J.G.
  TITLE     Localization of the gene for the trans-acting transcription factor
            Sp1 to the distal end of mouse chromosome 15
  JOURNAL   Genomics 8 (3), 571-574 (1990)
   PUBMED   1981055
REFERENCE   9  (bases 1 to 2433)
  AUTHORS   Handa,S., Ferguson,J.M., Wallace,M.E. and Bulfield,G.
  TITLE     Characterization and mapping of a viable anaemic mutant in the
            mouse: a new allele, mkvan, at the microcytic anaemia locus
  JOURNAL   Genet Res 51 (1), 41-45 (1988)
   PUBMED   3366378
REFERENCE   10 (bases 1 to 2433)
  AUTHORS   Tenenhouse,H.S., Gold,R.J. and Kachra,Z.
  TITLE     Biochemical marker in dominantly inherited ectodermal malformation
  JOURNAL   Nature 251 (5474), 431-432 (1974)
   PUBMED   4479485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160979.2.
            
            On Nov 17, 2006 this sequence version replaced NM_010464.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF193796.1, AY349616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-787               AC160979.2         174221-175007
            788-2433            AC160979.2         180259-181904
FEATURES             Location/Qualifiers
     source          1..2433
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15"
     gene            1..2433
                     /gene="Hoxc13"
                     /gene_synonym="N"
                     /note="homeobox C13"
                     /db_xref="GeneID:15422"
                     /db_xref="MGI:MGI:99560"
     exon            1..787
                     /gene="Hoxc13"
                     /gene_synonym="N"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1044
                     /gene="Hoxc13"
                     /gene_synonym="N"
                     /note="naked"
                     /codon_start=1
                     /product="homeobox protein Hox-C13"
                     /protein_id="NP_034594.1"
                     /db_xref="CCDS:CCDS27890.1"
                     /db_xref="GeneID:15422"
                     /db_xref="MGI:MGI:99560"
                     /translation="MTTSLLLHPRWPESLMYVYEDSAAESGSGGGGGGGGAGGAGGGC
                     SGASPGKAPSMDGLGGSCPASHCRDLLPHPVLARPPAPLGAPQGAVYTDIPAPEAARQ
                     CAPPPAPPTSSSATLGYGYPFGGSYYGCRLSHNVNLQQKPCAYHPGDKYPEPSGALPG
                     DDLSSRAKEFAFYPSFASSYQAMPGYLDVSVVPGISGHPEPRHDALIPVEGYQHWALS
                     NGWDSQVYCSKEQSQSAHLWKSPFPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKE
                     YAASKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLHST"
     exon            788..2433
                     /gene="Hoxc13"
                     /gene_synonym="N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxc13"
                     /gene_synonym="N"
                     /note="hexamer: AATAAA"
     polyA_site      2433
                     /gene="Hoxc13"
                     /gene_synonym="N"
                     /note="major polyA site"
ORIGIN      
        1 ccctagctcg ctgcctctgg caagtggagt ttttaaaaag ctggagcaga tcatgtcatg
       61 acgacttcgc tgctcctgca cccgcgctgg ccggagagcc ttatgtacgt ctatgaggac
      121 agcgcggcgg agagcggcag cggcggcggc gggggaggcg gcggcgcggg cggcgcgggg
      181 ggtggctgca gcggagcgag ccccggcaaa gccccgagca tggacgggct gggcggtagc
      241 tgcccggcca gccactgccg cgacctgctc ccgcaccctg tattggcccg cccgccggct
      301 cctctgggtg cccctcaggg cgccgtctac acggacatcc cagccccgga ggcggcgcgc
      361 caatgcgccc caccgccggc gccccccacc tcgtccagcg ccaccctggg ctatggttac
      421 ccatttgggg gcagctacta cggctgccgc ctgtcgcaca acgtgaacct gcagcagaag
      481 ccttgcgcct accatccggg ggacaagtac ccagagccgt cgggcgcgct gcctggtgac
      541 gacctgtcct ccagggctaa ggagttcgcc ttctacccca gcttcgccag ctcctaccag
      601 gcaatgcccg gctacctgga cgtgtcggtg gtgcctggga tcagcgggca cccggagccg
      661 cgtcacgacg cgctcatccc tgttgaaggc taccagcact gggctctttc caatggctgg
      721 gacagtcagg tgtactgctc caaggagcag tcgcagtccg cccacctctg gaagtctccc
      781 ttcccagacg tggttcctct acagcccgaa gtgagcagct accggcgcgg gcgcaagaag
      841 cgcgtgccct ataccaaggt gcagctgaag gagctagaga aggagtacgc agccagcaaa
      901 ttcatcacca aagagaagcg ccggcgcatc tcagccacca cgaacctctc ggagcgtcag
      961 gtcaccatct ggttccagaa tcgacgcgtg aaagagaaaa aggtggtcag caaatctaaa
     1021 gcgcctcatc tccactccac ctgacccgtc cgtttgcccg ccctccccgc ccgtcccgac
     1081 tatttatgtc acagctttgt accataacgg aatccacccg aaggacgctg caccggcgca
     1141 gaccactatt taatcttacc gagaaagaag aacagctctg ccttacccta gtcccattcc
     1201 acccctaatc tcaccgcccc ctgccagatg gcacccaact cagcatccgc agctgtagag
     1261 gtgggttcga atggggtacc agaggaagac tgtctctaaa cccctggcct ttgtgacttg
     1321 tcccactaga aagccgagtg gcctggagag cccagtcatt cctaccaaag caggactggg
     1381 gaattccaaa ttactcagtt cttgcctctt cctgtgcctc agcttgtgga agaacctact
     1441 tctggggtgc atggacacag gatctggggg agctctttct ttctttcctg ttctcccttt
     1501 ttactgtcat tactgaactc cgtaggcaag gttttcccag ttacgatttt tctgtgcatc
     1561 ttttaaaagt cgtgtgaata ttgatgctaa tccttagggc ctggcagtgt aatgtaattc
     1621 aaacggaacc gttcttgtag atcagatttt cttttctgtt tttcttttct tcccctctct
     1681 ctttctttct tttctttttt ttttttctgt ctgtctcaac aaaagctgga gttggtgcag
     1741 cccctagcca caccctaacc cagaaatgat tcccgggagg tgcctttgac cccactgcct
     1801 cctctgcttt gcactcttag tcctaaggaa atccaaggag gacaaaaaca aaacacacac
     1861 aaaaaaaaca aacaaacaaa aataaaaaac aacctccagc cacaatgcta agtgtggctt
     1921 ctgtctcttt ctctctcaag gtgaggttgg gaactaggcc aggcttagaa tcagaacttt
     1981 ttataaactt ctttaaagga gatagagggt gggtccctca gaagatcttc aatcttatct
     2041 ctacataagc agtagcagat agtggagagg agagaccaca cactttcatt tttcactgat
     2101 ttcctaagca tagcttgagg agctgactga ggaggggtga catcattggt cctggataaa
     2161 ccagctaaat gtagacgctg cctaatttct ccctcctcaa aagccaactt ggtgctgtgg
     2221 gggccccctc acctcttccc ttcccactgg ctcattacaa aacagtgttc ttttgaaatg
     2281 cccatctgaa ataggctcct ttttttttta aatgttgtgt atctgtatat agtattgtga
     2341 cgtctgaatg acaatgtatt gaatgcaaag aagaaaaaaa aaaccccaca aactcgtttt
     2401 taaaataaaa tatctttttg gttttggcct tga
//
