LOCUS       NM_010462               1914 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox C10 (Hoxc10), mRNA.
ACCESSION   NM_010462 XM_128109
VERSION     NM_010462.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1914)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1914)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   3  (bases 1 to 1914)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1914)
  AUTHORS   Sawai,A., Pfennig,S., Bulajic,M., Miller,A., Khodadadi-Jamayran,A.,
            Mazzoni,E.O. and Dasen,J.S.
  TITLE     PRC1 sustains the integrity of neural fate in the absence of PRC2
            function
  JOURNAL   Elife 11, e72769 (2022)
   PUBMED   34994686
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1914)
  AUTHORS   Ferdous,A., Singh,S., Luo,Y., Abedin,M.J., Jiang,N., Perry,C.E.,
            Evers,B.M., Gillette,T.G., Kyba,M., Trojanowska,M. and Hill,J.A.
  TITLE     Fli1 Promotes Vascular Morphogenesis by Regulating Endothelial
            Potential of Multipotent Myogenic Progenitors
  JOURNAL   Circ Res 129 (10), 949-964 (2021)
   PUBMED   34544261
REFERENCE   6  (bases 1 to 1914)
  AUTHORS   Peterson,R.L., Papenbrock,T., Davda,M.M. and Awgulewitsch,A.
  TITLE     The murine Hoxc cluster contains five neighboring AbdB-related Hox
            genes that show unique spatially coordinated expression in
            posterior embryonic subregions
  JOURNAL   Mech Dev 47 (3), 253-260 (1994)
   PUBMED   7848872
REFERENCE   7  (bases 1 to 1914)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   8  (bases 1 to 1914)
  AUTHORS   Peterson,R.L., Jacobs,D.F. and Awgulewitsch,A.
  TITLE     Hox-3.6: isolation and characterization of a new murine homeobox
            gene located in the 5' region of the Hox-3 cluster
  JOURNAL   Mech Dev 37 (3), 151-166 (1992)
   PUBMED   1353983
REFERENCE   9  (bases 1 to 1914)
  AUTHORS   Murtha,M.T., Leckman,J.F. and Ruddle,F.H.
  TITLE     Detection of homeobox genes in development and evolution
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10711-10715 (1991)
   PUBMED   1720547
REFERENCE   10 (bases 1 to 1914)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021667.21 and AK033186.1.
            
            On Mar 26, 2011 this sequence version replaced NM_010462.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053405.1, AK138664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC021667.21        69622-69690
            70-1593             AK033186.1         2-1525
            1594-1914           AC021667.21        74404-74724
FEATURES             Location/Qualifiers
     source          1..1914
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.03 cM"
     gene            1..1914
                     /gene="Hoxc10"
                     /gene_synonym="Hox-3.6"
                     /note="homeobox C10"
                     /db_xref="GeneID:209448"
                     /db_xref="MGI:MGI:96192"
     exon            1..813
                     /gene="Hoxc10"
                     /gene_synonym="Hox-3.6"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1091
                     /gene="Hoxc10"
                     /gene_synonym="Hox-3.6"
                     /note="homeo box C10; homeobox protein Hox-3.6"
                     /codon_start=1
                     /product="homeobox protein Hox-C10"
                     /protein_id="NP_034592.2"
                     /db_xref="CCDS:CCDS57014.1"
                     /db_xref="GeneID:209448"
                     /db_xref="MGI:MGI:96192"
                     /translation="MTCPRNVTPNSYAEPLAAPGGGERYNRNAGMYMQSGSDFNCGVM
                     RGCGLAPSLSKRDEGGSPNLALNTYPSYLSQLDSWGDPKAAYRLEQPVGRPLSSCSYP
                     PSVKEENVCCMYSAEKRAKSGPEAALYSHPLPESCLGEHEVPVPSYYRASPSYSALDK
                     TPHCAGANEFEAPFEQRASLNPRTEHLESPQLGGKVSFPETPKSDSQTPSPNEIKTEQ
                     SLAGPKASPSESEKERAKTADSSPDTSDNEAKEEIKAENTTGNWLTAKSGRKKRCPYT
                     KHQTLELEKEFLFNMYLTRERRLEISKTINLTDRQVKIWFQNRRMKLKKMNRENRIRE
                     LTSNFNFT"
     exon            814..1914
                     /gene="Hoxc10"
                     /gene_synonym="Hox-3.6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1886..1891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxc10"
                     /gene_synonym="Hox-3.6"
                     /note="hexamer: AATAAA"
     polyA_site      1914
                     /gene="Hoxc10"
                     /gene_synonym="Hox-3.6"
                     /note="major polyA site"
ORIGIN      
        1 gggaaaaaag atgtcagctc ctccgctgta gtattgctcc ttaaaaaccc ctctctctga
       61 aaatgacatg ccctcgcaat gtaactccga actcgtacgc ggagcccttg gctgcgccgg
      121 gaggaggaga gcgctataac cgtaacgcag gaatgtatat gcaatctggg agtgacttca
      181 actgcggggt gatgaggggc tgcgggctcg cgccctctct ctccaagagg gacgagggag
      241 gcagcccaaa cctagccctc aacacctacc cgtcctacct ctcgcagctg gactcctggg
      301 gcgaccccaa agccgcctac cgcctggaac aacctgttgg caggcctctg tcctcctgtt
      361 cctacccacc tagtgtcaag gaggagaatg tctgctgcat gtacagtgca gagaagcggg
      421 cgaaaagtgg ccctgaggca gctctctact cccaccccct gccggagtct tgccttgggg
      481 agcacgaggt acctgtaccc agctactacc gagccagccc gagctactcc gcgctggaca
      541 aaacgcccca ctgtgctggg gccaacgagt tcgaagcccc ctttgagcag cgggccagtc
      601 tcaacccgcg caccgaacat ctggaatcgc ctcagcttgg gggcaaagtg agttttcctg
      661 agacccccaa gtccgacagc cagaccccca gtcccaatga gatcaagaca gagcaaagcc
      721 tggcgggccc aaaagccagc ccctcggaga gcgagaagga acgggccaag accgcagact
      781 ccagtccaga cacctcggat aacgaagcta aagaggagat aaaggcagaa aacaccacag
      841 gaaattggct gacagcaaag agcggaagga agaagaggtg cccctatact aaacaccaga
      901 cgctggaatt ggagaaagaa tttctgttca atatgtattt gacgcgagag cgccgcctgg
      961 agattagcaa gaccattaac cttacagaca gacaagtcaa aatctggttt caaaatcgca
     1021 gaatgaaact caagaaaatg aaccgagaga atcggatccg ggaactgacc tccaatttta
     1081 atttcacctg agccagcgtc atctcctccc cctccccttc tcccctttcc ccgcccctcc
     1141 tccctttgtg cctggtgata tatttttttc cctccctgag tataaatgca actcgcctgc
     1201 aaaaaaaaaa aaaaaggcaa agacctcaga ctcttcttcc aagggaccta tggttcgtgc
     1261 ttcgaggatg cttccaccta aagcatgaaa tggggtgatg ggttttgggg tgttgtgtgt
     1321 gccctcatag atggggtggt agtgtggccg gtgtgtgtgt caactcttca gtcacccatg
     1381 cactcacata cagcattctg ttctccatgc aaagttgagg tcaaatgcac ccgattagag
     1441 gggaaagaaa gggggataat caaacagaga gggtctgtaa ccttgtagag cacagttagc
     1501 attgctcctt ccttgctgca tttcccccct tagaataata ggtagtcttg aaagttcagc
     1561 tagtatttgt gtgtttgtca tagtacccag tgtctagact aaaccctccc tctctctgtc
     1621 tttccctccc aatggctctg agaatatgct tgaagtattt gtactgcttt ctgcttttct
     1681 cccacccttc ccaacacact atatctctct catctcagaa attccatcca gaagaacaaa
     1741 aaaaaaatta aaaatagagc atagcaaagt aaaaacaacc ccccctccaa gttgtcctgc
     1801 tcctgtctgg gagttgtgtt atttaaagat attctgtatg ttgtatcttt tgcatgtagc
     1861 ttccttaatg gagaaaaaaa atcctaataa atttccggaa tcttaatcct caaa
//
