LOCUS       NM_008270               2711 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox B9 (Hoxb9), mRNA.
ACCESSION   NM_008270
VERSION     NM_008270.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2711)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2711)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2711)
  AUTHORS   Lopez-Delisle,L., Zakany,J., Bochaton,C., Osteil,P., Mayran,A.,
            Darbellay,F., Mascrez,B., Rekaik,H. and Duboule,D.
  TITLE     CTCF-dependent insulation of Hoxb13 and the heterochronic control
            of tail length
  JOURNAL   Proc Natl Acad Sci U S A 121 (46), e2414865121 (2024)
   PUBMED   39499640
REFERENCE   4  (bases 1 to 2711)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   5  (bases 1 to 2711)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   6  (bases 1 to 2711)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2711)
  AUTHORS   Kondo,T., Takahashi,N. and Muramatsu,M.
  TITLE     The regulation of the murine Hox-2.5 gene expression during cell
            differentiation
  JOURNAL   Nucleic Acids Res 20 (21), 5729-5735 (1992)
   PUBMED   1360646
REFERENCE   8  (bases 1 to 2711)
  AUTHORS   Conlon,R.A. and Rossant,J.
  TITLE     Exogenous retinoic acid rapidly induces anterior ectopic expression
            of murine Hox-2 genes in vivo
  JOURNAL   Development 116 (2), 357-368 (1992)
   PUBMED   1363087
REFERENCE   9  (bases 1 to 2711)
  AUTHORS   Jones,F.S., Prediger,E.A., Bittner,D.A., De Robertis,E.M. and
            Edelman,G.M.
  TITLE     Cell adhesion molecules as targets for Hox genes: neural cell
            adhesion molecule promoter activity is modulated by cotransfection
            with Hox-2.5 and -2.4
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2086-2090 (1992)
   PUBMED   1347944
REFERENCE   10 (bases 1 to 2711)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645478.15, AI116698.1 and AA386586.1.
            
            On Aug 31, 2006 this sequence version replaced NM_008270.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M34857.1, AI116698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-619               AL645478.15        85930-86548
            620-1020            AI116698.1         1-401
            1021-2508           AL645478.15        89515-91002
            2509-2711           AA386586.1         177-379
FEATURES             Location/Qualifiers
     source          1..2711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.81 cM"
     gene            1..2711
                     /gene="Hoxb9"
                     /gene_synonym="Hox-2.5"
                     /note="homeobox B9"
                     /db_xref="GeneID:15417"
                     /db_xref="MGI:MGI:96190"
     exon            1..729
                     /gene="Hoxb9"
                     /gene_synonym="Hox-2.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..965
                     /gene="Hoxb9"
                     /gene_synonym="Hox-2.5"
                     /note="homeobox protein Hox-2.5; homeo box B9"
                     /codon_start=1
                     /product="homeobox protein Hox-B9"
                     /protein_id="NP_032296.2"
                     /db_xref="CCDS:CCDS25292.1"
                     /db_xref="GeneID:15417"
                     /db_xref="MGI:MGI:96190"
                     /translation="MSISGTLSSYYVDSIISHESEDAPPAKFPSGQYANPRQPGHAEH
                     LDFPSCSFQPKAPVFGASWAPLSPHASGSLPSVYHPYLQPQGAPAAESRYLRTWLEPA
                     PRAEAAPGQGQAAVKAEPLLGAPGELLKQGTPEYSLETSAGREAVLSNQRAGYGDNKI
                     CEGSEDKERPDQTNPSANWLHARSSRKKRCPYTKYQTLELEKEFLFNMYLTRDRRHEV
                     ARLLNLSERQVKIWFQNRRMKMKKMNKEQGKE"
     exon            730..2701
                     /gene="Hoxb9"
                     /gene_synonym="Hox-2.5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2679..2684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxb9"
                     /gene_synonym="Hox-2.5"
                     /note="hexamer: AATATA"
     polyA_site      2701
                     /gene="Hoxb9"
                     /gene_synonym="Hox-2.5"
                     /note="major polyA site"
ORIGIN      
        1 aatcattttg caaggagctc cgagccgggc tgctccactg tactttgttg gctgagaagt
       61 tgagcagggg gtgggggtgg gagggtgggg gtctgggggg ggtcgcgtcc gaaagccctc
      121 tgcaccgggt ccgtgtgcca ccttttccct gcttgggcgc cgcggcgcga gcgcttccct
      181 tccccctgcg agcgcgcgga taatgtctga gaatgtccat ttctgggacg cttagcagct
      241 attatgtcga ctcgatcata agtcacgaga gcgaggacgc gcctccagcc aagtttcctt
      301 cgggccagta cgcgaacccg cggcagccgg gccacgccga gcacctggac ttcccctcgt
      361 gcagcttcca gcccaaagcg ccggtgttcg gcgcctcctg ggcgccgctg agcccgcacg
      421 cctcggggag cctgccgtct gtctaccacc cctacctgca gccccagggc gcgccggcgg
      481 ccgaaagcag gtacctccgc acctggctag agccggcgcc gcgcgccgag gccgccccgg
      541 ggcagggcca ggcggccgtg aaggcggagc cgctgctggg cgcgccgggg gagctgctca
      601 aacagggcac gcccgagtac agtttggaaa cttcggcggg cagggaggct gtcctgtcta
      661 atcaaagagc tggctacggg gacaataaaa tttgcgaagg aagcgaggac aaagagaggc
      721 cggatcaaac caacccctct gccaactggc tgcacgcccg ctcttcccgg aaaaagcgct
      781 gtccctacac caaataccag acgctggagc tagagaagga gtttctgttc aatatgtacc
      841 tcaccaggga ccgcaggcat gaagtggcca gactcctcaa tctgagtgag agacaagtca
      901 aaatctggtt tcagaaccgg cggatgaaaa tgaagaagat gaataaggag cagggcaaag
      961 agtaaagatg accacccccc cttccccagc tcactcttat tatttatgtg atggtcaaaa
     1021 agccactgct gtctgggttg tacccaagtg agtggggaag agtatctcct ctttaaaatc
     1081 cctcatctgc acctggagcc tgtctcctct cctttgcgcc tctctctctc tctctctctc
     1141 tctctctctc tctctctctc tctctctcca ctctcctggt gttaagagga aattttatta
     1201 agttagaagc tagctatact tggttcctag aaaagtgatg agcctcgctc cgaggaaaga
     1261 gaccctagtc gagctcctag catccctgct aatttttctg gaaaacccca gcccctctct
     1321 tccagtctgc ctgttccctc cctgtaacct agccagacgc cacccaggta cagtttaact
     1381 gcacacagcc cagtggatgc ccacagacat agagtttgga gtctatgcta atcatcgtgg
     1441 agaaaggaca tcaagacgtt gttcatcaaa ccaagcaggg cagctctcag atcaggttca
     1501 ttttggttgt gccctgatcc aaacacacac taggaagatg tctagagatg ccctcaatga
     1561 ggcactgcag tcccaaagtc tcaacatccc aatatgtatc ctatggaatt gccagctaga
     1621 ccccatatct ggggaggcct gtgggcagat gtggccattc ctgtccccaa gctgttgtga
     1681 gctagaaagg gcaagaaaaa gcagggagtg gttttatgaa ggtaccatta gtggagtccc
     1741 ctcgtatttt ccctgcagga agtgtttaat tctgcatgtt ttcctttcct tccaactaaa
     1801 ggaggtcaaa ttgtgggttg tagagccctg acagtgctgt ttccccattc atacattcct
     1861 atccccattt gacagaatgt aacttttctt gctgaccaca gtctcagatt cctctctatc
     1921 ctccaacttt gaaatcaact ctcctttcca ccaaacccat cttgcaccag caagacaagt
     1981 ctcccattgt aggaaaaaaa aaaaagtccc tttcctctct gctaggtcaa ccccaccata
     2041 gagaaggctg ggtcagaaga gtctgaaaat ttattgtgaa tcaattcccc agctcccttc
     2101 cagagtaggc agtcagggcc gggaggagca atggcctcag caagcagggc tagtgggtat
     2161 ctttccattt caccagtttc ctgacccagg aagaagagag ccccttggca tccagccaga
     2221 ggtccaaaag aagactcaga gtggggactt cacctcctgc aaagtccact gctgtatcca
     2281 tcctgttgct gctgcatgca tacgcttctg gcaaacagtc cagtgtgcac aggaaagagg
     2341 caaacatcgc acctccccat cgtgcagagg ggggtcctct ctgcctctct gcctctctgc
     2401 tctccctgct tctcaatccc ttccacccgt ggacttttgt tcccgcttct cctgactgca
     2461 aagaggtcat tccagtagaa ctttgaattt tattttatta attttttttt gcttttgtcg
     2521 gtggctgtgg tgacattgtg cttgtgtttt gtgatttctt tggcagtgat tttcagttgt
     2581 tgcttataag ggagggttga gggtgggagt ggggagggca aggggcctag agctctaatt
     2641 gtttgttttg gaagaaaaag gggaaaaaaa gaacaaaaaa tatacatatc actctagaaa
     2701 aaaaaaaaaa a
//
