LOCUS       NM_010461               2645 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox B8 (Hoxb8), mRNA.
ACCESSION   NM_010461
VERSION     NM_010461.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2645)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2645)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2645)
  AUTHORS   Bohic,M., Upadhyay,A., Eisdorfer,J.T., Keating,J., Simon,R.C.,
            Briones,B.A., Azadegan,C., Nacht,H.D., Oputa,O., Martinez,A.M.,
            Bethell,B.N., Gradwell,M.A., Romanienko,P., Ramer,M.S., Stuber,G.D.
            and Abraira,V.E.
  TITLE     A new Hoxb8FlpO mouse line for intersectional approaches to dissect
            developmentally defined adult sensorimotor circuits
  JOURNAL   Front Mol Neurosci 16, 1176823 (2023)
   PUBMED   37603775
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2645)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2645)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   6  (bases 1 to 2645)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2645)
  AUTHORS   Zwartkruis,F., Hoeijmakers,T., Deschamps,J. and Meijlink,F.
  TITLE     The murine Hox-2.4 promoter contains a functional octamer motif
  JOURNAL   Nucleic Acids Res 20 (7), 1599-1606 (1992)
   PUBMED   1349742
REFERENCE   8  (bases 1 to 2645)
  AUTHORS   Jones,F.S., Prediger,E.A., Bittner,D.A., De Robertis,E.M. and
            Edelman,G.M.
  TITLE     Cell adhesion molecules as targets for Hox genes: neural cell
            adhesion molecule promoter activity is modulated by cotransfection
            with Hox-2.5 and -2.4
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2086-2090 (1992)
   PUBMED   1347944
REFERENCE   9  (bases 1 to 2645)
  AUTHORS   Ben-David,L., Aberdam,D., Sachs,L. and Blatt,C.
  TITLE     A deletion and a rearrangement distinguish between the
            intracisternal A-particle of Hox-2.4 and that of interleukin-3 in
            the same leukemic cells
  JOURNAL   Virology 182 (1), 382-387 (1991)
   PUBMED   1673811
REFERENCE   10 (bases 1 to 2645)
  AUTHORS   Aberdam,D., Negreanu,V., Sachs,L. and Blatt,C.
  TITLE     The oncogenic potential of an activated Hox-2.4 homeobox gene in
            mouse fibroblasts
  JOURNAL   Mol Cell Biol 11 (1), 554-557 (1991)
   PUBMED   1670897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645478.15, AK083980.1 and AK131612.1.
            
            On Dec 21, 2006 this sequence version replaced NM_010461.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X13721.1, BC139209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               AL645478.15        96505-96970
            467-729             AK083980.1         2-264
            730-1482            AL645478.15        97234-97986
            1483-1585           AL645478.15        98763-98865
            1586-2635           AK131612.1         461-1510
            2636-2645           AL645478.15        99916-99925
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.82 cM"
     gene            1..2645
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="homeobox B8"
                     /db_xref="GeneID:15416"
                     /db_xref="MGI:MGI:96189"
     exon            1..1482
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1059..1790
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="homeobox protein Hox-2.4; homeo box B8"
                     /codon_start=1
                     /product="homeobox protein Hox-B8"
                     /protein_id="NP_034591.1"
                     /db_xref="CCDS:CCDS25293.1"
                     /db_xref="GeneID:15416"
                     /db_xref="MGI:MGI:96189"
                     /translation="MSSYFVNSLFSKYKTGESLRPNYYDCGFAQDLGGRPTVVYGPSS
                     GGSFQHPSQIQEFYHGPSSLSTAPYQQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDP
                     DLVQYADCKLAAASGLGEEAEGSEQSPSPTQLFPWMRPQAAAGRRRGRQTYSRYQTLE
                     LEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQE
                     ELEKEKLERAPETAEQGDAQKGDKK"
     exon            1483..2645
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2619..2624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="hexamer: AATAAA"
     polyA_site      2644
                     /gene="Hoxb8"
                     /gene_synonym="Hox-2.4"
                     /note="major polyA site"
ORIGIN      
        1 aagctttaaa tatgactacc tcgtttgttt gaaaatatgt ttaggagagg aagctgtatg
       61 atttgataac ttgtattaaa ataccaatta catttatagg accttttaaa actcggtgca
      121 attaaaccgt gttcttttac atttttccga agcgaccctg acatttagaa agactccaat
      181 tgcctcgtta aaatcgcgaa attaacagcg tgcctacgcc aggctcagcg ttgtggatgt
      241 gtgtgtatgg tgtttttccg tgactccccc acatcagtct ttgggggtgg tctgcgaagg
      301 tatttgattt gttgtgaggc aagagatatc tcattaatgt aggtagttaa acagatttaa
      361 tccgtattcg ttctctctct ctcccccctc cctctccccc cctctccccc tctttctccc
      421 tgggtgtttt tttctcttcc cctccttttt ttctgccctc tcctcactcc ctggcgctct
      481 ctcgctctag ctctctctcg cactcgctct ctctcgctct caccctcgct ctgcgttctg
      541 tccgggagga gtacccagaa gccaatagga tgcggggtct ctaatggatg caaatgatgg
      601 tgaaaagacg gggcaaaata tgaaacaact catttggagg gaagtaaatc accgaaaact
      661 gtttatgaac tggcatccct tcttcgaaat gtaaagcgag gacctcttta agtggcggta
      721 tatttttgtt tggggggtgg ggggtggggg gagggcgagc gagccgcggc tgccatgcag
      781 gcttagactt ttgcaggctt cgctcttcta ttcctggaaa tcacaaaaag tgtggcggct
      841 ttgagatctt cttcgtcttt tctttctttt ccttccttcc ttcttttttt tcccctcctc
      901 ccttttcctc tcctttcctg gcgagggtga ctaggagccg gcgaatccgc gttttttttt
      961 ctctctctct ccctcccttt tccccctccc caccccctcc ccaacagccc ccaactacag
     1021 cctgcgccgc cgccgccgcc gcctcaaaat tcaataaaat gagctcttat ttcgtcaact
     1081 cactgttctc caaatacaaa accggggagt ccctgcgccc caattattat gactgcggct
     1141 tcgcccagga cctgggcggc cgacccaccg tggtgtacgg tcccagcagc ggcggcagct
     1201 tccagcaccc ttcgcaaatc caggagttct accacgggcc atcgtcgctg tccacagctc
     1261 cctaccagca gaacccgtgc gccgtggcgt gccacggcga ccccggcaac ttctacggct
     1321 acgaccctct gcagcgccag agcctgttcg gtgcgcagga tccagacctg gtgcagtacg
     1381 cagactgcaa gctcgcggca gccagcggcc tgggcgagga ggccgagggg tctgagcaga
     1441 gcccgtcgcc cacacagctc tttccctgga tgcgccctca agcagccgcc ggacgcaggc
     1501 gaggccgcca gacctacagt cgctaccaga ccctggagct ggagaaggag ttcctattta
     1561 atccctatct gactcgcaag cggaggatcg aggtatcgca cgcgctggga ctgacagaga
     1621 gacaggtcaa aatctggttc cagaatcgga gaatgaagtg gaaaaaggag aacaacaaag
     1681 acaagtttcc cagcagtaaa tgcgagcagg aggagctgga gaaagagaag ctggagcggg
     1741 caccagagac cgccgagcag ggcgatgcgc agaagggtga caagaagtag gctccagctg
     1801 ggactgctcg ggcccggact agcccgcacg tccgccggtc ccccccgcga ccacgccgcc
     1861 gccgcccgcc ccccgcctcc gagagctccg gccccgcgag cggagccagg agctgggcct
     1921 cccacagcag cgtcccccgc cgcgccagtc cccgctagtg gtagtatctc gtaatagctt
     1981 ctgtgtgtga gctaccgtgg atctccttcc cttctcttgg gggtccgggg ggaaaaaaag
     2041 aaaaggattt taagcaagga ctccctcgtc ctgcgagggt gatcgactgc ggcctggcag
     2101 aaccccctcg cccccgcccc atgtaaaaaa gcctccttgt gcaatggtct gtttcctttg
     2161 aacgtgcttc tttgtaatga ccgaggtacc gatttctgct aagttttccc aacaacatga
     2221 aactgcctat tcacgccgta attctttctg tctcccgctc actttctctc tttctctcgc
     2281 tctctttctc tcaccgcgtc cccatctttc ctcgcaaccc cctctccccg ctgccctccc
     2341 tagctggctt tctctcttgc ttctctcttt tcctcctgtc cccccacccc cacccccttt
     2401 ggtttgacaa ttttgtctta agtgtttctc aaaagagatt actttagtta gcatgcgcgc
     2461 tgtgagcatt gttaaaagtg ttcttaggtt tactgtgaag agaatgtatc ctgtatctgt
     2521 gaattgcttt atggggggga gggagggcta attatatatt ttgttgttcc tctatacttt
     2581 gttctgttgt ctgcgcctga aaagggcgga agagttacaa taaagtttac aagcgagaac
     2641 ccgag
//
