LOCUS       NM_010460               1269 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox B7 (Hoxb7), mRNA.
ACCESSION   NM_010460
VERSION     NM_010460.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1269)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1269)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1269)
  AUTHORS   Vong,K.I., Lee,S., Au,K.S., Crowley,T.B., Capra,V., Martino,J.,
            Haller,M., Araujo,C., Machado,H.R., George,R., Gerding,B.,
            James,K.N., Stanley,V., Jiang,N., Alu,K., Meave,N., Nidhiry,A.S.,
            Jiwani,F., Tang,I., Nisal,A., Jhamb,I., Patel,A., Patel,A.,
            McEvoy-Venneri,J., Barrows,C., Shen,C., Ha,Y.J., Howarth,R.,
            Strain,M., Ashley-Koch,A.E., Azam,M., Mumtaz,S., Bot,G.M.,
            Finnell,R.H., Kibar,Z., Marwan,A.I., Melikishvili,G., Meltzer,H.S.,
            Mutchinick,O.M., Stevenson,D.A., Mroczkowski,H.J., Ostrander,B.,
            Schindewolf,E., Moldenhauer,J., Zackai,E.H., Emanuel,B.S.,
            Garcia-Minaur,S., Nowakowska,B.A., Stevenson,R.E., Zaki,M.S.,
            Northrup,H., McNamara,H.K., Aldinger,K.A., Phelps,I.G., Deng,M.,
            Glass,I.A., Morrow,B., McDonald-McGinn,D.M., Sanna-Cherchi,S.,
            Lamb,D.J. and Gleeson,J.G.
  CONSRTM   Spina Bifida Sequencing Consortiumdouble dagger
  TITLE     Risk of meningomyelocele mediated by the common 22q11.2 deletion
  JOURNAL   Science 384 (6695), 584-590 (2024)
   PUBMED   38696583
REFERENCE   4  (bases 1 to 1269)
  AUTHORS   Li,Y., Yu,M., Tan,L., Xue,S., Du,X., Wang,C., Wu,X., Xu,H. and
            Shen,Q.
  TITLE     Disruption of Gen1 causes ectopic budding and kidney hypoplasia in
            mice
  JOURNAL   Biochem Biophys Res Commun 589, 173-179 (2022)
   PUBMED   34922199
REFERENCE   5  (bases 1 to 1269)
  AUTHORS   Yogosawa,S., Ohkido,M., Horii,T., Okazaki,Y., Nakayama,J.,
            Yoshida,S., Toyokuni,S., Hatada,I., Morimoto,M. and Yoshida,K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1269)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 1269)
  AUTHORS   McLain,K., Schreiner,C., Yager,K.L., Stock,J.L. and Potter,S.S.
  TITLE     Ectopic expression of Hox-2.3 induces craniofacial and skeletal
            malformations in transgenic mice
  JOURNAL   Mech Dev 39 (1-2), 3-16 (1992)
   PUBMED   1362649
REFERENCE   8  (bases 1 to 1269)
  AUTHORS   de Jong,R., de Laaf,L., Vennema,H. and Meijlink,F.
  TITLE     DNA-binding activity of the murine homeodomain protein Hox-2.3
            produced by a hybrid phage T7/vaccinia virus system
  JOURNAL   Gene 116 (2), 195-203 (1992)
   PUBMED   1353046
REFERENCE   9  (bases 1 to 1269)
  AUTHORS   Wu,J., Zhu,J.Q., Zhu,D.X., Scharfman,A., Lamblin,G. and Han,K.K.
  TITLE     Selective inhibition of normal murine myelopoiesis 'in vitro' by a
            Hox 2.3 antisense oligodeoxynucleotide
  JOURNAL   Cell Mol Biol 38 (4), 367-376 (1992)
   PUBMED   1354076
REFERENCE   10 (bases 1 to 1269)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK136706.1 and AL645478.15.
            
            On Feb 17, 2006 this sequence version replaced NM_010460.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136706.1, BY721099.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               AK136706.1         1-512
            513-1269            AL645478.15        104007-104763
FEATURES             Location/Qualifiers
     source          1..1269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.82 cM"
     gene            1..1269
                     /gene="Hoxb7"
                     /gene_synonym="Hox-2.3"
                     /note="homeobox B7"
                     /db_xref="GeneID:15415"
                     /db_xref="MGI:MGI:96188"
     exon            1..482
                     /gene="Hoxb7"
                     /gene_synonym="Hox-2.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..736
                     /gene="Hoxb7"
                     /gene_synonym="Hox-2.3"
                     /note="homeobox protein MuB1; homeobox protein MH-22B;
                     homeobox protein Hox-2.3; homeo box B7"
                     /codon_start=1
                     /product="homeobox protein Hox-B7"
                     /protein_id="NP_034590.2"
                     /db_xref="CCDS:CCDS25294.1"
                     /db_xref="GeneID:15415"
                     /db_xref="MGI:MGI:96188"
                     /translation="MSSLYYANALFSKYPAASSVFAPGAFPEQTSCAFASNPQRPGYG
                     AGPGAPFSASVQGLYSGGGAMAGQSAAGVYAAGYGLEPSSFNMHCAPFEQNLSGVCPG
                     DPAKAAGAKEQRDSDLAAESNFRIYPWMRSSGPDRKRGRQTYTRYQTLELEKEFHYNR
                     YLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKENKTSGPGTTGQDKAEAEEEEEE"
     exon            483..1269
                     /gene="Hoxb7"
                     /gene_synonym="Hox-2.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1247..1252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxb7"
                     /gene_synonym="Hox-2.3"
                     /note="hexamer: AATAAA"
     polyA_site      1269
                     /gene="Hoxb7"
                     /gene_synonym="Hox-2.3"
                     /note="major polyA site"
ORIGIN      
        1 ggactctaat tctgtaatat atcaaggaat ctcgtaaaac cgacactaaa acgtccccga
       61 ctacaaatca tccggccaaa ttatgagttc attgtattat gcgaatgctt tattttctaa
      121 atatccagcc gcaagttcgg ttttcgctcc aggagccttc cccgaacaaa cttcttgcgc
      181 ctttgcttcc aacccccagc gcccgggcta tggagcaggt ccgggcgctc ctttctccgc
      241 ctcggtgcag ggtctgtact ccggcggggg ggccatggcg ggccagagcg cggctggcgt
      301 ctatgcggcc ggctacgggc tcgaaccgag ttccttcaac atgcactgcg cgccctttga
      361 gcagaacctc tccggggtgt gtccgggcga ccccgccaag gcggctggcg ccaaggagca
      421 gagggactcg gacttggcgg ccgagagtaa cttccggatc tacccctgga tgcgaagctc
      481 agggcctgac cgaaagcgag gccgccagac ctacacgcgc taccagaccc tggagctgga
      541 gaaagaattt cactacaatc gctacctgac tcggcggagg cgcatcgaga tcgcgcacac
      601 gctctgcctc accgaaagac agatcaagat ctggtttcag aaccggcgca tgaagtggaa
      661 aaaggagaac aaaacctcag gaccgggaac caccggccag gacaaggcgg aagcggagga
      721 ggaggaggaa gagtgaggga cagagaaagc caagaggagg aaagcgaaga gagggagaac
      781 ccaattatgg gaactgaagc atgaaactca aataaagggg caaactattt aaatgaagag
      841 gtctaaaaat aataaggaaa gagaagggtg aaatttgggt ttcttaacac tgtaaaaaaa
      901 tatactacct atgggaaagt gtgttgtctg tttttgtaca gtatcggaag gacattatct
      961 acctgttctg tggctttctg gaatgtgcct ccccttttct atgttgctag taaggtcttt
     1021 gtaaaatctt gctgttttgt aagccctctt tgaagctgtc tttgtgaact gtggttccag
     1081 atgaacagat tagtgcggtt ccttacctac cccatacttc ccagtagcag tactagaggg
     1141 gttgtatgga gccctgagga tccactagct tctgcgtctg gtgcattttg gctgctgttt
     1201 ctaggtccta ttcacgagcc tctttctgta tatctgaagg atggaaaata aaacaggatt
     1261 aaatatcaa
//
