LOCUS       NM_008269               1435 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox B6 (Hoxb6), mRNA.
ACCESSION   NM_008269
VERSION     NM_008269.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1435)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1435)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1435)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   4  (bases 1 to 1435)
  AUTHORS   Fernandez-Guerrero,M., Zdral,S., Castilla-Ibeas,A.,
            Lopez-Delisle,L., Duboule,D. and Ros,M.A.
  TITLE     Time-sequenced transcriptomes of developing distal mouse limb buds:
            A comparative tissue layer analysis
  JOURNAL   Dev Dyn 251 (9), 1550-1575 (2022)
   PUBMED   34254395
REFERENCE   5  (bases 1 to 1435)
  AUTHORS   Goodwin,K., Jaslove,J.M., Tao,H., Zhu,M., Hopyan,S. and Nelson,C.M.
  TITLE     Patterning the embryonic pulmonary mesenchyme
  JOURNAL   iScience 25 (3), 103838 (2022)
   PUBMED   35252804
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1435)
  AUTHORS   Kaur,S., Singh,G., Stock,J.L., Schreiner,C.M., Kier,A.B.,
            Yager,K.L., Mucenski,M.L., Scott,W.J. Jr. and Potter,S.S.
  TITLE     Dominant mutation of the murine Hox-2.2 gene results in
            developmental abnormalities
  JOURNAL   J Exp Zool 264 (3), 323-336 (1992)
   PUBMED   1358998
REFERENCE   7  (bases 1 to 1435)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   8  (bases 1 to 1435)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   9  (bases 1 to 1435)
  AUTHORS   Graham,A., Maden,M. and Krumlauf,R.
  TITLE     The murine Hox-2 genes display dynamic dorsoventral patterns of
            expression during central nervous system development
  JOURNAL   Development 112 (1), 255-264 (1991)
   PUBMED   1685115
REFERENCE   10 (bases 1 to 1435)
  AUTHORS   Shen,W.F., Detmer,K., Simonitch-Eason,T.A., Lawrence,H.J. and
            Largman,C.
  TITLE     Alternative splicing of the HOX 2.2 homeobox gene in human
            hematopoietic cells and murine embryonic and adult tissues
  JOURNAL   Nucleic Acids Res 19 (3), 539-545 (1991)
   PUBMED   1672751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645478.15 and BE948571.1.
            
            On Feb 15, 2018 this sequence version replaced NM_008269.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016893.1, AK011622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-518               AL645478.15        113674-114191
            519-1031            AL645478.15        115269-115781
            1032-1435           BE948571.1         1-404               c
FEATURES             Location/Qualifiers
     source          1..1435
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.82 cM"
     gene            1..1435
                     /gene="Hoxb6"
                     /gene_synonym="Hox-2.2"
                     /note="homeobox B6"
                     /db_xref="GeneID:15414"
                     /db_xref="MGI:MGI:96187"
     exon            1..518
                     /gene="Hoxb6"
                     /gene_synonym="Hox-2.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..778
                     /gene="Hoxb6"
                     /gene_synonym="Hox-2.2"
                     /note="homeobox protein MH-22A; homeobox protein Hox-2.2;
                     homeo box B6"
                     /codon_start=1
                     /product="homeobox protein Hox-B6"
                     /protein_id="NP_032295.1"
                     /db_xref="CCDS:CCDS25295.1"
                     /db_xref="GeneID:15414"
                     /db_xref="MGI:MGI:96187"
                     /translation="MSSYFVNSTFPVTLASGQESFLGQLPLYSSGYADPLRHYPAPYG
                     PGPGQDKGFAASSYYPPAGGGYGRAAPCDYGPAPAFYREKDAACALSGADEPPPFHPE
                     PRKSDCAQDKSVFGETEEQKCSTPVYPWMQRMNSCNSSSFGPSGRRGRQTYTRYQTLE
                     LEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEE
                     EEKPAE"
     exon            519..1419
                     /gene="Hoxb6"
                     /gene_synonym="Hox-2.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxb6"
                     /gene_synonym="Hox-2.2"
                     /note="hexamer: AATAAA"
     polyA_site      1419
                     /gene="Hoxb6"
                     /gene_synonym="Hox-2.2"
                     /note="major polyA site"
ORIGIN      
        1 ccaatctcgg ctatactact aataggcgcg gcgctcggac tataaaacac aacaaatcat
       61 aaacccggcg gagcagcagc ggcctcgcgc gcctcccctc ccgatgagtt cctatttcgt
      121 gaactccacc ttccccgtca ctctggccag cgggcaggag tccttcctgg gccagctgcc
      181 gctctactcg tctggctatg cggacccgct gcggcactac cccgcgcctt atgggccggg
      241 acccggccag gacaagggct ttgcggcgtc ctcctattac ccaccagccg gcggcggcta
      301 cggccgggcg gcgccctgtg attatgggcc ggcgcctgcc ttctaccggg agaaggacgc
      361 ggcctgcgct ctctccggcg ccgacgagcc gcccccgttc caccccgagc cgcgcaagtc
      421 cgactgcgca caggacaaga gcgtgttcgg agagaccgag gagcagaagt gctccacgcc
      481 cgtctacccg tggatgcagc gcatgaattc gtgcaacagt tcctcttttg ggcccagcgg
      541 tcggcgaggc cgccagacct acacacgcta ccagaccctg gagctggaga aggaatttca
      601 ctataatcgc tacctgaccc gccggcggcg catagagatc gcgcacgccc tgtgcctgac
      661 cgagcggcag atcaagattt ggtttcagaa ccggcgcatg aagtggaaaa aggagagcaa
      721 actgctcagt gcgtctcagc tcagtgcgga ggaggaggag gaaaagccag ccgagtgaag
      781 gtgctgcaaa gggagggggg acgcgaaggg agaggtctgt gggggaacct agggcacccg
      841 aaagccccag aaggctctgc ggtcggggga gtctggggac ttgctgtcca gagcacgacg
      901 ggcagggccc agtgcttgcc tggatgcccc cttctgcaga gctcttcctg ggcgcttggc
      961 ggatgcccac ccagcacccc cagcgcctcc tccctccccc gaagaaccca ccttggcctc
     1021 atcaggctct ctggtgagaa ctgagaatcg gactcacttg atgtctcctg gaagcagagc
     1081 agaatgctca tgtccttgtc gagtctcatt tcgtccatgt cccccgtgca cggttcaatg
     1141 gtagattcgc tgtcccctca gcagggacct gaaagactcc ctgaccccag acttgtctct
     1201 cctaccccct ccccaaagcc actggaagga gcacatacta cctagaagga agaagaggag
     1261 cctcagaaga aaacaaagtt ctattttatt aattttctat gtgttgtgtt tgtagtcttg
     1321 tcttagctcc ggacgtgaaa tacttcggta ataatattaa tattattaat aatgattatg
     1381 atgatgatga taataataat aaagatgtga aaactcgcaa aaaaaaaaaa aaaaa
//
