LOCUS       NM_008268               1912 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox B5 (Hoxb5), mRNA.
ACCESSION   NM_008268
VERSION     NM_008268.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1912)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1912)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1912)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   4  (bases 1 to 1912)
  AUTHORS   Zhao,Q., Zhang,M., Liu,X., Wang,T., Xia,C., Dong,Y., Geng,Y.,
            Du,J., Hu,F. and Cheng,J.
  TITLE     Transcription factor Hoxb5 reveals the unidirectional hierarchy of
            hematopoietic stem cell pool
  JOURNAL   Stem Cell Res 76, 103326 (2024)
   PUBMED   38324932
  REMARK    GeneRIF: Transcription factor Hoxb5 reveals the unidirectional
            hierarchy of hematopoietic stem cell pool.
REFERENCE   5  (bases 1 to 1912)
  AUTHORS   Wu,S.R., Butts,J.C., Caudill,M.S., Revelli,J.P., Dhindsa,R.S.,
            Durham,M.A. and Zoghbi,H.Y.
  TITLE     Atoh1 drives the heterogeneity of the pontine nuclei neurons and
            promotes their differentiation
  JOURNAL   Sci Adv 9 (26), eadg1671 (2023)
   PUBMED   37390208
REFERENCE   6  (bases 1 to 1912)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 1912)
  AUTHORS   Kuratani,S.C. and Wall,N.A.
  TITLE     Expression of Hox 2.1 protein in restricted populations of neural
            crest cells and pharyngeal ectoderm
  JOURNAL   Dev Dyn 195 (1), 15-28 (1992)
   PUBMED   1292750
REFERENCE   8  (bases 1 to 1912)
  AUTHORS   Wall,N.A., Jones,C.M., Hogan,B.L. and Wright,C.V.
  TITLE     Expression and modification of Hox 2.1 protein in mouse embryos
  JOURNAL   Mech Dev 37 (3), 111-120 (1992)
   PUBMED   1353982
REFERENCE   9  (bases 1 to 1912)
  AUTHORS   Nazarali,A., Kim,Y. and Nirenberg,M.
  TITLE     Hox-1.11 and Hox-4.9 homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2883-2887 (1992)
   PUBMED   1348361
REFERENCE   10 (bases 1 to 1912)
  AUTHORS   Takahashi,Y., Shimizu,A., Sakai,T., Endo,Y., Osawa,N., Shisa,H. and
            Honjo,T.
  TITLE     Mapping of the nu gene using congenic nude strains and in situ
            hybridization
  JOURNAL   J Exp Med 175 (3), 873-876 (1992)
   PUBMED   1346798
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M26283.1, AK133512.1 and AW490409.1.
            
            On Nov 16, 2007 this sequence version replaced NM_008268.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M26283.1, AK133512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               M26283.1           1-342
            343-343             AK133512.1         259-259
            344-1889            M26283.1           344-1889
            1890-1912           AW490409.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1912
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.82 cM"
     gene            1..1912
                     /gene="Hoxb5"
                     /gene_synonym="Hox-2.1"
                     /note="homeobox B5"
                     /db_xref="GeneID:15413"
                     /db_xref="MGI:MGI:96186"
     exon            1..664
                     /gene="Hoxb5"
                     /gene_synonym="Hox-2.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..912
                     /gene="Hoxb5"
                     /gene_synonym="Hox-2.1"
                     /note="homeobox protein Mu-1; homeobox protein H24.1;
                     homeobox protein Hox-2.1; homeo box B5"
                     /codon_start=1
                     /product="homeobox protein Hox-B5"
                     /protein_id="NP_032294.2"
                     /db_xref="CCDS:CCDS25296.1"
                     /db_xref="GeneID:15413"
                     /db_xref="MGI:MGI:96186"
                     /translation="MSSYFVNSFSGRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGS
                     YGYNYNGMDLSVNRSSASSSHFGAVGESSRAFPASAQEPRFRQATSSCSLSSPESLPC
                     TNGDSHGAKPSASSPSDQATPASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPE
                     PMATSTAAPEGQTPQIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRY
                     LTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQP"
     exon            665..1896
                     /gene="Hoxb5"
                     /gene_synonym="Hox-2.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1875..1880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxb5"
                     /gene_synonym="Hox-2.1"
                     /note="hexamer: AATAAA"
     polyA_site      1896
                     /gene="Hoxb5"
                     /gene_synonym="Hox-2.1"
                     /note="major polyA site"
ORIGIN      
        1 gaagtacagt gcatcgctat aattcattaa tacatcataa atcgtgaagc acagggttat
       61 aacgaccacg atccacaaat caagccctcc aaaatcaccc aaatgagctc gtactttgta
      121 aactccttct cggggcgtta tccaaatggc ccggactatc agttgctaaa ttatggcagt
      181 ggcagctctc tgagcggctc ttacagggat cccgctgcca tgcacaccgg ctcttacggc
      241 tacaattaca atgggatgga tctcagcgtc aaccgctcct cggcctcctc cagccacttt
      301 ggggcggtgg gcgagagctc gcgcgccttc cccgcgtccg cccaggaacc ccgcttcagg
      361 caggcgacgt ccagctgctc cctgtcctcg cccgagtccc tgccctgcac taacggcgac
      421 agccacggcg ccaagccctc tgcttcgtcc ccttccgacc aggcgacccc agccagctcc
      481 agcgccaatt tcaccgaaat agacgaggcc agcgcgtcct ctgagcccga ggaagcggcg
      541 agccagctaa gcagccccag cttggctcga gcacagccag agcccatggc cacctctacg
      601 gccgcgcccg aggggcagac tccacagata ttcccctgga tgaggaagct tcacatcagc
      661 cacgatatga ctgggccaga cggaaaaagg gcccggaccg cctatactcg ctaccagacc
      721 ctggagctgg aaaaggaatt ccacttcaat cgctacctga cccggcggcg acgtatcgag
      781 atcgcccacg cgctttgcct gtccgagcgt cagatcaaaa tctggttcca gaaccgtcgc
      841 atgaagtgga agaaagacaa caaactgaaa agtatgagtc tggctacagc cggcagcgcc
      901 ttccaacctt gagcccatcc ggaggagccc tgggcggccc gagagcccgc accaacccca
      961 gctcgaccct tccaatcttc cctgcactgc cgctgcccgc tggggaccag ttcccacgag
     1021 cctgtcacac cccagtcctg tgttacaatt tttcgtttgg tcttaggtct tcccatggct
     1081 ccctctctcc tggactggtt atcttgttat tattgttaat aataattatt attattattt
     1141 ccccctccgt gctccccact tctcttggct cgcccccccc caagttgcca gtgtttctga
     1201 atgtcctcgt gtctgtggtt gcgctccttt ccccaggaaa aagaaaagaa aaagaaattc
     1261 gcatgtttaa tgtgacttcc cctccccgtc tgtgttctaa cttatttata aaaggatgat
     1321 ggctgtattt tgagtttctg ctggaaactt ccataagggg cagcagttga ggttgggtag
     1381 tgctgggccc agctgagctg gcctgggaaa tggagcccac tgtctgtgtc tcttttctcc
     1441 cacctcatcc ttcttcagcc ccacccagcc cccactccct aggctcaggt agcttgttcc
     1501 ttggggtggg aagggagcta gggaagggtc aaagtgtgga cattgagaag aggagaggaa
     1561 aggagcaaga gctgaactcc tgctgcctgg taggccccac aaggcctagt ctggaagcgt
     1621 atggaatcag aaataatcct cagtgtaaaa tgtcttgtga tttttctctg tgaatccgtg
     1681 ggtctggcta gaaggcccaa tgctgtaaat atggggatag tctgggtcag gccaatcact
     1741 tcctctctca cccatttcgc ttccaagacc atttgtagtg agcgggtgga tgctgtgcta
     1801 cgtgtgaaat ctgtctttgc caggcctgtc tcagtgatta gcttttggta tgtctgtagc
     1861 tttccttgaa gttgaataaa tgtttccccc actccaaaaa aaaaaaaaaa aa
//
