LOCUS       NM_010459               2566 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus homeobox B4 (Hoxb4), mRNA.
ACCESSION   NM_010459
VERSION     NM_010459.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2566)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2566)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   3  (bases 1 to 2566)
  AUTHORS   Afzal,Z., Lange,J.J., Nolte,C., McKinney,S., Wood,C., Paulson,A.,
            De Kumar,B., Unruh,J., Slaughter,B.D. and Krumlauf,R.
  TITLE     Shared retinoic acid responsive enhancers coordinately regulate
            nascent transcription of Hoxb coding and non-coding RNAs in the
            developing mouse neural tube
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37102683
REFERENCE   4  (bases 1 to 2566)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   5  (bases 1 to 2566)
  AUTHORS   Brent,A.E., Buchholtz,E.A. and Mansfield,J.H.
  TITLE     Evolutionary assembly and disassembly of the mammalian sternum
  JOURNAL   Curr Biol 33 (1), 197-205 (2023)
   PUBMED   36563692
REFERENCE   6  (bases 1 to 2566)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2566)
  AUTHORS   Geada,A.M., Gaunt,S.J., Azzawi,M., Shimeld,S.M., Pearce,J. and
            Sharpe,P.T.
  TITLE     Sequence and embryonic expression of the murine Hox-3.5 gene
  JOURNAL   Development 116 (2), 497-506 (1992)
   PUBMED   1363091
REFERENCE   8  (bases 1 to 2566)
  AUTHORS   Conlon,R.A. and Rossant,J.
  TITLE     Exogenous retinoic acid rapidly induces anterior ectopic expression
            of murine Hox-2 genes in vivo
  JOURNAL   Development 116 (2), 357-368 (1992)
   PUBMED   1363087
REFERENCE   9  (bases 1 to 2566)
  AUTHORS   Sham,M.H., Hunt,P., Nonchev,S., Papalopulu,N., Graham,A.,
            Boncinelli,E. and Krumlauf,R.
  TITLE     Analysis of the murine Hox-2.7 gene: conserved alternative
            transcripts with differential distributions in the nervous system
            and the potential for shared regulatory regions
  JOURNAL   EMBO J 11 (5), 1825-1836 (1992)
   PUBMED   1582411
REFERENCE   10 (bases 1 to 2566)
  AUTHORS   Whiting,J., Marshall,H., Cook,M., Krumlauf,R., Rigby,P.W., Stott,D.
            and Allemann,R.K.
  TITLE     Multiple spatially specific enhancers are required to reconstruct
            the pattern of Hox-2.6 gene expression
  JOURNAL   Genes Dev 5 (11), 2048-2059 (1991)
   PUBMED   1682218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606824.13.
            
            On Apr 21, 2010 this sequence version replaced NM_010459.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095947.1, AK133945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-957               AL606824.13        13307-14263
            958-2566            AL606824.13        15070-16678
FEATURES             Location/Qualifiers
     source          1..2566
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.83 cM"
     gene            1..2566
                     /gene="Hoxb4"
                     /gene_synonym="Hox-2.6"
                     /note="homeobox B4"
                     /db_xref="GeneID:15412"
                     /db_xref="MGI:MGI:96185"
     exon            1..957
                     /gene="Hoxb4"
                     /gene_synonym="Hox-2.6"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..1256
                     /gene="Hoxb4"
                     /gene_synonym="Hox-2.6"
                     /note="homeobox protein Hox-2.6; homeo box B4"
                     /codon_start=1
                     /product="homeobox protein Hox-B4"
                     /protein_id="NP_034589.3"
                     /db_xref="CCDS:CCDS25297.1"
                     /db_xref="GeneID:15412"
                     /db_xref="MGI:MGI:96185"
                     /translation="MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRR
                     ESGFQPEAAFGRRAPCTVQRYAACRDPGPPPPPPPPPPPPPPGLSPRAPVQPTAGALL
                     PEPGQRSEAVSSSPPPPPCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGE
                     PKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKK
                     DHKLPNTKIRSGGTAGAAGGPPGRPNGGPPAL"
     exon            958..2566
                     /gene="Hoxb4"
                     /gene_synonym="Hox-2.6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2538..2543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxb4"
                     /gene_synonym="Hox-2.6"
                     /note="hexamer: AATAAA"
     polyA_site      2566
                     /gene="Hoxb4"
                     /gene_synonym="Hox-2.6"
                     /note="major polyA site"
ORIGIN      
        1 agctccctct tatcctgggg aggagatggg gccctatggg agtcagagaa aggttggtgg
       61 agattaggta gggcaggggt gggggctaca cccgcagccc caacttctga gggatgcagg
      121 gtttgtgctc tgcccagccc cctcaccccc aaacaggccc tccaattaac ctgctcactc
      181 tttcttagtt catcacccct ctctgttgtg gagaaagcca ggcgaggagg gggtctcccc
      241 gcgggagccc tatgtaaatc ctggtgttgg gtgggtgggg aggggtagag aaggggaaat
      301 aaacctcttt ggctggagta gggtccgggt gagcagattt ccttatccgg gaatcgcagg
      361 ccgggtggcc attggctcgg aggatcacgt gggcctctaa ctttgttcac ttgacagtaa
      421 gtaggagggc tttcggaaac aggaaaacga gtcaggggtc ggaataaatt ttagtatatt
      481 ttgtgggcaa ttcccagaaa ttaatggcta tgagttcctt tttgatcaac tcaaactatg
      541 tcgaccccaa gttccctccg tgcgaggagt attcacagag cgattaccta cccagcgacc
      601 actcgcccgg gtactacgcc ggcggccaga ggcgagagag cggcttccag ccggaggcgg
      661 cctttgggcg ccgggcgccg tgcactgtgc agcgctacgc ggcctgccga gaccccgggc
      721 ccccgccacc tccgccgccc ccgccgcccc cgccaccgcc cgggctgtcc cctcgggctc
      781 cagtgcagcc aacagccggg gccctcctcc cggagcccgg gcagcgcagc gaggcggtca
      841 gcagcagccc cccgccgcct ccctgcgccc agaaccccct gcatcccagc ccgtcccact
      901 ccgcgtgcaa agagcccgtc gtctacccct ggatgcgcaa agttcacgtg agcacggtaa
      961 accccaatta cgccggcggg gagcccaagc gctctcggac cgcctacact cgccagcagg
     1021 tcctggagtt ggagaaggag tttcactaca atcgctacct gacgcgccgc cggagggtgg
     1081 agatcgccca cgcgctctgc ctgtccgagc gccagatcaa gatctggttc cagaatcggc
     1141 gcatgaagtg gaaaaaagac cacaagttgc ccaacaccaa gatccgctcg ggtggcaccg
     1201 cgggcgcagc cggaggcccc cctggccggc ccaacggagg cccccctgcg ctctagtgcc
     1261 ccccaagcag gagttcgaac atgggggggt ggggggaaca gcgagcaccg aagggggtgc
     1321 ggggtatggg agggtccccg ggcttgagcc cagaaaaaat ctatctaccc taccctcact
     1381 ttatctataa ggaataaaca cagagaaggg gggtagggaa gccttattta tagaaaggac
     1441 aataagggag ccgggtaaag tccttcggag acaagattcg agtctcttgc tttcttcctt
     1501 taaaaaaaaa aaagaaagaa agaaagaagg aaagaaagag agagagagaa aagaaaaaga
     1561 agaaaggaag gaagcaagaa aaggaggaag aaaggaaaag acagaagaga aatggaggag
     1621 tctgctgcgc ctggttttca gctttggtga agatggatcc aggcttcatc tttaatcacg
     1681 ccaggcccgg gcccatctgt cttgtttact ctgccgagga gaagacgggc gagcgagctt
     1741 cggtggcgac cattacctcg acacttggct aacaaatgag gccaggctcg gccgctgccg
     1801 ccgcctctgc tgctgtcgct gctggatcac agcctggatt tttctttctt tgtcccctac
     1861 tcctgacacc cagcgaatgc accctcagac tgccagatag cacagtgttt tggccacggt
     1921 aacaaacaca cacacatata actttcctcc ctgtctgtac ccactttggg gtgggggtgg
     1981 gtgggaagac tgctcactcc cttccaccat agacttagaa gggggaacag aagggaattg
     2041 aagggcagtc tgcacaacgt gggttcccaa atccgagccc aagaaataaa tgaaaatgaa
     2101 aaaagaaagg tagcaattgg gacacccaag aaggccttct gctagaaggt ccagctaggc
     2161 ctggcagggt gaggggcagt tgagttctgg gagctgggaa tgtcttctgg gcagttcaca
     2221 gtagtagagt caaggccttc tcttaggtta caaatgaatg tgaaattagg aaataaaata
     2281 ctgtggccct cctactctgg aaggacaatg ttgcagaacc ctctcccgtt gttatcattg
     2341 ttgcatcgtt tattattatt attattatta ttattattat tattattatt attattatta
     2401 ttttatgtca tgtgtgtcct ctctcctgtt ctctttctga cattccaaaa ccaggcccct
     2461 tcctacctct ggggctgcct gagcctagaa ccttttgttg gtgtgaaaat ttgtgtcctg
     2521 tacagagtga caacagaaat aaatgtttgg tttcttgtga ccatca
//
