LOCUS       NM_001079869            3390 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox B3 (Hoxb3), transcript variant 1, mRNA.
ACCESSION   NM_001079869
VERSION     NM_001079869.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3390)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3390)
  AUTHORS   De Bono,C., Liu,Y., Ferrena,A., Valentine,A., Zheng,D. and
            Morrow,B.E.
  TITLE     Single-cell transcriptomics uncovers a non-autonomous
            Tbx1-dependent genetic program controlling cardiac neural crest
            cell development
  JOURNAL   Nat Commun 14 (1), 1551 (2023)
   PUBMED   36941249
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3390)
  AUTHORS   Chen,C.H. and Behringer,R.R.
  TITLE     Transgenic human HOXB1-9 directs anterior-posterior axial skeleton
            pattern in Hoxb1-9 deficient mice
  JOURNAL   Differentiation 127, 1-11 (2022)
   PUBMED   36041259
REFERENCE   4  (bases 1 to 3390)
  AUTHORS   Zhang,H., Xie,J., So,K.K.H., Tong,K.K., Sae-Pang,J.J., Wang,L.,
            Tsang,S.L., Chan,W.Y., Wong,E.Y.M. and Sham,M.H.
  TITLE     Hoxb3 Regulates Jag1 Expression in Pharyngeal Epithelium and
            Affects Interaction With Neural Crest Cells
  JOURNAL   Front Physiol 11, 612230 (2021)
   PUBMED   33505317
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3390)
  AUTHORS   Lopez-Delgado,A.C., Delgado,I., Cadenas,V., Sanchez-Cabo,F. and
            Torres,M.
  TITLE     Axial skeleton anterior-posterior patterning is regulated through
            feedback regulation between Meis transcription factors and retinoic
            acid
  JOURNAL   Development 148 (1) (2021)
   PUBMED   33298461
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3390)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 3390)
  AUTHORS   Sham,M.H., Hunt,P., Nonchev,S., Papalopulu,N., Graham,A.,
            Boncinelli,E. and Krumlauf,R.
  TITLE     Analysis of the murine Hox-2.7 gene: conserved alternative
            transcripts with differential distributions in the nervous system
            and the potential for shared regulatory regions
  JOURNAL   EMBO J 11 (5), 1825-1836 (1992)
   PUBMED   1582411
REFERENCE   8  (bases 1 to 3390)
  AUTHORS   Nazarali,A., Kim,Y. and Nirenberg,M.
  TITLE     Hox-1.11 and Hox-4.9 homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2883-2887 (1992)
   PUBMED   1348361
REFERENCE   9  (bases 1 to 3390)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   10 (bases 1 to 3390)
  AUTHORS   Hunt,P., Gulisano,M., Cook,M., Sham,M.H., Faiella,A., Wilkinson,D.,
            Boncinelli,E. and Krumlauf,R.
  TITLE     A distinct Hox code for the branchial region of the vertebrate head
  JOURNAL   Nature 353 (6347), 861-864 (1991)
   PUBMED   1682814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606824.13.
            
            Transcript Variant: This variant is the longer transcript. Variants
            1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849379 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AL606824.13        18166-18485
            321-408             AL606824.13        36104-36191
            409-1005            AL606824.13        39140-39736
            1006-3390           AL606824.13        40586-42970
FEATURES             Location/Qualifiers
     source          1..3390
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.84 cM"
     gene            1..3390
                     /gene="Hoxb3"
                     /gene_synonym="Hox-2.7"
                     /note="homeobox B3"
                     /db_xref="GeneID:15410"
                     /db_xref="MGI:MGI:96184"
     exon            1..320
                     /gene="Hoxb3"
                     /gene_synonym="Hox-2.7"
                     /inference="alignment:Splign:2.1.0"
     exon            321..408
                     /gene="Hoxb3"
                     /gene_synonym="Hox-2.7"
                     /inference="alignment:Splign:2.1.0"
     exon            409..1005
                     /gene="Hoxb3"
                     /gene_synonym="Hox-2.7"
                     /inference="alignment:Splign:2.1.0"
     CDS             558..1859
                     /gene="Hoxb3"
                     /gene_synonym="Hox-2.7"
                     /note="homeobox protein MH-23; homeobox protein Hox-2.7;
                     homeo box B3"
                     /codon_start=1
                     /product="homeobox protein Hox-B3"
                     /protein_id="NP_001073338.1"
                     /db_xref="CCDS:CCDS25299.1"
                     /db_xref="GeneID:15410"
                     /db_xref="MGI:MGI:96184"
                     /translation="MQKATYYDNTAAALFGGYSSYPGSNGFGYDGPPQPPFQAATHLE
                     GDYQRSACSLQSLGNAAPHAKSKELNGSCMRPGLAPEPLPAPPGSPPPSAAPTSTTSN
                     SNNGGGPSKSGPPKCGAGSNSTLTKQIFPWMKESRQTSKLKNSSPGTAEGCGGGGGGG
                     GGGGGGGGGSSGGGGGGGGGGDKSPPGSAASKRARTAYTSAQLVELEKEFHFNRYLCR
                     PRRVEMANLLNLSERQIKIWFQNRRMKYKKDQKAKGLASSSGGPSPAGSPPQPMQSTA
                     GFMNALHSMTPSYDSPSPPAFGKGHQNAYALPSNYQPPLKGCGAPQKYPPTPASEYEP
                     HVLQANGGAYGTPTMQGSPVYVGGGGYADPLPPPAGPSLYGLNHLSHHPSGNLDYNGA
                     APMGPNQHHGPCDPHPTYTDLSSHHAPPQGRIQEAPKLTHL"
     exon            1006..3390
                     /gene="Hoxb3"
                     /gene_synonym="Hox-2.7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3366..3371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxb3"
                     /gene_synonym="Hox-2.7"
                     /note="hexamer: AATAAA"
     polyA_site      3390
                     /gene="Hoxb3"
                     /gene_synonym="Hox-2.7"
                     /note="major polyA site"
ORIGIN      
        1 aagatttcta tagagcttaa agttcacagc cattctgtgt agacaagagc taagaaaaat
       61 gtgagaatta tacagaaaac cattaatcac ttcttttctt taaatacgta tcctctctcc
      121 tttgtcatta ttcaacagca aatctccgca gaccggctgt tgggggaaaa aagtgttagc
      181 cgtctctccg gatcggcaag ggggaaaaat tttggagcca taaagttgaa aacttttttc
      241 tctcagtttt ggaagaagcc ttcctttcgt catgaacggg accagaggag ctcaggcgag
      301 agcgggcaag aggctcagag gaggggagat ttctcgcctg ccgctcgcgc tggggctcga
      361 tgtgaatata tattatgtct gcctgttctc ccctcgtcgg tggctaaggt cagccgcttg
      421 gaacagaccc gagaggaggg gggcagaaag gggagggggg tccggcgtgt cacgtgaccc
      481 ccaggggtgc caatgtccgg tcgtgagggt atcaggccct tgcaagttgc cacccactgc
      541 ccgggcctcg cccagcgatg cagaaagcca cctactacga caacaccgca gctgcgctct
      601 tcggaggcta ctcctcgtac cctggcagca atggtttcgg ctacgacggg cctccccagc
      661 ccccctttca ggccgccacg cacctggagg gtgactacca gcgctcagcg tgttctctgc
      721 agtccctggg caacgccgcc ccacatgcca agagcaagga gctcaatggc agctgcatga
      781 ggccaggcct ggccccagag cccctgcccg cacctccggg ctcaccccca cccagcgccg
      841 cacctaccag taccactagc aacagcaata acgggggtgg gcccagcaaa agcggccccc
      901 ccaagtgcgg tgccggctcc aactccaccc tcaccaaaca gatattcccc tggatgaaag
      961 agtcgaggca aacgtccaag ctgaaaaaca gctcccccgg cacagcagaa ggttgtggtg
     1021 gtggcggcgg cggtggtggc ggcggcggcg gcggtggcgg cggcagcagc ggcgggggcg
     1081 gcggcggcgg cgggggaggg gacaagagcc ccccggggtc ggccgcgtcc aagcgggcgc
     1141 gcacggcgta cacaagcgcg cagctggtgg agctggagaa ggagttccac ttcaaccgtt
     1201 atttgtgccg gccgcgccgg gtcgagatgg ccaatctgct gaacctcagc gagcgccaga
     1261 tcaagatctg gttccagaac cgtcgcatga agtacaagaa agaccagaag gccaaggggc
     1321 tggcctcgtc ctctgggggt ccctctccgg ccggaagccc cccgcagccc atgcagtcca
     1381 cggccggctt catgaacgcc ttacactcca tgacccccag ctacgacagc ccgtccccac
     1441 cagctttcgg caaaggccac cagaatgcct acgcgctgcc ttccaactac cagccccctc
     1501 ttaagggttg cggcgcccca cagaagtacc ccccgacccc ggcgtcggag tatgagcccc
     1561 acgtcctcca agctaacggg ggcgcctacg ggacgcccac catgcagggc agtccggtgt
     1621 atgtgggcgg gggtggctac gcggatccgc tgccgccccc tgccggcccc tccctctacg
     1681 gcctcaatca cctttcccac cacccctcgg ggaacctgga ctacaacggg gcggccccta
     1741 tgggccccaa ccagcatcat ggaccctgtg accctcaccc cacgtacaca gacctctcct
     1801 ctcaccacgc accgcctcag ggtagaatcc aagaagcgcc caaactgaca cacctgtgat
     1861 gggaggggcg ggctggggag ggaggggtga ggttaagggc cagggagacg gcggacttgg
     1921 gggatgggcg cggtttagag tcctgaaaga ggtgtgggat ggggttgtcg ccaggtttcc
     1981 agaaacagaa caggcctggg gtgccttccc agctcccagg ccccctcccc gcccccaggg
     2041 gctgtctttt aagtcctcca tgcctggttc catctgtctg ccaacaaccc ttggaaagga
     2101 atccacagca ggttggagac gggaccacat caatcccagg gttcccaggg ttccagcact
     2161 accaagtggg aatttcagat tggagaggtg acgtggagtc gggtagaggg agccaagaca
     2221 ggcaagcagg gcagagaagc acattcaaca cttaatggct tggctatcag caagcaatca
     2281 acttaccttg catctctgtg ggtaatttcc ccaaaatctt gatttttttt gttctccctt
     2341 tcagtctccc tgtgaaaaat aagaaaatac atttaaatcg aagggcacaa agtatgtttc
     2401 tctcctactt ccctgaagct tcaactcccc ccatccccca tctgttaggc ttcttactat
     2461 atctatcatt tactatggcc ctacggttgg ttttctgctc taaggacatt catatctaca
     2521 ccccacccct attgattaca attttcagag ggctcaggga tggtaagata tcctgaaagt
     2581 cagagctgcc tataatataa ataaatatat attttttttc ttttaaagaa aagttaagag
     2641 gctaaggcag gcaagttgtc aggactggag gcttgcccat tctccagtct ctcagctccc
     2701 accccatccc actccctcca ctttcttttt acttctgttc ttctcttgac ttaacgtgaa
     2761 aacagggtat atttgaacaa actgtctgtc ctggcaggtg ctgcagctgg acctgtggac
     2821 cttgctccag ttcctgacag gacagtcttg ttgcacttgg agtttacatt ttaatggata
     2881 ttaaaaaaaa aaaaaacaac tgtgagagat gtctgggcct gcagaaagtc cagcttcgct
     2941 caaaaagcgt gtgttctagt gaacattttc atatatattt attggttata gcctgttaaa
     3001 atattttctt ttttgtatta tttatccccc tacattatgt atttatatga gggacaaaaa
     3061 aaaaaaagaa aaatgtactt ttttagtatt tacttgttat aaaggttgtt gtgtttcctg
     3121 tcatgtaaaa ccagctattt tagtttttat tgtattctag acaagagctg tagatttatg
     3181 ttaaactcgt acatatgagg aattgtaatt agttctaaaa ggcatgaact cagctcctaa
     3241 atgtcactgt atagtcccga atttgtagag ataagaagtt aattctctct tggaactttc
     3301 tttgttcttc cgtagttatt tttttccccc ttagttaaaa gagttgtctg tcaaaacaat
     3361 tcttgaataa actttctgtt attaatttta
//
