LOCUS       NM_134032               1631 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox B2 (Hoxb2), mRNA.
ACCESSION   NM_134032 XM_001052073 XM_001052074 XM_001052075
VERSION     NM_134032.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1631)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1631)
  AUTHORS   Singh,N., Singh,D., Bhide,A., Sharma,R., Bhowmick,S., Patel,V. and
            Modi,D.
  TITLE     LHX2 in germ cells control tubular organization in the developing
            mouse testis
  JOURNAL   Exp Cell Res 425 (1), 113511 (2023)
   PUBMED   36796745
REFERENCE   3  (bases 1 to 1631)
  AUTHORS   Chen,C.H. and Behringer,R.R.
  TITLE     Transgenic human HOXB1-9 directs anterior-posterior axial skeleton
            pattern in Hoxb1-9 deficient mice
  JOURNAL   Differentiation 127, 1-11 (2022)
   PUBMED   36041259
REFERENCE   4  (bases 1 to 1631)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   5  (bases 1 to 1631)
  AUTHORS   Zhang,H., Xie,J., So,K.K.H., Tong,K.K., Sae-Pang,J.J., Wang,L.,
            Tsang,S.L., Chan,W.Y., Wong,E.Y.M. and Sham,M.H.
  TITLE     Hoxb3 Regulates Jag1 Expression in Pharyngeal Epithelium and
            Affects Interaction With Neural Crest Cells
  JOURNAL   Front Physiol 11, 612230 (2021)
   PUBMED   33505317
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1631)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 1631)
  AUTHORS   Conlon,R.A. and Rossant,J.
  TITLE     Exogenous retinoic acid rapidly induces anterior ectopic expression
            of murine Hox-2 genes in vivo
  JOURNAL   Development 116 (2), 357-368 (1992)
   PUBMED   1363087
REFERENCE   8  (bases 1 to 1631)
  AUTHORS   Sham,M.H., Hunt,P., Nonchev,S., Papalopulu,N., Graham,A.,
            Boncinelli,E. and Krumlauf,R.
  TITLE     Analysis of the murine Hox-2.7 gene: conserved alternative
            transcripts with differential distributions in the nervous system
            and the potential for shared regulatory regions
  JOURNAL   EMBO J 11 (5), 1825-1836 (1992)
   PUBMED   1582411
REFERENCE   9  (bases 1 to 1631)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   10 (bases 1 to 1631)
  AUTHORS   Hunt,P., Gulisano,M., Cook,M., Sham,M.H., Faiella,A., Wilkinson,D.,
            Boncinelli,E. and Krumlauf,R.
  TITLE     A distinct Hox code for the branchial region of the vertebrate head
  JOURNAL   Nature 353 (6347), 861-864 (1991)
   PUBMED   1682814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606824.13 and AI893165.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001052073.1, XM_001052074.1, XM_001052075.1, NM_134032.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138494.1, CF581760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-382               AL606824.13        46672-47053
            383-896             AI893165.1         16-529
            897-1631            AL606824.13        48322-49056
FEATURES             Location/Qualifiers
     source          1..1631
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.85 cM"
     gene            1..1631
                     /gene="Hoxb2"
                     /gene_synonym="Hox-2.8; Hoxbes2"
                     /note="homeobox B2"
                     /db_xref="GeneID:103889"
                     /db_xref="MGI:MGI:96183"
     exon            1..564
                     /gene="Hoxb2"
                     /gene_synonym="Hox-2.8; Hoxbes2"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1244
                     /gene="Hoxb2"
                     /gene_synonym="Hox-2.8; Hoxbes2"
                     /note="homeo box B2; homeobox protein Hox-2.8"
                     /codon_start=1
                     /product="homeobox protein Hox-B2"
                     /protein_id="NP_598793.2"
                     /db_xref="CCDS:CCDS36290.1"
                     /db_xref="GeneID:103889"
                     /db_xref="MGI:MGI:96183"
                     /translation="MNFEFEREIGFINSQPSLAECLTSFPAVLETFQTSSIKESTLIP
                     PPPPLEQTFPSLQLGASTLQRPGSQKQAGDGPALRSPPPLPVAPPAPEFPWMKEKKST
                     KKPSQSAASPSPAASSVRASEVGSPSDGPGLPECGGSGSRRLRTAYTNTQLLELEKEF
                     HFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQHREPPEGEPGGPSAQDD
                     AGEPAEEPTVSPGDVATHRLREACFHPAEAAQGPRGAPPSALPATTLESVGASSPGCT
                     MLRAGGRQSEPLPEDACPERQDSPFLPDLNFFAADSCLQMSGGLSPSLQGSLDSPVPF
                     SEEELDFFTSTLCAIDLQFP"
     exon            565..1631
                     /gene="Hoxb2"
                     /gene_synonym="Hox-2.8; Hoxbes2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1607..1612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxb2"
                     /gene_synonym="Hox-2.8; Hoxbes2"
                     /note="hexamer: AATAAA"
     polyA_site      1631
                     /gene="Hoxb2"
                     /gene_synonym="Hox-2.8; Hoxbes2"
                     /note="major polyA site"
ORIGIN      
        1 atcagcaata tacaattata aaggcctaaa tttaaaaaaa aaagagagag agcgaaatct
       61 cccccccccc gcgaaattgc tccattgcat aaacctgggg ggggcgggag aggggggtcc
      121 ctctgattct ccctcctgac gcccccccca gcaggccccc tcccccacca ttgaaagcca
      181 tgaattttga atttgagagg gagattgggt ttataaacag ccagccatcg ctcgccgagt
      241 gtctgacttc cttccccgct gtcttggaga catttcaaac ttcatcaatc aaggagtcga
      301 cattaattcc tcctcctcct cctctggagc aaaccttccc cagcctccag ctcggcgcct
      361 ccacccttca gagaccaggg agccaaaagc aagccggaga tgggcctgct ctgcggtcac
      421 cgccgccact ccccgttgcc cccccagccc ccgagttccc ctggatgaaa gagaagaaat
      481 ccaccaagaa acccagccaa tccgccgcat ccccttctcc agccgcctcc tcggtccggg
      541 cctccgaggt cggatcacca tcagatggcc ccggattgcc agaatgcggc ggcagcggct
      601 cccgcagact gcgcacggcc tacaccaaca cgcaactgct ggagctggag aaggagttcc
      661 acttcaataa gtacctgtgc cggccgcgtc gcgtcgagat cgctgccttg ctggacctca
      721 ccgaaaggca ggtcaaagtc tggttccaga accgacgcat gaaacacaag cggcagacgc
      781 agcatcgaga gccgcccgag ggagaaccag gcgggccgag cgcccaggac gacgcgggag
      841 agccagccga ggaacccacg gtcagcccgg gcgacgtcgc gactcaccgg ctgcgggaag
      901 cctgcttcca ccccgccgag gccgcgcagg gaccccgggg cgcaccgccg tcagcgctgc
      961 ctgccaccac cctggagagt gtgggcgcat cgagccccgg ctgcacaatg ctcagagccg
     1021 gaggccggca gagcgagccc ctacccgaag acgcctgccc cgagcggcag gattcgcctt
     1081 ttctaccgga cctcaatttc ttcgctgcag actcctgtct ccagatgtcc ggaggccttt
     1141 cacccagcct gcagggttct ctcgatagcc ccgtgccctt ttccgaggaa gagctggact
     1201 tcttcaccag cacgctctgt gccatcgact tgcagtttcc ctaactgttt tccatctttg
     1261 gtcctttccg tctggtcctc cttggctgtt gggggcgggg ggaatcgggc cttctccact
     1321 cgtggataca tttatgccgt tttgttaaaa tccagatagt aacgaattag cgtttcattc
     1381 actccttttc gctttttaaa accacacaca aaaaattcca cttggtaaaa ctccttccaa
     1441 cgaaatctca ggaataatta aactctagtg ggagagggtt ttcttacaaa gaactagagg
     1501 gacctatttt cctctttttt aagttttaga ttgtagatta tttattaaaa ttgtttaata
     1561 ataggaaagg gggaaagtat ttattgtaca ttattttcat agcgtaaata aatgtcttta
     1621 taatatgaaa a
//
