LOCUS       NP_598793                354 aa            linear   ROD 12-JUN-2025
DEFINITION  homeobox protein Hox-B2 [Mus musculus].
ACCESSION   NP_598793 XP_001052073 XP_001052074 XP_001052075
VERSION     NP_598793.2
DBSOURCE    REFSEQ: accession NM_134032.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 354)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 354)
  AUTHORS   Wang,H., Liu,X., Liu,Y., Yang,C., Ye,Y., Yu,X., Sheng,N., Zhang,S.,
            Mao,B. and Ma,P.
  TITLE     The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression
            patterns through regulation of WDR5 stability
  JOURNAL   Elife 13, 94657 (2024)
   PUBMED   39526890
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 354)
  AUTHORS   Singh,N., Singh,D., Bhide,A., Sharma,R., Bhowmick,S., Patel,V. and
            Modi,D.
  TITLE     LHX2 in germ cells control tubular organization in the developing
            mouse testis
  JOURNAL   Exp Cell Res 425 (1), 113511 (2023)
   PUBMED   36796745
REFERENCE   4  (residues 1 to 354)
  AUTHORS   Chen,C.H. and Behringer,R.R.
  TITLE     Transgenic human HOXB1-9 directs anterior-posterior axial skeleton
            pattern in Hoxb1-9 deficient mice
  JOURNAL   Differentiation 127, 1-11 (2022)
   PUBMED   36041259
REFERENCE   5  (residues 1 to 354)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   6  (residues 1 to 354)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (residues 1 to 354)
  AUTHORS   Conlon,R.A. and Rossant,J.
  TITLE     Exogenous retinoic acid rapidly induces anterior ectopic expression
            of murine Hox-2 genes in vivo
  JOURNAL   Development 116 (2), 357-368 (1992)
   PUBMED   1363087
REFERENCE   8  (residues 1 to 354)
  AUTHORS   Sham,M.H., Hunt,P., Nonchev,S., Papalopulu,N., Graham,A.,
            Boncinelli,E. and Krumlauf,R.
  TITLE     Analysis of the murine Hox-2.7 gene: conserved alternative
            transcripts with differential distributions in the nervous system
            and the potential for shared regulatory regions
  JOURNAL   EMBO J 11 (5), 1825-1836 (1992)
   PUBMED   1582411
REFERENCE   9  (residues 1 to 354)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   10 (residues 1 to 354)
  AUTHORS   Hunt,P., Gulisano,M., Cook,M., Sham,M.H., Faiella,A., Wilkinson,D.,
            Boncinelli,E. and Krumlauf,R.
  TITLE     A distinct Hox code for the branchial region of the vertebrate head
  JOURNAL   Nature 353 (6347), 861-864 (1991)
   PUBMED   1682814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606824.13 and AI893165.1.
            
            On or before May 4, 2006 this sequence version replaced
            XP_001052073.1, XP_001052074.1, XP_001052075.1, NP_598793.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138494.1, CF581760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.85 cM"
     Protein         1..354
                     /product="homeobox protein Hox-B2"
                     /note="homeo box B2; homeobox protein Hox-2.8"
                     /calculated_mol_wt=37965
     Region          39..143
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C1T1.1)"
     Region          92..97
                     /region_name="Antp-type hexapeptide"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C1T1.1)"
     Region          142..198
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     Region          193..231
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C1T1.1)"
     Region          246..295
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0C1T1.1)"
     Site            272
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P14652; propagated from
                     UniProtKB/Swiss-Prot (P0C1T1.1)"
     CDS             1..354
                     /gene="Hoxb2"
                     /gene_synonym="Hox-2.8; Hoxbes2"
                     /coded_by="NM_134032.2:180..1244"
                     /db_xref="CCDS:CCDS36290.1"
                     /db_xref="GeneID:103889"
                     /db_xref="MGI:MGI:96183"
ORIGIN      
        1 mnfefereig finsqpslae cltsfpavle tfqtssikes tlippppple qtfpslqlga
       61 stlqrpgsqk qagdgpalrs ppplpvappa pefpwmkekk stkkpsqsaa spspaassvr
      121 asevgspsdg pglpecggsg srrlrtaytn tqllelekef hfnkylcrpr rveiaalldl
      181 terqvkvwfq nrrmkhkrqt qhreppegep ggpsaqddag epaeeptvsp gdvathrlre
      241 acfhpaeaaq gprgappsal pattlesvga sspgctmlra ggrqseplpe dacperqdsp
      301 flpdlnffaa dsclqmsggl spslqgslds pvpfseeeld fftstlcaid lqfp
//
