LOCUS       NM_008267               1369 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus homeobox B13 (Hoxb13), mRNA.
ACCESSION   NM_008267
VERSION     NM_008267.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1369)
  AUTHORS   Lopez-Delisle,L., Zakany,J., Bochaton,C., Osteil,P., Mayran,A.,
            Darbellay,F., Mascrez,B., Rekaik,H. and Duboule,D.
  TITLE     CTCF-dependent insulation of Hoxb13 and the heterochronic control
            of tail length
  JOURNAL   Proc Natl Acad Sci U S A 121 (46), e2414865121 (2024)
   PUBMED   39499640
REFERENCE   2  (bases 1 to 1369)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1369)
  AUTHORS   Patel,R.A., Sayar,E., Coleman,I., Roudier,M.P., Hanratty,B.,
            Low,J.Y., Jaiswal,N., Ajkunic,A., Dumpit,R., Ercan,C., Salama,N.,
            O'Brien,V.P., Isaacs,W.B., Epstein,J.I., De Marzo,A.M., Trock,B.J.,
            Luo,J., Brennen,W.N., Tretiakova,M., Vakar-Lopez,F., True,L.D.,
            Goodrich,D.W., Corey,E., Morrissey,C., Nelson,P.S., Hurley,P.J.,
            Gulati,R. and Haffner,M.C.
  TITLE     Characterization of HOXB13 expression patterns in localized and
            metastatic castration-resistant prostate cancer
  JOURNAL   J Pathol 262 (1), 105-120 (2024)
   PUBMED   37850574
  REMARK    GeneRIF: Characterization of HOXB13 expression patterns in
            localized and metastatic castration-resistant prostate cancer.
REFERENCE   4  (bases 1 to 1369)
  AUTHORS   Chen,Y., Dufour,C.R., Han,L., Li,T., Xia,H. and Giguere,V.
  TITLE     Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its
            Activity and Oncogenic Function in Prostate Cancer
  JOURNAL   Mol Cancer Res 21 (10), 1050-1063 (2023)
   PUBMED   37409967
  REMARK    GeneRIF: Hierarchical Phosphorylation of HOXB13 by mTOR Dictates
            Its Activity and Oncogenic Function in Prostate Cancer.
REFERENCE   5  (bases 1 to 1369)
  AUTHORS   Li,M., Tan,T., Geng,Y., Tao,Y., Pan,J., Zhang,J., Xu,Q., Shen,H.,
            Zuo,L. and Chen,Y.
  TITLE     HOXB13 facilitates hepatocellular carcinoma progression by
            activating AKT/mTOR signaling pathway
  JOURNAL   Ann Hepatol 28 (1), 100759 (2023)
   PUBMED   36179794
  REMARK    GeneRIF: HOXB13 facilitates hepatocellular carcinoma progression by
            activating AKT/mTOR signaling pathway.
REFERENCE   6  (bases 1 to 1369)
  AUTHORS   Landgren,C., Beier,D.R., Fassler,R., Heinegard,D. and Sommarin,Y.
  TITLE     The mouse chondroadherin gene: characterization and chromosomal
            localization
  JOURNAL   Genomics 47 (1), 84-91 (1998)
   PUBMED   9465299
REFERENCE   7  (bases 1 to 1369)
  AUTHORS   Shen,W.F., Montgomery,J.C., Rozenfeld,S., Moskow,J.J.,
            Lawrence,H.J., Buchberg,A.M. and Largman,C.
  TITLE     AbdB-like Hox proteins stabilize DNA binding by the Meis1
            homeodomain proteins
  JOURNAL   Mol Cell Biol 17 (11), 6448-6458 (1997)
   PUBMED   9343407
REFERENCE   8  (bases 1 to 1369)
  AUTHORS   Kohda,K., Matsuda,Y., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     Structural analysis and chromosomal localization of the mouse Psmb5
            gene coding for the constitutively expressed beta-type proteasome
            subunit
  JOURNAL   Immunogenetics 47 (1), 77-87 (1997)
   PUBMED   9382924
REFERENCE   9  (bases 1 to 1369)
  AUTHORS   Kandil,E., Kohda,K., Ishibashi,T., Tanaka,K. and Kasahara,M.
  TITLE     PA28 subunits of the mouse proteasome: primary structures and
            chromosomal localization of the genes
  JOURNAL   Immunogenetics 46 (4), 337-344 (1997)
   PUBMED   9218537
REFERENCE   10 (bases 1 to 1369)
  AUTHORS   Zeltser,L., Desplan,C. and Heintz,N.
  TITLE     Hoxb-13: a new Hox gene in a distant region of the HOXB cluster
            maintains colinearity
  JOURNAL   Development 122 (8), 2475-2484 (1996)
   PUBMED   8756292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645478.15.
            
            On Feb 16, 2018 this sequence version replaced NM_008267.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051087.1, BQ960077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-731               AL645478.15        8916-9646
            732-1369            AL645478.15        10573-11210
FEATURES             Location/Qualifiers
     source          1..1369
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.63 cM"
     gene            1..1369
                     /gene="Hoxb13"
                     /note="homeobox B13"
                     /db_xref="GeneID:15408"
                     /db_xref="MGI:MGI:107730"
     exon            1..731
                     /gene="Hoxb13"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..988
                     /gene="Hoxb13"
                     /note="homeo box B13"
                     /codon_start=1
                     /product="homeobox protein Hox-B13"
                     /protein_id="NP_032293.1"
                     /db_xref="CCDS:CCDS25291.1"
                     /db_xref="GeneID:15408"
                     /db_xref="MGI:MGI:107730"
                     /translation="MEPGNYATLDGAKDIEGLLGAGGGRNLVSHSSPLASHPAAPTLM
                     PTVNYAPLDLPGSAEPPKQCHPCPGVPQGASPAPVPYGYFGGGYYSCRVSRSSLKPCA
                     QTAALATYPSETPAPGEEYPSRPTEFAFYPGYPGPYQPMASYLDVSVVQTLGAPGEPR
                     HDSLLPVDSYQPWALAGGWNSQMCCQGEQNPPGPFWKAAFAEPSVQHPPPDGCAFRRG
                     RKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRRVKEKKV
                     LAKVKTSTTP"
     exon            732..1369
                     /gene="Hoxb13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1329..1334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxb13"
                     /note="hexamer: AATAAA"
     polyA_site      1353
                     /gene="Hoxb13"
                     /note="major polyA site"
ORIGIN      
        1 tgcaggcgcc gttcgagctg ggagcgattt aaaacgctta ggattccctg ggcctgggtg
       61 gggagagaca gcttgctgcc ccctagaacc ctcaccctcg gctccccatg agccgatcat
      121 tggctccatg gagcccggca attatgccac cttggacggg gccaaggata tcgaaggctt
      181 gctgggagct ggagggggtc ggaatctagt ctcccactcc tccccactgg ctagccatcc
      241 cgcggctcca acgctgatgc caactgtcaa ctatgccccc ctggatctgc caggctctgc
      301 agagccacca aagcagtgcc acccttgtcc tggggtgcct cagggggcat ctccagctcc
      361 tgtgccttat ggctactttg gaggcgggta ctactcttgc cgagtatcca ggagctccct
      421 gaaaccctgt gcccagacgg ccgccctggc tacctaccct tcggaaactc ctgcacctgg
      481 ggaggagtat cccagccgtc ccaccgagtt tgccttctat ccgggctacc cgggaccata
      541 ccagcctatg gccagttacc tggatgtgtc tgtggtgcag accctgggag cccccggaga
      601 gcctcgccac gattctctgc ttcccgtgga cagttaccag ccctgggccc tggccggtgg
      661 ctggaacagc cagatgtgtt gccaaggtga acagaaccca ccaggtccat tctggaaagc
      721 agcgtttgca gagcccagtg tccagcaccc tcctcccgac ggctgtgcct tccgccgagg
      781 ccgcaaaaaa cgcattccct atagcaaggg gcagttgcgg gagttggagc gggagtatgc
      841 agccaacaag tttatcacta aggacaagag gcgcaagatc tcggcagcca ccagcctctc
      901 tgaacgccag attaccatct ggtttcagaa ccgccgggtc aaggagaaga aggttcttgc
      961 caaggtcaag accagcacta ccccgtgagc accagagggg atgggcaggg gaagagggct
     1021 tgtcctggag aactgggagc ctgccagggc caggactggc agaggactcg gctgagggac
     1081 cccaagagat gacaccttta gcaggcttct gagttctgga ctgttcctcg gggctatcct
     1141 gcatgtgccg ggagcgggag gctcctccat cacggttctg aagaacctgt atcagtcata
     1201 atcattcatc tggaccgtgg tgataatctc ataaccagta ctagttgtca tgataattag
     1261 cctcatattt tctatctaga gctctgttga gcacttagaa atcgctttca tgagttgagc
     1321 tgattgtgaa taaattcgga agacgatctt gtaggacagt ttcctctca
//
