LOCUS       NM_010453               1713 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox A5 (Hoxa5), mRNA.
ACCESSION   NM_010453
VERSION     NM_010453.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1713)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1713)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1713)
  AUTHORS   Xiao,X., Wang,W., Guo,C., Wu,J., Zhang,S., Shi,H., Kwon,S., Chen,J.
            and Dong,Z.
  TITLE     Hypermethylation leads to the loss of HOXA5, resulting in JAG1
            expression and NOTCH signaling contributing to kidney fibrosis
  JOURNAL   Kidney Int 106 (1), 98-114 (2024)
   PUBMED   38521405
  REMARK    GeneRIF: Hypermethylation leads to the loss of HOXA5, resulting in
            JAG1 expression and NOTCH signaling contributing to kidney
            fibrosis.
REFERENCE   4  (bases 1 to 1713)
  AUTHORS   Parrillo,L., Spinelli,R., Longo,M., Zatterale,F., Santamaria,G.,
            Leone,A., Campitelli,M., Raciti,G.A. and Beguinot,F.
  TITLE     The Transcription Factor HOXA5: Novel Insights into Metabolic
            Diseases and Adipose Tissue Dysfunction
  JOURNAL   Cells 12 (16), 2090 (2023)
   PUBMED   37626900
  REMARK    GeneRIF: The Transcription Factor HOXA5: Novel Insights into
            Metabolic Diseases and Adipose Tissue Dysfunction.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1713)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   6  (bases 1 to 1713)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 1713)
  AUTHORS   Nazarali,A., Kim,Y. and Nirenberg,M.
  TITLE     Hox-1.11 and Hox-4.9 homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2883-2887 (1992)
   PUBMED   1348361
REFERENCE   8  (bases 1 to 1713)
  AUTHORS   Moore,K.J., D'Amore-Bruno,M.A., Korfhagen,T.R., Glasser,S.W.,
            Whitsett,J.A., Jenkins,N.A. and Copeland,N.G.
  TITLE     Chromosomal localization of three pulmonary surfactant protein
            genes in the mouse
  JOURNAL   Genomics 12 (2), 388-393 (1992)
   PUBMED   1346779
REFERENCE   9  (bases 1 to 1713)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   10 (bases 1 to 1713)
  AUTHORS   Siracusa,L.D., Rosner,M.H., Vigano,M.A., Gilbert,D.J., Staudt,L.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of the octamer transcription factors, Otf-1,
            Otf-2, and Otf-3, defines multiple Otf-3-related sequences
            dispersed in the mouse genome
  JOURNAL   Genomics 10 (2), 313-326 (1991)
   PUBMED   1676977
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015583.34.
            
            On Mar 28, 2023 this sequence version replaced NM_010453.5.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M28021.1, X16840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-669               AC015583.34        108909-109577
            670-1713            AC015583.34        110535-111578
FEATURES             Location/Qualifiers
     source          1..1713
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 25.4 cM"
     gene            1..1713
                     /gene="Hoxa5"
                     /gene_synonym="Hox-1.3"
                     /note="homeobox A5"
                     /db_xref="GeneID:15402"
                     /db_xref="MGI:MGI:96177"
     exon            1..669
                     /gene="Hoxa5"
                     /gene_synonym="Hox-1.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..920
                     /gene="Hoxa5"
                     /gene_synonym="Hox-1.3"
                     /note="homeobox protein M2; homeobox protein Hox-1.3;
                     homeo box A5"
                     /codon_start=1
                     /product="homeobox protein Hox-A5"
                     /protein_id="NP_034583.1"
                     /db_xref="CCDS:CCDS20143.1"
                     /db_xref="GeneID:15402"
                     /db_xref="MGI:MGI:96177"
                     /translation="MSSYFVNSFCGRYPNGPDYQLHNYGDHSSVSEQFRDSASMHSGR
                     YGYGYNGMDLSVGRSGSGHFGSGERARSYAAGASAAPAEPRYSQPATSTHSPPPDPLP
                     CSAVAPSPGSDSHHGGKNSLGNSSGASANAGSTHISSREGVGTASAAEEDAPASSEQA
                     GAQSEPSPAPPAQPQIYPWMRKLHISHDNIGGPEGKRARTAYTRYQTLELEKEFHFNR
                     YLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSMAAAGGAFRP"
     exon            670..1713
                     /gene="Hoxa5"
                     /gene_synonym="Hox-1.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1695..1700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxa5"
                     /gene_synonym="Hox-1.3"
                     /note="hexamer: AATAAA"
     polyA_site      1713
                     /gene="Hoxa5"
                     /gene_synonym="Hox-1.3"
                     /note="major polyA site"
ORIGIN      
        1 gagtacatgt cccagtcatt tccataattc atcataaatt gtgcaagggt gctatagacg
       61 cacaaacgac cgcgagccac aaatcaagca cacatatcaa aaaacaaatg agctcttatt
      121 ttgtaaactc attttgcggt cgctatccaa atggcccgga ctaccagttg cataattatg
      181 gagatcatag ttccgtgagc gaacaattca gggactcggc gagcatgcac tccggcaggt
      241 acggctacgg ctacaatggc atggatctca gcgtcggccg ttcgggttcc ggccactttg
      301 gctccggcga gcgcgcccgc agctacgcgg ctggggccag tgcggcgccc gccgagccca
      361 ggtacagcca gccggccacg tccacgcact cgccaccgcc cgacccgctg ccctgctcag
      421 cggtggcccc ctcgcccggc agcgacagcc accacggcgg gaaaaactcc ctgggcaact
      481 ccagcggcgc ctcggccaac gccggcagca cccacatcag cagcagagag ggggttggca
      541 cggcgtccgc agccgaggag gacgcccctg ccagcagcga gcaggcgggc gcccagagcg
      601 agccgagccc ggcgccgccc gctcagcccc agatctaccc ctggatgcgc aagctgcaca
      661 ttagtcacga caatataggt ggcccagaag gcaaaagggc ccggacggcc tacactcgct
      721 accagaccct ggagctggag aaagaattcc acttcaaccg ctacctgacc cgccgaagaa
      781 ggatcgaaat agctcatgcc ctttgcctct ccgagagaca aattaaaatc tggttccaaa
      841 acaggaggat gaagtggaaa aaagataata agctgaaaag catgagtatg gccgcggcag
      901 ggggggcttt ccgcccctga gcatctgagc ggccaaagta ctgagcagta gtagccgggc
      961 agctctctgt agtgtcagta ctaaggtgac tttctgaaac tccccttgtg ttccttctgt
     1021 gaagaagccc tgttctcgtt gccctaattc atcttttaat catgagcctg tttattgcca
     1081 ttatagcgcc tgtataagta gatctgcttc tgttcatctc tttgtcctga atggctttgt
     1141 cttgaaaaaa aaatagatgt tttaacttat ttatatgaag caagctgtgt tacttgaagt
     1201 aactaaaaca aaaaaaaaaa aaaaagaaaa gagaaaaaaa aactacacac acaaaaagcc
     1261 cccccacctc gtttagtgcc aatgttgtgt gttgcacttg agttctttaa tgtgcatgta
     1321 cgtggaagtg ttcctgtctc aatagctcca agctgttaaa gatattttta ttcaaactac
     1381 ctatattcct tgtgtaatta atgctgttgt agaggtgact tgataagaca caaattaact
     1441 tgttcaacgt gtagtggcta gtggctctgt gacgaaaact gtgactccaa gcggtgtgtc
     1501 cctgcgtgcc tttgtaggac cctttgcacg aactctggaa gtggctctta taagcgcagc
     1561 ttcagtgatg tatgtttttg tgaaaaagtt acaaatattg tccaagtctg gctgtttaag
     1621 caaactgtga tcagcttttt tttttttttg tatttgtttt taaggaaaaa aaacactgac
     1681 tggaaacaaa acaaaataaa ctttctattg taa
//
