LOCUS       NM_008265               1546 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox A4 (Hoxa4), mRNA.
ACCESSION   NM_008265
VERSION     NM_008265.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1546)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1546)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1546)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   4  (bases 1 to 1546)
  AUTHORS   Aonuma,T., Moukette,B., Kawaguchi,S., Barupala,N.P.,
            Sepulveda,M.N., Frick,K., Tang,Y., Guglin,M., Raman,S.V., Cai,C.,
            Liangpunsakul,S., Nakagawa,S. and Kim,I.M.
  TITLE     MiR-150 Attenuates Maladaptive Cardiac Remodeling Mediated by Long
            Noncoding RNA MIAT and Directly Represses Profibrotic Hoxa4
  JOURNAL   Circ Heart Fail 15 (4), e008686 (2022)
   PUBMED   35000421
REFERENCE   5  (bases 1 to 1546)
  AUTHORS   Lopez-Delgado,A.C., Delgado,I., Cadenas,V., Sanchez-Cabo,F. and
            Torres,M.
  TITLE     Axial skeleton anterior-posterior patterning is regulated through
            feedback regulation between Meis transcription factors and retinoic
            acid
  JOURNAL   Development 148 (1) (2021)
   PUBMED   33298461
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1546)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 1546)
  AUTHORS   Geada,A.M., Gaunt,S.J., Azzawi,M., Shimeld,S.M., Pearce,J. and
            Sharpe,P.T.
  TITLE     Sequence and embryonic expression of the murine Hox-3.5 gene
  JOURNAL   Development 116 (2), 497-506 (1992)
   PUBMED   1363091
REFERENCE   8  (bases 1 to 1546)
  AUTHORS   Cornall,R.J., Friedman,J.M. and Todd,J.A.
  TITLE     Mouse microsatellites from a flow-sorted 4:6 Robertsonian
            chromosome
  JOURNAL   Mamm Genome 3 (11), 620-624 (1992)
   PUBMED   1450512
REFERENCE   9  (bases 1 to 1546)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   10 (bases 1 to 1546)
  AUTHORS   Hunt,P., Gulisano,M., Cook,M., Sham,M.H., Faiella,A., Wilkinson,D.,
            Boncinelli,E. and Krumlauf,R.
  TITLE     A distinct Hox code for the branchial region of the vertebrate head
  JOURNAL   Nature 353 (6347), 861-864 (1991)
   PUBMED   1682814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076098.1 and BQ176943.1.
            
            On Feb 24, 2018 this sequence version replaced NM_008265.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076098.1, BB611128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1528              AK076098.1         2-1529
            1529-1546           BQ176943.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1546
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 25.4 cM"
     gene            1..1546
                     /gene="Hoxa4"
                     /gene_synonym="Hox-1.4"
                     /note="homeobox A4"
                     /db_xref="GeneID:15401"
                     /db_xref="MGI:MGI:96176"
     exon            1..526
                     /gene="Hoxa4"
                     /gene_synonym="Hox-1.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..873
                     /gene="Hoxa4"
                     /gene_synonym="Hox-1.4"
                     /note="homeobox protein MH-3; homeobox protein Hox-1.4;
                     homeo box A4"
                     /codon_start=1
                     /product="homeobox protein Hox-A4"
                     /protein_id="NP_032291.1"
                     /db_xref="CCDS:CCDS20142.1"
                     /db_xref="GeneID:15401"
                     /db_xref="MGI:MGI:96176"
                     /translation="MTMSSFLINSNYIEPKFPPFEEFAPHGGPGGGDGAVGGGPGYPR
                     PQSAPHLPAPNPHAARQPPAYYAPRAREPSYPGGLYPAPAAACPYACRGASPARPEQS
                     PAPGAHPSPAPQPPAPPRHCAPGPTTPAVATGGSAPACPLLLADQGPAGPKGKEPVVY
                     PWMKKIHVSAVNSSYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLC
                     LSERQVKIWFQNRRMKWKKDHKLPNTKMRSSNTASAPAGPPGKAQTHSPHPHPHPLPG
                     ASTPIPSSI"
     exon            527..1533
                     /gene="Hoxa4"
                     /gene_synonym="Hox-1.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1504..1509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxa4"
                     /gene_synonym="Hox-1.4"
                     /note="hexamer: AATAAA"
     polyA_site      1533
                     /gene="Hoxa4"
                     /gene_synonym="Hox-1.4"
                     /note="major polyA site"
ORIGIN      
        1 gcacttcaca aattaatgac catgagctcg tttttgataa actccaacta catcgagccc
       61 aagttccctc ctttcgagga gttcgccccg cacggtggcc cgggcggtgg ggacggcgcc
      121 gtgggcgggg gtcccggcta cccgcggccc cagagcgccc cgcacctgcc ggccccgaac
      181 ccgcacgcgg cccgccagcc ccccgcttac tacgcgccgc gggcgcgcga gcccagctac
      241 cccgggggcc tgtaccccgc gcccgccgcc gcctgtccct acgcctgccg cggggccagc
      301 cccgcgcgac ccgagcagtc cccggccccc ggcgcgcacc ccagcccggc cccgcagccc
      361 cccgcgcccc ctcggcactg cgctcccggc cccaccaccc cggctgtcgc gacggggggc
      421 agcgcccccg cgtgcccgct gctgctggcg gaccagggcc cggcgggccc gaagggcaag
      481 gagccggtgg tgtacccctg gatgaagaag atccacgtga gcgccgtcaa ctccagttat
      541 aacggaggcg aacctaagcg ctctcgaacc gcctataccc ggcagcaagt cttggaactg
      601 gagaaggaat tccactttaa ccgctacctg acccggcggc gccgcatcga gatcgcccac
      661 acgctctgct tgtcggagcg ccaggtcaag atctggtttc agaaccggag aatgaagtgg
      721 aagaaagacc acaaacttcc caacaccaag atgcgatctt ccaacactgc ctcggcccct
      781 gccggcccgc ctgggaaagc acaaactcac agcccacacc cccatcccca ccctctccct
      841 ggtgcttcca cacccattcc ctcctccata taatctagag acctggatca gtttctctca
      901 cttatgtgcc ctactcatct cctgctcctg tcctcatctg ctcttcccta agtaaacccg
      961 agacaccaaa acaaaatcca acttgctgga aaccataacc aaaaagaaga cattatccct
     1021 ggttggtgtg acccctccaa gaggacgtct gtcctcgtcc tcgttactgc ttagtggaac
     1081 aacctgctga cctggacaac tttgccagga ttggacacct gtaagaaagc actggccatc
     1141 gactaccttt gagtcagcca gacagcacgt gctgactggg gacatgtact tgtatgcaga
     1201 agaagcaggc cggttcccag cttcccagct ttctaacctt ccttcctctt ctgcgttaag
     1261 gcagctcaca tgagctttac tgagtagact ttgtggacct caccagatta tttaattttc
     1321 aaagtgtgta gaccttgatg gtaggtgtgg catgtagttt cctctccttg catttattta
     1381 agatactgtt agagagatat tgttgtctta tactggggca cagcgttggg gagagggaaa
     1441 tgcatttaga ctcacttaca actgtacaga gagatatggt tgtataaaga ggaatgtgct
     1501 aagaataaac ttcagtttat aagacattaa aaaaaaaaaa aaaaaa
//
