LOCUS       NM_010452               2812 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus homeobox A3 (Hoxa3), mRNA.
ACCESSION   NM_010452
VERSION     NM_010452.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2812)
  AUTHORS   Frenette,B., Gueno,J., Houde,N., Landry-Truchon,K., Giguere,A.,
            Ashok,T., Ryckman,A., Morton,B.R., Mansfield,J.H. and Jeannotte,L.
  TITLE     Loss of Hoxa5 function affects Hox gene expression in different
            biological contexts
  JOURNAL   Sci Rep 14 (1), 30903 (2024)
   PUBMED   39730789
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2812)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   3  (bases 1 to 2812)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2812)
  AUTHORS   Parella,K., Moody,K., Wortel,D., Colegrove,H. and Elser,J.A.
  TITLE     HOXA3 accelerates wound healing in diabetic and aged non-diabetic
            mammals
  JOURNAL   Sci Rep 13 (1), 9923 (2023)
   PUBMED   37337031
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2812)
  AUTHORS   Kessler,S., Minoux,M., Joshi,O., Ben Zouari,Y., Ducret,S., Ross,F.,
            Vilain,N., Salvi,A., Wolff,J., Kohler,H., Stadler,M.B. and
            Rijli,F.M.
  TITLE     A multiple super-enhancer region establishes inter-TAD interactions
            and controls Hoxa function in cranial neural crest
  JOURNAL   Nat Commun 14 (1), 3242 (2023)
   PUBMED   37277355
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2812)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2812)
  AUTHORS   Nazarali,A., Kim,Y. and Nirenberg,M.
  TITLE     Hox-1.11 and Hox-4.9 homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 89 (7), 2883-2887 (1992)
   PUBMED   1348361
REFERENCE   8  (bases 1 to 2812)
  AUTHORS   Nadeau,J.H., Bedigian,H.G., Bouchard,G., Denial,T., Kosowsky,M.,
            Norberg,R., Pugh,S., Sargeant,E., Turner,R. and Paigen,B.
  TITLE     Multilocus markers for mouse genome analysis: PCR amplification
            based on single primers of arbitrary nucleotide sequence
  JOURNAL   Mamm Genome 3 (2), 55-64 (1992)
   PUBMED   1617215
REFERENCE   9  (bases 1 to 2812)
  AUTHORS   Lufkin,T., Dierich,A., LeMeur,M., Mark,M. and Chambon,P.
  TITLE     Disruption of the Hox-1.6 homeobox gene results in defects in a
            region corresponding to its rostral domain of expression
  JOURNAL   Cell 66 (6), 1105-1119 (1991)
   PUBMED   1680563
REFERENCE   10 (bases 1 to 2812)
  AUTHORS   Chisaka,O. and Capecchi,M.R.
  TITLE     Regionally restricted developmental defects resulting from targeted
            disruption of the mouse homeobox gene hox-1.5
  JOURNAL   Nature 350 (6318), 473-479 (1991)
   PUBMED   1673020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015583.34 and AC091106.17.
            
            On Jul 26, 2022 this sequence version replaced NM_010452.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y11717.1, SRR13422601.2135624.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               AC015583.34        100030-100326
            298-399             AC015583.34        112428-112529
            400-482             AC091106.17        5191-5273
            483-1131            AC091106.17        16212-16860
            1132-2812           AC091106.17        18239-19919
FEATURES             Location/Qualifiers
     source          1..2812
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 25.4 cM"
     gene            1..2812
                     /gene="Hoxa3"
                     /gene_synonym="Hox-1.5; Mo-10"
                     /note="homeobox A3"
                     /db_xref="GeneID:15400"
                     /db_xref="MGI:MGI:96175"
     exon            1..297
                     /gene="Hoxa3"
                     /gene_synonym="Hox-1.5; Mo-10"
                     /inference="alignment:Splign:2.1.0"
     exon            298..399
                     /gene="Hoxa3"
                     /gene_synonym="Hox-1.5; Mo-10"
                     /inference="alignment:Splign:2.1.0"
     exon            400..482
                     /gene="Hoxa3"
                     /gene_synonym="Hox-1.5; Mo-10"
                     /inference="alignment:Splign:2.1.0"
     exon            483..1131
                     /gene="Hoxa3"
                     /gene_synonym="Hox-1.5; Mo-10"
                     /inference="alignment:Splign:2.1.0"
     CDS             603..1934
                     /gene="Hoxa3"
                     /gene_synonym="Hox-1.5; Mo-10"
                     /note="homeobox protein MO-10; homeobox protein Hox-1.5;
                     homeo box A3"
                     /codon_start=1
                     /product="homeobox protein Hox-A3"
                     /protein_id="NP_034582.1"
                     /db_xref="CCDS:CCDS20140.1"
                     /db_xref="GeneID:15400"
                     /db_xref="MGI:MGI:96175"
                     /translation="MQKATYYDSSAIYGGYPYQAANGFAYNASQQPYAPSAALGTDGV
                     EYHRPACSLQSPASAGGHPKTHELSEACLRTLSGPPSQPPGLGEPPLPPPPPQAAPPA
                     PQPPQPPPQPPAPTPAAPPPPSSVSPPQSANSNPTPASTAKSPLLNSPTVGKQIFPWM
                     KESRQNTKQKTSGSSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLC
                     RPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGG
                     YLNSMHSLVNSVPYEPQSPPPFSKPPQGAYGLPPASYPAPLPSCAPPPPPQKRYTAAG
                     SGAGGTPDYDPHAHGLQGNGSYGTPHLQGSPVFVGGSYVEPMSNSGPLFGLTHLPHTT
                     SAAMDYGGTGPLGSGHHHGPGPGEPHPTYTDLTAHHPSQGRIQEAPKLTHL"
     exon            1132..2812
                     /gene="Hoxa3"
                     /gene_synonym="Hox-1.5; Mo-10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2791..2796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxa3"
                     /gene_synonym="Hox-1.5; Mo-10"
                     /note="hexamer: AATAAA"
     polyA_site      2812
                     /gene="Hoxa3"
                     /gene_synonym="Hox-1.5; Mo-10"
                     /note="major polyA site"
ORIGIN      
        1 gcattctttt gctccgctcc atcctgcgtg cttcggagct ctgccttgcc agcctgcctg
       61 ggctgcgctt tgtccggcga tggcgagcga ggggaagccg ctgccaggcc caggccagcc
      121 gttgtcgctg gaggtggagc gcgtccagtt cctggagcag ccgccgctgc tttgcaactt
      181 gcaacctggc taatttcctg cgtcctctgg caccaggaag gaggacaatt cgtctcttgg
      241 gctgccgaag cgacagctgt cagagaggca gaagcttctg ggagccgcgg tctgaaggct
      301 acgtgtgctg cctggtcatt caaagtgtca attttaggtc cagaagtgtc caaaccacaa
      361 gttctcaaaa ctctgaaaaa tggctccctc catgttaaga gtgcctggac actggaaaaa
      421 aagattccct gagcacctgg aactggagac cattcctggt tcagatttaa acatctttgg
      481 aggtttgcgc gcggcggcca ttggcggcgg agtgtcacgt gaccgcgggg gcgtgccaat
      541 gtgctccctt acgggtgtca agcccttgtc agagagtgtg atcacgatcg tgaaacatcg
      601 cgatgcaaaa agcgacctac tacgacagct cagcgatcta cggtggctac ccctaccaag
      661 cagccaatgg gttcgcttac aatgccagtc agcagccata cgcgccgtcc gccgctctgg
      721 gcaccgatgg cgttgagtac catcgacctg cctgctccct ccagtctccc gccagcgctg
      781 ggggccaccc caaaactcat gagctgagcg aagcttgtct gcgcaccctg agcggccctc
      841 ctagtcagcc cccaggcctg ggtgaaccac ctttgcctcc acctcctccc caggcagcgc
      901 ccccagcgcc ccagcctcca cagcccccac cacagccccc tgcgcccacc cctgcagctc
      961 ctccgcctcc ctcgtctgtc tctccccctc aaagtgccaa cagcaaccct acccctgcca
     1021 gcacagccaa gagccccctg ctcaactctc ccaccgtggg caaacaaatc tttccctgga
     1081 tgaaagagtc aaggcagaac actaagcaga aaaccagcgg ctccagctca ggggagagct
     1141 gcgctggtga caagagcccg cctgggcagg cctcgtccaa gcgcgcgcgc acggcgtaca
     1201 cgagcgcgca gctggtagag ctggagaagg agttccactt caaccgctac ctatgccggc
     1261 cgcgccgggt ggagatggcc aacctgctga acctcaccga gcgccagatc aagatctggt
     1321 tccagaaccg ccgcatgaag tacaagaaag accagaaggg caaaggcatg ctgacctcgt
     1381 ctgggggcca gtccccaagt cggagccctg tgcctcccgg tgcaggaggc tatctgaatt
     1441 ctatgcattc gctggtcaac agtgtcccat atgagcccca gtcaccccct cctttctcca
     1501 agcctcccca aggcgcctat gggttgcctc cggcctccta ccctgctccc ctgcccagct
     1561 gcgctccccc acctccccca cagaaacgct acacagcggc ggggtcaggc gcagggggca
     1621 cccctgacta cgacccgcat gctcacggcc tgcagggcaa tggcagctat gggaccccac
     1681 acttacaggg aagccccgtc ttcgtagggg gcagctatgt ggagcccatg agcaactctg
     1741 ggccactctt tggcctaact cacctccccc acaccacctc ggctgccatg gactacgggg
     1801 gcactgggcc gctgggcagc ggacaccacc atgggccggg gcctggggag ccacacccca
     1861 cctacacgga ccttactgcc caccatcctt ctcagggaag aattcaggaa gcgcccaagc
     1921 tcacccacct gtgatgatgg gcccagggct gtgagccagg agagttgccc acccgacctt
     1981 ctttggttac tttttccttt ttttgttttg ttctatgttc ttgcctttcc cttttctcct
     2041 ctgcacccct ccctcatttt gttttctttg gtaatgcgtt tttatagttt atgtgacgta
     2101 gcaatcttgg ttgctggaaa ggctgtcagt atcagtagca acatttacca ccacccctcc
     2161 tcgccctggc ctctggccct gcatcctttt ccttctctac tctttgataa gaaacagggt
     2221 atatgaacaa actttctagt cgagttttca atgtgaattt gttcatactt tatggctccc
     2281 gagaggaagc aactgcgttt ttttttttta agttttagtt tttaaaattg cacttcttgt
     2341 actgatcgag aaaaagaaat caaaggcgct ttgaaacagg gactccctgt gcaaagatga
     2401 ctacgtgtac gtctttccgt gtgtgtgtgc ttgtgaacag tcagatttat ttatattttt
     2461 tgcaagcatt gaatagtcta agttttaaat attatttatc cccatccgtt cgtatttata
     2521 ttaaagaaat tctgtaccct gattgttcag aaggtttctt gagccttttg ttcaatggtg
     2581 tattggcata catataaaat ttatttgaaa gggaaataaa attcctttat taaaaaccgt
     2641 agcaatgcaa taagaacaga gaggacccag agtttgaaaa tagtggttta ggtttgtaac
     2701 atctggccaa actgaacgct aaaaatgcta gatttgtttt gagagtttta cattccttgc
     2761 tgctcacatt ctgagaaaca aaacaaaaaa aataaagttt ttattctgat ta
//
