LOCUS       NM_010450               2281 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus homeobox A11 (Hoxa11), mRNA.
ACCESSION   NM_010450
VERSION     NM_010450.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2281)
  AUTHORS   Thomson,E., Tran,M., Robevska,G., Ayers,K., van der Bergen,J.,
            Gopalakrishnan Bhaskaran,P., Haan,E., Cereghini,S.,
            Vash-Margita,A., Margetts,M., Hensley,A., Nguyen,Q., Sinclair,A.,
            Koopman,P. and Pelosi,E.
  TITLE     Functional genomics analysis identifies loss of HNF1B function as a
            cause of Mayer-Rokitansky-Kuster-Hauser syndrome
  JOURNAL   Hum Mol Genet 32 (6), 1032-1047 (2023)
   PUBMED   36282544
REFERENCE   2  (bases 1 to 2281)
  AUTHORS   Flynn,C.G.K., Ginkel,P.R.V., Hubert,K.A., Guo,Q., Hrycaj,S.M.,
            McDermott,A.E., Madruga,A., Miller,A.P. and Wellik,D.M.
  TITLE     Hox11-expressing interstitial cells contribute to adult skeletal
            muscle at homeostasis
  JOURNAL   Development 150 (4) (2023)
   PUBMED   36815629
REFERENCE   3  (bases 1 to 2281)
  AUTHORS   Patel,N.K., Nunez,J.H., Sorkin,M., Marini,S., Pagani,C.A.,
            Strong,A.L., Hwang,C.D., Li,S., Padmanabhan,K.R., Kumar,R.,
            Bancroft,A.C., Greenstein,J.A., Nelson,R., Rasheed,H.A.,
            Livingston,N., Vasquez,K., Huber,A.K. and Levi,B.
  TITLE     Macrophage TGF-beta signaling is critical for wound healing with
            heterotopic ossification after trauma
  JOURNAL   JCI Insight 7 (20), e144925 (2022)
   PUBMED   36099022
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2281)
  AUTHORS   Fu,J.F., Wen,C.J., Yen,T.H. and Shih,L.Y.
  TITLE     Hoxa11-mediated reduction of cell migration contributes to myeloid
            sarcoma formation induced by cooperation of MLL/AF10 with
            activating KRAS mutation in a mouse transplantation model: Hoxa11
            in myeloid sarcoma formation
  JOURNAL   Neoplasia 29, 100802 (2022)
   PUBMED   35500545
  REMARK    GeneRIF: Hoxa11-mediated reduction of cell migration contributes to
            myeloid sarcoma formation induced by cooperation of MLL/AF10 with
            activating KRAS mutation in a mouse transplantation model: Hoxa11
            in myeloid sarcoma formation.
REFERENCE   5  (bases 1 to 2281)
  AUTHORS   Chau,Y.M., Pando,S. and Taylor,H.S.
  TITLE     HOXA11 silencing and endogenous HOXA11 antisense ribonucleic acid
            in the uterine endometrium
  JOURNAL   J Clin Endocrinol Metab 87 (6), 2674-2680 (2002)
   PUBMED   12050232
REFERENCE   6  (bases 1 to 2281)
  AUTHORS   Davis,A.P., Witte,D.P., Hsieh-Li,H.M., Potter,S.S. and
            Capecchi,M.R.
  TITLE     Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11
  JOURNAL   Nature 375 (6534), 791-795 (1995)
   PUBMED   7596412
  REMARK    GeneRIF: mice mutant for Hoxd11 and Hoxa11 show absence of radius
            and ulna, anterior homeotic transformation of vertebra, and severe
            kidney defects, suggesting Hoxd11 and Hoxa11 act together to
            specify limb outgrowth and patterning of proximodistal axis
REFERENCE   7  (bases 1 to 2281)
  AUTHORS   Hsieh-Li,H.M., Witte,D.P., Weinstein,M., Branford,W., Li,H.,
            Small,K. and Potter,S.S.
  TITLE     Hoxa 11 structure, extensive antisense transcription, and function
            in male and female fertility
  JOURNAL   Development 121 (5), 1373-1385 (1995)
   PUBMED   7789268
REFERENCE   8  (bases 1 to 2281)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   9  (bases 1 to 2281)
  AUTHORS   Kessel,M.
  TITLE     Respecification of vertebral identities by retinoic acid
  JOURNAL   Development 115 (2), 487-501 (1992)
   PUBMED   1358593
REFERENCE   10 (bases 1 to 2281)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015583.34.
            
            On Mar 30, 2023 this sequence version replaced NM_010450.3.
            
            Summary: This gene is located in a cluster of developmentally and
            temporally regulated genes on chromosome 6 encoding proteins
            involved in pattern formation. These proteins contain a
            characteristic DNA-binding motif called a homeodomain and function
            in transcriptional regulation. There are four distinct clusters of
            related genes on chromosomes 2, 6, 11, and 15. The protein encoded
            by this gene is important in the development of the skeleton,
            limbs, and urogenital tract. Expression of this gene may be
            regulated by overlapping transcription from an adjacent locus on
            the opposite strand (GeneID: 15397). [provided by RefSeq, Mar
            2013].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U20370.1, BC052232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-794               AC015583.34        67562-68355
            795-2281            AC015583.34        69774-71260
FEATURES             Location/Qualifiers
     source          1..2281
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 25.4 cM"
     gene            1..2281
                     /gene="Hoxa11"
                     /gene_synonym="Hox-1.9; Hoxa-11"
                     /note="homeobox A11"
                     /db_xref="GeneID:15396"
                     /db_xref="MGI:MGI:96172"
     exon            1..794
                     /gene="Hoxa11"
                     /gene_synonym="Hox-1.9; Hoxa-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1027
                     /gene="Hoxa11"
                     /gene_synonym="Hox-1.9; Hoxa-11"
                     /note="homeobox protein Hox-1.9; homeo box A11"
                     /codon_start=1
                     /product="homeobox protein Hox-A11"
                     /protein_id="NP_034580.1"
                     /db_xref="CCDS:CCDS20148.1"
                     /db_xref="GeneID:15396"
                     /db_xref="MGI:MGI:96172"
                     /translation="MMDFDERGPCSSNMYLPSCTYYVSGPDFSSLPSFLPQTPSSRPM
                     TYSYSSNLPQVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAG
                     VPGDVLAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQFFETAYGTPENLASSDY
                     PGDKNAEKGPQAAAATSAAAVAAAATGAPATSSSDGGGGGGCQEAAAEEKERRRRPES
                     SSSPESSSGHTEDKAGGSGGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSR
                     MLNLTDRQVKIWFQNRRMKEKKINRDRLQYYSANPLL"
     exon            795..2281
                     /gene="Hoxa11"
                     /gene_synonym="Hox-1.9; Hoxa-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2262..2267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxa11"
                     /gene_synonym="Hox-1.9; Hoxa-11"
                     /note="hexamer: AATAAA"
     polyA_site      2281
                     /gene="Hoxa11"
                     /gene_synonym="Hox-1.9; Hoxa-11"
                     /note="major polyA site"
ORIGIN      
        1 ctacttcacg gatccgcttc aaagaggcag ctgcagtgga gaatcatgtt aagctcggct
       61 actgcggaga gcccaaggta gcccaatgat ggattttgat gagcgtggtc cctgctcctc
      121 taacatgtat ttgccaagtt gtacttacta cgtctcgggt ccagatttct ccagcctccc
      181 ttcttttttg ccccagaccc cgtcttcgcg cccaatgaca tactcctact cctccaacct
      241 gccccaggtc caacccgtgc gcgaagtgac cttcagagag tacgccattg agcccgccac
      301 taaatggcac ccccgcggca atctggccca ctgctactcc gcggaggagc tcgtgcacag
      361 agactgtctg caggcgccca gcgcggccgg cgtgcctggc gacgtgctgg ccaagagctc
      421 ggccaacgtc taccaccacc ccacccccgc cgtctcgtcc aatttctata gcacggtggg
      481 caggaacggc gttctgccac aggctttcga ccagtttttc gagacggctt acggcacccc
      541 ggaaaacctc gcttcctccg actaccccgg ggacaagaac gccgagaagg ggccccaagc
      601 agcagctgcg acctccgctg cggcggtggc ggcggcggcc acgggcgcgc cggcaacttc
      661 aagttcggac ggcggcggtg gcggcggctg tcaggaggcg gcggcggagg agaaggagcg
      721 acggcggcga cccgagagca gcagcagccc cgagtcgtct tccggccaca ctgaggacaa
      781 ggccggtggc tccggtggcc aacgcacccg caaaaagcgc tgcccttata ccaaatacca
      841 gatccgagag ctggagcgag agttcttctt cagcgtctac atcaacaaag agaagcgtct
      901 gcaactgtcc cgcatgctca acctcaccga ccgtcaagtc aaaatctggt ttcagaacag
      961 aagaatgaag gaaaaaaaga ttaacagaga ccggttacag tactactcag ctaatccact
     1021 tctctaaggc tccagcctac tggaattggg aggggggctt catacatgtg aaataatatg
     1081 cagattttgc ccttgacaag gtcaagccac attgcgactt ggaaaagggg ggtgatatag
     1141 gagagaggag aggtttcctt atcagagatt cgtccaatag gaagggggcc tgaaactctc
     1201 ttggttcaga tctccgtggt taagcttcct attagtaatt gaattctaag ggttgtgaat
     1261 caacagaatg aatggtttgg gacccctggt ggttcactct tagagcctgc aaaagctttg
     1321 agctgggtgt ggtcactgga gattgggccc cctgccaaac cctaaggagg ccacccgctc
     1381 aagaccctct gcacagagcc tgcccacccc caggtctccc aagtcaagaa actgtgtgcc
     1441 ccaagcctag ttcagcttgg ggataggagc aggaggaaag gggatgactc ctagagattc
     1501 aggctggggt tgctttccaa aagtaatgtg aaagacagtt aaccaaaagg tggctgtgaa
     1561 aagggagaga gagtgggagg ggggtgtcct ggaggaagga gaaacctatc cagatgtcat
     1621 taatatcatc ccaccactga tctgcaccca aacctgagct cctagcagcc accttctgca
     1681 gcctacctgg gttttctacc tcccaatggt ggtgatgggt cttccatctc agagctgact
     1741 attcctaggg tagaagacat tgaaaactcc agaggctgtg ctggttcctg gcccctcaat
     1801 ctctacagga aatgcctgcg gagggctaca gtttggcaaa ctcttcacca cattaaggaa
     1861 acttggattt ggtgtctgtc aggcagcaga gcagcaggcc tggccagtgg gtccttggcc
     1921 tttggctgtg aggggctgaa gttccccccc ccctcccaaa tccctcattc ctaccctgca
     1981 ctctgtgctc atcaactcag aactgagctt ggaagcttct ggcaatcttc taagagccgg
     2041 agagtgattt ggagctattt taaaagataa atattatatt atatatatat atttccccga
     2101 aggaaccaaa gcgaatttta agaagcaatg tagagggggg ggtggggata ataaaaatat
     2161 ttaaaggctc tatctgttta cagtgttcca aggttaaact cgctcactgc taaaatattt
     2221 gaatgtatgc ttcatacagg gatggtgttc aaaagactgt aaataaagaa accataacct
     2281 a
//
