LOCUS       NM_008263               2574 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus homeobox A10 (Hoxa10), transcript variant 1, mRNA.
ACCESSION   NM_008263
VERSION     NM_008263.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2574)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2574)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2574)
  AUTHORS   Murakami,T., Ruengsinpinya,L., Takahata,Y., Nakaminami,Y., Hata,K.
            and Nishimura,R.
  TITLE     HOXA10 promotes Gdf5 expression in articular chondrocytes
  JOURNAL   Sci Rep 13 (1), 22778 (2023)
   PUBMED   38123662
  REMARK    GeneRIF: HOXA10 promotes Gdf5 expression in articular chondrocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2574)
  AUTHORS   Sirohi,V.K., Medrano,T.I., Kannan,A., Bagchi,I.C. and Cooke,P.S.
  TITLE     Uterine-specific Ezh2 deletion enhances stromal cell senescence and
            impairs placentation, resulting in pregnancy loss
  JOURNAL   iScience 26 (7), 107028 (2023)
   PUBMED   37360688
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2574)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   6  (bases 1 to 2574)
  AUTHORS   Scott,M.P.
  TITLE     Vertebrate homeobox gene nomenclature
  JOURNAL   Cell 71 (4), 551-553 (1992)
   PUBMED   1358459
REFERENCE   7  (bases 1 to 2574)
  AUTHORS   Kessel,M.
  TITLE     Respecification of vertebral identities by retinoic acid
  JOURNAL   Development 115 (2), 487-501 (1992)
   PUBMED   1358593
REFERENCE   8  (bases 1 to 2574)
  AUTHORS   Murtha,M.T., Leckman,J.F. and Ruddle,F.H.
  TITLE     Detection of homeobox genes in development and evolution
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10711-10715 (1991)
   PUBMED   1720547
REFERENCE   9  (bases 1 to 2574)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   10 (bases 1 to 2574)
  AUTHORS   Hunt,P., Gulisano,M., Cook,M., Sham,M.H., Faiella,A., Wilkinson,D.,
            Boncinelli,E. and Krumlauf,R.
  TITLE     A distinct Hox code for the branchial region of the vertebrate head
  JOURNAL   Nature 353 (6347), 861-864 (1991)
   PUBMED   1682814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015583.34.
            
            On Mar 31, 2023 this sequence version replaced NM_008263.3.
            
            Summary: In vertebrates, the genes encoding the class of
            transcription factors called homeobox genes are found in clusters
            named A, B, C, and D on four separate chromosomes. Expression of
            these proteins is spatially and temporally regulated during
            embryonic development. This gene is part of a cluster on chromosome
            6 and encodes a DNA-binding transcription factor that may regulate
            gene expression, morphogenesis, and differentiation. More
            specifically, it may function in fertility, embryo viability, and
            regulation of hematopoietic lineage commitment. Alternatively
            spliced transcript variants encoding different isoforms have been
            described. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050839.1, SRR13422598.1392892.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-990               AC015583.34        78418-79407
            991-2574            AC015583.34        80586-82169
FEATURES             Location/Qualifiers
     source          1..2574
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 25.4 cM"
     gene            1..2574
                     /gene="Hoxa10"
                     /gene_synonym="Hox-1.8; Hoxa-10"
                     /note="homeobox A10"
                     /db_xref="GeneID:15395"
                     /db_xref="MGI:MGI:96171"
     exon            1..990
                     /gene="Hoxa10"
                     /gene_synonym="Hox-1.8; Hoxa-10"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1265
                     /gene="Hoxa10"
                     /gene_synonym="Hox-1.8; Hoxa-10"
                     /note="isoform a is encoded by transcript variant 1;
                     homeobox protein Hox-A10; homeobox protein Hox-1.8; homeo
                     box A10"
                     /codon_start=1
                     /product="homeobox protein Hox-A10 isoform a"
                     /protein_id="NP_032289.2"
                     /db_xref="CCDS:CCDS20147.2"
                     /db_xref="GeneID:15395"
                     /db_xref="MGI:MGI:96171"
                     /translation="MSARKGYLLPSPNYPTTMSCSESPAANSFLVDSLISSGRGEAGV
                     GGGSAGGGGGGYYAHGGVYLPPASDLPYGLQSCGLFPALGSKRNEAPSPGGGGGGGSG
                     GLGPGTHGYAPAPLDLWLDAPRSCRMEPPDGPPPPQPQPQQQQQQPPPPPPQPPQPQP
                     QATSCSFAQNIKEESSYCLYDAADKCPKGSAAADLAPFPRGPPPDGCALGASSGVPVP
                     GYFRLSQAYGTAKGFGSGGGGTQQLASPFPAQPPGRGFDPPPALASGSTEAAGKERVL
                     DSTPPPTLVCTGGGGSQGDEEAHASSSAAEELSPAPSENSKASPEKDSLGSSKGENAA
                     NWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRSVHLTDRQVKIWFQN
                     RRMKLKKMNRENRIRELTANFNFS"
     exon            991..2574
                     /gene="Hoxa10"
                     /gene_synonym="Hox-1.8; Hoxa-10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2555..2560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoxa10"
                     /gene_synonym="Hox-1.8; Hoxa-10"
                     /note="hexamer: AATAAA"
     polyA_site      2574
                     /gene="Hoxa10"
                     /gene_synonym="Hox-1.8; Hoxa-10"
                     /note="major polyA site"
ORIGIN      
        1 gttttgcaca agaaatgtca gccagaaagg gctatctgct cccttcgcca aattatccca
       61 caacaatgtc atgctcggag agccctgccg cgaactcctt tttggtcgac tcgctcatca
      121 gctcaggcag aggcgaggct ggtgttggtg gcggtagcgc ggggggcggt ggaggtggct
      181 actacgccca cggtggggtc tacctgccgc ctgccagcga cctgccctac gggctgcaaa
      241 gctgcgggct cttccccgcg ctgggcagca agcgtaatga agcgccgtcg cccggaggcg
      301 gtggcggtgg tggcagcggg ggcctgggtc ctgggacgca tggctacgcg cccgcgcccc
      361 tagacctgtg gctggacgcg ccccgctcct gccggatgga gccgcccgac gggccgccgc
      421 caccgcagcc acaaccccag cagcagcagc agcagccgcc gccgcccccg ccgcagccac
      481 ctcaacccca gccacaggcc acttcgtgtt cttttgcgca gaacatcaaa gaagagagct
      541 cctactgcct ctacgatgct gcggacaaat gccccaaggg ctcggccgcc gctgatctgg
      601 cccctttccc gcggggcccg ccgcccgacg gctgcgccct gggcgcctcc agcggagtgc
      661 cagtacccgg ctacttccgc ctgtcgcagg cctacggcac ggccaagggc ttcggcagtg
      721 gcggcggcgg cacgcagcag ctcgctagtc cctttcctgc gcagcccccg gggcgcggtt
      781 tcgacccgcc gcccgcactg gcctctggct cgaccgaggc agccgggaag gagcgagtcc
      841 tagactccac gccaccaccc actctggttt gcaccggtgg cggcggctcg cagggcgacg
      901 aggaggcaca cgcgtcatcc tcggcggctg aggagctgtc tccagcccct tcagaaaaca
      961 gtaaagcttc gccggagaag gactccctgg gcagttccaa aggcgaaaat gcagccaact
     1021 ggctcacagc aaagagcggc cggaagaaac gctgccctta cacgaagcac cagacgctgg
     1081 agctggagaa ggagtttcta ttcaacatgt accttactcg agagcggcgc ctagagatca
     1141 gccgtagcgt ccacctcacg gacagacaag tgaaaatctg gtttcagaat cgcaggatga
     1201 aactgaagaa aatgaaccga gaaaaccgaa tccgggagct cacagccaac tttaattttt
     1261 cctgatgaaa cttccagaca acgtcttttc gcttcctgag cgcctggacc catcctctgc
     1321 ctccagcctc tgccccagaa ctcacacctg tgccggagcc cctttctccc tcccacactc
     1381 gccatctccc aggccgtttc gtctgtgcag ggctggtttg ttctggcttt ttttgtttgt
     1441 ttgtttcttt gtctgtttgc ttggtgtttg tttgcttgtt ttctggggga aaaagccata
     1501 tcgctaaaat tctatagagg ttgagatctt tctcagtgtc aagtcctgaa tgggctgggt
     1561 ttgctgcctc tgggacccac tgctaggaaa gggccccagt actcctccac ggatctggtt
     1621 tcctgcccag ccctgggtaa acttagccgg aagccttagg tcccattgtc ggcgctgagg
     1681 tgtctggcct gaggtcaatg gtgcaaggag ccgccaccgg gttcgccagc ctggagtgct
     1741 gggctgtgtt taatcaggga gtccaggcct ggtttctctt ttctttcttc ttttcttcct
     1801 tggccaagag cagagtatgg aagcatggac attcaggtta gctaaagggc ttgacctggc
     1861 tggttgaaaa agtgaaaaag aaataatcag taagattaat ttttccttct tttgtaagat
     1921 ctcccagctt taaatgaaaa ttaaaatggg caagagaagg aaacctctct tcccgtttgc
     1981 ctaaggtctt gcttgcctgg ctaaaatcct tcattcacct ttgagtttcc atatccctgc
     2041 tgttaacaaa taatgcaggt ttgtttatac atgtggaact ggtggatttt cgtcattaaa
     2101 actgttacca attggtaaca caagaaaagc acaccacaat tctccctatt taatggaggt
     2161 tgtttttttt tttttgcttt aattcacttt ttgtttttgt ttttgttttt tattttgtag
     2221 gctttctgaa attcatggaa gcctaggtgg gctggggcaa gcagaaataa aaatgagaga
     2281 agggagatat tgtttggatt tcctttatac tgtgaagtta catgcataaa agggtcaaac
     2341 ctgtaggtgc agaaaagaaa aaaaaaacct ataaatacaa atctgtataa atgtctatta
     2401 ttatgaaaaa ttgccaatct tgtttaagca aatgcattct atcgttatta taaatgttag
     2461 ttctagcttt atttacttca aaatcttaaa tcagaataaa ttaatattgt attgctgctg
     2521 tgcgtggaaa aagatgatgt ttatgttctt atagaataaa agctgtggaa tgaa
//
