LOCUS       NM_029458               2058 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus HORMA domain containing 2 (Hormad2), transcript
            variant 1, mRNA.
ACCESSION   NM_029458 XM_908089 XM_973907 XM_987942
VERSION     NM_029458.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2058)
  AUTHORS   Cossu,I.G., Leu,N.A., Guan,Y. and Wang,P.J.
  TITLE     The N-terminal modification of HORMAD2 causes its ectopic
            persistence on synapsed chromosomes without meiotic blockade
  JOURNAL   Reproduction 167 (4), e230330 (2024)
   PUBMED   38401263
  REMARK    GeneRIF: The N-terminal modification of HORMAD2 causes its ectopic
            persistence on synapsed chromosomes without meiotic blockade.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2058)
  AUTHORS   Guan,Y., Leu,N.A., Ma,J., Chmatal,L., Ruthel,G., Bloom,J.C.,
            Lampson,M.A., Schimenti,J.C., Luo,M. and Wang,P.J.
  TITLE     SKP1 drives the prophase I to metaphase I transition during male
            meiosis
  JOURNAL   Sci Adv 6 (13), eaaz2129 (2020)
   PUBMED   32232159
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2058)
  AUTHORS   Hirota,T., Blakeley,P., Sangrithi,M.N., Mahadevaiah,S.K.,
            Encheva,V., Snijders,A.P., ElInati,E., Ojarikre,O.A., de
            Rooij,D.G., Niakan,K.K. and Turner,J.M.A.
  TITLE     SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome
            Silencing in Mice
  JOURNAL   Dev Cell 47 (5), 645-659 (2018)
   PUBMED   30393076
REFERENCE   4  (bases 1 to 2058)
  AUTHORS   Rinaldi,V.D., Bolcun-Filas,E., Kogo,H., Kurahashi,H. and
            Schimenti,J.C.
  TITLE     The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome
            Synapsis Failure
  JOURNAL   Mol Cell 67 (6), 1026-1036 (2017)
   PUBMED   28844861
REFERENCE   5  (bases 1 to 2058)
  AUTHORS   Ni,L., Xie,H. and Tan,L.
  TITLE     Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3
            conditional knockout mouse models
  JOURNAL   Mol Reprod Dev 83 (12), 1060-1069 (2016)
   PUBMED   27739607
REFERENCE   6  (bases 1 to 2058)
  AUTHORS   Jordan,P.W., Karppinen,J. and Handel,M.A.
  TITLE     Polo-like kinase is required for synaptonemal complex disassembly
            and phosphorylation in mouse spermatocytes
  JOURNAL   J Cell Sci 125 (Pt 21), 5061-5072 (2012)
   PUBMED   22854038
REFERENCE   7  (bases 1 to 2058)
  AUTHORS   Wojtasz,L., Cloutier,J.M., Baumann,M., Daniel,K., Varga,J., Fu,J.,
            Anastassiadis,K., Stewart,A.F., Remenyi,A., Turner,J.M. and Toth,A.
  TITLE     Meiotic DNA double-strand breaks and chromosome asynapsis in mice
            are monitored by distinct HORMAD2-independent and -dependent
            mechanisms
  JOURNAL   Genes Dev 26 (9), 958-973 (2012)
   PUBMED   22549958
  REMARK    GeneRIF: these observations strongly suggest that HORMAD2-dependent
            recruitment of ATR to unsynapsed chromosome axes constitutes a
            mechanism for the surveillance of asynapsis.
REFERENCE   8  (bases 1 to 2058)
  AUTHORS   Fukuda,T., Pratto,F., Schimenti,J.C., Turner,J.M.,
            Camerini-Otero,R.D. and Hoog,C.
  TITLE     Phosphorylation of chromosome core components may serve as axis
            marks for the status of chromosomal events during mammalian meiosis
  JOURNAL   PLoS Genet 8 (2), e1002485 (2012)
   PUBMED   22346761
REFERENCE   9  (bases 1 to 2058)
  AUTHORS   Shin,Y.H., Choi,Y., Erdin,S.U., Yatsenko,S.A., Kloc,M., Yang,F.,
            Wang,P.J., Meistrich,M.L. and Rajkovic,A.
  TITLE     Hormad1 mutation disrupts synaptonemal complex formation,
            recombination, and chromosome segregation in mammalian meiosis
  JOURNAL   PLoS Genet 6 (11), e1001190 (2010)
   PUBMED   21079677
  REMARK    Erratum:[PLoS Genet. 2011;7(2). doi:
            10.1371/annotation/8aa656b6-55f7-4795-a441-cf243ea62175]
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2058)
  AUTHORS   Wojtasz,L., Daniel,K., Roig,I., Bolcun-Filas,E., Xu,H.,
            Boonsanay,V., Eckmann,C.R., Cooke,H.J., Jasin,M., Keeney,S.,
            McKay,M.J. and Toth,A.
  TITLE     Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal
            proteins, are depleted from synapsed chromosome axes with the help
            of TRIP13 AAA-ATPase
  JOURNAL   PLoS Genet 5 (10), e1000702 (2009)
   PUBMED   19851446
  REMARK    GeneRIF: HORMAD1 and HORMAD2 are depleted from synapsed chromosome
            axes with the help of TRIP13.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645910.8 and AL731658.20.
            
            On Mar 14, 2023 this sequence version replaced NM_029458.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144842.1, SRR5189685.193691.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849382,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               AL645910.8         63048-63386         c
            340-427             AL645910.8         57173-57260         c
            428-569             AL645910.8         49415-49556         c
            570-633             AL645910.8         46927-46990         c
            634-670             AL645910.8         46442-46478         c
            671-691             AL645910.8         43760-43780         c
            692-718             AL645910.8         42875-42901         c
            719-786             AL645910.8         34384-34451         c
            787-938             AL645910.8         31178-31329         c
            939-1192            AL645910.8         30761-31014         c
            1193-2058           AL731658.20        103491-104356       c
FEATURES             Location/Qualifiers
     source          1..2058
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.94 cM"
     gene            1..2058
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /note="HORMA domain containing 2"
                     /db_xref="GeneID:75828"
                     /db_xref="MGI:MGI:1923078"
     exon            1..339
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            340..427
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..1297
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /codon_start=1
                     /product="HORMA domain-containing protein 2"
                     /protein_id="NP_083734.1"
                     /db_xref="CCDS:CCDS36096.1"
                     /db_xref="GeneID:75828"
                     /db_xref="MGI:MGI:1923078"
                     /translation="MATAQLSHNTRTLKASKNTIFPSQVTNEHESLVVVKKLFATCIS
                     CITYLRGLFPESSYRDRRLDDLSLKILREDKKCPGSLHIIKWIQGCFDALEKRYLHMA
                     VLTLYTNPKEPEKVTEIYQFRFKYTKKGTTMDFDSSSTSFESGTDSEDIKKACSLLIR
                     QLYILMQNLGPLPNDVILTMKLHYYNSVTPHDYQPPGFKEAVNSHFLLFEGEPVSLRM
                     GSVSSGFHSMKVKVTTEATRMLDGENSVSQDDGTTEIAHQGLDCDEEEEACGSQVQRM
                     NFVHIEPSFESSRKKKKVSEPVTVFIPNRK"
     exon            428..569
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            570..633
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            634..670
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            671..691
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            692..718
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            719..786
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            787..938
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1192
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..2058
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2030..2035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2058
                     /gene="Hormad2"
                     /gene_synonym="4930529M09Rik"
                     /note="major polyA site"
ORIGIN      
        1 attcatgagg tagagcaagg cctgctgagg ggccaacctt agacttaggc atgaggagac
       61 tcctgtggcc ctggccggaa agtcgtaaag ccgaggggtg ggctttgcca ggaaaagccg
      121 ttggcctctg ctgaggtaaa ggccgagggg aaggcctcgc cgcgtgttca cacgcggggt
      181 ctccggagga aggcgttcgg gtgggttctg gggtcttcaa gttcacactt ctctgttctt
      241 tttaattgac tgggttcatc tgtggaactc gccagccctc tgaggagaag tgtaatcgtg
      301 taatcgtggc ggagggccaa cgaggaccgg aagcttcagg ttggaattgt tgaaagaatc
      361 ctgattcatt ctcacgatgg ctactgcgca gctctctcac aacaccagaa cactgaaggc
      421 gtctaagaac acgattttcc cgtcccaagt gacaaatgag catgagtcac tggtggtggt
      481 gaagaagctt tttgctactt gtatctcatg tataacgtac ctgaggggct tgtttccaga
      541 gagctcctac agagaccgcc gtttggatga cctcagttta aaaattctcc gggaagacaa
      601 aaagtgtccg gggtcattac atattattaa atggattcaa ggttgttttg atgctttgga
      661 aaagagatac ctacacatgg cagtattaac actttacaca aatcccaagg aacctgagaa
      721 agtgactgag atataccaat tcagattcaa atacacaaaa aaaggaacca ctatggactt
      781 tgacagcagc agcacaagct ttgaaagtgg gacagacagt gaagatatta agaaagcctg
      841 ttccctacta atccgtcaat tgtatatact gatgcagaat cttggacccc ttccgaatga
      901 tgttatactt actatgaaac tccattatta taactcagtg accccacatg attaccaacc
      961 ccctggcttt aaagaagcgg tgaattcaca cttcctgctg tttgaggggg agcctgtgag
     1021 ccttcgaatg ggttcagtct cctctggctt tcacagcatg aaagtaaaag tcacaacgga
     1081 ggccaccaga atgctcgatg gggagaacag tgtcagtcag gacgatggca ctactgagat
     1141 agctcatcag gggctagact gtgacgagga agaggaggcc tgcggcagtc aagtccaaag
     1201 aatgaatttt gtgcacattg agccaagttt tgaaagttcc agaaagaaga agaaggtcag
     1261 cgaaccagtg acagtcttca ttcctaacag aaaatgaaac ttaggtgcct ttgctacacc
     1321 tgttttgcaa aaatctatga agtgctgtaa caggataatg accaagcctt ctttcttcct
     1381 acggctttgc tccactctct cctcagtctg tgaaaggcta agctattgag caggccctag
     1441 gttcacttct ccagaaggaa cctggatcgc agagctgcct tgggatggga tgacctcgcg
     1501 gccgagttag agaggagaca cgctctgtgt ttgcaaaaaa ccacagcagt tagtttggaa
     1561 agaaataagc tgctgttctt caagtaaagg gtttttcttt acataattaa attctccagg
     1621 tatctctgtg aaatactctg acttgttaga acctgtgagt tggaatcctt ctatagcttt
     1681 actaaaactc acacagcgca gcataggata tgtgtggagg tgcttagcca ggcatgattt
     1741 atatgttgat ttcagtcaca aagttgatca gcagcatgtg aatccagatg ccctccctcc
     1801 ctgtgcagtt cctcagctct gccccaggcc ctgccccagg ccctgtgctg ttggccaatc
     1861 ccaaacagct gacatgcagt tcaggagcct ggttcccctg taagacctat gttgtgtatt
     1921 ttctccaaaa tacttgagtt tatctgtctg taacttgcag gtgatgctat ttgtcccctc
     1981 catattctgg aagaattttg ataggctttt gtactaatgt gatatgaata ataaatgact
     2041 tacagaattg tttgataa
//
