LOCUS       NM_001289532            1654 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus HORMA domain containing 1 (Hormad1), transcript
            variant 1, mRNA.
ACCESSION   NM_001289532 XM_006501957
VERSION     NM_001289532.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1654)
  AUTHORS   Chotiner,J.Y., Leu,N.A., Yang,F., Cossu,I.G., Guan,Y., Lin,H. and
            Wang,P.J.
  TITLE     TRIP13 localizes to synapsed chromosomes and functions as a
            dosage-sensitive regulator of meiosis
  JOURNAL   Elife 12, 92195 (2024)
   PUBMED   39207914
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1654)
  AUTHORS   Kogo,H., Kikuchi-Kokubo,Y., Tajika,Y., Iizuka-Kogo,A., Yamamoto,H.,
            Ikezawa,M., Kurahashi,H. and Matsuzaki,T.
  TITLE     Differential phosphorylation of two serine clusters in mouse
            HORMAD1 during meiotic prophase I progression
  JOURNAL   Exp Cell Res 440 (1), 114133 (2024)
   PUBMED   38897409
  REMARK    GeneRIF: Differential phosphorylation of two serine clusters in
            mouse HORMAD1 during meiotic prophase I progression.
REFERENCE   3  (bases 1 to 1654)
  AUTHORS   Biot,M., Toth,A., Brun,C., Guichard,L., de Massy,B. and Grey,C.
  TITLE     Principles of chromosome organization for meiotic recombination
  JOURNAL   Mol Cell 84 (10), 1826-1841 (2024)
   PUBMED   38657614
REFERENCE   4  (bases 1 to 1654)
  AUTHORS   Bai,L., Li,P., Xiang,Y., Jiao,X., Chen,J., Song,L., Liang,Z.,
            Liu,Y., Zhu,Y. and Lu,L.Y.
  TITLE     BRCA1 safeguards genome integrity by activating chromosome
            asynapsis checkpoint to eliminate recombination-defective oocytes
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2401386121 (2024)
   PUBMED   38696471
REFERENCE   5  (bases 1 to 1654)
  AUTHORS   Dereli,I., Telychko,V., Papanikos,F., Raveendran,K., Xu,J.,
            Boekhout,M., Stanzione,M., Neuditschko,B., Imjeti,N.S.,
            Selezneva,E., Tuncay,H., Demir,S., Giannattasio,T., Gentzel,M.,
            Bondarieva,A., Stevense,M., Barchi,M., Schnittger,A., Weir,J.R.,
            Herzog,F., Keeney,S. and Toth,A.
  TITLE     Seeding the meiotic DNA break machinery and initiating
            recombination on chromosome axes
  JOURNAL   Nat Commun 15 (1), 2941 (2024)
   PUBMED   38580643
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1654)
  AUTHORS   Fukuda,T., Daniel,K., Wojtasz,L., Toth,A. and Hoog,C.
  TITLE     A novel mammalian HORMA domain-containing protein, HORMAD1,
            preferentially associates with unsynapsed meiotic chromosomes
  JOURNAL   Exp Cell Res 316 (2), 158-171 (2010)
   PUBMED   19686734
  REMARK    GeneRIF: Results suggest that also mammalian cells use a HORMA
            domain-containing protein (HORMAD1) as part of a surveillance
            system that monitors chromosomal synapsis or other interactions
            between homologs.
REFERENCE   7  (bases 1 to 1654)
  AUTHORS   Wojtasz,L., Daniel,K., Roig,I., Bolcun-Filas,E., Xu,H.,
            Boonsanay,V., Eckmann,C.R., Cooke,H.J., Jasin,M., Keeney,S.,
            McKay,M.J. and Toth,A.
  TITLE     Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal
            proteins, are depleted from synapsed chromosome axes with the help
            of TRIP13 AAA-ATPase
  JOURNAL   PLoS Genet 5 (10), e1000702 (2009)
   PUBMED   19851446
  REMARK    GeneRIF: HORMAD1 and HORMAD2 are depleted from synapsed chromosome
            axes with the help of TRIP13.
REFERENCE   8  (bases 1 to 1654)
  AUTHORS   Pangas,S.A., Choi,Y., Ballow,D.J., Zhao,Y., Westphal,H.,
            Matzuk,M.M. and Rajkovic,A.
  TITLE     Oogenesis requires germ cell-specific transcriptional regulators
            Sohlh1 and Lhx8
  JOURNAL   Proc Natl Acad Sci U S A 103 (21), 8090-8095 (2006)
   PUBMED   16690745
REFERENCE   9  (bases 1 to 1654)
  AUTHORS   Osipovich,A.B., Singh,A. and Ruley,H.E.
  TITLE     Post-entrapment genome engineering: first exon size does not affect
            the expression of fusion transcripts generated by gene entrapment
  JOURNAL   Genome Res 15 (3), 428-435 (2005)
   PUBMED   15741512
REFERENCE   10 (bases 1 to 1654)
  AUTHORS   Pangas,S.A., Yan,W., Matzuk,M.M. and Rajkovic,A.
  TITLE     Restricted germ cell expression of a gene encoding a novel
            mammalian HORMA domain-containing protein
  JOURNAL   Gene Expr Patterns 5 (2), 257-263 (2004)
   PUBMED   15567723
  REMARK    GeneRIF: The expression pattern of Nohma suggests that it may be a
            critical regulatory protein in germ cell meiosis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016743.1, AK014945.1, AW552644.2 and AV259564.1.
            
            On Jan 23, 2014 this sequence version replaced XM_006501957.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014945.1, AY626343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK016743.1         4-5
            3-1386              AK014945.1         2-1385
            1387-1465           AK016743.1         1436-1514
            1466-1643           AW552644.2         6-183               c
            1644-1654           AV259564.1         321-331
FEATURES             Location/Qualifiers
     source          1..1654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..1654
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /note="HORMA domain containing 1"
                     /db_xref="GeneID:67981"
                     /db_xref="MGI:MGI:1915231"
     exon            1..56
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            57..109
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1252
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /note="isoform a is encoded by transcript variant 1; HORMA
                     domain containing protein; HORMA domain-containing protein
                     1; newborn ovary HORMA protein"
                     /codon_start=1
                     /product="HORMA domain-containing protein 1 isoform a"
                     /protein_id="NP_001276461.1"
                     /db_xref="CCDS:CCDS71292.1"
                     /db_xref="GeneID:67981"
                     /db_xref="MGI:MGI:1915231"
                     /translation="MATMQLQRTASLSALVFPNKISTEHQSLMFVKRLLAVSVSCITY
                     LRGIFPERAYGTRYLDDLCVKILKEDKNCPGSSQLVKWMLGCYDALQKKYLRMIILAV
                     YTNPGDPQTISECYQFKFKYTKNGPIMDFISKNQNNKSSTTSADTKKASILLIRKIYV
                     LMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFDGDPTYLNVGEVPT
                     PFHTFRLKVTTEKERMENIDSTILKPKESKTQFEKILMDKDDVEDENHNNFDIKTKMN
                     EQNENSGASEIKEPNLDCKEEETMQFKKSQSPSISHCQVEQLVSKTSELDVSESKTRS
                     GKIFQSKMVNGNNQQGQTSKENRKRSLRQFRKTVLHVLESSQESVLKKRRVSEPKEHT
                     "
     exon            110..254
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            255..318
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            319..355
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            356..376
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            377..403
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            404..471
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            472..623
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            624..871
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            872..938
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1015
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1099
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1174
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1654
                     /gene="Hormad1"
                     /gene_synonym="4921522K05Rik; Nohma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacttcaag actcttgcct gtcgctgccg gacgcttccc tcaggcggtg cgtaaaaaaa
       61 tatttcttgg aagatggcca ctatgcagtt gcagaggaca gcttccctga gtgcattggt
      121 atttcccaat aagatatcaa ctgagcatca atctttgatg tttgtgaaga ggctcctagc
      181 tgtttcagta tcttgcatca cctatttgag aggaatattt ccagaacgtg cttatgggac
      241 aagatatctg gatgatctct gtgtcaaaat tctgaaagaa gataaaaatt gtccaggttc
      301 ttcacagcta gtgaagtgga tgcttggatg ctatgatgct ttacagaaga aatatctaag
      361 gatgatcatt ctagctgtat acaccaatcc aggagatcct cagacaattt cagaatgtta
      421 ccagtttaaa ttcaagtaca ccaaaaatgg accaatcatg gactttataa gcaaaaatca
      481 aaacaataaa tctagtacaa catctgctga caccaagaaa gcaagtattc tcctcattcg
      541 gaagatttat gtcttaatgc aaaatctagg accattacct aatgatgttt gtctgaccat
      601 gaaacttttt tactatgatg aagttacacc cccagattac caaccaccag gttttaagga
      661 tggtgactgt gaaggagtaa tatttgatgg ggaccctaca tacttaaatg tgggagaagt
      721 cccaacacct tttcacacct tcagattaaa agtgaccact gagaaggaac gaatggaaaa
      781 tattgattca accatactaa aaccaaaaga atcaaaaaca caatttgaaa aaattctaat
      841 ggacaaagat gatgtggaag atgaaaatca taataatttt gacattaaaa ctaaaatgaa
      901 cgaacagaat gaaaactctg gagcttctga aatcaaagaa ccaaatttag attgtaagga
      961 agaagaaact atgcaattca aaaagagcca aagtccttca atttctcatt gtcaggttga
     1021 acagttagtc agtaaaacat ctgaacttga tgtgtctgaa agcaaaacaa gaagcggaaa
     1081 aatctttcag agtaaaatgg taaatggaaa taatcaacaa ggacaaactt ctaaagaaaa
     1141 tcggaagaga agtcttcgtc aatttaggaa aacagtcctt cacgtcttgg aatctagtca
     1201 agagtcagtg ctgaagaaaa ggagagttag tgaaccaaag gaacatacct aaaaattatt
     1261 tttcttatgc aaatttgcag ttctcaacat ttaaactaat atgctgtatt atttgaaggt
     1321 gtgccttctg tacctctgaa aattattttg tagttcatag ttattaaact aataaaagtt
     1381 ttagctatta tattgtgttt acctgagata aatccaaggg aacttttgac taaacaaaaa
     1441 tacaaatgtc attgattctg ctcatatcca ctgaatacaa cctgccttct attttaaaga
     1501 aagctttttt tttaaatgtg ttaagtttta aggccctcta aaaccatttt tgaagtgttt
     1561 attctgactt taaaattctg taaggataca ctttttactt atgttaaaac tgtaccattt
     1621 acttggtgct attaaaacaa tgtttgctat tttg
//
