LOCUS       NM_001159900            1105 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus HOP homeobox (Hopx), transcript variant 2, mRNA.
ACCESSION   NM_001159900
VERSION     NM_001159900.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1105)
  AUTHORS   Zhang,F., Fu,Y., Jimenez-Cyrus,D., Zhao,T., Shen,Y., Sun,Y.,
            Zhang,Z., Wang,Q., Kawaguchi,R., Geschwind,D.H., He,C., Ming,G.L.
            and Song,H.
  TITLE     m6A/YTHDF2-mediated mRNA decay targets TGF-beta signaling to
            suppress the quiescence acquisition of early postnatal mouse
            hippocampal NSCs
  JOURNAL   Cell Stem Cell 32 (1), 144-156 (2025)
   PUBMED   39476834
REFERENCE   2  (bases 1 to 1105)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   3  (bases 1 to 1105)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1105)
  AUTHORS   Zhao,T., Hong,Y., Yan,B., Huang,S., Ming,G.L. and Song,H.
  TITLE     Epigenetic maintenance of adult neural stem cell quiescence in the
            mouse hippocampus via Setd1a
  JOURNAL   Nat Commun 15 (1), 5674 (2024)
   PUBMED   38971831
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1105)
  AUTHORS   Jimenez-Cyrus,D., Adusumilli,V.S., Stempel,M.H., Maday,S.,
            Ming,G.L., Song,H. and Bond,A.M.
  TITLE     Molecular cascade reveals sequential milestones underlying
            hippocampal neural stem cell development into an adult state
  JOURNAL   Cell Rep 43 (6), 114339 (2024)
   PUBMED   38852158
REFERENCE   6  (bases 1 to 1105)
  AUTHORS   Kook,H., Lepore,J.J., Gitler,A.D., Lu,M.M., Wing-Man Yung,W.,
            Mackay,J., Zhou,R., Ferrari,V., Gruber,P. and Epstein,J.A.
  TITLE     Cardiac hypertrophy and histone deacetylase-dependent
            transcriptional repression mediated by the atypical homeodomain
            protein Hop
  JOURNAL   J Clin Invest 112 (6), 863-871 (2003)
   PUBMED   12975471
  REMARK    GeneRIF: data show that Hop can inhibit serum response
            factor-dependent transcriptional activation by recruiting histone
            deacetylase (HDAC) activity and can form a complex that includes
            HDAC2
REFERENCE   7  (bases 1 to 1105)
  AUTHORS   Adu,J., Leong,F.T., Smith,N.R., Leek,J.P., Markham,A.F.,
            Robinson,P.A. and Mighell,A.J.
  TITLE     Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain
            protein, during mouse development
  JOURNAL   Mech Dev 119 Suppl 1, S43-S47 (2002)
   PUBMED   14516659
REFERENCE   8  (bases 1 to 1105)
  AUTHORS   Shin,C.H., Liu,Z.P., Passier,R., Zhang,C.L., Wang,D.Z.,
            Harris,T.M., Yamagishi,H., Richardson,J.A., Childs,G. and
            Olson,E.N.
  TITLE     Modulation of cardiac growth and development by HOP, an unusual
            homeodomain protein
  JOURNAL   Cell 110 (6), 725-735 (2002)
   PUBMED   12297046
  REMARK    GeneRIF: HOP is highly expressed in the developing heart, dependent
            on the cardiac-restricted homeodomain protein Nkx2.5. Mice
            homozygous for a HOP null allele segregate into two phenotypic
            classes characterized by an excess or deficiency of cardiac
            myocytes.
REFERENCE   9  (bases 1 to 1105)
  AUTHORS   Chen,F., Kook,H., Milewski,R., Gitler,A.D., Lu,M.M., Li,J.,
            Nazarian,R., Schnepp,R., Jen,K., Biben,C., Runke,G., Mackay,J.P.,
            Novotny,J., Schwartz,R.J., Harvey,R.P., Mullins,M.C. and
            Epstein,J.A.
  TITLE     Hop is an unusual homeobox gene that modulates cardiac development
  JOURNAL   Cell 110 (6), 713-723 (2002)
   PUBMED   12297045
  REMARK    GeneRIF: Inactivation of Hop in mice by homologous recombination
            results in a partially penetrant embryonic lethal phenotype with
            severe developmental cardiac defects involving the myocardium.
REFERENCE   10 (bases 1 to 1105)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB598275.1, AK003784.1, CO044889.1 and BM123896.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF492704.1, CB182771.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BB598275.1         2-13
            13-510              AK003784.1         2-499
            511-1103            CO044889.1         15-607              c
            1104-1105           BM123896.2         2-3                 c
FEATURES             Location/Qualifiers
     source          1..1105
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 41.45 cM"
     gene            1..1105
                     /gene="Hopx"
                     /gene_synonym="1110018K11Rik; 1200015P04Rik;
                     2300002F06Rik; Cameo; Hdop; Hod; Hop; Ob1; Obl; Toto"
                     /note="HOP homeobox"
                     /db_xref="GeneID:74318"
                     /db_xref="MGI:MGI:1916782"
     exon            1..117
                     /gene="Hopx"
                     /gene_synonym="1110018K11Rik; 1200015P04Rik;
                     2300002F06Rik; Cameo; Hdop; Hod; Hop; Ob1; Obl; Toto"
                     /inference="alignment:Splign:2.1.0"
     exon            118..274
                     /gene="Hopx"
                     /gene_synonym="1110018K11Rik; 1200015P04Rik;
                     2300002F06Rik; Cameo; Hdop; Hod; Hop; Ob1; Obl; Toto"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..352
                     /gene="Hopx"
                     /gene_synonym="1110018K11Rik; 1200015P04Rik;
                     2300002F06Rik; Cameo; Hdop; Hod; Hop; Ob1; Obl; Toto"
                     /note="homeobox only domain; odd homeobox 1; mOB1;
                     homeobox-only protein; odd homeobox protein 1"
                     /codon_start=1
                     /product="homeodomain-only protein"
                     /protein_id="NP_001153372.1"
                     /db_xref="CCDS:CCDS39120.1"
                     /db_xref="GeneID:74318"
                     /db_xref="MGI:MGI:1916782"
                     /translation="MSAQTASGPTEDQVEILEYNFNKVNKHPDPTTLCLIAAEAGLTE
                     EQTQKWFKQRLAEWRRSEGLPSECRSVTD"
     exon            275..1105
                     /gene="Hopx"
                     /gene_synonym="1110018K11Rik; 1200015P04Rik;
                     2300002F06Rik; Cameo; Hdop; Hod; Hop; Ob1; Obl; Toto"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1079..1084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hopx"
                     /gene_synonym="1110018K11Rik; 1200015P04Rik;
                     2300002F06Rik; Cameo; Hdop; Hod; Hop; Ob1; Obl; Toto"
                     /note="hexamer: ATTAAA"
     polyA_site      1103
                     /gene="Hopx"
                     /gene_synonym="1110018K11Rik; 1200015P04Rik;
                     2300002F06Rik; Cameo; Hdop; Hod; Hop; Ob1; Obl; Toto"
                     /note="major polyA site"
ORIGIN      
        1 agtccctagg gcagctccgg atctccggag gcagcacttg aggcgcttcc tcagtatact
       61 gtcccctcgg agtgtcaggc gggaggcgtc ttcttcctcc tctccatcct tagtcagacg
      121 cgcacggacc atgtcggcgc agaccgcgag cggccccacg gaggaccagg tggagatcct
      181 ggagtacaac ttcaacaagg tcaacaagca cccggacccc accacgctgt gcctcatcgc
      241 agccgaggcg ggtctcacgg aggagcagac gcagaaatgg tttaagcagc gcctggcaga
      301 gtggcggcgg tcagaaggct tgccttcgga atgcagatct gttacggact agggagccag
      361 gcccttgagc ttgctcttgg aactccatct cttcttcctt ccctcggctt acccaggctg
      421 ttttgatgtt tcagtgcagt gttgaatgtc tcattgtttt gctgtcctgc tatttaacac
      481 aatgtgtttt ttttttttat gtatataact aaaaaaaaaa aaatccaaaa taacagggag
      541 ctaaatgcag ttctgtgtaa agtgatggct tggctggggg caggggtgtg gcttgccttt
      601 ggattttaat gaaagatgat gtgggaaccg tcttcgtttg cccttggcca tcaccttcca
      661 gtagtaattc atatggacca tccccttcag agctgcctgg cttctattga aaagataaca
      721 gaacaggcag gggaacacct cctgagttca cttccctgtg ctccctcctt ctgcttcact
      781 aaacacactg gtggttgaat gagaacgtgg gtgtatttga gtcattcaaa ttatatatat
      841 atatatatat atatatatat atatatatat atgaatgaat gaacagttcc ttcccttaca
      901 gctgtgttac cttggaaagc aacctagtat agcagctatg gattccaagg ggcagaaaag
      961 caagtagcta aggaaaaaaa aagttacaga gtctagaatt taccttattt aaatgaactt
     1021 gttaaattta ttttgctgaa taaaatgaac tgcttttgtg ttaaaaatta tattctaaat
     1081 taaaaaaaac gttaagttga aaatt
//
