LOCUS       NM_030014               4252 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus hook microtubule tethering protein 1 (Hook1), mRNA.
ACCESSION   NM_030014
VERSION     NM_030014.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4252)
  AUTHORS   Suarez-Martinez,E., Piersma,S.R., Pham,T.V., Bijnsdorp,I.V.,
            Jimenez,C.R. and Carnero,A.
  TITLE     Protein homeostasis maintained by HOOK1 levels promotes the
            tumorigenic and stemness properties of ovarian cancer cells through
            reticulum stress and autophagy
  JOURNAL   J Exp Clin Cancer Res 43 (1), 150 (2024)
   PUBMED   38807192
  REMARK    GeneRIF: Protein homeostasis maintained by HOOK1 levels promotes
            the tumorigenic and stemness properties of ovarian cancer cells
            through reticulum stress and autophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4252)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4252)
  AUTHORS   Snider,P.L., Snider,E., Simmons,O., Lilly,B. and Conway,S.J.
  TITLE     Analysis of Uncharacterized mKiaa1211 Expression during Mouse
            Development and Cardiovascular Morphogenesis
  JOURNAL   J Cardiovasc Dev Dis 6 (2), 24 (2019)
   PUBMED   31234534
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4252)
  AUTHORS   Xie,J.C., Ma,X.Y., Liu,X.H., Yu,J., Zhao,Y.C., Tan,Y., Liu,X.Y. and
            Zhao,Y.X.
  TITLE     Hypoxia increases amyloid-beta level in exosomes by enhancing the
            interaction between CD147 and Hook1
  JOURNAL   Am J Transl Res 10 (1), 150-163 (2018)
   PUBMED   29423001
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4252)
  AUTHORS   Schwarz,T., Prieler,B., Schmid,J.A., Grzmil,P. and Neesen,J.
  TITLE     Ccdc181 is a microtubule-binding protein that interacts with Hook1
            in haploid male germ cells and localizes to the sperm tail and
            motile cilia
  JOURNAL   Eur J Cell Biol 96 (3), 276-288 (2017)
   PUBMED   28283191
  REMARK    GeneRIF: Hook1 is a binding partner of Ccdc181.
REFERENCE   6  (bases 1 to 4252)
  AUTHORS   Schumacher,J.M., Artzt,K. and Braun,R.E.
  TITLE     Spermatid perinuclear ribonucleic acid-binding protein binds
            microtubules in vitro and associates with abnormal manchettes in
            vivo in mice
  JOURNAL   Biol Reprod 59 (1), 69-76 (1998)
   PUBMED   9674995
REFERENCE   7  (bases 1 to 4252)
  AUTHORS   Meistrich,M.L., Kasai,K., Olds-Clarke,P., MacGregor,G.R.,
            Berkowitz,A.D. and Tung,K.S.
  TITLE     Deficiency in fertilization by morphologically abnormal sperm
            produced by azh mutant mice
  JOURNAL   Mol Reprod Dev 37 (1), 69-77 (1994)
   PUBMED   8129933
REFERENCE   8  (bases 1 to 4252)
  AUTHORS   Meistrich,M.L., Trostle-Weige,P.K. and Womack,J.E.
  TITLE     Mapping of the azh locus to mouse chromosome 4
  JOURNAL   J Hered 83 (1), 56-61 (1992)
   PUBMED   1552159
REFERENCE   9  (bases 1 to 4252)
  AUTHORS   Russell,L.D., Russell,J.A., MacGregor,G.R. and Meistrich,M.L.
  TITLE     Linkage of manchette microtubules to the nuclear envelope and
            observations of the role of the manchette in nuclear shaping during
            spermiogenesis in rodents
  JOURNAL   Am J Anat 192 (2), 97-120 (1991)
   PUBMED   1759685
REFERENCE   10 (bases 1 to 4252)
  AUTHORS   Meistrich,M.L., Trostle-Weige,P.K. and Russell,L.D.
  TITLE     Abnormal manchette development in spermatids of azh/azh mutant mice
  JOURNAL   Am J Anat 188 (1), 74-86 (1990)
   PUBMED   2346121
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061688.1.
            
            On Dec 20, 2003 this sequence version replaced NM_030014.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061688.1, SRR1660815.254063.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4252
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 44.17 cM"
     gene            1..4252
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /note="hook microtubule tethering protein 1"
                     /db_xref="GeneID:77963"
                     /db_xref="MGI:MGI:1925213"
     exon            1..178
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            179..264
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            265..337
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            338..388
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            389..521
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            522..589
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            590..652
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            653..736
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            737..903
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1044
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1246
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1357
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1445
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1506
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1647
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1741
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1776
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1859
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1960
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2062
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2131
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..4242
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2349..2354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /note="hexamer: AAGAAA"
     polyA_site      2390
                     /gene="Hook1"
                     /gene_synonym="A930033L17Rik; azh"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcgggcg ccaggcctgg ccgccgagct ccagtggcgg gcgcggaggt cgttgacgcg
       61 ggcccggtcg gaggcgcgtc cgtcgctgtg agcgcggcgt cgaggttctc ggaccatgga
      121 ggacccgcag ccgctgccac agtccgagct gccgctgtgt gacagcctca tcatctggct
      181 gcagacattc aagactgcct caccttgtca agatgtcaaa cagctgacta atggagtgac
      241 catggcacaa gttcttcatc aaattgatgt agcttggttc agcgaatctt ggttaagccg
      301 aattaaagat gatgttggag acaactggag aataaaggct agtaacctga agaaggtcct
      361 ccatggaatt acaagttact atcatgagtt tttggggcag cagatttctg aagaacttat
      421 ccctgattta aatcaaatca ctgagtgtgc agatcctgtg gagcttggga ggttgcttca
      481 gctaattcta ggatgtgcag tcaactgtga aaagaagcaa gaacatatta aaaatataat
      541 gaccctggaa gaatctgttc aacatgtggt catgactgca attcaggagc tgatgagtaa
      601 agaaatagtg atctctcctg caagtgacac ggtgggagaa ttagaacagc agcttaaaag
      661 ggctttagaa gagcttcagg aggccatagc agaaaaggaa gagctgaagc agaggtgcca
      721 ggaactggat atgcaggtga ctacacttca ggatgagaag aattcactgg tctctgagaa
      781 tgagatgatg aatgaaaagc ttgaccagtt ggatggctct tttgatgatc caaatacaat
      841 ggttgcaaag aaatattttc acgtacagct acaactagaa caattacaag aagaaaacta
      901 taggcttgaa gctgcaaaag atgattaccg tgttcactgt gaggaacttg aaaagcaact
      961 gattgaattt cagcacagga atgatgagct gacgagcctt gctgaagaga ccagagccct
     1021 aaaagatgag atagatgttc ttagggctac gtcagacaaa gcaaataaac tggagtcaac
     1081 agtggaggta tatcgtcaga agctacaaga tttaaatgac ctccgcaaac aggtgaaatc
     1141 tttacaggag acaaatatga tgtatatgca taacactgtg agcttggaag aagagctgaa
     1201 gaaggccaac gcagctcggg cacagttaga gacctataag cgccaggttc aggaccttca
     1261 cacaaagctt tcctctgaat ccaaaagggc agatacacta gcatttgaaa tgaagaggct
     1321 tgaagaaaaa catgaaactt tactcaagga aaaagagcga ttgatagaac agcgtgacac
     1381 tctgaaggag acgaatgagg agctgcggtg ctcaaaagca cagcaagatc acttaaacca
     1441 agctgatgca tctgctacaa aaagttatga aaatcttgct gctgagatca tgcccgtgga
     1501 atacagagag gtgttcattc gactccagca tgaaaacaaa atgcttcgcc tacagcaaga
     1561 agggacggag aatgaacgca ttgagcagct gcaggagcaa ctggagcaga agcaccgcaa
     1621 gatgaatgag ctggaaaccg agcaaaggtt gagcaaagag cgcatcggag aactacagca
     1681 gcaaattgag gacctccaga agtcattaca agaacagggc tctaagtctg aaggtgaaag
     1741 ttccagcaaa ttaaagcaga agttggaagc tcatatggaa aaactaacag aagtccatga
     1801 agaattacag aagaaacagg agctcattga agaccttcag ccagatataa gtcagaatgc
     1861 ccaaaagatc agtgaacttg aagcggctct tcagaagaaa gatgaagaca tgaaagcaat
     1921 ggaggagaga tacaaaatgt acttagagaa agccaggaat gtaataaaaa ctttagatcc
     1981 caaattaaat ccagcatcag cagaaataat gttactcaga aagcagctgg cggagaagga
     2041 aagaagaatt gagattctag agagtgaatg taaagtagca aaattgaggg attatgagga
     2101 aaaactcatt gtttctgcct ggtataacaa gagcctggcg tttcagaaat tgggcatgga
     2161 gtctcggctg gtgagtggtg ctagtgcttg caaagacagc gttgcggctg ctcctgcacg
     2221 ttccttctta gcgcagcagc ggcacatcac caacacccga agaaacctct ctgttaaggt
     2281 cccagctgca gcatctgact agtctgcaaa gcaaacacaa cggaagtgcc tcagaatatc
     2341 tgtaccccaa gaaactacca gatagaaaac aaaggttaag atgcttggta gcagctagtc
     2401 ttattttggt ttcactttga gacagggtct cataatcctg aactggcata gaaatgacag
     2461 tgtgttcaag gatgaccttg aacagcggat cagtccttcc tgcagtctct gcacgctggt
     2521 gggattaacg gaagtagttg tagaccacat ggcaggtttg tatagttcta ggggtcaaac
     2581 tcagaagctc tgctcatcga gctgcattct caacctcaca atcaactata tttaagtcag
     2641 attatatcaa attaatattt tcagcttact tagaaagcag agcacagtat cagctctgtc
     2701 tctgggcagg acattggagt agttggaagt gtgatgaagc gaatacttgt cttgaaatgg
     2761 catcctgtga gggaaagcaa atgcatattc caactttatg tttttagttg taacagcaag
     2821 tcaagttaat ttgcataaag taatgggtag tttgtcattt aatatctaga tttgctttat
     2881 ggaaaagttt cctgttacac atgtggagaa aaactgtgca aggtgaattc cttagtctgg
     2941 tgtgtatagt ttcctctctt tgcaaattct gccctctaga ggatgcttca gcatgctgta
     3001 gaagctataa tgcttggaaa actgctgttg cagtgacttt gtctgtaaaa gtgactcatt
     3061 agaaatttgc agcttctctg agttgtatgc cagtttgaac atgtactgct gtgaatgagg
     3121 actgaactat taggatagga agtaaactga catttgtgtt tctgatgaaa agcaagctac
     3181 actttgcaat agccacatgc tttggagcat ggtgttcttg tgggcattgc tttctaagaa
     3241 ggagtatatc atgtataatt ttgcctcttt attgaaaaga aatagtgatg gaatagctta
     3301 taaccatttt ggtttctgct tgcctctaag gagtgtctgg agctgtattt gtggcattcg
     3361 gttcatttct gcccaacatt gttttttcca gaggtgttac tttccaattt ggggtcactt
     3421 tttaaagtca cagctttgga atattagttg ttaaatccca ttgcttaatg tagccacagg
     3481 tggtttgctc ttgagtcagt cacacatcca acactttgta gccacgtttc catcattgtt
     3541 gagagtttgt tgagagttca tgtgcagcga gtcacaatct tggtttttgg taacttgaag
     3601 aaattctttg atccttagac tacagattta agaagtgtta cgtccatttc acttgtacag
     3661 aggaatcaga tggggaaagg agtgcagcag acacaaggga gacaacagtg tgctttccca
     3721 gaacattgcc agtcattggg tgaaggtgta aacttgcagg ctgcatgacc cttgttgggt
     3781 cagcttctca cctctgccct catcatagca tgaaagaagg gatatgtaat atataaacaa
     3841 aaagggggtg gtggtggctg agtaagccag attgagctgg caggctgtgg agctgtggtc
     3901 tacattttat tcttagtcct tcataaatat gagtattgtt ctatttgcag tgttaactca
     3961 tttagataat tgcctgtaaa tccttgccca gtaattctta accacttaaa ataacaagaa
     4021 tttcacaatg atttggggtc tttgagatta gtggcatctg ccaggatatt ttgttttatc
     4081 agggttcctt ctgttcacta cctcttagat tttgatgatt cttgtctaca ttttacactg
     4141 ttggtttgta tttttgtatg tttatggtgt ctgcttgcct gtgtctttta gtaaaataag
     4201 actttaaaat tacttagcat gctatttaac attttctaaa aaaaaaaaaa aa
//
