LOCUS       NM_183174               5633 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus homeodomain leucine zipper-encoding gene (Homez),
            transcript variant 2, mRNA.
ACCESSION   NM_183174 XM_001471891
VERSION     NM_183174.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5633)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5633)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5633)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   4  (bases 1 to 5633)
  AUTHORS   Carmona-Mora,P., Widagdo,J., Tomasetig,F., Canales,C.P., Cha,Y.,
            Lee,W., Alshawaf,A., Dottori,M., Whan,R.M., Hardeman,E.C. and
            Palmer,S.J.
  TITLE     The nuclear localization pattern and interaction partners of
            GTF2IRD1 demonstrate a role in chromatin regulation
  JOURNAL   Hum Genet 134 (10), 1099-1115 (2015)
   PUBMED   26275350
REFERENCE   5  (bases 1 to 5633)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 5633)
  AUTHORS   Bayarsaihan,D., Enkhmandakh,B., Makeyev,A., Greally,J.M.,
            Leckman,J.F. and Ruddle,F.H.
  TITLE     Homez, a homeobox leucine zipper gene specific to the vertebrate
            lineage
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10358-10363 (2003)
   PUBMED   12925734
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC094669.1 and AC116591.4.
            
            On Apr 25, 2010 this sequence version replaced NM_183174.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094669.1, CK781136.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-568               BC094669.1         1-568
            569-569             AC116591.4         45327-45327
            570-5633            BC094669.1         570-5633
FEATURES             Location/Qualifiers
     source          1..5633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.96 cM"
     gene            1..5633
                     /gene="Homez"
                     /gene_synonym="mKIAA1443"
                     /note="homeodomain leucine zipper-encoding gene"
                     /db_xref="GeneID:239099"
                     /db_xref="MGI:MGI:2678023"
     exon            1..63
                     /gene="Homez"
                     /gene_synonym="mKIAA1443"
                     /inference="alignment:Splign:2.1.0"
     exon            64..5609
                     /gene="Homez"
                     /gene_synonym="mKIAA1443"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1652
                     /gene="Homez"
                     /gene_synonym="mKIAA1443"
                     /note="isoform 1 is encoded by transcript variant 2;
                     homeobox and leucine zipper protein Homez; homeodomain
                     leucine zipper-containing factor"
                     /codon_start=1
                     /product="homeobox and leucine zipper protein Homez
                     isoform 1"
                     /protein_id="NP_898997.2"
                     /db_xref="CCDS:CCDS27102.1"
                     /db_xref="GeneID:239099"
                     /db_xref="MGI:MGI:2678023"
                     /translation="MSPNKDASSLNSSAAGLVCLPPVSEELQLVWTQAIQTSELDGNE
                     HLLQAFSYFPYPSLADIALLCLRHGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARV
                     VYHRDQLLFKSLLSFTQQSVRPPQERPPVLRPEQVALGLSPLAPSEQPTHMKGLKVEP
                     EEPSQVSQLPLNHQNAKEPLMMGSRTFSHQSDCQDLQISGLSKEQAGRGPDQSCGKTA
                     SWNHFTAVHQPDKPASVSLLDNSCKEESEPSGIPPSSSTSSPSFQALANGTTATPKPL
                     QPLGCISQSLSPSKKALSPQVEPLWPQRLWNNSEPNSAGPTEYLSPDMQHQRKTKRKT
                     KEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDN
                     AVLGTPSFQDPAIPTPSTRSLKEWAKTPPLPAPPPPPDIRPLEKYWAAHQQLQEADIL
                     KLSQASRLSTQQVLDWFDSRLPKPAEVVVCLDEEDEEDEEDELPEDGEEEEEEEEDDD
                     DGDDDVIIWD"
     regulatory      2772..2777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Homez"
                     /gene_synonym="mKIAA1443"
                     /note="hexamer: AATAAA"
     polyA_site      2794
                     /gene="Homez"
                     /gene_synonym="mKIAA1443"
                     /note="major polyA site"
     regulatory      4533..4538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Homez"
                     /gene_synonym="mKIAA1443"
                     /note="hexamer: AATAAA"
     polyA_site      4554
                     /gene="Homez"
                     /gene_synonym="mKIAA1443"
     regulatory      5586..5591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Homez"
                     /gene_synonym="mKIAA1443"
                     /note="hexamer: AATACA"
     polyA_site      5609
                     /gene="Homez"
                     /gene_synonym="mKIAA1443"
ORIGIN      
        1 gctgtatgta gcttattgtt aaaatgcttg gccaccgact cctgcccagt ttagacttcc
       61 cagctgtctc tgaagggtac aaaccagagc acgacatgag tcctaataaa gatgccagca
      121 gtctcaacag ctctgcagca gggcttgtct gtctcccgcc agtctcagag gagctacagc
      181 ttgtgtggac tcaagccatc caaaccagtg agctggatgg aaatgagcac ctgctacaag
      241 ccttcagcta cttcccctat ccaagcctgg cagatatcgc tctcctctgc ctgcggcatg
      301 ggctgcagat ggagaaggta aagacctggt tcatggccca acgtctccgc tgcggcatta
      361 gctggtcatc tgaagagata gaggagactc gtgccagagt ggtgtaccac cgagatcagc
      421 tccttttcaa gtctcttctc tctttcacac agcagtcagt gaggccccca caggagaggc
      481 ctccagtgct ccgtccggag caggttgctc ttggactgag tcctctggcg cctagtgagc
      541 agcccactca tatgaaagga ttgaaggttg agcctgagga gccctctcag gtatcacagc
      601 tgccactgaa tcatcagaac gctaaggagc ctctgatgat gggcagcaga acattctccc
      661 accaatcaga ctgtcaggat cttcagatca gtggcctctc taaggagcag gcaggcagag
      721 gtcctgacca gtcatgtgga aagactgctt cctggaatca cttcacagct gtccatcagc
      781 cagataagcc cgcatcggtc tcattacttg ataatagttg taaggaggaa tccgaaccta
      841 gtggaatacc tccatcttcc tctacctctt ctccctcttt ccaggcattg gctaatggaa
      901 ccactgccac ccctaagccc ctccagcctt tgggttgtat ctcacagtca ctctcaccta
      961 gtaagaaggc actgtctcca caagtagaac cactctggcc ccaaaggcta tggaataact
     1021 cagaaccaaa ttcagctggc cccacagaat acctttcccc agatatgcaa caccagcgaa
     1081 agactaagcg gaaaaccaaa gaacagttgg ccatcctcaa atcctttttc ctacagtgcc
     1141 aatgggcacg acgagaagat taccataaat tagaacagat cactggttta cctcgcccgg
     1201 agatcattca atggtttggt gacacacgat atgccttgaa gcatggacag ctgaaatggt
     1261 ttcgggacaa tgcagtactt ggtaccccta gttttcaaga tccagccatt cctacacctt
     1321 caactcgttc cttgaaagaa tgggccaaga caccacctct accagcccca ccgcccccac
     1381 cagatatacg acctttggag aagtactggg cagcccacca gcagctgcag gaagctgata
     1441 tccttaaact gagtcaggca tcacgactaa gcactcagca agtgttggac tggtttgact
     1501 ctcgattgcc taagccagca gaagtggtag tttgtctaga tgaagaagac gaggaggatg
     1561 aggaggatga actgccagaa gatggtgagg aagaggagga ggaggaggaa gatgatgatg
     1621 atggtgatga tgatgtcatc atatgggact gagggaggct gaggcaaagg ggagtcttta
     1681 ctgaaatatt aaccaactta gtgactgttc aaaccttttt gaaattgctc ttgtaaaaag
     1741 ttttgtgttc ctgtgtaggc aaagggggta atctgcagta aactggagag ggtgaccagg
     1801 acaaactgaa gtattggatc aacacaaatc caattctcca gcctccgtgt agagagagtt
     1861 tgggatctgg gcagatactg gctgaaaaga gctcttgctt tgctcttgct ccttaggact
     1921 ctttaagtcg tgtctcagcc ccacatctac agggaacctg aatggagaga agtattgtga
     1981 tccaattgat cccagtgcac cccagcattt gtcagagact ccttgtgcct ggcctgtctt
     2041 tctgagcaca tgttcaggca cactgcagct agtgtttgca gggtcttggc tttataacag
     2101 gcacatcgtc agacccctga taatgtctga ctcgatttgt cactaattca cagcagcctg
     2161 ttcttgcttt tgacactggg gccaatctgc tctctaccat tttatttcta tgaaatcccc
     2221 tctttgctta ctattgtctc agggtaaatc tttacataga gagtttgtga aactttttaa
     2281 taatcagagt gtgaatatta gcctgtgtat ttattggagg cggggatgag ccggcatagt
     2341 gactgtgact actatacttg gcaggtagag gcaggaggat caaggggttc aaggtcagcc
     2401 ttgactacat atgaagttaa aggccaacct ggactatgtg agactctgtt ttgaaacata
     2461 acagtgagtc agaggagaag ggcggtgggg tagttacagg tttggattta caaacctgac
     2521 actattttct gcccagattg atatagattg tttggttggt tttttaatta ttttttcctt
     2581 ttttaactag tgcttcaatt tgtatctaac aagagatgtt tccctcttta taggatctgt
     2641 cttgtggaca gaaggaccat ggtcttctaa ctcaatgatg ttctagaact gggaattact
     2701 ggtaacaatt ggttagtcat ctgaaaatag agtgcaagac ccaaattgct taataataaa
     2761 aaaaggccaa aaataaaatt gtttcttttc tccactttgc cacttctgtg tttcaagatt
     2821 tatctccgtc tatctatcca tccactttcc tttaggtata tgagtacact gttgctgtct
     2881 tcagacacac cggaaggggg cataagatcc cactacagat ggttgtgagc caccatgggg
     2941 ttgatgggaa ttgcactcag gacctctgga agagcagtgt tcttaactgc tgagccatct
     3001 ctctagcccc atcttcactt tcttaaatgc ttgtcttgaa ctcactgtga agccatggct
     3061 gctgctgttc ttatcttcct gtttccatct cctaaacgct gattagaagt atgtgccatt
     3121 atgcccagct tatgcagtac tggggatcaa accaggcctt tatgtatggt aggcaggtac
     3181 tctgccaact gggctacatc tgtacctagc ctgagtctag gaatttaatg ctggcatgta
     3241 gcccagtggt agacctctta cctagcatgt gtgacaccct agtttcaagc ccagcatcac
     3301 tttaaaatca tttctggttt agtttatttt tttaaagagt tagtcaggac acgctgcagt
     3361 agataaaaat tgaagacagt aattcagcat ctattgctac atgcatggtt tgcagccatc
     3421 agatgacaag gtttattggc cctccagcag tgacaacagg ttgtaactcc acttgctcat
     3481 cctaccattt gagaaactat tttagcaaga gtggcagaag ccataaaagg gtatgttaat
     3541 gatttttttc ctctttatta gtctatatac cttactaagg tggaaatcta cctgttgtca
     3601 aagctggaaa tgtattctac ctattgtttg gataaaggaa aatcagaaca tttcatagca
     3661 gctgggtgta gaacaatagg taaaaagtat aatacatgag ggtggggaac agttgtttat
     3721 taacattggc cacaggatag caacgtccag agctaagcag tgaaatccag aaatgaacca
     3781 ggataaatat attatctagt cttcctatgc caaagcatga ggctaaggat ttttgcaacc
     3841 ttagtctcaa actaggaaat gaaaggccgc acatatggga gagatgaaga tcttcctgaa
     3901 gccctgggga agacagccac tgagatggca cttgccacca agtctagaga cttgagttgg
     3961 atccccagga ctaactttgt tggaaagaac tgactcctgc aagttgtcct cagacccccc
     4021 acaagtacgt acacaaagta aacaaaaccc agggggctgg agacgtggct cagcagttta
     4081 gtatgctttg tgccgggctc cccagcaccc atgtcagtca gctcacacgc tgcctataac
     4141 cctggcttta ggggatcata caccctcttc tggtctctga gggcacctgc atcacaggca
     4201 cccatatgca agtagtatac cctcatacaa cacacacagt ttttaaaaat ttttttaatg
     4261 tttggagaga aagacatgta agataacgtt caagaaaaca agctgcagac tgaaaccagg
     4321 aaccagcaag tgcccatagc ccctgagaga actggacact gcaggccaac cttgagcatt
     4381 atgcacagag cagacctgga agagggatgt ctatctggaa atgttccatc cgtctttcct
     4441 ggctagtccc atctgcctct gttggtagaa cgtctgcagc agagaacaga tttgcatgtt
     4501 atgacaatac agactactaa aggtgtccta ccaataaagt tttattgaac aaaatcaact
     4561 gctactgctt ctccatggtt tttcctcatt gtatgatgac taacttacaa acaaaaagaa
     4621 attttgtttg agacagggtc tcattattgc tattgctatg tagaccatgg ctggccttga
     4681 attcacagca atctgcctgc ttctgttttc caaaagggca gggattaaag gtgccaccat
     4741 gcccaaccta gattaagagc tgatgcgtcc tgtgagacaa ggcctttgtt gttactgaag
     4801 aaactgtacg cttcagtgct tgatgatgat gatgtaaaat atctgaggaa ctttgggaag
     4861 atttggaaca tctgactact gtatcaaaag acaattacca gggaggcaaa gatcttacac
     4921 ctctagtgat gtggtacttt tcagtaacta tttttaactt tataatgttt tattttgaag
     4981 ttttcatatt tatggatgtt ttgttgaatg tatttctgtg ctcagagaca actctggaga
     5041 tcccctggga ctggagttac agaggattgt gatccaccat gtgggtgctg gaatcgaacc
     5101 caggtaccct ggaagagcag ccactattct taactgctga atcatctctc cagtcccaat
     5161 aggttttgtt ttaaaacagt agttcttaac ctgttggtct ccaccccttt cgggtcaaat
     5221 gaccctttca caggagtcac atatcagata tcctgcatat cagatattta tatgattcat
     5281 aacaatagca gagttacagt tatgaagtag taataattct atggttgggg tcaccacaca
     5341 tgagggactg tattaaaggg ttacagcagt aggaaggcta ggaactactg ttttaaagga
     5401 tagaccagaa taatgaacct gtcatccaat atcaacaaaa ctcgtggcta atatttattg
     5461 ttctttctat tgcttccttt tagtaaatta tactaaagca aaatctagat accatttaac
     5521 ttcataaaat ttttatttac atatatatgg atatgtactt gtttgtgttt gtgtatttgt
     5581 gagtaaatac aaagtcatca gacctgaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
