LOCUS       NM_001146153            2445 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus homer scaffolding protein 3 (Homer3), transcript
            variant 1, mRNA.
ACCESSION   NM_001146153
VERSION     NM_001146153.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2445)
  AUTHORS   Lin,R., Learman,L.N., Bangash,M.A., Melnikova,T., Leyder,E.,
            Reddy,S.C., Naidoo,N., Park,J.M., Savonenko,A. and Worley,P.F.
  TITLE     Homer1a regulates Shank3 expression and underlies behavioral
            vulnerability to stress in a model of Phelan-McDermid syndrome
  JOURNAL   Cell Rep 37 (7), 110014 (2021)
   PUBMED   34788607
REFERENCE   2  (bases 1 to 2445)
  AUTHORS   Liu,Q., He,L., Li,S., Li,F., Deng,G., Huang,X., Yang,M., Xiao,Y.,
            Chen,X., Ouyang,Y., Chen,J., Wu,X., Wang,X., Song,L. and Lin,C.
  TITLE     HOMER3 facilitates growth factor-mediated beta-Catenin tyrosine
            phosphorylation and activation to promote metastasis in triple
            negative breast cancer
  JOURNAL   J Hematol Oncol 14 (1), 6 (2021)
   PUBMED   33407765
  REMARK    GeneRIF: HOMER3 facilitates growth factor-mediated beta-Catenin
            tyrosine phosphorylation and activation to promote metastasis in
            triple negative breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2445)
  AUTHORS   Reibring,C.G., Hallberg,K., Linde,A. and Gritli-Linde,A.
  TITLE     Distinct and Overlapping Expression Patterns of the Homer Family of
            Scaffolding Proteins and Their Encoding Genes in Developing Murine
            Cephalic Tissues
  JOURNAL   Int J Mol Sci 21 (4), 1264 (2020)
   PUBMED   32070057
  REMARK    GeneRIF: Distinct and Overlapping Expression Patterns of the Homer
            Family of Scaffolding Proteins and Their Encoding Genes in
            Developing Murine Cephalic Tissues.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2445)
  AUTHORS   Son,A., Kang,N., Oh,S.Y., Kim,K.W., Muallem,S., Yang,Y.M. and
            Shin,D.M.
  TITLE     Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in
            osteoclastogenesis and bone metabolism
  JOURNAL   J Endocrinol 242 (3), 241-249 (2019)
   PUBMED   31319381
  REMARK    GeneRIF: Data indicate decreased bone density in homer scaffolding
            proteins (Homer2/3) double knockout (DKO) mice.
REFERENCE   5  (bases 1 to 2445)
  AUTHORS   Su,X., Wu,C., Ye,X., Zeng,M., Zhang,Z., Che,Y., Zhang,Y., Liu,L.,
            Lin,Y. and Yang,R.
  TITLE     Embryonic lethality in mice lacking Trim59 due to impaired
            gastrulation development
  JOURNAL   Cell Death Dis 9 (3), 302 (2018)
   PUBMED   29467473
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2445)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2445)
  AUTHORS   Ango,F., Prezeau,L., Muller,T., Tu,J.C., Xiao,B., Worley,P.F.,
            Pin,J.P., Bockaert,J. and Fagni,L.
  TITLE     Agonist-independent activation of metabotropic glutamate receptors
            by the intracellular protein Homer
  JOURNAL   Nature 411 (6840), 962-965 (2001)
   PUBMED   11418862
REFERENCE   8  (bases 1 to 2445)
  AUTHORS   Shiraishi,Y., Mizutani,A., Bito,H., Fujisawa,K., Narumiya,S.,
            Mikoshiba,K. and Furuichi,T.
  TITLE     Cupidin, an isoform of Homer/Vesl, interacts with the actin
            cytoskeleton and activated rho family small GTPases and is
            expressed in developing mouse cerebellar granule cells
  JOURNAL   J Neurosci 19 (19), 8389-8400 (1999)
   PUBMED   10493740
REFERENCE   9  (bases 1 to 2445)
  AUTHORS   Tu,J.C., Xiao,B., Yuan,J.P., Lanahan,A.A., Leoffert,K., Li,M.,
            Linden,D.J. and Worley,P.F.
  TITLE     Homer binds a novel proline-rich motif and links group 1
            metabotropic glutamate receptors with IP3 receptors
  JOURNAL   Neuron 21 (4), 717-726 (1998)
   PUBMED   9808459
REFERENCE   10 (bases 1 to 2445)
  AUTHORS   Xiao,B., Tu,J.C., Petralia,R.S., Yuan,J.P., Doan,A., Breder,C.D.,
            Ruggiero,A., Lanahan,A.A., Wenthold,R.J. and Worley,P.F.
  TITLE     Homer regulates the association of group 1 metabotropic glutamate
            receptors with multivalent complexes of homer-related, synaptic
            proteins
  JOURNAL   Neuron 21 (4), 707-716 (1998)
   PUBMED   9808458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158553.13, CX208892.1 and BU054773.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1731369.1,
                                           SRR7652917.791193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC158553.13        181625-181645       c
            22-394              CX208892.1         1-373
            395-1070            BU054773.1         99-774
            1071-2445           AC158553.13        170283-171657       c
FEATURES             Location/Qualifiers
     source          1..2445
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..2445
                     /gene="Homer3"
                     /note="homer scaffolding protein 3"
                     /db_xref="GeneID:26558"
                     /db_xref="MGI:MGI:1347359"
     exon            1..102
                     /gene="Homer3"
                     /inference="alignment:Splign:2.1.0"
     exon            103..184
                     /gene="Homer3"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1250
                     /gene="Homer3"
                     /note="isoform 1 is encoded by transcript variant 1; homer
                     protein homolog 3; homer-3; homer, neuronal immediate
                     early gene, 3; homer homolog 3"
                     /codon_start=1
                     /product="homer protein homolog 3 isoform 1"
                     /protein_id="NP_001139625.1"
                     /db_xref="CCDS:CCDS52569.1"
                     /db_xref="GeneID:26558"
                     /db_xref="MGI:MGI:1347359"
                     /translation="MSTAREQPIFSTRAHVFQIDPTTKRNWIPAGKHALTVSYFYDAT
                     RNVYRIISIGGAKAIINSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQQLTQF
                     AEKFQEVKEAARLAREKSQDGGEFTSTGLALASHQVPPSPLVSTNGPGEEKLFRSQSA
                     DTPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNQRLAGALREANAAATQWRQQLE
                     VQRAEAELLRQRVAELEAQVAVEPVRAGEKEATSQSVEQLEARVQTKDQEIQTLKNQS
                     TGTREAPDTAEREETQQQVQDLETRNAELEQQLRSMECNLEEARAERERARAEVGRAA
                     QLLDVRLFELSELREGLARLAEAAP"
     exon            185..341
                     /gene="Homer3"
                     /inference="alignment:Splign:2.1.0"
     exon            342..473
                     /gene="Homer3"
                     /inference="alignment:Splign:2.1.0"
     exon            474..581
                     /gene="Homer3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..703
                     /gene="Homer3"
                     /inference="alignment:Splign:2.1.0"
     exon            704..860
                     /gene="Homer3"
                     /inference="alignment:Splign:2.1.0"
     exon            861..971
                     /gene="Homer3"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1058
                     /gene="Homer3"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..2445
                     /gene="Homer3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2420..2425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Homer3"
                     /note="hexamer: AACAAA"
     regulatory      2424..2429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Homer3"
                     /note="hexamer: AATGAA"
     polyA_site      2437
                     /gene="Homer3"
                     /note="major polyA site"
     polyA_site      2441
                     /gene="Homer3"
ORIGIN      
        1 gggactggcc gcgatgggac cggaggcggc gcagacaaag gcgcgggcgg cgcggggcgc
       61 gcggagggcg cgggccggag gctgcagcga cgacgacgcg gggggacaaa caagtgactc
      121 ctgtcacccc tctgggtgcc ccttagaggc catccagccc aacctgacca atgtccacag
      181 ccagggaaca gccaatcttc agcacccggg cgcacgtatt ccagatcgac cccactacaa
      241 agcggaactg gatccccgcc ggcaagcacg cacttaccgt gtcctatttc tatgatgcaa
      301 cccgaaatgt gtaccgcatc atcagcatcg ggggtgccaa ggccatcatc aacagcactg
      361 tcactcccaa catgaccttc accaaaacct ctcagaagtt cgggcaatgg gcagacagtc
      421 gagccaacac tgtctacggc ctaggctttg cctctgaaca gcagctgacc cagtttgctg
      481 agaagtttca ggaggtgaaa gaagctgcca ggctggctcg agagaaatct caagatggtg
      541 gagaattcac tagtactggc ctggcccttg cctcccatca ggttcctcca agccccttgg
      601 tcagcaccaa tggtccaggc gaggaaaagc tgttccgtag ccagagtgcg gacacccctg
      661 gccccaccga gcgggaacgg ttgaagaaga tgctgtcaga aggctctgta ggggaggtcc
      721 agtgggaggc agagttcttc gcgcttcagg acagcaacca gaggttggcg ggagcccttc
      781 gggaggccaa cgcagcggcc actcagtgga ggcaacaact ggaggtccaa cgtgcagagg
      841 ctgaactctt gaggcagcgg gtagcagagc tggaggccca ggtggctgta gagccagtcc
      901 gggcaggaga gaaagaagca accagccagt cggtggagca gctggaggct cgggtgcaga
      961 ccaaggacca ggagatccag actttgaaga atcagagcac tggcacccga gaggctccag
     1021 acactgccga gcgcgaagag acacagcagc aagttcagga cctggagacc cggaatgcag
     1081 agctggagca gcagctgcgg tcgatggagt gcaacctgga ggaggcgcgg gccgagcggg
     1141 agcgcgcacg ggcggaggtg ggccgggctg cgcagctgct ggatgttcgg ctgtttgagc
     1201 tcagcgagct gcgtgaaggc ctggcacgcc tggcagaggc agcaccctag tctgccatgg
     1261 agtgtctgcg gcctcaaggc gccctggcag gggccagggg accccagctg tctctgagct
     1321 ttgcactgtg tagagttttc tagaatcctt gggcagtgct tctacccagg ttacatttct
     1381 acgtgtggcg ttgctgtccc tggctgctgc tgccctgcgc cccagggaca ctgcgaggga
     1441 aggctgcact agtcatcccc atggggcaac agaggctttg ggatcctgag acctgaaggc
     1501 cctgtactca tcccacccca ttctcaagtc agactgacaa cttcaaagag tgtttactga
     1561 agtcaggggc caccagcacc aggtttacag ctcagtcctg agcctcagcc tgggctggct
     1621 cttggggccg agatctggga ggacgcgacc gtcggacagt gctccctgct ttctgccgcc
     1681 gaagtgtctg ccccactttc tccttgaagc gtcggttttg ttgcttgatc ttggccagct
     1741 cagctttgcg tttggcctcc aggtctgggt cctgcggaag ggagctgaga atgtaactgg
     1801 gcagcttccc agggactggc tcccccaccc ctacccgacc ccaggtccca cccaccctta
     1861 ctggccacac tcttatgcct gtccctgcat acccatgcct ccctatacta ccttcccctc
     1921 caggatcatc tgtttccgct tgttgatctc tttcttttca tcaaaatgcg aagcctccag
     1981 tttctagggg tggggagggg aacaggtcag tcaggcctgg ggcaggaagc cccgcccacc
     2041 tcaccccact ccaccctacc ctgacaggct ggccacactt actatttcgc actcccttcg
     2101 cactacgttg acctgcgtga ggatttgtag aacctcagcc tcctccacca ccagctctgc
     2161 cagctgctgc tctgcaggga caggaaacac tgagttgggc tgggagtgca accagccctc
     2221 tgcaccccca gctctggatg tctggatcca accaaatgtg gactgatgat atttagaaaa
     2281 agcaaaatgc tgccaagctt ggcagcacat gcttgtcatc acagcactgg gaggttggag
     2341 gcagggggat cactcgttcc agctgagttc caggccagct ctgtagagca agaatctgtc
     2401 tcaaattaat gactgaataa acaaatgaac aagtaaatga agtga
//
