LOCUS       NM_001164086           10966 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus homer scaffolding protein 2 (Homer2), transcript
            variant 2, mRNA.
ACCESSION   NM_001164086
VERSION     NM_001164086.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10966)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 10966)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10966)
  AUTHORS   Blottner,D., Trautmann,G., Furlan,S., Gambara,G., Block,K.,
            Gutsmann,M., Sun,L.W., Worley,P.F., Gorza,L., Scano,M.,
            Lorenzon,P., Vida,I., Volpe,P. and Salanova,M.
  TITLE     Reciprocal Homer1a and Homer2 Isoform Expression Is a Key Mechanism
            for Muscle Soleus Atrophy in Spaceflown Mice
  JOURNAL   Int J Mol Sci 23 (1), 75 (2021)
   PUBMED   35008503
  REMARK    GeneRIF: Reciprocal Homer1a and Homer2 Isoform Expression Is a Key
            Mechanism for Muscle Soleus Atrophy in Spaceflown Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10966)
  AUTHORS   Lin,R., Learman,L.N., Bangash,M.A., Melnikova,T., Leyder,E.,
            Reddy,S.C., Naidoo,N., Park,J.M., Savonenko,A. and Worley,P.F.
  TITLE     Homer1a regulates Shank3 expression and underlies behavioral
            vulnerability to stress in a model of Phelan-McDermid syndrome
  JOURNAL   Cell Rep 37 (7), 110014 (2021)
   PUBMED   34788607
REFERENCE   5  (bases 1 to 10966)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10966)
  AUTHORS   Shin,D.M., Dehoff,M., Luo,X., Kang,S.H., Tu,J., Nayak,S.K.,
            Ross,E.M., Worley,P.F. and Muallem,S.
  TITLE     Homer 2 tunes G protein-coupled receptors stimulus intensity by
            regulating RGS proteins and PLCbeta GAP activities
  JOURNAL   J Cell Biol 162 (2), 293-303 (2003)
   PUBMED   12860966
  REMARK    GeneRIF: Homer2 tunes G protein-coupled receptors stimulus
            intensity by regulating RGS proteins and PLCbeta GAP activities.
REFERENCE   7  (bases 1 to 10966)
  AUTHORS   Barzik,M., Carl,U.D., Schubert,W.D., Frank,R., Wehland,J. and
            Heinz,D.W.
  TITLE     The N-terminal domain of Homer/Vesl is a new class II EVH1 domain
  JOURNAL   J Mol Biol 309 (1), 155-169 (2001)
   PUBMED   11491285
REFERENCE   8  (bases 1 to 10966)
  AUTHORS   Shiraishi,Y., Mizutani,A., Bito,H., Fujisawa,K., Narumiya,S.,
            Mikoshiba,K. and Furuichi,T.
  TITLE     Cupidin, an isoform of Homer/Vesl, interacts with the actin
            cytoskeleton and activated rho family small GTPases and is
            expressed in developing mouse cerebellar granule cells
  JOURNAL   J Neurosci 19 (19), 8389-8400 (1999)
   PUBMED   10493740
REFERENCE   9  (bases 1 to 10966)
  AUTHORS   Tu,J.C., Xiao,B., Yuan,J.P., Lanahan,A.A., Leoffert,K., Li,M.,
            Linden,D.J. and Worley,P.F.
  TITLE     Homer binds a novel proline-rich motif and links group 1
            metabotropic glutamate receptors with IP3 receptors
  JOURNAL   Neuron 21 (4), 717-726 (1998)
   PUBMED   9808459
REFERENCE   10 (bases 1 to 10966)
  AUTHORS   Xiao,B., Tu,J.C., Petralia,R.S., Yuan,J.P., Doan,A., Breder,C.D.,
            Ruggiero,A., Lanahan,A.A., Wenthold,R.J. and Worley,P.F.
  TITLE     Homer regulates the association of group 1 metabotropic glutamate
            receptors with multivalent complexes of homer-related, synaptic
            proteins
  JOURNAL   Neuron 21 (4), 707-716 (1998)
   PUBMED   9808458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163423.1, AF093259.2 and AC140366.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The resulting isoform (2) lacks an internal segment, compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017136.1, AF093259.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AK163423.1         2-132
            132-1732            AF093259.2         9-1609
            1733-10966          AC140366.2         53132-62365         c
FEATURES             Location/Qualifiers
     source          1..10966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.71 cM"
     gene            1..10966
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /note="homer scaffolding protein 2"
                     /db_xref="GeneID:26557"
                     /db_xref="MGI:MGI:1347354"
     exon            1..167
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1194
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /note="isoform 2 is encoded by transcript variant 2; homer
                     protein homolog 2; cupidin; homer-2; VASP/Ena-related gene
                     up-regulated during seizure and LTP 2; homer homolog 2;
                     homer, neuronal immediate early gene, 2"
                     /codon_start=1
                     /product="homer protein homolog 2 isoform 2"
                     /protein_id="NP_001157558.1"
                     /db_xref="CCDS:CCDS85329.1"
                     /db_xref="GeneID:26557"
                     /db_xref="MGI:MGI:1347354"
                     /translation="MGEQPIFTTRAHVFQIDPSTKKNWVPASKQAVTVSYFYDVTRNS
                     YRIISVDGAKVIINSTITPNMTFTKTSQKFGQWADSRANTVFGLGFSSELQLTKFAEK
                     FQEVREAARLARDKSQEKTETSSNHSQASSVNGTDDEKASHASPADTHLKSENDKLKI
                     ALTQSAANVKKWEMELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRSKI
                     EELEEQCSEINREKEKNTQLKRRIEELESEVRDKEMELKDLRKQSEIIPQLMSECEYV
                     SEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKGELKSFLEVLDGKIDDLHDFRR
                     GLSKLGTDN"
     exon            168..324
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            325..456
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            457..549
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..656
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..813
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..924
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1005
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..10966
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2085..2090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /note="hexamer: AATAAA"
     polyA_site      2110
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /note="major polyA site"
     regulatory      10631..10636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /note="hexamer: AATAAA"
     polyA_site      10656
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
     regulatory      10731..10736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /note="hexamer: AATATA"
     polyA_site      10753
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
     regulatory      10940..10945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
                     /note="hexamer: AATAGA"
     polyA_site      10966
                     /gene="Homer2"
                     /gene_synonym="9330120H11Rik; CPD; Vesl-2"
ORIGIN      
        1 gacaccggca gagcagccgc gcagccggcg gaatggaacg gcgccggggc tgagccgggc
       61 gcactcgggc cgccgcatgt gccgcgcggg gagcagctgc cgagcgggcg gagagcgaac
      121 gccaggggcc ccgtcggagc ggccgcacga gcagcgccgg agatgggaga acagcccatc
      181 ttcaccacgc gagcgcacgt cttccagatt gaccccagca ccaagaagaa ctgggtgccg
      241 gcaagcaagc aggccgtcac ggtttcctac ttctatgatg tcaccaggaa cagctatcgg
      301 atcatcagtg tggatggagc caaggtgatc ataaacagca ctatcacccc gaacatgact
      361 ttcaccaaaa cgtcacagaa gttcgggcag tgggctgaca gcagagccaa caccgtgttc
      421 ggtttgggat tctcctccga gctgcagctc acgaagtttg cagagaagtt ccaggaggta
      481 agagaagctg ccaggctagc cagagacaag tcccaggaga aaaccgagac ctccagcaat
      541 cattcccaag catccagcgt caatggcaca gacgacgaaa aggcctctca cgcgagccca
      601 gccgacactc acctcaagtc tgagaatgac aagctgaaga tcgcgctgac acagagtgct
      661 gccaatgtga agaagtggga gatggagctg cagaccctgc gggagagcaa cgcccggctg
      721 accacggcac tgcaggagtc ggcggccagc gtggagcagt ggaagcggca gttctccatc
      781 tgcagggacg agaatgacag gctccgcagc aagatcgagg agctggaaga acagtgcagc
      841 gagataaaca gggagaagga gaagaacaca cagctgaaga ggaggatcga ggagctggag
      901 tcagaggtcc gagacaagga gatggagttg aaagatctcc gaaaacagag tgaaatcata
      961 cctcagctca tgtccgagtg tgaatatgtc tctgagaagt tagaggcggc cgaaagagac
     1021 aatcaaaact tggaagacaa agtgcggtct ctaaagacag acatcgagga gagtaaatac
     1081 cgacagcgcc acctgaaggg ggagctgaag agcttccttg aggtgctgga tggaaagatc
     1141 gacgacctcc atgacttccg tagaggactc tccaagttag gcacagataa ctagggcggg
     1201 gcggagcaag tgtgtgtgag aggtgtggta gacgtaggac attctccatt tgcttctgta
     1261 aatgcaggtg cgatctgtct gtctccagac caattgtgcc gtccgctcac tcctccagaa
     1321 taggaaatct ctcgcttctc tggctttgtg aggtcatgga cagctggaag cttctgactc
     1381 aggaatccag aacttggtct accttagccg tttacgcagt cagggcaggg atgtttagat
     1441 cttcccttaa gggctgttgt aaccctatga accggggatg ggggagtatt ttctaatcca
     1501 agtaccatta tcctttacag caggccctcg ggtgccttct gctgcgtggc attcagtgta
     1561 tgtgactctc cagcaggttc tagaccacgg gcatgtggag ggagcatctt ttcccagtat
     1621 gcattttgtt gctttagcag atgtgacatg acattgtcaa ccacaaagtt cacactcaaa
     1681 aactgcacaa ctgacttact caaaaagaaa taattgtaaa aaaaaaaaaa aagttttaag
     1741 taaatacact attttgggtt ggagcacatt cacggttacc cttggctgcc tgtgaccttt
     1801 gggctgtagg tcagacatac ctacttgaaa ggaaacattt agtggagacc tctctagagg
     1861 gaagataaac cagaagtttt ggggtgtgcg tactgacagg gaatgactag ttcctgctaa
     1921 gacccatcct cccctgattt attgtgattg cagcaatgtt cttgtttgtt tgtttgtttt
     1981 ttgttttgtt tgtttttgtt tctgatttca gagcagatgc ttaagctgtg ggaacagaat
     2041 gcagggaggg tgtctagcgg agtctgggca cttaataggt gcttaataaa cattcgttca
     2101 attaaacata taagcagaac ttagtgtttt aatcaaacca cacagcagag ttcagaccct
     2161 tgttgaataa cacatcatct ttgttgtgct gaaataattc tcagaaatga atgcagtttg
     2221 ctgttctcaa acctagactt ggctctgagg cacagactgt ggcaatgtaa tcatcataga
     2281 ctactctgag gccctcctgc agggacccca gccacgatcc tggaggacat tgcctgtggg
     2341 accttccttc tcttccaggc agagggcctg gagttggaga ctttctggat accaggagag
     2401 cattgtatag gagctagcct gggcttagaa gacaggctgg gcttcctgta ataggtttga
     2461 acaatacaaa gccatccttc acgccatgag gatgagagcc cctcaggtgg cagcttagcc
     2521 ttagagacag agatgctcct cccaggtctg ccttcccttt cccagttcct gctaaggaag
     2581 ggcctgcagc caaaaagctc tctgctcaca gagaacttct taaaggaacc attggacttt
     2641 caggtccaca ggcattcctc tttaggagag tttgcacaca ggaggcaagg tttgttaacc
     2701 ctgaccccca acacttcaga atgccttgag caagggaaac gttggttccc tacccatctg
     2761 agaaccctct agatgtatcc acatgggatc agaaattctt cctcttgaat gagaaaacag
     2821 cctgaggaca gggctagggt cggcacgttt aagacccagg ccctgtggcg acttccaagt
     2881 cctcatcttt ccttgcagtg gctgatgagt cactctgagc aaggaattcg atcgggacaa
     2941 aaaaaaagga aggaaggctg gtgatgtgga aggctgagtt ctgttagggg gtgaccccat
     3001 caatttggga tgctttatac aacagagtgg tcacctctga tgtaattcag ccagggtgct
     3061 gccgttcccc acagctccca atagttctca agtcagtagc agctgctact ggtgcaccaa
     3121 gagaacatag actgggttag ctatggccca gcatgggcta aggggaattc ttcttaggcc
     3181 accccagccc ctttgcctac caacagcctg gacacatggc tcccaagagc agtggacact
     3241 ggggctgtca gctcaggctt cagatgagct tccattatca ggtagaagga gcgctctcgg
     3301 ctggctggag tatgatctgg tgacatgacc atatgaggac acttgctaag gctactgaac
     3361 tggaagtgta gaaagttcta gaagttatga gcccagtggg ctggctgtaa ggttgagacc
     3421 catgacccct gttgttagca ctgggggcgt gggggggtta gcaagtttct aatagccagt
     3481 aggtggggga aatagttttt gtactcttgg attcaagcag cccccaaact gtcacaaccc
     3541 atgatcctaa gacactagga cgcccctgaa gagtgattta ggctccacag ctaaagcccc
     3601 aagcaagcac ggaacctccc tttcatctgc ttcctctaaa gacatcatga ttcttcattt
     3661 tctttctttt taagaacagt catggcccag gaatggcctg gaaggtcaac agtaggctag
     3721 ccctgtctgt agcctctggc actgtaaaag gcagactctg tacggcgcaa acgacccact
     3781 aaaattgttc cgtatccact cacactagtg ggacatacct ccattttttc tgatgtccag
     3841 cccagtctta ggactgttgt cgtggcctca aatcccatac agatggtgtg agctgttttc
     3901 ccccagcaat tacggccaca gagtgctgcc tgcagagcct ggagtcagat gagctctggc
     3961 cttggcatct ctgagactag cagtctgcac cttgcttagc ttgcattctg cagccatcca
     4021 catggaacct aaaagaggcc aagaaaacct cagagccctt tagccgtgat ccgcatgcat
     4081 ttctgacatg agctggggta gggtggtgcc taggaatgag agaccgctgg aaggaaggat
     4141 tgggagagaa gaaacagccc gtgcttgacc tctgatcatc tccttccatt gcttctcccc
     4201 aagagctgtc actttagacc ttaattgggt gagagaactt ggcagagatt atcaacagga
     4261 agtggaggca gagtagccca gagtaaccca gctgtggcca gcagcgtggg ctcttgggtc
     4321 tcctggacct tgatccgctg ctctcctatg agccatattg tcactctccc tttggtgtcc
     4381 cttaggtgcc aagaagaaat aaatactcct ctgccctact aaaagcatgt tgcaactata
     4441 ttaattggag tgtgtgtcca cagcaaggaa tagccgacag ggacacggca gaactgtcca
     4501 ccatacacag taaagtctgt ttcctttgaa tgattctgct ctgtagggat ctcttcaatg
     4561 atctctgtgc ttggtgaggc cagtttggtg gaacactgtc tggctttgaa ttctttgctg
     4621 atgactttaa tgaaggtcca ctcacgtttt taaagagggg aggaggcctt tgatggcaga
     4681 gacataaaca ggaacagaac agacgagcca cagttgggga ggtgcagact catccagtgc
     4741 ctagagcagt ttgcatgcat gcctggctgt ccacagaggg aactagctgc tctccagcct
     4801 gcttgctcca cagacatagc cttaagcagc atgatggcag gtgcaggtac tgcatttgat
     4861 atgagtgtga gagagctcac atgcagccca aaagcatcac aagcaagccc gtttgacagg
     4921 ggctctttct atagccaaga cccctgcaga caccagtggc gactgtgaat gagacccaac
     4981 ttagacctca cgtgcagcca ggtgcgtgct tggaaactgg gcggtctggg aggagctcaa
     5041 gcgatgctgc ccttcaggga gcaccagcca ctgctcttta ctggtaactg aagtgggtca
     5101 ctagaagtta cactcactca attcttggga acatcactgg attttgaagc acttgcaaca
     5161 taaggcagaa gctttcaatt caatgtccat acatatcttg aatgatagcc atgacctaaa
     5221 tagaccgtga cttctgaata catggcttcc ctcaaagaaa cagactgtat tctggggaca
     5281 gtgggtgtga cggcatggag gtgggtccct acatagaagt gtgagctatt tacatgtctt
     5341 tttcttacaa ctttctaaag aatataaatc cctctttaaa aacaagcctg gcaagaaggt
     5401 gactttggta ggaattttga gctgtatgaa atgttcgtgt gtgtgtgtgt gtgtgtgtgt
     5461 gtgtgtgtgt gcacatgtgc atgggcactg gaggggagga agcatcagga aaaaccagag
     5521 aaacaattag gaggaattca attataactt cataaccagg agtcattgaa tatttctggt
     5581 ggtgatagtg aatgttctgg aatctgctta caggactttg tggggctttg ggtttgtgtg
     5641 aacttgtaca gttctctttg acagtgtagc acttgctgtg gagtggcctc tgagtcacag
     5701 ggacccctgc agaggcccac gtggaccaca gcggagtcca ggcttgcctg ctctatcaga
     5761 aaggcagcag gactgatacc tcgcagatgt tagggacacg ttgatgcctc tctgtcctgt
     5821 accagttttg ataagaaggc ctgactgtca ctccattgtg acagtgaatg tgacagcagg
     5881 aagatgtttc ttacatctcc acaagagctt aatgctaact atggattgga taagcaaatt
     5941 atttcatgag tcattttttt tctttttaaa tgcttttttg gaatataagt aatagataat
     6001 ttttttaaaa aaatgaaatt aaagataaaa ggaacaaaaa aaattcacct attgttccac
     6061 ggtctgattg taaccactgt taacccaccc cagtggcttt tcagcatccc atccaattgt
     6121 aacactgtta accccgtggc ttttcagcat cccatccaat tgtaacactg ttaaccccgt
     6181 ggcttttcag catcccatcc aattgtatca ctgttaaccc agtgggtctt cagcattcca
     6241 tctgattgta gcactgttaa cccacgtgac tcttcagcat ccctatctga ttttaacagt
     6301 taacctgagt ggctcttcag tgtcctcacc cagcttgctt ttgttccttt tccatgaaat
     6361 ctcctggtct catgcacacc cttctaataa ctcacttgtc tccttttact ctgtatcaca
     6421 aatgtatttc tctatcggta agtatgtaac tactactttt taacagctgt gtaacattcc
     6481 ttggatagtt aagctgtttc cagttttcta ctcttgtagt caggacacag taacatggtt
     6541 ctgacatctt tgtaaaccct ttagagtatt tgcttagact aaatttctaa tattagcctt
     6601 ttctaatctc caaaccctgg ttcctttcct tcctaaacat gtgagagact ctactcactg
     6661 gcccctcggt ggtcagctat tcagggccct gggaatgatt ctggtcaatg atgtgagcag
     6721 acatagtatc tgaaactcta gccaggactg tggactgtgc catgcatgac ttcagtgtct
     6781 ctgatcctta gccttagcaa atggtaacat cccggggtta gggattctcc cagcctaggt
     6841 ccttgagtga ctgtagggga caggtcctct caccttaccc tacctgccat tgacacagac
     6901 atgtggctca cacagagata gaccttatag gttttaccac tgggattcca aggctgatga
     6961 tttactgcgg cataacatag ccctatttta actaataaaa aaggaagcat acacgttttt
     7021 aggattttaa acatagcact tcaaattacc tttcagaaat atgcgtgtcc cccgaccccc
     7081 aactatacct ccgctctgtg agcgccgtgt ctgtgagcac cgtgctccct ctagctctgt
     7141 catcatcatg ggggcaggag ctaagaaagt tacatttttg tttttattaa aatatgatcc
     7201 tcattaacaa atgagacctg cctgcctctg cctcccaagt gctgggatcc aaggtgtgag
     7261 ccacagcctg gcttcaggcc tgctttctta taaggtcttt agtggtctca ttcattcctt
     7321 tttaaaacag gactactaca caagtactac ttgtacctga taatcaagag accagaagag
     7381 aggttatcag atctctggaa ctggagctac agaaggttgt gagctgccat gtgcatgctg
     7441 gaagtcaaac ccaggccctc tgcaagtgta gctaatgctc ttaaccactg agccagctct
     7501 ccagccctca gccccccttt ggtctgctat ttatttatta ttattattat tattattatt
     7561 gttgttgttg ttgttgttgt tgttgttgtt gttttgaaac aaggtcttaa ccatataact
     7621 gtggctagcc tggagctcct gtgtagacca cactagcctt aaatttgtgg caatcctcct
     7681 gtctcagcct tctaagaact ggaattatag gcttgctcca ccacatacag cagtctcact
     7741 gatgtcaaag tttttttcat aaatattata gaggttaaag ttgtatcatg gccttcagag
     7801 aaattcttac acattaagaa gaatccattt tagtcttttc ctttatagtt agttctctgc
     7861 tgtcacaatt gtgaacgctt ttccaattct aatcccagcc cactctgttc atcagcgtgt
     7921 tgctcttgta cattcattgc ccctttcagc tgtggagtct ctgatctcag ccaggcgtgg
     7981 tggaattctt ataatcccag tagctgggat gtggaggcag gacgatcagc tgcatagaaa
     8041 gtttaagagc cagcctgggc tacagagacc ctgtctcaaa aaaaaaaaga aaagaaaaga
     8101 caaaaacaaa acaaaacaaa aacaaacaaa ccagctttaa tcccagtaca aaggagacag
     8161 aggcaggcag atctctgtga gtttgaggcc agcatggtct acatggttaa gtccaagacc
     8221 agccagggct gcacagtgag atctcatctc caaaacagaa taaaacaaca aaacaaaact
     8281 acccttttat gctattccta atatatttct aaattgcacc aatactgttt tggggaaaaa
     8341 tgaccctttc tccactgaca tcaaattgca ttttatgttc cccacccttc taggtgtgtg
     8401 agcatgccac acttatctgt ctgtgtgctc tagtgctagg actatactgt ttggtaatcc
     8461 taactttagg tttaaaatcc ctactaacga ttttttttaa tttcctagtt tattatatat
     8521 tctaatattt ccaaaagata ttcaggggct attttgtaaa ttttggaatc attggaaatt
     8581 ggattatata ctatttctat cttacaagag aagttacatc tttatagcct cttttgtttc
     8641 actaaattta taatgttcag tctagttttt tataaaggta atttttttca ttgtggttat
     8701 tgctataaat gagatctttt ccaacagttt acagttatat aggtataaca ttgctttgct
     8761 aatgaaaatc cttccccctt agatatctat ttgaggacat caaataaatg ttacacaaat
     8821 ttagacagaa aaacaactgt agaaaatcaa aatctcctat aattaaaatt ccttctatcc
     8881 aagatactca acaattatgt aaagctctct ctctctcccc ctctgccccc cccctcacac
     8941 acacacacac acacacaaac acagtgtttt atcgttttga cagtttgata cagcccctat
     9001 gccatacaca ttctttcctt ggagaagatc ttgtccatca ggaagcatcg atcaatctac
     9061 ctcattttta tctgcgtaaa agagtgtgtc tgcacacaag tccatttcat tgtgtccagc
     9121 cagtcactga ttctttttat cctaatcctt ttggtctgaa tttcatttgc cttcctagta
     9181 ggcgatatcc ttgattagtg atgataatat ttcccgattt ttctcttgct tgccttccca
     9241 cactgaccag accttctgta acagtgacag agttgtcgtc tatgattgtg ctggtcttaa
     9301 acatgcatct ccacgtacct tccccttggt gaggatattt ttagtgtctt gacagaagta
     9361 cacatgtgac tcttgcttgt atattcaatt catactcttg tgtgtgtctc tagtttgctg
     9421 acaattttac aagcaagggg tattgggatt ttaggaaatg aaattttaac atctgtcaag
     9481 ctgttggaat gattttcctc tatcacgact taagatgagt tggtatggtt aagtccttcc
     9541 ctctgtttct ccgaaccctg atgtagtcgc agtgcgttac tcttttaata tacaccttat
     9601 gaagttaaca gtggttactc cggattggtc ggtctttggt acattttcac tttgtctgtc
     9661 ttatttgtgc tttcaaattt ttctacaaaa gttgcctatt acttgtataa taaaatcaag
     9721 agctttacac gagaaaagat tcttcttgat ttcagcggtt ccttttattt tggaatttca
     9781 tatcttatta ataagatgaa taattgtgat ttttttctgc tgtctttgtc aggtgttttt
     9841 atgtgaactt cctttaaaat atatcttggg ccactttcta tctctttttc tatgccctgg
     9901 aatagttcaa ataatattca gaactccttg ctctctgaag tttttataac ctgtataaaa
     9961 ctgtcccaag tctagtgcct tttaaagaaa taatccttcg ataattttaa aaagttttcc
    10021 atattcattg gtctcttcaa agtttcctct cattctgtaa gacttttgac aatttaactt
    10081 ttactaaatg atgatgtcgt ccaggttttt ggggtatgtt gacgtaggat tgtattattt
    10141 ccccttagtg ttgtatgtct ctgcttccca tttttattct gattattttt tcaataatta
    10201 gtccattttt attcgtcttt tcaaaaaacc agctttggga tttctatgtc tatttccaga
    10261 tttatcattt tatgattgtt gtttttccct tggcatttct ccagctttcc atgttacagg
    10321 ccatgctgac ttcttgcaca gagacagggt agctcttgct gtaggcctgt gacctttcct
    10381 ctgagtatat ctgtatccca taaatgttta tatatgatgt gattgtcata aataactcat
    10441 cccttcaaac tggagtttat cttttactga ggagagagtt gaaattatac ttttagactt
    10501 cctgatcgtt tgtctttgtt gctgttgttt ttaactttgt tacagactct gctttatcgc
    10561 ctgttgtcaa ggagggtatg gcttgtacaa cttgtgcatt tcggagttca ttaacatttt
    10621 gttgagacct aataaatttt tagttttaat aagataccca ggaagttgta gaaggtatat
    10681 tctttgaaag caacaatatt tgatctatgt atattaattt gactttacta aatatactat
    10741 tatggacttt aaattttatt ttcttaattc attaaagact aagaaaggcg tgttcccatg
    10801 atcactgtct gtcagccctt ctcctatgtg tctaacgcct tcttctgtat ctgttgccat
    10861 agaaaatgac ccttttatat gtaagggaaa attgttttcc taaagacctg tgtccgttgg
    10921 gtttacctgg ctttgttgta atagagttgt ttatgtagaa atacga
//
