LOCUS       NM_147176               5542 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus homer scaffolding protein 1 (Homer1), transcript
            variant L, mRNA.
ACCESSION   NM_147176
VERSION     NM_147176.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5542)
  AUTHORS   Lv,W., Zhang,Q., Li,Y., Liu,D., Wu,X., He,X., Han,Y., Fei,X.,
            Zhang,L. and Fei,Z.
  TITLE     Homer1 ameliorates ischemic stroke by inhibiting
            necroptosis-induced neuronal damage and neuroinflammation
  JOURNAL   Inflamm Res 73 (1), 131-144 (2024)
   PUBMED   38091015
  REMARK    GeneRIF: Homer1 ameliorates ischemic stroke by inhibiting
            necroptosis-induced neuronal damage and neuroinflammation.
REFERENCE   2  (bases 1 to 5542)
  AUTHORS   Lv,W., Wu,X., Dou,Y., Yan,Y., Chen,L., Fei,Z. and Fei,F.
  TITLE     Homer1 Protects against Retinal Ganglion Cell Pyroptosis by
            Inhibiting Endoplasmic Reticulum Stress-Associated TXNIP/NLRP3
            Inflammasome Activation after Middle Cerebral Artery
            Occlusion-Induced Retinal Ischemia
  JOURNAL   Int J Mol Sci 24 (23), 16811 (2023)
   PUBMED   38069134
  REMARK    GeneRIF: Homer1 Protects against Retinal Ganglion Cell Pyroptosis
            by Inhibiting Endoplasmic Reticulum Stress-Associated TXNIP/NLRP3
            Inflammasome Activation after Middle Cerebral Artery
            Occlusion-Induced Retinal Ischemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5542)
  AUTHORS   Koutsioumpa,C., Santiago,C., Jacobs,K., Lehnert,B.P., Barrera,V.,
            Hutchinson,J.N., Schmelyun,D., Lehoczky,J.A., Paul,D.L. and
            Ginty,D.D.
  TITLE     Skin-type-dependent development of murine mechanosensory neurons
  JOURNAL   Dev Cell 58 (20), 2032-2047 (2023)
   PUBMED   37607547
REFERENCE   4  (bases 1 to 5542)
  AUTHORS   Cserep,C., Schwarcz,A.D., Posfai,B., Laszlo,Z.I., Kellermayer,A.,
            Kornyei,Z., Kisfali,M., Nyerges,M., Lele,Z., Katona,I. and
            Adam,Denes.
  TITLE     Microglial control of neuronal development via somatic purinergic
            junctions
  JOURNAL   Cell Rep 40 (12), 111369 (2022)
   PUBMED   36130488
REFERENCE   5  (bases 1 to 5542)
  AUTHORS   Saito,H., Kimura,M., Inanobe,A., Ohe,T. and Kurachi,Y.
  TITLE     An N-terminal sequence specific for a novel Homer1 isoform controls
            trafficking of group I metabotropic glutamate receptor in mammalian
            cells
  JOURNAL   Biochem Biophys Res Commun 296 (3), 523-529 (2002)
   PUBMED   12176012
  REMARK    GeneRIF: molecular cloning of Homer1d, an alternativly splice
            isoform, that controls trafficking of group I metabotropic
            glutamate receptor
REFERENCE   6  (bases 1 to 5542)
  AUTHORS   Morioka,R., Kato,A., Fueta,Y. and Sugiyama,H.
  TITLE     Expression of vesl-1S/homer-1a, a gene associated with long-term
            potentiation, in the brain of the epileptic EI mouse
  JOURNAL   Neurosci Lett 313 (1-2), 99-101 (2001)
   PUBMED   11684349
REFERENCE   7  (bases 1 to 5542)
  AUTHORS   Xiao,B., Tu,J.C. and Worley,P.F.
  TITLE     Homer: a link between neural activity and glutamate receptor
            function
  JOURNAL   Curr Opin Neurobiol 10 (3), 370-374 (2000)
   PUBMED   10851183
  REMARK    Review article
REFERENCE   8  (bases 1 to 5542)
  AUTHORS   Shiraishi,Y., Mizutani,A., Bito,H., Fujisawa,K., Narumiya,S.,
            Mikoshiba,K. and Furuichi,T.
  TITLE     Cupidin, an isoform of Homer/Vesl, interacts with the actin
            cytoskeleton and activated rho family small GTPases and is
            expressed in developing mouse cerebellar granule cells
  JOURNAL   J Neurosci 19 (19), 8389-8400 (1999)
   PUBMED   10493740
REFERENCE   9  (bases 1 to 5542)
  AUTHORS   Tu,J.C., Xiao,B., Yuan,J.P., Lanahan,A.A., Leoffert,K., Li,M.,
            Linden,D.J. and Worley,P.F.
  TITLE     Homer binds a novel proline-rich motif and links group 1
            metabotropic glutamate receptors with IP3 receptors
  JOURNAL   Neuron 21 (4), 717-726 (1998)
   PUBMED   9808459
REFERENCE   10 (bases 1 to 5542)
  AUTHORS   Xiao,B., Tu,J.C., Petralia,R.S., Yuan,J.P., Doan,A., Breder,C.D.,
            Ruggiero,A., Lanahan,A.A., Wenthold,R.J. and Worley,P.F.
  TITLE     Homer regulates the association of group 1 metabotropic glutamate
            receptors with multivalent complexes of homer-related, synaptic
            proteins
  JOURNAL   Neuron 21 (4), 707-716 (1998)
   PUBMED   9808458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137151.1, CJ130737.1, AB019479.1, AF093258.1, AC154231.2 and
            BY644449.1.
            
            On Dec 2, 2016 this sequence version replaced NM_147176.3.
            
            Transcript Variant: This variant (L, also known as Vesl-1L)
            represents the longest transcript and encodes isoform L.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB019479.1, SRR7974084.16725.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-723               AK137151.1         2-724
            724-763             CJ130737.1         376-415
            764-1042            AK137151.1         765-1043
            1043-2119           AB019479.1         1-1077
            2120-2800           AF093258.1         695-1375
            2801-5321           AC154231.2         56562-59082
            5322-5542           BY644449.1         170-390
FEATURES             Location/Qualifiers
     source          1..5542
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.83 cM"
     gene            1..5542
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /note="homer scaffolding protein 1"
                     /db_xref="GeneID:26556"
                     /db_xref="MGI:MGI:1347345"
     exon            1..1546
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1542..2642
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /note="isoform L is encoded by transcript variant L; homer
                     protein homolog 1; immediate early gene protein Homer1A;
                     VASP/Ena-related gene up-regulated during seizure and LTP
                     1; homer, neuronal immediate early gene, 1; homer homolog
                     1"
                     /codon_start=1
                     /product="homer protein homolog 1 isoform L"
                     /protein_id="NP_671705.2"
                     /db_xref="CCDS:CCDS36745.1"
                     /db_xref="GeneID:26556"
                     /db_xref="MGI:MGI:1347345"
                     /translation="MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNV
                     YRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEK
                     FQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNS
                     EPRAEPTQNALPFPHSAGDRTQALSHASSAISKHWEAELATLKGNNAKLTAALLESTA
                     NVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHSHKTELNQTVQELEETLKVKE
                     EEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAF
                     RSNLKTLLEILDGKIFELTELRDNLAKLLECS"
     exon            1547..1703
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1835
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1928
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2068
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2104
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2261
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2372
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2453
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..5542
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5521..5526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /note="hexamer: CATAAA"
     polyA_site      5540
                     /gene="Homer1"
                     /gene_synonym="homer-1; PSD-Zip45; SYN47; Ves-1; vesl-1"
                     /note="major polyA site"
ORIGIN      
        1 aaaggtcctt ctgcggggag gatggagaca cagcgcgagc acccggcgtg cggagcggac
       61 gaggccgtgg cggcccagag ccagcgcagg agccgagcgc actgcccgtc cgccgccggc
      121 cgctagggga ggggaaggaa aaagggacgg accgacggac cggccagctc atcccctccg
      181 gtgttgttcc tcagcgcccc ggtccgagcc cgggccccgc ctccgccgcg ccccacctcc
      241 tccgccggcc tgcggcggcg gcagcgctcc gcccctcgag ccgggagggc cgcgctctcc
      301 gccccgcccc gccccgcccc gccccctctc ctgctccgct gccgtgctcg tctcacgccg
      361 gcggcgcgga ccgggaagcg gcgccctcgg ctgcgctcgg ttcggagccc gctccgtgga
      421 gtcagaggca gcgacgggcg ccaggccgcc cgggccgacg gagtcagccg ctgaggggag
      481 tgtaaggagg cagcggcagc cccgggaatg tgaggcggcg cggagcggga gagacgagcc
      541 ggggtggggg cacgagccgc ggctgccgtg cctcggacga gccgccagcc tctcgcctca
      601 gcgcgcggcc gccgggagct tgggggctgg gtgcagggga ccgcgcgggg ttgggttctc
      661 tgattcattc attctccgcc gtcgggagcc cgaggccgcg ggtgctgcga ggagaggcgg
      721 gaagaggggg cggccgcgag cggggctcca ttgtgctcgg cgggggccgg gaagccaaag
      781 gaggtgggct cgggcccctg cgctgctccc cggcggctgc gcccccagct agctgccagc
      841 ctggaaatgg ctccgctgct gctcctcggg aaaacgaatc gatccttccc agccttctct
      901 gcctgctctc cacctcctct ctgctccgag tcttaggagg acgaacattc aaaggacaga
      961 ttccaatgtg gtgtgccgtg cacatcggga gcggctgggg tttgcacttc gagatttctt
     1021 ctatataatt ttttttttta aacgtaaggg aggcagtagc attgctgcct gtaggatttt
     1081 tattcaagtg cacgtcgcgt tgggttgcac gctccacccc cagggacctg gtgtggtgaa
     1141 atttgaaccc accgccttag cccaaaaagg ccgagtaacc tggctgcctg agtgtcgtgg
     1201 aagacgtgag cgaaatgacc agcgaactca ttttttatca gacttgctga agctggcttt
     1261 tgcgtttttt ctacacgtac gcttaatttt gtggaatagt taagtgctat attctccgcg
     1321 caaccttttc aaattccaaa tgtttgaaca ttttggtgtc agcgcgagtg aaatcatttt
     1381 accgacaaga actaactgaa ttgtctgcct tgttgagttg cctccggaaa agatctcggg
     1441 ggtggaaaag caactgcaaa ataacagacg gagaaaattc cttggaagtt atttctgtag
     1501 cataagagca gaaacttcag agcaagtttt cattgggcaa aatgggggag caacctatct
     1561 tcagcactcg agctcatgtc ttccagattg acccgaacac aaagaagaac tgggtaccca
     1621 ccagcaagca tgcagttact gtatcttatt tttatgacag cacaagaaat gtgtatagga
     1681 taatcagttt agatggctca aaggcaataa taaatagcac catcacacca aacatgacat
     1741 ttactaaaac atctcaaaag tttggccaat gggctgatag ccgggcaaac actgtttatg
     1801 gactgggatt ctcctctgag catcatcttt caaaattcgc agaaaagttt caggaattta
     1861 aggaagctgc tcggcttgca aaggagaagt cgcaggagaa gatggagctg accagtaccc
     1921 cttcacagga atcagcagga ggagatcttc agtctccttt gacaccagaa agtatcaatg
     1981 ggacagacga tgagagaaca cccgatgtga cacagaactc agagccaagg gctgagccaa
     2041 ctcagaatgc attgccattt ccacatagtg ctggggatcg aacccaggcc ctctctcatg
     2101 ctagttcagc aatcagcaaa cactgggagg ctgagctagc taccctcaaa ggcaacaatg
     2161 ccaaactcac tgcagccctg ctggagtcca ctgccaatgt gaagcagtgg aagcaacagc
     2221 ttgctgcgta ccaggaggaa gcagagcggc tgcacaagcg ggtcactgag ctggagtgtg
     2281 ttagtagtca agcaaacgct gtgcacagcc acaagacaga gctgaaccag acagtgcagg
     2341 aactggaaga gaccctgaaa gtaaaggaag aggaaataga aagattaaaa caagaaatcg
     2401 ataatgccag agaactccaa gaacagaggg actctttgac tcagaaacta caggaagttg
     2461 aaattcgaaa taaagacctg gaggggcagc tgtctgacct agaacagcgc ctggagaaga
     2521 gccagaacga acaagaggct ttccgcagta acctgaagac actcctagaa attctggatg
     2581 gaaaaatatt tgaactaaca gaattacgag ataatttggc caagctactg gaatgcagct
     2641 aaagagagtg aaatttcagt gccaatagat ggagagatgc tgtctgtctt cctaggactg
     2701 tttgggctcc gtaccaagat tgcacaaaat tttttgaata tcattcctcc aggaggaggg
     2761 tgttttgaaa attggaattg tatatttcag tataaatttt agaatttagc ttatagctag
     2821 ttggggaaaa aaaaagacat gaaaaacttg aactacaaat tacctccatg tatattggcc
     2881 atagttaact ggaaagttat aagtagacac tttaatgcaa tcttttcccc ctgatattag
     2941 ccaatgggag aattaacaat gtctgggtcc cttctcctct tttgttcaac acagtgaaga
     3001 ttatatgctt tttaaattta tttatgatat ctacagctgt gttttgtgca aaaacttagt
     3061 aatggaagcc ctgtctttgt tgttatctga ataatttctc aggataattt ttcgctgctg
     3121 agaaagggcc attaccaatt aatccttgcc aggagttggg gagctatgcc tctaagtgaa
     3181 actcactatc aacgggtgtc tggagttctt ccctttttgt actgagagtg ttttcactct
     3241 agtgactact ctggtacact ctgctatctc caatcttgtc tgttatatag tttacttttc
     3301 catattgatt ccatgtattt atgagaggat actgtctccc agtttattat acattttaaa
     3361 gccaactaaa caaaggcagc tgagtccctc agatattttt ctttttaaat ttatagtaaa
     3421 tttgacacac agaactgaaa tacagcagtc cgtccttgac ggtttagtct agcaatgtta
     3481 agtatattta cagaaaatat gcagttacat ttatttatat atttggcaag aaatcttttc
     3541 tgagtgatca atgcatttca atttatgaaa aataatggtt agggggcact gtttattata
     3601 gataatttta aggtatataa ctgttttcaa ggacggccac ttccacctag cggtcaagcc
     3661 gagaggactg catctaaatt gtgactgtgg cagatgggtc ttcacagaaa ccatgtcttt
     3721 attcaaactt cacaaggcta tattttgaac tgttaactag gcatttcaaa acaggagata
     3781 ccttcaacag actcttctcc aagagcaggt tttactgttt ttttgatgta attttaagac
     3841 atttagcaaa catgcatttc tttatatgat acatttcttt cacaaaacaa tttaaaagta
     3901 agccaagtgc tgcctgctct gcgagtagga actgcatcag aatcgtgtat cttgctgtac
     3961 aatgcctgtg atagtgaaga gggttcttct tagtgtatgc ttgggtacct aactctggag
     4021 tcaatgaatg cacccaattt tttttgtttg taccccaaat gattgaattg ttaaatacaa
     4081 attaagcaga ttaacccatc tttctcactc aaacagattc tttagtatgt tttatattta
     4141 tgtgtatgta tgtcaataca tacatactaa tttatattag aatgaaaata aatcgtttgt
     4201 ttctaaaggt agtttctaca gtaaggtgtc tctgacacat gtgtatcaga cactggacca
     4261 ccatgtattc tctgtgctat tccatcctgc ctgtcacctc catcaacctt agggtatttc
     4321 cctcacctgt ctattataga aggaatcttt tgggtacaca tgctcagaga tgagatactt
     4381 ctctgagaaa tcaggtaata aaatttattt gatggataga attttgaaaa catatgattt
     4441 tatctatgag tttctgaata tcaaagaata ccacgttttc atttaaatag aggactaaca
     4501 ctagggatca gggaatttag ttatgaagag tttcaaaaaa aatccaaaaa aaaaaaaaaa
     4561 aaaaaaaaca gtgtaagctg ttgatatggt aagcgaatta ttttaatgat gtaataaaat
     4621 atttttaaat tttggcatag tgatcattta atgggaaaat aactcaccaa aatgtctcca
     4681 cttgaattgt actgataatg tgaggcatat gtgtaattca atatatacat atacctatat
     4741 gtatatacag aaattatttt taatattttc ctactgctgt gaaatttaaa attggaaaat
     4801 tttgtgagtg ttttccatgt ccaatagagc ctaattgttt ctttttttag taacttaaca
     4861 atctcttgag ggctgcacct ataaattccc agcttgtcag tagacatgta cagtgtttgg
     4921 gataaggtgg acacaagtgc acatataaat aaaaccttct tcttgactat tttaaacctt
     4981 cactcacatg aggagagcct ctagaaatca tagcctctga gctataggta cgtcactcac
     5041 acaaggagag cctccagaac tcatcgcctc tgagctatag gttgtgtgcc tactgtagct
     5101 tttccaccgc tgtattatat agacatttgc atattaaaat ttgatttttc ccagagataa
     5161 atattatata gtgtatctat atttagatca aactgtggta atatattgat cagaacatag
     5221 tgttggggac tatagcctga acatgtggac ttgcagtgac ccaggaggag agcaggggtc
     5281 agtcccatct gtgtataagt tattataact atgaaatctt gtacaaaagc aaaaactgga
     5341 aaaaaaacaa aaatacagtt tttattttga aatacatttg ttctctggag aatgtacttg
     5401 atcgtctcct cagtcttcta aggctactta agcgtttaag ggacggcagc gtttacttca
     5461 accctacagg tgctactgga ttctgcatta gtatgtgatg ttttaaaatc ctaactttga
     5521 cataaaaggt tttataagta tt
//
