LOCUS       NM_026152               1620 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus 4-hydroxy-2-oxoglutarate aldolase 1 (Hoga1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_026152
VERSION     NM_026152.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1620)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1620)
  AUTHORS   Martinez-Turrillas,R., Martin-Mallo,A., Rodriguez-Diaz,S.,
            Zapata-Linares,N., Rodriguez-Marquez,P., San Martin-Uriz,P.,
            Vilas-Zornoza,A., Calleja-Cervantes,M.E., Salido,E., Prosper,F. and
            Rodriguez-Madoz,J.R.
  TITLE     In vivo CRISPR-Cas9 inhibition of hepatic LDH as treatment of
            primary hyperoxaluria
  JOURNAL   Mol Ther Methods Clin Dev 25, 137-146 (2022)
   PUBMED   35402636
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1620)
  AUTHORS   Li,X., Knight,J., Todd Lowther,W. and Holmes,R.P.
  TITLE     Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria
            Type 3
  JOURNAL   Biochim Biophys Acta 1852 (12), 2700-2705 (2015)
   PUBMED   26428388
REFERENCE   4  (bases 1 to 1620)
  AUTHORS   Srivastava,U., Paigen,B.J. and Korstanje,R.
  TITLE     Differences in health status affect susceptibility and mapping of
            genetic loci for atherosclerosis (fatty streak) in inbred mice
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (10), 2380-2386 (2012)
   PUBMED   22837474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK002457.1 and AC133503.4.
            
            On Jul 24, 2018 this sequence version replaced NM_026152.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016430.1, AK002457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1616              AK002457.1         20-1635
            1617-1620           AC133503.4         77357-77360         c
FEATURES             Location/Qualifiers
     source          1..1620
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 35.67 cM"
     gene            1..1620
                     /gene="Hoga1"
                     /gene_synonym="0610010D20Rik; Dhdpsl; Npl2"
                     /note="4-hydroxy-2-oxoglutarate aldolase 1"
                     /db_xref="GeneID:67432"
                     /db_xref="MGI:MGI:1914682"
     exon            1..241
                     /gene="Hoga1"
                     /gene_synonym="0610010D20Rik; Dhdpsl; Npl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1014
                     /gene="Hoga1"
                     /gene_synonym="0610010D20Rik; Dhdpsl; Npl2"
                     /EC_number="4.1.3.16"
                     /note="DHDPS-like protein; probable KHG-aldolase; probable
                     2-keto-4-hydroxyglutarate aldolase; dihydrodipicolinate
                     synthase-like, mitochondrial; N-acetylneuraminate pyruvate
                     lyase 2 (putative); 4-hydroxy-2-oxoglutarate aldolase,
                     mitochondrial"
                     /codon_start=1
                     /product="4-hydroxy-2-oxoglutarate aldolase, mitochondrial
                     precursor"
                     /protein_id="NP_080428.1"
                     /db_xref="CCDS:CCDS29820.1"
                     /db_xref="GeneID:67432"
                     /db_xref="MGI:MGI:1914682"
                     /translation="MLGPQIWASMRQGLSRGLSRNVKGKKVDIAGIYPPVTTPFTATA
                     EVDYGKLEENLNRLATFPFRGFVVQGSTGEFPFLTSLERLEVVSRVRQAIPKDKFLIA
                     GSGCESTQATVEMTVSMAQVGADVAMVVTPCYYRGRMSSAALIHHYTKVADVSPIPVV
                     LYSVPANTGLELPVDAVVTLSQHPNIIGLKDSGGDVTRIGLIVHKTSKQDFQVLAGSA
                     GFLLASYAVGAVGGICGLANVLGAQVCQLERLCLTGQWEAAQELQHRLIEPNTAVTRR
                     FGIPGLKKTMDWFGYYGGPCRAPLQELSPTEEEALRLDFSNNGWL"
     exon            242..370
                     /gene="Hoga1"
                     /gene_synonym="0610010D20Rik; Dhdpsl; Npl2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..498
                     /gene="Hoga1"
                     /gene_synonym="0610010D20Rik; Dhdpsl; Npl2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..633
                     /gene="Hoga1"
                     /gene_synonym="0610010D20Rik; Dhdpsl; Npl2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..730
                     /gene="Hoga1"
                     /gene_synonym="0610010D20Rik; Dhdpsl; Npl2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..864
                     /gene="Hoga1"
                     /gene_synonym="0610010D20Rik; Dhdpsl; Npl2"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1620
                     /gene="Hoga1"
                     /gene_synonym="0610010D20Rik; Dhdpsl; Npl2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1504..1509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hoga1"
                     /gene_synonym="0610010D20Rik; Dhdpsl; Npl2"
                     /note="hexamer: ATTATA"
     polyA_site      1539
                     /gene="Hoga1"
                     /gene_synonym="0610010D20Rik; Dhdpsl; Npl2"
ORIGIN      
        1 agttcccctg tggtcacaga cagctgaggc tccagacctc ccgcagaaat gctgggcccc
       61 caaatttggg cctccatgag gcagggtctg agcaggggct tgtctaggaa tgtgaagggc
      121 aagaaggtag acattgccgg catctaccca cccgtgacca ccccattcac cgccaccgca
      181 gaggtagact atgggaaact ggaagagaac ctgaacagac tggccacctt cccctttcga
      241 ggcttcgtgg tccagggttc gactggagag tttccgttcc tgaccagcct cgagcgcctg
      301 gaggtggtga gccgcgtgcg ccaggccata cccaaggaca agttcctgat agccggctct
      361 ggctgcgagt ccacgcaagc cacagtagag atgactgtca gcatggctca ggtgggtgct
      421 gatgtcgcca tggtggtgac cccttgttac tatcgtggcc gcatgagcag cgctgccctc
      481 attcaccact acaccaaggt tgctgacgtt tctccaatcc ctgtggtgtt gtacagtgtc
      541 ccagccaata cggggctaga gctacctgtg gatgccgtgg ttacattgtc tcagcaccca
      601 aatatcatcg gcttgaagga cagtggtgga gatgtgacca ggattggact gatagttcac
      661 aagaccagca agcaggattt ccaggtgttg gctgggtcag ctggcttcct cctggccagc
      721 tatgctgtgg gagctgttgg gggcatatgt ggcttggcca atgtcttggg ggcccaggtg
      781 tgccagctgg agagactctg cctcacaggg cagtgggaag ctgcccagga actacagcac
      841 cgtctcatcg agcccaacac tgcggtgacc cggcgctttg gaataccagg gctgaagaaa
      901 accatggact ggtttggcta ctatggaggt ccctgccgcg ccccgttgca ggagctgagc
      961 cccacagagg aggaggcact gcgcttggat ttcagcaaca atggctggct ttaatgacaa
     1021 gcaggagacg cctggcctga gctatctggg acttttgttc ccacagcctg aggaggagca
     1081 gcagggcatt aggaattagg gcttattttt gtctgtgttc tcttgctgtg aaaagacgcc
     1141 aagaccatgg caactcataa aagaaagtgt ttaagggtgg ctggcttaca gtttcagagg
     1201 ttcagtccat catcatcatg gcagggagca tggcggcctg caggcagtca tggtgctgaa
     1261 gaagaagcag agagttctac atctagatct acaggaagca ggaagagaaa gctactcggc
     1321 cttgcttgga cttttgaaaa cctcaaagcc cacctccagt gacacagcct ccaacaaggc
     1381 cacaccttct aatcctttca aatagtgcca ctccctaagc atttatatat gttaacttga
     1441 ggggggggca ttcttaatca aaccaccaca ttccgtccca ggcctcatag gccctgtagc
     1501 catattataa tgcaaaatgc attcagtcca agttcaaaag tttccgtagt ctatcagtct
     1561 gaagactgct taaaagttta aagtgtaaag tctcttctga ggctcactgt aaaatcaaaa
//
