LOCUS       NM_016805               5281 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus heterogeneous nuclear ribonucleoprotein U (Hnrnpu),
            transcript variant 1, mRNA.
ACCESSION   NM_016805 XM_975248
VERSION     NM_016805.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5281)
  AUTHORS   Hong,S.P., Batzorig,U., Fernandez-Mendez,C., Chen,Y., Liu,Y.,
            Mahapatra,S. and Sen,G.L.
  TITLE     Hnrnpu Is Essential for Proper Murine Skin Development
  JOURNAL   J Invest Dermatol (2024) In press
   PUBMED   39393506
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 5281)
  AUTHORS   Lee,E.J., Charles,J.F., Sinha,I. and Neppl,R.L.
  TITLE     Loss of HNRNPU in Skeletal Muscle Increases Intramuscular
            Infiltration of Ly6C Positive Cells, leading to Muscle Atrophy
            through Activation of NF-kappaB Signaling
  JOURNAL   Adv Biol (Weinh) 8 (7), e2400152 (2024)
   PUBMED   38797891
  REMARK    GeneRIF: Loss of HNRNPU in Skeletal Muscle Increases Intramuscular
            Infiltration of Ly6C Positive Cells, leading to Muscle Atrophy
            through Activation of NF-kappaB Signaling.
REFERENCE   3  (bases 1 to 5281)
  AUTHORS   Wen,Y., Zhou,S., Gui,Y., Li,Z., Yin,L., Xu,W., Feng,S., Ma,X.,
            Gan,S., Xiong,M., Dong,J., Cheng,K., Wang,X. and Yuan,S.
  TITLE     hnRNPU is required for spermatogonial stem cell pool establishment
            in mice
  JOURNAL   Cell Rep 43 (4), 114113 (2024)
   PUBMED   38625792
  REMARK    GeneRIF: hnRNPU is required for spermatogonial stem cell pool
            establishment in mice.
REFERENCE   4  (bases 1 to 5281)
  AUTHORS   Wang,X., Xu,J., Li,Q., Zhang,Y., Lin,Z., Zhai,X., Wang,F.,
            Huang,J., Gao,Q., Wen,J., Li,L., Feng,Y., Luo,H., Li,Q., Liu,X.,
            Li,J., Zhao,F., Zhang,L., Niu,T., Sun,C. and Zheng,Y.
  TITLE     RNA-binding protein hnRNPU regulates multiple myeloma resistance to
            selinexor
  JOURNAL   Cancer Lett 580, 216486 (2024)
   PUBMED   37984724
  REMARK    GeneRIF: RNA-binding protein hnRNPU regulates multiple myeloma
            resistance to selinexor.
REFERENCE   5  (bases 1 to 5281)
  AUTHORS   Wen,X., Fang,G., Li,H., Jiang,Z., Du,X., Liao,Z., Liu,R., Huang,G.,
            Meng,F., Liao,W. and Zhang,Z.
  TITLE     CircIRAK3 exerts negative feedback regulation on inflammation by
            binding to HNRNP U and destabilizing proinflammatory cytokine mRNA
            in osteoarthritis and chondrogenesis
  JOURNAL   Int J Biol Macromol 256 (Pt 2), 128453 (2024)
   PUBMED   38016613
  REMARK    GeneRIF: CircIRAK3 exerts negative feedback regulation on
            inflammation by binding to HNRNP U and destabilizing
            proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis.
REFERENCE   6  (bases 1 to 5281)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   7  (bases 1 to 5281)
  AUTHORS   Tamaru,T., Isojima,Y., Nagai,K. and Takamatsu,K.
  TITLE     Circadian expression of hnRNP U, a nuclear multi-potent regulatory
            protein, in the murine suprachiasmatic nucleus
  JOURNAL   Neurosci Lett 341 (2), 111-114 (2003)
   PUBMED   12686378
  REMARK    GeneRIF: hnRNP U participates in nuclear regulatory events that are
            involved in mammalian central and peripheral circadian clocks.
REFERENCE   8  (bases 1 to 5281)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5281)
  AUTHORS   Davis,M., Hatzubai,A., Andersen,J.S., Ben-Shushan,E., Fisher,G.Z.,
            Yaron,A., Bauskin,A., Mercurio,F., Mann,M. and Ben-Neriah,Y.
  TITLE     Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase
            by hnRNP-U
  JOURNAL   Genes Dev 16 (4), 439-451 (2002)
   PUBMED   11850407
  REMARK    GeneRIF: hnRNP-U engages a highly neddylated active SCF beta-TrCP
            which dissociates in the presence of a high-affinity substrate,
            resulting in the ubiquitination of the latter.
REFERENCE   10 (bases 1 to 5281)
  AUTHORS   von Melchner,H., DeGregori,J.V., Rayburn,H., Reddy,S., Friedel,C.
            and Ruley,H.E.
  TITLE     Selective disruption of genes expressed in totipotent embryonal
            stem cells
  JOURNAL   Genes Dev 6 (6), 919-927 (1992)
   PUBMED   1317320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY766801.1, AK145499.1, AC166710.7, CX567350.1, AK049600.1 and
            AW123430.1.
            
            On Sep 26, 2017 this sequence version replaced NM_016805.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165844.1, AK159614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BY766801.1         2-29
            29-1424             AK145499.1         1-1396
            1425-1425           AC166710.7         143819-143819       c
            1426-2799           AK145499.1         1398-2771
            2800-3433           CX567350.1         146-779
            3434-3964           AK049600.1         425-955
            3965-3965           AC166710.7         139521-139521       c
            3966-4840           AK049600.1         956-1830
            4841-5281           AW123430.1         1-441               c
FEATURES             Location/Qualifiers
     source          1..5281
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 83.16 cM"
     gene            1..5281
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /note="heterogeneous nuclear ribonucleoprotein U"
                     /db_xref="GeneID:51810"
                     /db_xref="MGI:MGI:1858195"
     exon            1..863
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            864..975
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1049
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1189
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1289
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1402
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1666
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1786
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1915
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2084
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2339
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2521
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2593
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..5267
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2947..2952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /note="hexamer: AGTAAA"
     polyA_site      2965
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /note="major polyA site"
     regulatory      3413..3418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /note="hexamer: ATTAAA"
     polyA_site      3433
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
     regulatory      3683..3688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /note="hexamer: AATAAA"
     polyA_site      3702
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
     regulatory      3868..3873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /note="hexamer: TATAAA"
     polyA_site      3902
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
     regulatory      5241..5246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
                     /note="hexamer: ATTAAA"
     polyA_site      5267
                     /gene="Hnrnpu"
                     /gene_synonym="hnRNP U; Hnrpu; SAFA; Sp120"
ORIGIN      
        1 atattacgtg cgcggcgccg cccctgcgag aggacgttgc gtgctcgctc gcgccgggcg
       61 agtctccgcg tcttgcctcg cgaactcggt gaaaggaatt ggcgccgttc gacaccaggc
      121 gggtccgttc tgcagcagca ctcagccatc tccagccgca gccgccgccc gggccgacca
      181 gcagcagccg ccgccgccac aggccgaggg agccagcagt cagcggggaa ccggggccct
      241 caacatgagt tcttcgcctg ttaatgtcaa gaagctgaag gtgtcggagc tgaaggagga
      301 gctcaagaag cggcgcctct ccgacaaggg cctcaaggcc gatctcatgg atcgactcca
      361 ggccgcgctg gacaacgagg caggaggccg ccccgccatg gagcccggga acggcagtct
      421 cgacctaggt ggcgatgcgg ccgggcgctc gggagcgggc ctagagcagg aggccgcggc
      481 tggcgccgaa gacgacgagg aggaggaggg catcgccgct ctggacggcg accagatgga
      541 gctgggcgag gagaacgggg cggcgggggc ggctgacgcc ggcgcgatgg aggaagagga
      601 ggcagcgtcg gaagacgaga acggcgacga ccagggcttc caggaggggg aagacgagct
      661 cggcgacgag gaggagggcg cgggcgacga gaacggtcac ggggagcagc agtcccaacc
      721 gccggcagcg gcggcgcagc agcagccttc ccagcagcgt ggtgccggca aggaggccgc
      781 gggcaagagc agcggcccca cctcgctctt cgcggtgacg gtggcgccgc caggggcgag
      841 gcagggccaa cagcaggcgg gaggagacgg caaaacagaa cagaaaggtg gagataaaaa
      901 gagaggcgtt aaaagaccgc gagaagatca tggccgaggg tattttgagt acatcgaaga
      961 aaacaagtac agcagagcca agtctcctca gccacctgtt gaagaagaag acgaacactt
     1021 cgatgacaca gtggtttgtc ttgatactta taattgtgat ctgcatttta aaatctcgag
     1081 agaccgtctg agtgcttctt cccttactat ggagagtttt gctttcctgt gggctggagg
     1141 aagagcttcc tacggtgtgt caaaaggcaa agtctgcttt gagatgaagg taacagagaa
     1201 gattccagta agacacttat atacaaaaga tattgatata catgaagttc ggattggctg
     1261 gtcactaacc acaagtggaa tgttgcttgg tgaagaagaa ttttcttacg ggtattctct
     1321 gaaaggaata aaaacatgca actgtgagac agaagattat ggggagaagt ttgatgaaaa
     1381 tgatgtgatt acatgctttg ctaactttga aactgatgaa gttgaactct cttatgcgaa
     1441 gaatggacaa gatcttggtg ttgcctttaa gatcagtaag gaagttcttg ctgaccggcc
     1501 actattccca catgttctct gccataactg tgcagttgaa tttaatttcg gtcaaaagga
     1561 aaagccatac tttccaatac ctgaagactg tacttttatc caaaatgtcc ccttagagga
     1621 ccgagttaga ggaccaaaag gacctgaaga gaagaaggat tgtgaggttg taatgatgat
     1681 tggcttgcca ggagctggaa aaactacctg ggttactaaa catgcagctg aaaaccctgg
     1741 gaaatacaac attcttggaa caaatacgat tatggacaag atgatggtgg caggttttaa
     1801 gaagcaaatg gcagatactg gaaaactgaa cacactgttg cagagagccc cacagtgtct
     1861 tggcaagttt attgaaattg ctgcccgtaa gaagcgaaat tttattctgg atcagacaaa
     1921 tgtgtctgct gctgcccaga gaagaaaaat gtgcctgttt gcaggcttcc agcggaaagc
     1981 tgttgtagtg tgcccaaaag atgaagacta taagcagagg acacagaaga aggcagaagt
     2041 agaggggaag gacctaccag aacatgctgt cctcaagatg aaaggaaact tcacccttcc
     2101 agaggttgca gaatgctttg atgaaataac ctatgttgaa cttcagaaag aggaagccca
     2161 aaagcttttg gagcaatata aagaagaaag caaaaaggca ctgccaccag aaaagaagca
     2221 aaacactggc tcaaagaaaa gcaataagaa taagagtggc aagaaccagt tcaacagagg
     2281 tggtggccat agaggccgtg gaggattcaa tatgcgaggt ggcaatttca gaggaggagc
     2341 tcctgggaat cgtggtggat ataataggag aggcaacatg ccacagagag gtggtggcgg
     2401 tggaagtggt ggaattggct atccataccc acgtggccct gtttttcctg gccgaggtgg
     2461 ttactcaaac agagggaatt acaacagagg tggaatgccc aacagaggga actataacca
     2521 gaacttcaga ggacgaggaa ataatcgtgg ctacaaaaat caatctcagg gctacaatca
     2581 gtggcagcag ggtcaattct ggggtcagaa gccatggagt cagcattatc accaaggata
     2641 ttattgaata cccaaataaa acgaactgat acatatttct ccaaaacctt cacaagaagt
     2701 cgactgtttt ctttagtagg ctaacttttt aaacattcca caagaggaag tgcctgcggg
     2761 ttcctttttt agaagctttg tgggttgatt tttttttttt tcttttcttt tttgtacatt
     2821 tttaattgca gttttaaagt gaatcgtaag agaacctcag cattgtgcac gataagagaa
     2881 tgtgtcagta tttcagggtt ctacatttta tctgtaaaat gtgacttttt tttttatcac
     2941 aacaaaagta aaatgttgct ttgtacctgg tgtcttttat taagcattta ctcccccatt
     3001 tctcacagag aataacagtc gggagtcatt gtcacaataa aatagcaatg ttagcagcca
     3061 gattcatgga aggactaagg ggtcctcatg aattgcatta agattctgta ctgctcatga
     3121 tacactccat cctctctaga ctgcctgccg ggtaatagtg gacgggtaat ctctgacaaa
     3181 acgggaaggc tatttttttt ctgtttgaca atggaattgg cataattggg aatgaagata
     3241 aaatttggaa ccaagattga gaagatggag tgtatgtaga agggctgttc aaaaatgtaa
     3301 acttggttgc attatatgtg gaggctcaaa cttgtgaagg ttaaatacca taaaattttc
     3361 catttgttct gcattttgat tctgaaaaga aagctggctt tgcccatttc ttattaaaaa
     3421 aacttgttgt aaatccagtt gtctaatggg atctatatga agttagctat gtctgtatgc
     3481 ccttctccca caaatactgt attactagtg tgcttgtagt agttaactcc accatctttg
     3541 taagctaatg aaattgtgag tcacccattt atatcttaat ttttaatcat gtcagttctt
     3601 gaatgggtat ctccttagcc tgctgatttc tttttctttc taaagaaagt gggtggagaa
     3661 attaatttag acgtttgttt gcaataaaaa gaattcattt tactcttgtt tgggattctc
     3721 gccatcaagg tctaaatccc tttatagtat gactcccaag aggagaaact ttaagtgtgt
     3781 gctttctgga cagcttattc tttactctgt acttcggaac atttaggttt taaaaactta
     3841 aatgtatact gatgattgat tttataatat aaagttgaat tcttcccttc ccctcccccc
     3901 aagactgctt ttaacattta tgaggggcaa aggtactggc tgggagaagt taatgttcag
     3961 ttgaccatgt ttatgaaatg tgagtggctg tcctcacctg ataatagaca tataatacat
     4021 gaaactttgg gaacagatgc ttttagaagc catcatgcaa gccagtcatt gatttcacta
     4081 ctacacaatg ctgctaactt aactagctat gtgataaatt agatccccta attgtaattt
     4141 tattgggttt gcacagaaca cttaaatctt gtaaaggagc ctcactgtgt gaagtgagga
     4201 atcaggagtc aaactgtaga actaaaatta gaatttagtc tagttgttag tgtttatagc
     4261 ctgcttctgg taagttcagg ttttcctgta ttattaattg ctgtagaact ttgttttaaa
     4321 tcagattttt tttttaatac tttattatac tctaggaatt actacaggct agtttctgca
     4381 atcaggttgc ctcagaaata acactacaaa gtagtatctt ctcggcttag ttaactgcta
     4441 taaaccattg gtatgagtat ctgccctaca tacgtaacat tatgattata tattcctaac
     4501 tctgggagta attcagttca gtggttatcc taatatttta atctgtgcct ttcaaaaatc
     4561 ttgtatagac ctagtactag agacgcatgg ctacaaaaaa gggtcaaatg acaaagtaga
     4621 acatgataca tgcattgcct gaaaaattgg atgggaggga aagcttgcta tctgaagtga
     4681 tctcactagt tacatctgta catgaaagtt ttctttaatg gaaaagaggc aatccattca
     4741 gagggggaaa aatggcttaa gtttttgaaa gaatcccaaa tattgatagg atcagaattg
     4801 acttgataat caagctgggc atgacaacac aggggctttt aaaaaagata caagctggag
     4861 ggcagcctgg gctatattct atattgtgag gtgttctctc tgtaattaag taccagcaga
     4921 gccaaaagct ggggaaggtg gctgccattg tagatcagtg gtagagcact tattatcagc
     4981 acctaagagg taataaatta gttaactttg ttactgagaa aatggtgtag attaatagta
     5041 gcaaagaggc gttctcacta atgtctatag actattttaa tggcaaatat tttaatcaca
     5101 tttcaatggc attttaggta gtatgcactt gggtgtgaaa gactagttct gtgtacatca
     5161 atgtgaatat aattgatttt tttaaaatgt agaataagct taaactaatt tcttttttac
     5221 ataaatgtaa tatatttttt attaaagtga acaaaatttg tagcagaaaa aaaaaaaaaa
     5281 a
//
