LOCUS       NM_001277121            8022 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus heterogeneous nuclear ribonucleoprotein R (Hnrnpr),
            transcript variant 2, mRNA.
ACCESSION   NM_001277121
VERSION     NM_001277121.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8022)
  AUTHORS   Zare,A., Salehi,S., Bader,J., Schneider,C., Fischer,U., Veh,A.,
            Arampatzi,P., Mann,M., Briese,M. and Sendtner,M.
  TITLE     hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal
            protein synthesis
  JOURNAL   Nat Commun 15 (1), 7430 (2024)
   PUBMED   39198412
  REMARK    GeneRIF: hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates
            axonal protein synthesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8022)
  AUTHORS   Salehi,S., Zare,A., Prezza,G., Bader,J., Schneider,C., Fischer,U.,
            Meissner,F., Mann,M., Briese,M. and Sendtner,M.
  TITLE     Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal
            localization and translation of Hnrnpr
  JOURNAL   Nat Commun 14 (1), 4158 (2023)
   PUBMED   37438340
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8022)
  AUTHORS   Ghanawi,H., Hennlein,L., Zare,A., Bader,J., Salehi,S., Hornburg,D.,
            Ji,C., Sivadasan,R., Drepper,C., Meissner,F., Mann,M., Jablonka,S.,
            Briese,M. and Sendtner,M.
  TITLE     Loss of full-length hnRNP R isoform impairs DNA damage response in
            motoneurons by inhibiting Yb1 recruitment to chromatin
  JOURNAL   Nucleic Acids Res 49 (21), 12284-12305 (2021)
   PUBMED   34850154
  REMARK    GeneRIF: Loss of full-length hnRNP R isoform impairs DNA damage
            response in motoneurons by inhibiting Yb1 recruitment to chromatin.
REFERENCE   4  (bases 1 to 8022)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8022)
  AUTHORS   Briese,M., Saal-Bauernschubert,L., Ji,C., Moradi,M., Ghanawi,H.,
            Uhl,M., Appenzeller,S., Backofen,R. and Sendtner,M.
  TITLE     hnRNP R and its main interactor, the noncoding RNA 7SK, coregulate
            the axonal transcriptome of motoneurons
  JOURNAL   Proc Natl Acad Sci U S A 115 (12), E2859-E2868 (2018)
   PUBMED   29507242
  REMARK    GeneRIF: HnRNP R shapes the axonal transcriptome and its activity
            toward RNA localization is intricately linked to its main binding
            partner, noncoding RNA 7SK.
REFERENCE   6  (bases 1 to 8022)
  AUTHORS   Gabanella,F., Carissimi,C., Usiello,A. and Pellizzoni,L.
  TITLE     The activity of the spinal muscular atrophy protein is regulated
            during development and cellular differentiation
  JOURNAL   Hum Mol Genet 14 (23), 3629-3642 (2005)
   PUBMED   16236758
REFERENCE   7  (bases 1 to 8022)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   8  (bases 1 to 8022)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8022)
  AUTHORS   Rossoll,W., Kroning,A.K., Ohndorf,U.M., Steegborn,C., Jablonka,S.
            and Sendtner,M.
  TITLE     Specific interaction of Smn, the spinal muscular atrophy
            determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role
            for Smn in RNA processing in motor axons?
  JOURNAL   Hum Mol Genet 11 (1), 93-105 (2002)
   PUBMED   11773003
REFERENCE   10 (bases 1 to 8022)
  AUTHORS   Mizutani,A., Fukuda,M., Ibata,K., Shiraishi,Y. and Mikoshiba,K.
  TITLE     SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear
            ribonucleoprotein R, interacts with ubiquitous synaptotagmin
            isoforms
  JOURNAL   J Biol Chem 275 (13), 9823-9831 (2000)
   PUBMED   10734137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935264.12, AK152039.1, BX537311.3, AK138916.1, AL670673.15 and
            AW060625.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 5' UTR, compared to variant 1. Variants 1, 2 and 6 encode
            the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662774.4464454.1, AK152039.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL935264.12        204983-205008
            27-1077             AK152039.1         2-1052
            1078-1078           AL935264.12        226548-226548
            1079-1483           AK152039.1         1054-1458
            1484-3124           BX537311.3         4611-6251
            3125-4996           AK138916.1         1-1872
            4997-7727           AL670673.15        6130-8860
            7728-8022           AW060625.1         1-295               c
FEATURES             Location/Qualifiers
     source          1..8022
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.4 cM"
     gene            1..8022
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /note="heterogeneous nuclear ribonucleoprotein R"
                     /db_xref="GeneID:74326"
                     /db_xref="MGI:MGI:1891692"
     exon            1..148
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            149..314
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2056
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein R
                     isoform a"
                     /protein_id="NP_001264050.1"
                     /db_xref="CCDS:CCDS18805.1"
                     /db_xref="GeneID:74326"
                     /db_xref="MGI:MGI:1891692"
                     /translation="MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAE
                     RLDEIFQTGLVAYVDLDERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVM
                     KTYRQREKQGSKVQESTKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQ
                     PGIGTEVFVGKIPRDLYEDELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEA
                     AQEAVKLCDSYEIRPGKHLGVCISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDV
                     ILYHQPDDKKKNRGFCFLEYEDHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDP
                     EVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMD
                     EMNGKEIEGEEIEIVLAKPPDKKRKERQAARQASRSTAYEDYYYHPPPRMPPPMRGRG
                     RGGRGGYGYPPDYYGYEDYYDDYYGYDYHDYRGGYEDPYYGYDDGYAVRGRGGGRGGR
                     GAPPPPRGRGAPPPRGRAGYSQRGAPLGPPRGSRGGRGGPAQQQRGRGSRGARGNRGG
                     NVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIAQQPLQQGGDYSGNYGYNNDNQEFYQ
                     DTYGQQWK"
     exon            315..433
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            434..541
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            542..655
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            656..832
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            833..968
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1174
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1324
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1446
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..8009
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2679..2684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /note="hexamer: AATAAA"
     polyA_site      2706
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /note="major polyA site"
     polyA_site      2725
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
     regulatory      3533..3538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /note="hexamer: ATTAAA"
     polyA_site      3556
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
     regulatory      7987..7992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
                     /note="hexamer: AATAAA"
     polyA_site      8009
                     /gene="Hnrnpr"
                     /gene_synonym="2610003J05Rik; 2610528B01Rik; Hnrpr"
ORIGIN      
        1 agttccggga aaccccgcgt gctgccggga tcgcgtctcg gtccatgcga gggggggagg
       61 gggtggcgcg cgcgccattt cttgtcgttt tcaaagcgcc tcgcgctgct tctcacgggc
      121 caggccgcca gcccccagct ctgccctgca taataaaatg gctaatcagg tgaatggtaa
      181 tgcggtacag ttaaaagaag aggaagaacc aatggatact tccagtgtaa ctcacacaga
      241 acactacaag acactgatag aggcaggcct cccacagaag gtggcagaaa gacttgatga
      301 aatatttcag acaggattgg tagcttatgt ggatcttgat gaaagagcaa tcgatgctct
      361 cagggagttt aatgaggaag gagctctgtc tgtactgcag cagttcaaag aaagtgacct
      421 gtctcatgtc cagaacaaaa gtgcattttt atgtggagtt atgaagacct acaggcaaag
      481 agagaaacaa ggcagcaagg tacaagagtc cacgaaaggg cccgatgaag caaaaatcaa
      541 ggccttgctt gagaggactg gttatacttt ggatgtgacc acgggacaga ggaagtatgg
      601 cggtccccca ccagacagtg tgtactcggg tgtgcagcct gggattggga cagaggtctt
      661 cgtaggtaaa atcccaagag acttgtatga ggatgaattg gtgccccttt ttgagaaggc
      721 tggtcctatc tgggatctac ggctcatgat ggatccactc tctggtcaga acagaggcta
      781 tgcattcatc accttctgtg gaaaagaagc tgcgcaggaa gcagttaagc tgtgtgacag
      841 ctatgagatt cgccctggta aacacctggg agtgtgcatt tctgtggcaa acaacagact
      901 ttttgttgga tccattccaa agaataaaac taaagagaac attctggaag agttcagtaa
      961 agtcacagag ggtttggtgg acgttattct ctatcatcaa cccgatgaca aaaagaagaa
     1021 tcgggggttc tgcttccttg aatatgagga tcacaagtca gcagcacaag ccagacgccg
     1081 gctgatgagt ggaaaagtca aagtgtgggg aaatgtggtt acagtagagt gggctgaccc
     1141 cgtggaggag ccggatccag aagtcatggc aaaggtaaaa gttttatttg tgagaaactt
     1201 ggcaactacg gtgacagaag aaatattaga gaagtcattt tctgagtttg gaaaactgga
     1261 gcgagtgaag aagttgaagg attatgcgtt cgttcatttt gaggacaggg gagctgctgt
     1321 taaggctatg gatgaaatga atggaaaaga aatagaaggg gaagaaattg aaattgtctt
     1381 agctaagcca ccagacaaga aaaggaaaga gcgccaagct gctagacagg cctccagaag
     1441 cactgcgtat gaagattatt attatcaccc tcctccccga atgccacctc caatgagagg
     1501 ccgaggtcgt ggagggagag gtggatatgg ctaccctcca gattattatg gctatgaaga
     1561 ctactatgat gattactatg gttatgatta tcacgactat cgtggaggct atgaagatcc
     1621 ctactacggc tatgatgatg gctatgcagt aagaggaaga ggaggaggaa ggggggggcg
     1681 aggtgctcca ccaccaccaa gggggcgggg agcaccacct ccaagaggta gagctggcta
     1741 ttcacagagg ggggcacctt tgggaccacc aagaggctca aggggtggca gagggggtcc
     1801 tgcacaacag cagagaggcc gtggttctcg tggagctcgg ggcaatcgag ggggcaatgt
     1861 aggaggcaag agaaaggcag atgggtacaa ccaacctgat tccaaacgtc gtcagaccaa
     1921 caaccaacag aactggggtt cccaacccat cgctcagcag ccgcttcagc aaggtggtga
     1981 ctattctggt aactatggtt acaataatga caaccaagaa ttttatcagg atacttatgg
     2041 gcaacagtgg aaatagacaa gtgagggctt gaaaacgatt ctgtcaagat ccaattggct
     2101 ctagatctac attcttcaaa caaaattggc gtaactgttt catctttaag tagcagtttg
     2161 ctgccatttg tattcagctg aagaagtcac tattgtgtat atactcaagg cttcttattt
     2221 ttcttctttt ctaaatgctc ttggacatta ttgggcttgc agagttccct tattctgggg
     2281 ctacaatgct tttatcgttc caagcttcat cttagcttca gaacaaactg ttaaatcatg
     2341 attttgcaga acctttggtt tggacagttc tgttcttttg gatttggaat agattacata
     2401 ggagtatgaa gtatgctgta aataaaagta caagccagtg ctttgtctta gtagttttaa
     2461 gaaattaaag caaacagact taagtttcct tgtattgaag ataacctatg actgtatgtt
     2521 ttgcattcct agaagcaggt taactgtgtt tttaaattgt tataaccaca cctttttgaa
     2581 atctgcccta caaaatttgt ttggcttaaa cgtcaaagcc gtgacaattt gttctttgat
     2641 gtgattgtat ttccaatttc ttgttcatgt aagatttcaa taaaactcaa aaatctattc
     2701 aaaacatcac ctatttcaaa ttcaattgtg tctaaaacat tactttattc gtaatccttg
     2761 aaggaatact gttttcaaag tagaactgcc tatgtgagtg atcaaattca tgaaaaattt
     2821 ctcgtctatt ccatcatgta ttgtggatat tagatttgag gattattcta aattcacata
     2881 ttccaaatac catttcattg attggtgttc tttcataatc tcttctaatt ttgaaatttt
     2941 atccttaaaa gaaaacaaac agactccaat gtttttgaac aggtattgga tcatttttat
     3001 taaagcaaaa tggagctggg gaagcgcact gcagtttgtt ttgacccaca ttctttcaaa
     3061 tcaaggacaa tttgtgactg aagaccttat ttgctggata aaaaattaca catacagaga
     3121 aaacttagta ttgtgatgtc atttgcactg tgaactaaag tcatttttag tgttcatgat
     3181 gagcacccct attttactgg tttaggactg tgattcccat cgctgtgtaa acttgctttg
     3241 ggaagcagcc atgctttaga agagacttaa atatcaagtg gttatgtctc tggctttctg
     3301 ataagacctt taattttttt accatgtcta ctgacttcag ttttgttcca atttattcta
     3361 atgactttgc taaatgaaaa gagcagaaga atgtaaactt tcattttgaa attttttccc
     3421 cccgtttggt gctgggaatt gaaaccagga cctgcgcaca tgctaccgtt gagttgtatc
     3481 actaacccct ctaaaatgtt ttacattata aagcataagc cactggggga taattaaaat
     3541 ggactccctt gttttacgct ctgttcctgt ttggtgtctt ttgtgatcac agtttcaggt
     3601 ttcagaatca taagccatcc acttcttgtc cgcacagtca atcacgtttc cagtctcatg
     3661 acttcatttt gagctttaac atttgctgat gaaagccaaa taccacattt ctttttcaaa
     3721 gtttattcat acagtatagt agtttaacag gctttattaa attttattct atagaagttg
     3781 ataaaggaat catgtggcct gttgtagtta tgttagcatg ggtgttagta aggtttagat
     3841 tatagtcttt ttaagttttt ctaatgcccg tatataaaaa taaagagagc agacagacac
     3901 tctaactgct gcttttaaac ttataataat ttgaggcctt gagtataaat tagacttaaa
     3961 gaattaattt tttcttggaa agaaaaacat aactaaaagt tttatttttt ttccccctaa
     4021 atacatgttt tgggctagca agatttccca gcaagtgctg ccaaacctga ctatgatccc
     4081 cagacccact cggtggaagg agtcacagtt gtgttgtagc acacttgtgg aagtcagagg
     4141 atatgtttca cacatacaca attaatcgat taaaaacatt ttaattagat gtttgtcata
     4201 aagaagatta tgaaaggaaa tagaaatgat ctgaaaatgc aatttattgc acttctgcca
     4261 ataaccctaa aatataaact agtaaaacct caagttccat ttcaaaatcc tttcattgta
     4321 tagtctattt caagttttaa gtgggcactt cctattctgt tcctctcact aaagatatat
     4381 ctgcagagat ttcctttaat ctttgcttta taagttttta cttagttaaa agtcagtgac
     4441 cctatataaa atttcccttt agagctttcc ctttttgatg tcatgtgagt cattgcttgt
     4501 agtatcgaga aaaagataac cccggtgctc agcttctcgt agacagtgaa cgaatgtcaa
     4561 tcaaggagag gcgcacattc attcacagta gggagggttt ggtcttttaa gtgactaggc
     4621 acagattagg agttctgagg ggcttgactt cctatcctac cttgccatct ttttttctcc
     4681 ccacccaatt tagttgatga gactttattt atgagcctgt cagattaaat gagtgttggg
     4741 aagtaatacc tatattgagg tagacctctc tgtaggtatc ctcctgacat taacaagtat
     4801 attccttccc cataatggaa tgcaaatttt tatttgatca ctcatttata gcagttgttt
     4861 aaatgtgtat atttatatga aggtgttcta attaaaaaca aaaaagttct aataagttgc
     4921 cagattccta attaaatttg agttttacct gatcaaaaga taaggaaaaa tgagttttgg
     4981 ttttaaaagt tcctttaaaa aaaaaaaaag tagagcagaa ttgtttttca tttttcttag
     5041 ttcctgggat tattctgcag aagaaagccc agtgctttct cctagttaga tgatttttct
     5101 cattgacttt ggtataggat gtgaaccctc ttacataaat tctgtacaga agagaaaggg
     5161 cataaaattt cactcctatc ataaagcctt ataaaagtat tcttgaaact cattacatca
     5221 tttgcctcct actcatttaa atataatcat acctatgttt tattaattgt gtattatttg
     5281 taaaaccagt cccttccagt aaatacttgc tataaggcta gtccttgttt gtaaatttga
     5341 tttgtaaatt tgctaaaagt ttgcctttca gagacagtct tactgtcctg agctgttgtc
     5401 aggcagtcag ttgtgcttac tgtttccgct attctgacga tttggaatct cctaagtgag
     5461 cagtgaagag aaagccttat agaaagactg cactggacct agaaatgtgt ttgtttctct
     5521 gaaatggagc ttctgttaac ttaggggtag agtgctggta gagccagtgg attccatgac
     5581 taactgcaaa gtcctcgaac caaacgtgtt tacttctgca ttacaagttt gtagatcagg
     5641 tcttactttt gaaacccaaa cccaaagctt tcaaatatta actcacttaa tatattggtc
     5701 aataatttaa tattaatatt taaagtagtt actggtactg tttctagaaa tatttttctt
     5761 ttaaaaatac atgtttatat gtgtgtgtgt atatatatat ataaatatat tcattactat
     5821 tgttattact ttgaggttac cagaagctct ggttttgctt tggttttgct tttttatcat
     5881 tttcagacgt tgtccagaaa tctgcaagtg ttctcttcct gttttaactc cttcctttta
     5941 tcacctgact atcagggaag cgaggttgag gctgccctgc cctgacatgt catgatgtcg
     6001 acttgctagg tggggttcgc tggggaccat aaccagtgga attgttggta agaacttttt
     6061 ttttctattt ctttttcttt ctgtttttct gtttttattt ttgtttttgt ttttagttta
     6121 tttacaagtg ggacattagt tgtgggaaaa tgttgcccat tatcttgtaa gcaggaaatt
     6181 atgttggctt taaggaaaaa taagtgtcta agtagaattt gtattctcaa caggaacata
     6241 taataaatac ctaactcatt ttcaaattag tagatcagca gaatattaag atatgaaatt
     6301 ttccagttac aatttatcaa accatacctt acaatctaga atatctgttg aagcaataat
     6361 gatattttac tgtgatttta gtctctctgg tatcatctat tacattttta taggatatta
     6421 gtgtataagt attttaagag atttattgta cactaatgtt taatgaaaat gagaaggtat
     6481 tgcctagatt ggagggttta aatagtatat atatttttta attctataaa attttaatat
     6541 tgcaaaatta aacttgagaa ttctggcagt ttaataaaat agtagtattg gttttaaaga
     6601 tccgtttata tagtaactta ggatccagag gaagtttacg tggctgcagt cttgagacct
     6661 agagcataag tagaaacaaa ggtggggctg aggacgtggg ttagtgagag cttgtattta
     6721 acaatgttag aggcactaag ttcagtcctc agcaccccgt actaggtaaa aataaaacaa
     6781 ttagtaaata ctgctagagt caacagtcta gattcctaga catggaaatg gtgaactaac
     6841 tgcctgaggt gtgcttacct ggaatcccag cactggggga gtatgagccc caggctggca
     6901 cacaatggaa acttgcctca aaaaagacca aggctcagga tgtagttcag tggtagagcg
     6961 cttgcctgac atacataaag ctctaggtca atgcctagta gcacaaaaaa attaaacagc
     7021 taaaaacaaa aatcctccca gcttatactc agggtatatc atgatgattg agtataaatt
     7081 gagggaaacc aatttaacaa ctaggcaaaa ataattataa tttgtgacac tgaataaaag
     7141 taattgcaag tgttgatgtt tgaagagctg cctcagtatt cttgtggacc tttgcgttct
     7201 ggtggcagtg tcagtctaga acctggtagg cattacacat gtgctagtca gcactgggac
     7261 tgacgtgctt agctcttggt gtcacagtga agtcacgtgc ttagctcttg gtgtcacagt
     7321 gaagtcgtgc agaatcacta gcagtttcag ggttgagtta aggttttgtt cctttgtcca
     7381 cattttattg tgcgtgcatc agtgccagaa aaagtgaggt gtagaacttg gttgcttgca
     7441 ctaaacagct tcttgggaat aaagttaatg gtgttaggga cattcaattt ggatgagttt
     7501 gtgtaaatta agagaaataa cagtacaatt tattaaccat atgcatttgc aacaaaatac
     7561 acttgatggg accagaaagg aagtgggcgc tatggaagaa ctcttaaatt gctccaataa
     7621 ggggcttcca gtccatgtag cagctgtgtc aggatctcag aacattactt actgtggttt
     7681 ttcacaggta aagatttggc taaagaggtg cttctggcct gctaaagaaa ataggtggaa
     7741 ttgtacttta aagagtcact gcagtattta gagttatgtt ctctggctat ttctagaatt
     7801 ggacagaaaa tgcctacaaa acactaaaaa actttctggt gtactacagt acagtaacat
     7861 gagatatatc caaattggga cagttacatg acatgtccat ttaatcattt caagaaaaac
     7921 ctgcttttgg tacagtgttc atgtaccata cctgtattgg aatatttgta tgatgttaat
     7981 atttttaata aaatttaaca tgttcaaaaa aaaaaaaaaa aa
//
