LOCUS       NM_029804               2532 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus heterogeneous nuclear ribonucleoprotein M (Hnrnpm),
            transcript variant 1, mRNA.
ACCESSION   NM_029804
VERSION     NM_029804.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2532)
  AUTHORS   Akinyemi,A.R., Li,D., Zhang,J. and Liu,Q.
  TITLE     hnRNPM deficiency leads to cognitive deficits via disrupting
            synaptic plasticity
  JOURNAL   Neurosci Lett 751, 135824 (2021)
   PUBMED   33727124
  REMARK    GeneRIF: hnRNPM deficiency leads to cognitive deficits via
            disrupting synaptic plasticity.
REFERENCE   2  (bases 1 to 2532)
  AUTHORS   West,K.O., Scott,H.M., Torres-Odio,S., West,A.P., Patrick,K.L. and
            Watson,R.O.
  TITLE     The Splicing Factor hnRNP M Is a Critical Regulator of Innate
            Immune Gene Expression in Macrophages
  JOURNAL   Cell Rep 29 (6), 1594-1609 (2019)
   PUBMED   31693898
  REMARK    GeneRIF: The Splicing Factor hnRNP M Is a Critical Regulator of
            Innate Immune Gene Expression in Macrophages.
REFERENCE   3  (bases 1 to 2532)
  AUTHORS   Liu,H.B., Muhammad,T., Guo,Y., Li,M.J., Sha,Q.Q., Zhang,C.X.,
            Liu,H., Zhao,S.G., Zhao,H., Zhang,H., Du,Y.Z., Sun,K., Liu,K.,
            Lu,G., Guo,X.J., Sha,J., Fan,H.Y., Gao,F. and Chen,Z.J.
  TITLE     RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator
            in Early Zygotic Genome Activation
  JOURNAL   Adv Sci (Weinh) 6 (15), 1900295 (2019)
   PUBMED   31406667
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2532)
  AUTHORS   Li,S., Mi,L., Yu,L., Yu,Q., Liu,T., Wang,G.X., Zhao,X.Y., Wu,J. and
            Lin,J.D.
  TITLE     Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and
            beige fat development and thermogenesis
  JOURNAL   Proc Natl Acad Sci U S A 114 (34), E7111-E7120 (2017)
   PUBMED   28784777
REFERENCE   5  (bases 1 to 2532)
  AUTHORS   Chen,W.Y., Lin,C.L., Chuang,J.H., Chiu,F.Y., Sun,Y.Y., Liang,M.C.
            and Lin,Y.
  TITLE     Heterogeneous nuclear ribonucleoprotein M associates with mTORC2
            and regulates muscle differentiation
  JOURNAL   Sci Rep 7, 41159 (2017)
   PUBMED   28106162
  REMARK    GeneRIF: Results have identified a novel Rictor associated protein,
            hnRNPM which was found to be able to affect the phosphorylation of
            SGK1 S422, a direct phosphorylation site of mTORC2. hnRNP M seem to
            mediate the SGK1 signaling that regulates muscle differentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2532)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
REFERENCE   7  (bases 1 to 2532)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   8  (bases 1 to 2532)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2532)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Large-scale screen for genes involved in gonad development
  JOURNAL   Mech Dev 98 (1-2), 51-70 (2000)
   PUBMED   11044607
REFERENCE   10 (bases 1 to 2532)
  AUTHORS   Mahe,D., Fischer,N., Decimo,D. and Fuchs,J.P.
  TITLE     Spatiotemporal regulation of hnRNP M and 2H9 gene expression during
            mouse embryonic development
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 414-424 (2000)
   PUBMED   11004512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054785.1 and AK220299.1.
            
            On Oct 12, 2007 this sequence version replaced NM_029804.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054785.1, SRR1660813.179841.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2529              BC054785.1         1403-3931
            2530-2532           AK220299.1         2373-2375
FEATURES             Location/Qualifiers
     source          1..2532
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2532
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /note="heterogeneous nuclear ribonucleoprotein M"
                     /db_xref="GeneID:76936"
                     /db_xref="MGI:MGI:1926465"
     exon            1..192
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..2269
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /note="isoform a is encoded by transcript variant 1; hnRNP
                     M"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein M
                     isoform a"
                     /protein_id="NP_084080.1"
                     /db_xref="CCDS:CCDS37570.1"
                     /db_xref="GeneID:76936"
                     /db_xref="MGI:MGI:1926465"
                     /translation="MAAGVEAAAEVAATEPKMEEESGAPCVPSGNGAPGPKGEERPTQ
                     NEKRKEKNIKRGGNRFEPYSNPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVEL
                     LMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVM
                     ATTGGMGMGPGGPGMINIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWKK
                     LKEVFSMAGVVVRADILEDKDGKSRGIGIVTFEQSIEAVQAISMFNGQLLFDRPMHVK
                     MDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLSKGIGMGNLGPAGMG
                     MEGIGFGINKIGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGGG
                     AGGSVPGIERMGPGIDRISGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMG
                     SSIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIE
                     RMGSGVERMGPAIERMGLSMDRMVPTGMGASLERMGPVMDRMATGLERMGANNLERMG
                     LERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGAGGASFDRAIEM
                     ERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYAD
                     IKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA"
     exon            193..359
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            360..412
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            413..420
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            421..514
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            515..706
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            707..860
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            861..910
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            911..971
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1073
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1118
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1196
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1250
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..2053
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2105
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2532
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2509..2514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /note="hexamer: AATAAA"
     polyA_site      2529
                     /gene="Hnrnpm"
                     /gene_synonym="2610023M21Rik; Hnrpm; mKIAA4193"
                     /note="major polyA site"
ORIGIN      
        1 ggtcgttcgg ggtcacgtga gcgcgcaggc gcagctcgac agagcccgct ccctcacaca
       61 aagcccagac gcggagaaaa tggcggcagg ggtcgaagcg gcagccgaag tggcggcgac
      121 agaacccaaa atggaggaag agagcggcgc gccctgcgtg ccgagcggca acggagctcc
      181 gggcccgaag ggtgaagaac gacctactca gaatgagaag aggaaggaga aaaacataaa
      241 aagaggaggc aatcgctttg agccatattc caacccaact aaaagataca gagccttcat
      301 tacaaatata ccttttgatg tgaaatggca gtcacttaaa gacctggtta aagaaaaagt
      361 tggtgaggta acatacgtgg agctcttaat ggacgctgaa ggaaagtcaa ggggatgtgc
      421 tgttgttgaa ttcaagatgg aggagagcat gaaaaaagct gctgaagttc taaacaagca
      481 tagtctgagt ggaaggccac tgaaagtcaa ggaagatcct gatggtgaac atgcaaggag
      541 agcaatgcaa aaggtgatgg ctacgactgg tgggatgggt atgggaccag gtggcccagg
      601 aatgattaat atcccaccca gtatcctaaa taatcctaac atcccaaatg agattatcca
      661 tgcattacag gctggaagac ttggaagcac agtatttgta gcaaatctgg attataaagt
      721 tggctggaag aaactgaagg aagtatttag tatggctggt gtggtggtcc gagcagacat
      781 tctggaagat aaagatggga aaagtcgtgg aataggcatt gtgacttttg aacagtccat
      841 tgaagctgtg caagcaatat ctatgtttaa tggccagttg ctgtttgata gaccgatgca
      901 cgtcaagatg gatgagaggg ctttaccaaa gggagacttt tttcctcctg aacgcccaca
      961 gcaacttccc catggacttg gtggtattgg catgggatta ggacctggag gtcagcctat
     1021 tgatgccaac catctgagca aaggcattgg aatgggaaac ctaggacctg cagggatggg
     1081 aatggaaggc ataggatttg gaataaataa aattggaggc atggaaggac cctttggtgg
     1141 tggtatggaa aacatgggcc gatttggatc cgggatgaac atgggccgaa taaatgaaat
     1201 cctaagtaat gcactgaaga gaggagagat cattgcaaaa cagggaggag gtggagctgg
     1261 aggcagtgtc cctgggatcg agaggatggg ccctggcatt gaccgcatta gcggtgctgg
     1321 catggagcgc atgggcgcag gcttaggcca tggcatggat cgagtgggct ctgagattga
     1381 gcgcatgggc ctggtcatgg accgcatggg ctcagttgag cgcatgggct ccagcattga
     1441 gcgcatgggc ccactaggcc ttgaccacat ggcctccagt attgagcgca tgggccagac
     1501 catggagcgc attggttctg gcgtggagcg catgggtgcc ggcatgggct tcggcctgga
     1561 gcgcatggcc gcacccattg accgtgtggg ccaaaccatt gagcgcatgg gctctggtgt
     1621 agagcgcatg ggtcctgcca ttgaacgcat gggcctaagc atggatcgga tggtgcccac
     1681 aggcatgggg gccagcctgg agcgcatggg tcctgtgatg gatcggatgg ccaccggcct
     1741 ggagcgcatg ggcgccaaca acctggagcg catgggcctg gagcgtatgg gagccaacag
     1801 tcttgagcgc atgggcctgg agcgaatggg cgccaacagc ctggaacgta tgggccctgc
     1861 catgggccca gcattgggcg ctggtattga gcgaatgggc ctggccatgg gtggagccgg
     1921 aggtgctagc tttgaccgag ccattgagat ggagcggggc aactttggag gaagcttcgc
     1981 aggttccttt ggcggagctg gaggccatgc acctggagta gccaggaagg cctgccagat
     2041 atttgtgaga aatctcccat ttgattttac atggaagatg ctaaaggaca agttcaatga
     2101 atgtggccac gtgctgtacg ccgacatcaa gatggagaac ggaaagtcca aggggtgcgg
     2161 tgtggttaag tttgagtctc cagaggtggc tgagagagcc tgccggatga tgaatggcat
     2221 gaagctgagt ggccgagaga ttgatgttcg aattgataga aatgcttaag cagttgcctt
     2281 ttttaaacat caataccaga cctctgaatt tgtatttttt cttgttaacc attttaattt
     2341 gttggctgga tgtataaaga tgtttaaaaa attcagttgc ttttttgggg taatttgaat
     2401 taatttttta atgattgggg ttccatttga ctgtttgcat tgagattgca atgtgcgcaa
     2461 ttttttttgt agttgtggca tcttgttgac atcgaatatg actttgataa taaataccag
     2521 ttcctgaaag tg
//
