LOCUS       NM_144802               3050 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus heterogeneous nuclear ribonucleoprotein L-like
            (Hnrnpll), transcript variant 1, mRNA.
ACCESSION   NM_144802
VERSION     NM_144802.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3050)
  AUTHORS   Yabas,M., Yazicioglu,Y.F., Hoyne,G.F., Goodnow,C.C. and Enders,A.
  TITLE     Loss of hnRNPLL-dependent splicing of Ptprc has no impact on B-cell
            development, activation and terminal differentiation into
            antibody-secreting cells
  JOURNAL   Immunol Cell Biol 99 (5), 532-541 (2021)
   PUBMED   33331104
  REMARK    GeneRIF: Loss of hnRNPLL-dependent splicing of Ptprc has no impact
            on B-cell development, activation and terminal differentiation into
            antibody-secreting cells.
REFERENCE   2  (bases 1 to 3050)
  AUTHORS   van den Buuse,M., Halley,P. and Hoyne,G.F.
  TITLE     Behavioural phenotyping of thunder mice with a hypomorphic mutation
            of heterogeneous nuclear ribonuclear protein L-like (hnRNPLL) and
            reduced T cell function
  JOURNAL   Neurosci Lett 740, 135469 (2021)
   PUBMED   33152455
  REMARK    GeneRIF: Behavioural phenotyping of thunder mice with a hypomorphic
            mutation of heterogeneous nuclear ribonuclear protein L-like
            (hnRNPLL) and reduced T cell function.
REFERENCE   3  (bases 1 to 3050)
  AUTHORS   Sakuma,K., Sasaki,E., Kimura,K., Komori,K., Shimizu,Y., Yatabe,Y.
            and Aoki,M.
  TITLE     HNRNPLL, a newly identified colorectal cancer metastasis
            suppressor, modulates alternative splicing of CD44 during
            epithelial-mesenchymal transition
  JOURNAL   Gut 67 (6), 1103-1111 (2018)
   PUBMED   28360095
  REMARK    GeneRIF: HNRNPLL is a novel metastasis suppressor of colorectal
            cancer, and modulates alternative splicing of CD44 during
            epithelial-mesenchymal transition.
REFERENCE   4  (bases 1 to 3050)
  AUTHORS   Peng,Y., Yuan,J., Zhang,Z. and Chang,X.
  TITLE     Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the
            RNA-binding protein hnRNPLL and thereby regulates immunoglobulin
            secretion in plasma cells
  JOURNAL   J Biol Chem 292 (29), 12285-12295 (2017)
   PUBMED   28611064
  REMARK    GeneRIF: Data suggest that hnRNPLL specifically associates with
            cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1
            promotes binding of hnRNPLL to immunoglobulin H (IgH, heavy chain)
            mRNA and regulates switching from mIgH (membrane isoform) to sIgH
            (secreted isoform) in plasma cells. (hnRNPLL = heterogeneous
            nuclear ribonucleoprotein L-like protein; PABPC1 = cytoplasmic
            poly[A]-binding protein 1)
REFERENCE   5  (bases 1 to 3050)
  AUTHORS   Yu,C., Ji,S.Y., Dang,Y.J., Sha,Q.Q., Yuan,Y.F., Zhou,J.J.,
            Yan,L.Y., Qiao,J., Tang,F. and Fan,H.Y.
  TITLE     Oocyte-expressed yes-associated protein is a key activator of the
            early zygotic genome in mouse
  JOURNAL   Cell Res 26 (3), 275-287 (2016)
   PUBMED   26902285
REFERENCE   6  (bases 1 to 3050)
  AUTHORS   Yabas,M., Godfrey,D.I., Goodnow,C.C. and Hoyne,G.F.
  TITLE     Differential requirement for the CD45 splicing regulator hnRNPLL
            for accumulation of NKT and conventional T cells
  JOURNAL   PLoS One 6 (11), e26440 (2011)
   PUBMED   22073166
  REMARK    GeneRIF: results highlight both overlapping and divergent roles for
            hnRNPLL between conventional T cells and NKT cells
REFERENCE   7  (bases 1 to 3050)
  AUTHORS   Wu,Z., Yates,A.L., Hoyne,G.F. and Goodnow,C.C.
  TITLE     Consequences of increased CD45RA and RC isoforms for TCR signaling
            and peripheral T cell deficiency resulting from heterogeneous
            nuclear ribonucleoprotein L-like mutation
  JOURNAL   J Immunol 185 (1), 231-238 (2010)
   PUBMED   20505149
  REMARK    GeneRIF: In T cells with no CD45 protein, hnRNPLL mutation
            diminishes peripheral T cell accumulation and demonstrates that
            hnRNPLL regulates T cell longevity independently from its effects
            on CD45 splicing.
REFERENCE   8  (bases 1 to 3050)
  AUTHORS   Yamamoto,M.L., Clark,T.A., Gee,S.L., Kang,J.A., Schweitzer,A.C.,
            Wickrema,A. and Conboy,J.G.
  TITLE     Alternative pre-mRNA splicing switches modulate gene expression in
            late erythropoiesis
  JOURNAL   Blood 113 (14), 3363-3370 (2009)
   PUBMED   19196664
REFERENCE   9  (bases 1 to 3050)
  AUTHORS   Wu,Z., Jia,X., de la Cruz,L., Su,X.C., Marzolf,B., Troisch,P.,
            Zak,D., Hamilton,A., Whittle,B., Yu,D., Sheahan,D., Bertram,E.,
            Aderem,A., Otting,G., Goodnow,C.C. and Hoyne,G.F.
  TITLE     Memory T cell RNA rearrangement programmed by heterogeneous nuclear
            ribonucleoprotein hnRNPLL
  JOURNAL   Immunity 29 (6), 863-875 (2008)
   PUBMED   19100700
  REMARK    GeneRIF: A single substitution in a memory-induced RNA-binding
            protein, hnRNPLL, destabilized an RNA-recognition domain that bound
            with micromolar affinity to RNA containing the Ptprc exon-silencing
            sequence.
REFERENCE   10 (bases 1 to 3050)
  AUTHORS   Borchert,A., Schnurr,K., Thiele,B.J. and Kuhn,H.
  TITLE     Cloning of the mouse phospholipid hydroperoxide glutathione
            peroxidase gene
  JOURNAL   FEBS Lett 446 (2-3), 223-227 (1999)
   PUBMED   10100845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ052186.1, AK146879.1, AV106949.2 and AK034420.1.
            
            On Mar 12, 2014 this sequence version replaced NM_144802.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012849.1, AK146879.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                CJ052186.1         1-41
            42-2192             AK146879.1         4-2154
            2193-2695           AV106949.2         525-1027
            2696-3050           AK034420.1         478-832
FEATURES             Location/Qualifiers
     source          1..3050
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.3 cM"
     gene            1..3050
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /note="heterogeneous nuclear ribonucleoprotein L-like"
                     /db_xref="GeneID:72692"
                     /db_xref="MGI:MGI:1919942"
     exon            1..612
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..2052
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein L-like"
                     /protein_id="NP_659051.3"
                     /db_xref="CCDS:CCDS70845.1"
                     /db_xref="GeneID:72692"
                     /db_xref="MGI:MGI:1919942"
                     /translation="MSSSSSSSPKEETYEEDREFESQAKRLKTEEGEIVYSAEESENR
                     QEATPQAGSDSDSGGGDGGDGDGGSGGGGDGEEGEGGEEGDEGDGDEGGSGGDEGGSG
                     GGPRSMPLSTEGGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTICYVMMMPFK
                     RQALVEFENIDSAKECVTFAADVPVYIAGQQAFFNYSTSKRITRPGNTDDPSGGNKVL
                     LLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCAQKAKAALNG
                     ADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQAILGDHPSS
                     FRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGSPSGSVVMVSGLH
                     QLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHLNNVKLFGKR
                     LNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQPPSCVLHYY
                     NVPLCVTEETFTKLCNDHEVLPFIKYKVFDAKASAKTLSGLLEWKCKTDAVEALTALN
                     HYQIRVPNGSNPYTLKLCFSTSSHL"
     exon            613..731
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     exon            732..969
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1055
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1152
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1225
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1297
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1515
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1637
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1839
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1897
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1996
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..3050
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2176..2181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /note="hexamer: AATAAA"
     polyA_site      2200
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /note="major polyA site"
     regulatory      2681..2686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /note="hexamer: TATAAA"
     polyA_site      2699
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /note="major polyA site"
     regulatory      3006..3011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /note="hexamer: ATTAAA"
     polyA_site      3025
                     /gene="Hnrnpll"
                     /gene_synonym="2510028H02Rik; 2810036L13Rik; Hnrpll"
                     /note="major polyA site"
ORIGIN      
        1 gaagaccgga agccacggcc cggccccatc cttactttcg cgtccccccc ggggctggga
       61 gccgcgaagc tggcggaggg agaggctgga ggctggctga gagataaagg gaagcgtccc
      121 ctcagcccgc gctcccttct cagtcacggg ctcctggagc gcgccgcgga ggacgccggg
      181 ccagctcaga cccgcgccga ggaggcgcag cccgcggcgg ggaccgatca gcgacatctg
      241 aggcccgtct cccgcgccgt ctccaccgcc gccgccatgt cctcctcctc ctcctcctcc
      301 cccaaggagg agacgtacga ggaggaccgg gagttcgaga gccaggccaa gcgcctcaag
      361 accgaggagg gagagatcgt ctactcggcc gaggagagcg agaatcgcca ggaagcgacg
      421 cctcaggcgg ggagcgatag cgacagcggc ggcggcgacg gaggcgacgg agacggaggc
      481 agcggcggcg gcggcgacgg cgaggaaggc gaaggtggag aagaaggcga cgaaggcgac
      541 ggcgatgagg gagggagcgg cggcgacgaa ggtggcagcg gcggtggccc tcggagcatg
      601 cccctgtcca cggagggagg tggaagtcat cataaagttt ctgtttcccc tgttgtccat
      661 gttcgagggc tctgtgaatc tgttgtggaa gctgaccttg tggaggcact ggagaaattt
      721 gggacaatat gctatgtgat gatgatgcca tttaaacgac aggctctcgt ggagtttgaa
      781 aatatagata gtgccaaaga atgtgtgaca tttgctgcag atgtgcctgt gtacattgct
      841 ggccagcagg ctttcttcaa ctattctaca agtaaaagaa tcactcggcc aggaaatacc
      901 gacgatccat cagggggcaa caaagtgctc ttgctctcta ttcagaatcc tctttaccca
      961 attacggtgg atgttctgta tactgtatgc aaccctgttg gaaaagtaca gcgtattgtt
     1021 atcttcaaga gaaatgggat acaagcaatg gttgagtttg agtcagtcct ttgcgcccag
     1081 aaggctaaag cagcactcaa tggagctgat atatatgccg gatgttgcac actaaaaatt
     1141 gaatatgcaa ggccaactcg tctaaatgtt attaggaatg acaatgacag ttgggactac
     1201 actaaacctt atttgggaag acgagataga ggaaagggtc gccagagaca agccattttg
     1261 ggagaccatc cttcttcgtt tagacatgat ggctatggat cgcatggtcc gctactgcct
     1321 ttaccaagtc gttatagaat gggctctaga gatacacctg aacttgttgc ttatccatta
     1381 ccacaagcgt cttcctctta catgcatgga ggcagtccgt ctggctccgt tgtaatggtt
     1441 agtggattac atcagctcaa aatgaattgt tcaagagtct tcaacctgtt ctgcttgtat
     1501 ggaaatattg aaaaggtaaa gtttatgaag accattcctg gcacagcact cgtagaaatg
     1561 ggtgacgagt acgctgtgga aagagctgtc acccacctta ataatgtcaa actctttggg
     1621 aaaagactta atgtttgtgt gtctaaacag cactcagttg ttcccagtca aatatttgag
     1681 ctagaggatg gtacgagcag ctacaaagat tttgcaatga gcaaaaataa tcgctttaca
     1741 agtgctggac aagcatctaa gaatataatc cagccaccgt catgtgtgct gcattattac
     1801 aatgttccgc tgtgtgtcac agaagagacc ttcacaaagt tgtgtaacga ccacgaagtt
     1861 cttccgttca tcaaatataa agtgtttgac gcgaaagctt ccgcgaaaac tctgtctggg
     1921 ctattggagt ggaagtgcaa aactgatgcc gtggaagctc tcactgcgct caatcactac
     1981 cagatacgag tcccgaatgg atccaacccc tatacgttga agctttgctt ttctacatca
     2041 tcccatttat aagaagagaa gagcatgtta gaatttatgt tcatctttat tgcagtttta
     2101 aagctatact tcatccataa taatctaaaa tggttggtct aatgttgcct tgcttactat
     2161 aagatcctgt tctgtaataa acatattttg cctcaagtaa gtttgttgtt aacttaaata
     2221 ttgttttcac cttaagatag agtaccataa tgtagactgt ctacagcttc tttgtagatt
     2281 atacaaatgt atggtttcta acattattat gaattttgtt ccatggtaaa atatatttgc
     2341 attcttaata gtaattatct gcagatgttt ttccattgtg tattagatta atgcaggtga
     2401 aagtattgca ttttaatacc gaattcctac aatagatgat tgagtctgtt acagttactc
     2461 atattaaata taatttgtat ttattattta atcaaatttg agaatgacgc tgcatatgtt
     2521 gacttcagga actacagact tagctgacgt caatctctaa aaggcttaat agacacgaac
     2581 acacttgtat ggtatgcact caaactcaga ttgctgtttc ttttaaaaag tcatcatttg
     2641 tattgacatg cttctgttcc tagttccagt ttggaggttt tataaagtta taataataag
     2701 ttaatgtgtt catcttcatt attttgcatg tgacctaatc tgaaaagtac atgtagtatt
     2761 tgacattgat attttaatac tgtagaagct aaaattaaca attcttctat ataataatct
     2821 gggttccata aatgagtttc agagaacttg tgagcccttc caaaattgtg tgtagagttt
     2881 ggaatatatg catttttatt tcttaatctt tgatccatca taatatatgt atttttctat
     2941 atggtgtaag atttaagagt taattttatt tttgatcaaa acagctattt gtctcaacac
     3001 catttattaa acattctccc tctgggtttg tttctttctc ttttaagtga
//
