LOCUS       NM_001402935            2509 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus heterogeneous nuclear ribonucleoprotein L (Hnrnpl),
            transcript variant 1, mRNA.
ACCESSION   NM_001402935 XM_006539556
VERSION     NM_001402935.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2509)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2509)
  AUTHORS   Lin,L., Zhao,J., Kubota,N., Li,Z., Lam,Y.L., Nguyen,L.P., Yang,L.,
            Pokharel,S.P., Blue,S.M., Yee,B.A., Chen,R., Yeo,G.W., Chen,C.W.,
            Chen,L. and Zheng,S.
  TITLE     Epistatic interactions between NMD and TRP53 control progenitor
            cell maintenance and brain size
  JOURNAL   Neuron 112 (13), 2157-2176 (2024)
   PUBMED   38697111
REFERENCE   3  (bases 1 to 2509)
  AUTHORS   Subramani,P.G., Fraszczak,J., Helness,A., Estall,J.L., Moroy,T. and
            Di Noia,J.M.
  TITLE     Conserved role of hnRNPL in alternative splicing of epigenetic
            modifiers enables B cell activation
  JOURNAL   EMBO Rep 25 (6), 2662-2697 (2024)
   PUBMED   38744970
  REMARK    GeneRIF: Conserved role of hnRNPL in alternative splicing of
            epigenetic modifiers enables B cell activation.
REFERENCE   4  (bases 1 to 2509)
  AUTHORS   Jiang,Z. and Jiang,Y.
  TITLE     Circular RNA CircPDS5B impairs angiogenesis following ischemic
            stroke through its interaction with hnRNPL to inactivate VEGF-A
  JOURNAL   Neurobiol Dis 181, 106080 (2023)
   PUBMED   36925052
  REMARK    GeneRIF: Circular RNA CircPDS5B impairs angiogenesis following
            ischemic stroke through its interaction with hnRNPL to inactivate
            VEGF-A.
REFERENCE   5  (bases 1 to 2509)
  AUTHORS   Mathew,V., Mei,A., Giwa,H., Cheong,A., Chander,A., Zou,A.,
            Blanton,R.M., Kashpur,O., Cui,W., Slonim,D., Mahmoud,T.,
            O'Tierney-Ginn,P., Mager,J., Draper,I. and Wallingford,M.C.
  TITLE     hnRNPL expression dynamics in the embryo and placenta
  JOURNAL   Gene Expr Patterns 48, 119319 (2023)
   PUBMED   37148985
  REMARK    GeneRIF: hnRNPL expression dynamics in the embryo and placenta.
REFERENCE   6  (bases 1 to 2509)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2509)
  AUTHORS   Soderberg,M., Raffalli-Mathieu,F. and Lang,M.A.
  TITLE     Inflammation modulates the interaction of heterogeneous nuclear
            ribonucleoprotein (hnRNP) I/polypyrimidine tract binding protein
            and hnRNP L with the 3'untranslated region of the murine inducible
            nitric-oxide synthase mRNA
  JOURNAL   Mol Pharmacol 62 (2), 423-431 (2002)
   PUBMED   12130696
  REMARK    GeneRIF: Inflammation modulates the interaction of hnRNP I and
            hnRNP L with the 3'untranslated region of the murine inducible
            nitric-oxide synthase mRNA
REFERENCE   8  (bases 1 to 2509)
  AUTHORS   Polydorides,A.D., Okano,H.J., Yang,Y.Y., Stefani,G. and
            Darnell,R.B.
  TITLE     A brain-enriched polypyrimidine tract-binding protein antagonizes
            the ability of Nova to regulate neuron-specific alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6350-6355 (2000)
   PUBMED   10829067
REFERENCE   9  (bases 1 to 2509)
  AUTHORS   Funke,B., Zuleger,B., Benavente,R., Schuster,T., Goller,M.,
            Stevenin,J. and Horak,I.
  TITLE     The mouse poly(C)-binding protein exists in multiple isoforms and
            interacts with several RNA-binding proteins
  JOURNAL   Nucleic Acids Res 24 (19), 3821-3828 (1996)
   PUBMED   8871564
REFERENCE   10 (bases 1 to 2509)
  AUTHORS   Ferreira,J. and Carmo-Fonseca,M.
  TITLE     The biogenesis of the coiled body during early mouse development
  JOURNAL   Development 121 (2), 601-612 (1995)
   PUBMED   7768196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171210.1.
            
            On Mar 23, 2022 this sequence version replaced XM_006539556.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK144684.1, SRR13948564.4438506.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC171210.1         81694-81748         c
            56-552              AC171210.1         79385-79881         c
            553-671             AC171210.1         77156-77274         c
            672-909             AC171210.1         76462-76699         c
            910-995             AC171210.1         76266-76351         c
            996-1092            AC171210.1         75358-75454         c
            1093-1165           AC171210.1         75201-75273         c
            1166-1629           AC171210.1         71629-72092         c
            1630-1751           AC171210.1         70279-70400         c
            1752-1953           AC171210.1         69807-70008         c
            1954-2011           AC171210.1         69280-69337         c
            2012-2107           AC171210.1         69066-69161         c
            2108-2509           AC171210.1         68304-68705         c
FEATURES             Location/Qualifiers
     source          1..2509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.93 cM"
     gene            1..2509
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /note="heterogeneous nuclear ribonucleoprotein L"
                     /db_xref="GeneID:15388"
                     /db_xref="MGI:MGI:104816"
     exon            1..55
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            56..552
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..2166
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /note="isoform a is encoded by transcript variant 1; hnRNP
                     L"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein L
                     isoform a"
                     /protein_id="NP_001389864.1"
                     /db_xref="GeneID:15388"
                     /db_xref="MGI:MGI:104816"
                     /translation="MSRRLLPRAEKRRRRLEQRQQPDEQLRRAGAMVKMAAAGGGGGG
                     GRYYGGGNEGGRAPKRLKTENAGDQHGGGGGGGSGAAGGGGGENYDDPHKTPASPVVH
                     IRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIY
                     IAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPV
                     QRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKND
                     QDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGEGRGFPSVDSRGSCAPARR
                     PPRKFSPVLPLFPSHPPGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSR
                     YGPQYGHPPPPPPPPDYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMK
                     SKPGAAMVEMADGYAVDRAITHLNNNFMFGQKMNVCVSKQPAIMPGQSYGLEDGSCSY
                     KDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPTSV
                     KVFSGKSERSSSGLLEWDSKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS"
     exon            553..671
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            672..909
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            910..995
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1092
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1165
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1629
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1751
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1953
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2011
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2107
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2509
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2503..2508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /note="hexamer: AATAAA"
     polyA_site      2509
                     /gene="Hnrnpl"
                     /gene_synonym="D830027H13Rik; Hnrpl"
                     /note="major polyA site"
ORIGIN      
        1 cccagtgtct gctcttttcg atcccggacg gccggccaag ctcgccgccg agctggaggt
       61 ggggcctggc ggaatgactg gcaagaagcg ttcacctata aggagtgcga ttggcgaaca
      121 gaggcggtct ttccaataga acggcatgcg tcctatccaa tagaaatgaa ccgtgaggaa
      181 acttcccctc cccccaagat agggccagtg gctcccccta tcgggtgggg gcggcgagtg
      241 acgggcgtgt ccctccccca atgagaggcg gggggaggcg ggttctgcgc cgccatgtcg
      301 cggaggctgc tgccccgggc ggagaagcgg cgtcggcggc tcgagcagag gcagcagccg
      361 gacgagcagc tgaggcgggc gggagcgatg gtgaagatgg cggctgcggg cggcggaggt
      421 ggcggtggtc gctattacgg cggcggcaac gagggaggcc gagcccctaa acggctgaag
      481 actgaaaacg ccggcgacca gcacggaggc ggcggcggcg gaggctccgg ggcggcgggc
      541 ggcggcggcg gggagaacta cgatgacccc cacaaaaccc ctgcctcccc agttgttcac
      601 atcaggggcc tgattgacgg agtagtggaa gctgaccttg tggaagccct gcaagaattt
      661 ggacccatca gctatgtggt ggtgatgcca aagaagaggc aggcactggt agagtttgaa
      721 gacgtgctgg gggcttgtaa tgccgtaaac tacgctgcag acaaccagat ctacattgcc
      781 ggtcaccctg catttgtcaa ttattctacc agccagaaga tctctcgccc gggcgactct
      841 gatgactccc ggagcgtaaa cagcgtgctt ctgtttacca tcctaaaccc catctactcc
      901 ataaccacgg atgttcttta caccatctgt aacccttgtg gccctgtcca gagaattgtc
      961 attttccgga agaacggagt tcaggctatg gtggagtttg attctgtgca aagtgcccag
     1021 cgcgccaagg cctcactcaa tggggctgac atctattccg gctgttgtac tctgaaaatt
     1081 gagtacgcaa agcctacgcg tttaaatgta ttcaagaacg atcaagatac ttgggactac
     1141 acgaacccca acctcagtgg acaaggtgac cctggcagta accccaacaa acgccagcgg
     1201 cagccccctc tcctgggaga tcatcccgca gaatatggtg agggcagggg gttcccctcc
     1261 gtggactccc gtggctcatg tgcccctgcc cgtcgtccgc cgcgaaaatt ctcacccgtc
     1321 ctccctctct ttccttccca ccccccagga gggccccatg gtgggtacca cagccattac
     1381 catgatgagg gctacgggcc ccccccacct cactacgaag ggagaaggat gggcccacct
     1441 gtggggggtc accgccgggg cccaagtcgc tatggccccc agtatggtca tcccccaccc
     1501 cctcccccac cacccgacta tggcccccac gctgacagcc ctgtgctcat ggtctatggc
     1561 ttggatcaat ctaagatgaa ctgtgatcga gtcttcaatg tcttctgctt gtatggcaat
     1621 gtggagaagg tgaaatttat gaaaagcaag ccgggggccg ccatggtgga aatggctgat
     1681 ggctatgctg tggaccgagc cattactcac ctcaacaaca acttcatgtt tgggcagaag
     1741 atgaatgtct gtgtctccaa gcaaccagcc attatgcctg gtcagtcata cgggctagaa
     1801 gatggatcct gcagctataa agacttcagc gagtcaagga acaatcggtt ctccactcca
     1861 gagcaggcag ctaagaaccg catccagcac cctagcaatg tactgcactt cttcaatgct
     1921 cccctcgagg tgactgagga gaacttcttt gagatctgcg atgaactggg agtgaagcgg
     1981 ccaacctctg tcaaagtatt ttcaggcaaa agcgagcgga gctcctctgg gctgctggag
     2041 tgggactcga agagcgatgc cctggagacc ttgggcttcc tgaaccatta ccagatgaaa
     2101 aacccaaatg gcccgtaccc atacactctg aagttgtgct tctccactgc acagcacgcc
     2161 tcctaattgg atgctgggaa ggaagactcc atccgagcag gaaaatgttc ctttccttta
     2221 tgctgttggt ttgtttggtt tttttttttt ttttcttgtt tttttttttc tttttggttt
     2281 tgttttgatt tatttttgca gttttttcct tttaaatgct aggtcagtag aggcttaacc
     2341 acaacagaaa tgctggaact ctggaggggg ggaggggaac tggtatctcc caagattaac
     2401 cttcactttt taaaatgact gtatgtgtga tttttttttt ttcctgttca tacatttgtg
     2461 ctgcccatgt atcttggcac atttcaataa aattgtttgg aaaataaaa
//
