LOCUS       NM_025279               2793 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus heterogeneous nuclear ribonucleoprotein K (Hnrnpk),
            transcript variant 4, mRNA.
ACCESSION   NM_025279
VERSION     NM_025279.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2793)
  AUTHORS   Zhang,S., Zhang,B., Liao,Z., Chen,Y., Guo,W., Wu,J., Liu,H.,
            Weng,R., Su,D., Chen,G., Zhang,Z., Li,C., Long,J., Xiao,Y., Ma,Y.,
            Zhou,T., Xu,C. and Su,P.
  TITLE     Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA
            and inhibiting Hippo signaling pathway
  JOURNAL   Mol Ther 32 (5), 1461-1478 (2024)
   PUBMED   38414246
  REMARK    GeneRIF: Hnrnpk protects against osteoarthritis through targeting
            WWC1 mRNA and inhibiting Hippo signaling pathway.
REFERENCE   2  (bases 1 to 2793)
  AUTHORS   Rahn,K., Abdallah,A.T., Gan,L., Herbrich,S., Sonntag,R.,
            Benitez,O., Malaney,P., Zhang,X., Rodriguez,A.G., Brottem,J.,
            Marx,G., Brummendorf,T.H., Ostareck,D.H., Ostareck-Lederer,A.,
            Crysandt,M., Post,S.M. and Naarmann-de Vries,I.S.
  TITLE     Insight into the mechanism of AML del(9q) progression: hnRNP K
            targets the myeloid master regulators CEBPA (C/EBPalpha) and SPI1
            (PU.1)
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1867 (1), 195004 (2024)
   PUBMED   38008244
REFERENCE   3  (bases 1 to 2793)
  AUTHORS   Chen,Y., Zhou,T., Liao,Z., Gao,W., Wu,J., Zhang,S., Li,Y., Liu,H.,
            Zhou,H., Xu,C. and Su,P.
  TITLE     Hnrnpk is essential for embryonic limb bud development as a
            transcription activator and a collaborator of insulator protein
            Ctcf
  JOURNAL   Cell Death Differ 30 (10), 2293-2308 (2023)
   PUBMED   37608075
REFERENCE   4  (bases 1 to 2793)
  AUTHORS   Zhuang,L.P., Gao,W.J., Fang,L.L., Zeng,G.R., Ye,Q.Y., Dai,X.M.,
            Zhang,J. and Chen,X.C.
  TITLE     HnRNPK is involved in stress-induced depression-like behavior via
            ERK-BDNF pathway in mice
  JOURNAL   Neurochem Int 169, 105589 (2023)
   PUBMED   37543308
  REMARK    GeneRIF: HnRNPK is involved in stress-induced depression-like
            behavior via ERK-BDNF pathway in mice.
REFERENCE   5  (bases 1 to 2793)
  AUTHORS   Bomsztyk,K., Denisenko,O. and Ostrowski,J.
  TITLE     hnRNP K: one protein multiple processes
  JOURNAL   Bioessays 26 (6), 629-638 (2004)
   PUBMED   15170860
  REMARK    Review article
REFERENCE   6  (bases 1 to 2793)
  AUTHORS   Ostrowski,J., Wyrwicz,L., Rychlewski,L. and Bomsztyk,K.
  TITLE     Heterogeneous nuclear ribonucleoprotein K protein associates with
            multiple mitochondrial transcripts within the organelle
  JOURNAL   J Biol Chem 277 (8), 6303-6310 (2002)
   PUBMED   11741984
REFERENCE   7  (bases 1 to 2793)
  AUTHORS   Kai,N., Mishina,M. and Yagi,T.
  TITLE     Molecular cloning of Fyn-associated molecules in the mouse central
            nervous system
  JOURNAL   J Neurosci Res 48 (5), 407-424 (1997)
   PUBMED   9185665
REFERENCE   8  (bases 1 to 2793)
  AUTHORS   Denisenko,O.N., O'Neill,B., Ostrowski,J., Van Seuningen,I. and
            Bomsztyk,K.
  TITLE     Zik1, a transcriptional repressor that interacts with the
            heterogeneous nuclear ribonucleoprotein particle K protein
  JOURNAL   J Biol Chem 271 (44), 27701-27706 (1996)
   PUBMED   8910362
REFERENCE   9  (bases 1 to 2793)
  AUTHORS   Bustelo,X.R., Suen,K.L., Michael,W.M., Dreyfuss,G. and Barbacid,M.
  TITLE     Association of the vav proto-oncogene product with
            poly(rC)-specific RNA-binding proteins
  JOURNAL   Mol Cell Biol 15 (3), 1324-1332 (1995)
   PUBMED   7862126
REFERENCE   10 (bases 1 to 2793)
  AUTHORS   Ostrowski,J., Van Seuningen,I., Seger,R., Rauch,C.T., Sleath,P.R.,
            McMullen,B.A. and Bomsztyk,K.
  TITLE     Purification, cloning, and expression of a murine phosphoprotein
            that binds the kappa B motif in vitro identifies it as the homolog
            of the human heterogeneous nuclear ribonucleoprotein K protein.
            Description of a novel DNA-dependent phosphorylation process
  JOURNAL   J Biol Chem 269 (26), 17626-17634 (1994)
   PUBMED   8021272
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK011428.1, BC089328.1,
            BE993983.1 and AV367088.1.
            
            On Aug 13, 2014 this sequence version replaced NM_025279.2.
            
            Summary: The protein encoded by this gene is a component of the
            heterogeneous nuclear ribonucleoprotein (hnRNP) complex, and is a
            poly-cytosine binding protein (PCBP). It is found in multiple
            subcellular compartments including the nucleus, cytoplasm and
            mitochondria. This gene product is thought to interact with RNA,
            DNA, and protein, and is involved in multiple cellular processes,
            including transcription, chromatin remodeling, DNA damage response,
            signal transduction, mRNA splicing, export, and translation.
            Multiple transcript variants and protein isoforms exist, with some
            isoforms containing a unique C-terminus. There are four pseudogenes
            of this gene, found on chromosomes 2, 3, 7 and 13. [provided by
            RefSeq, Aug 2014].
            
            Transcript Variant: This variant (4) uses an alternative splice
            site in the 3' terminal exon, which results in a frameshift,
            compared to variant 1. It encodes isoform 2 which has a distinct
            and shorter C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160887.1, AK167600.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 11741984
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1974              AK011428.1         6-1979
            1975-2699           BC089328.1         1959-2683
            2700-2783           BE993983.1         18-101              c
            2784-2793           AV367088.1         230-239
FEATURES             Location/Qualifiers
     source          1..2793
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 31.04 cM"
     gene            1..2793
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /note="heterogeneous nuclear ribonucleoprotein K"
                     /db_xref="GeneID:15387"
                     /db_xref="MGI:MGI:99894"
     exon            1..120
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            121..205
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            206..303
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            304..360
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            361..404
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            405..477
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            478..549
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            550..663
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            664..792
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1100
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1155
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1239
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1255
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1338
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1508
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..2793
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2667..2672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /note="hexamer: AATAAA"
     polyA_site      2687
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /note="major polyA site"
     regulatory      2764..2769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
                     /note="hexamer: AATACA"
     polyA_site      2783
                     /gene="Hnrnpk"
                     /gene_synonym="Hnrpk; KBBP; NOVA"
ORIGIN      
        1 agtgcgcgaa cgagaaagga ggagggcgct acaggcgaca gcgctgcaga cgccattatc
       61 ctctgcttct ccgctgcacg gacgtcgccg tcgtgctcgt ctcccactcg attgcggcct
      121 attggtggat ccatttaatt caagaaaatg gagaccgaac agccagaaga aaccttcccc
      181 aacaccgaaa ccaatggtga atttggtaaa cgccctgcag aagatatgga agaggagcaa
      241 gcctttaaaa gatctagaaa tactgatgag atggttgaat tgcgcatttt gcttcagagc
      301 aagaatgctg gagcagtgat tggaaaagga ggcaagaata ttaaggctct ccgtacagac
      361 tacaatgcca gtgtttcagt cccagacagc agtggccccg agcgcatact gagtatcagt
      421 gctgatattg agacgattgg agaaattctg aagaaaatca tccctacctt ggaagagggc
      481 ctgcagttgc catcacccac tgcaaccagc cagctcccgc tcgaatctga tgctgtggaa
      541 tgcttaaatt accaacatta taaaggaagt gactttgatt gcgagttgag actgttgatt
      601 catcagagtc tggcaggagg aataattggt gttaaaggtg ctaaaatcaa agaacttcga
      661 gaaaacactc agacaacaat caagcttttc caggagtgct gccctcactc tactgacaga
      721 gttgttctta ttggaggaaa acctgatagg gttgtagaat gcatcaagat catccttgac
      781 cttatatctg agtctcccat caaaggacgt gcacaacctt atgatcccaa cttttatgat
      841 gagacctatg attatggtgg ttttacaatg atgtttgatg accgccgagg acgacctgtg
      901 ggattcccca tgaggggaag aggtggtttt gacagaatgc ctcctggtcg gggtgggcgt
      961 cccatgcctc cttctagaag agattatgat gatatgagcc ctcgtcgagg acctccacca
     1021 ccaccacctg gtcgaggtgg ccggggtggc agcagagccc ggaatctgcc tcttcctcct
     1081 ccaccaccac ccagaggggg agatctaatg gcttatgaca gaagaggaag gcctggagac
     1141 cgctatgatg gcatggttgg gttcagtgct gatgaaactt gggattctgc aattgacaca
     1201 tggagcccat cagaatggca aatggcttat gaaccacagg gtggttctgg atatgactat
     1261 tcttatgcag ggggccgtgg ctcatatggt gatcttggcg gacctattat cactacacaa
     1321 gtaactattc ccaaagattt ggctggatct attattggca aaggtggtca gcggattaaa
     1381 caaattcgtc atgaatctgg agcatcaatc aaaattgatg aacctttaga aggatctgaa
     1441 gatcggatca ttaccattac aggaacacag gaccagatac agaacgcaca gtatttgctg
     1501 cagaacagtg tgaagcagta ttctggaaag tttttctaag actagtgaag aactgaagga
     1561 gtcctgcatc tttttttttt tatctgcttc tgtttaaaaa gccaacattc ctctgcttca
     1621 taggtgttct gcatttgagg tgtagtgaaa tctttgctgt tcaccagatg taatgtttta
     1681 gttccttaca aacagggttg gggggagggc atgcaaaaac taacattgaa attttgaaac
     1741 agcagcagag tgagtgactt ttattttttg ttcattgttg gtggttttaa aaaaaattcc
     1801 ccccatgtaa ttattgtgaa caccttactt tgtggtcact gtaacattgg ggggtgggac
     1861 agggaggaaa gtaatagtcc acatgtccct ggcatttgtt cagagcagtg tgcagaatgt
     1921 aatgctcttt tgtaagaaac gttttatgat ttttaaaata aatttagtga atctattttt
     1981 ggtggtcttt ttttttttta agacaatttc aaatggtggt tgaattttcc agcccacccc
     2041 taaactaaac actaagtttg attttcagca gctcctctgt tggatataag tgcacctctt
     2101 ggacatagac aaaatacatt ggcaaactca gtttgggtga cttcttaatg gttggaaaga
     2161 cttggcttga taaatttcca tcacatattc atgcttataa taagcttggg attttgtttg
     2221 tttttgcaaa tgtttgccac tacttttcaa cagttttctg ttagttgtgg agaactgcgg
     2281 tggggagcaa tactacaaga gttacgcatc ttaagtatat gccagaagcc tgatgggcaa
     2341 tgagctttat taaccagagt aaacttggtt atggaagtgg ctgatgctga ataaatcctg
     2401 gttatttttg ttagataatt tctcacctat agacttaaag ctgtcaacct gctagtgtct
     2461 tgttagttga actttgtaaa aatatatata tatacttgtt tttccattgt atgcacaatg
     2521 aaagaaaaaa gatgtaccat ttctctgttg tgtgttgaat tatgtaggaa atgtttgtga
     2581 acgattcgaa aaaaatggaa aaagttcctg tggatgtttt gtgtagtaac ttggcatctg
     2641 tattgatagt tcaaaatcca catctaaata aaacttccat gatgttagtt atgacgtgtg
     2701 cccaatttga aaaggggttg attaatacat gtaaagtttg ttgaagtgtt cctcttgtaa
     2761 ggaaatacag taatcttaaa ttatggggtt ttg
//
