LOCUS       NM_001079824            2170 bp    mRNA    linear   ROD 11-OCT-2023
DEFINITION  Mus musculus heterogeneous nuclear ribonucleoprotein H3 (Hnrnph3),
            transcript variant 1, mRNA.
ACCESSION   NM_001079824 XM_897051 XM_897074 XM_897083 XM_920255 XM_920276
VERSION     NM_001079824.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2170)
  AUTHORS   Korff A, Yang X, O'Donovan K, Gonzalez A, Teubner BJ, Nakamura H,
            Messing J, Yang F, Carisey AF, Wang YD, Patni T, Sheppard H,
            Zakharenko SS, Chook YM, Taylor JP and Kim HJ.
  TITLE     A murine model of hnRNPH2-related neurodevelopmental disorder
            reveals a mechanism for genetic compensation by Hnrnph1
  JOURNAL   J Clin Invest 133 (14), e160309 (2023)
   PUBMED   37463454
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2170)
  AUTHORS   Cho KI, Yoon D, Qiu S, Danziger Z, Grill WM, Wetsel WC and Ferreira
            PA.
  TITLE     Loss of Ranbp2 in motoneurons causes disruption of
            nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3
            and Mmp28, and development of amyotrophic lateral sclerosis-like
            syndromes
  JOURNAL   Dis Model Mech 10 (5), 559-579 (2017)
   PUBMED   28100513
  REMARK    GeneRIF: effects were accompanied by paracrine and autocrine
            neuroglial deregulation of hnRNPH3 proteostasis in sciatic nerve
            and motoneurons, respectively, and post-transcriptional
            downregulation of metalloproteinase 28 in the sciatic nerve
REFERENCE   3  (bases 1 to 2170)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (bases 1 to 2170)
  AUTHORS   Mahe D, Fischer N, Decimo D and Fuchs JP.
  TITLE     Spatiotemporal regulation of hnRNP M and 2H9 gene expression during
            mouse embryonic development
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 414-424 (2000)
   PUBMED   11004512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU946493.1, BQ443117.1, BX514270.1, AC113107.15 and AI666703.1.
            
            On or before Dec 25, 2006 this sequence version replaced
            XM_897083.2, XM_897051.2, XM_897074.2, XM_920255.2, XM_920276.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 3
            encode the same isoform (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               BU946493.1         2-160
            160-315             BQ443117.1         1-156
            316-889             BQ443117.1         158-731
            890-1285            BX514270.1         119-514
            1286-1736           AC113107.15        124544-124994       c
            1737-2170           AI666703.1         1-434               c
FEATURES             Location/Qualifiers
     source          1..2170
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.52 cM"
     gene            1..2170
                     /gene="Hnrnph3"
                     /gene_synonym="Hnrph3"
                     /note="heterogeneous nuclear ribonucleoprotein H3"
                     /db_xref="GeneID:432467"
                     /db_xref="MGI:MGI:1926462"
     exon            1..130
                     /gene="Hnrnph3"
                     /gene_synonym="Hnrph3"
                     /inference="alignment:Splign:2.1.0"
     exon            131..265
                     /gene="Hnrnph3"
                     /gene_synonym="Hnrph3"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1194
                     /gene="Hnrnph3"
                     /gene_synonym="Hnrph3"
                     /note="isoform 1 is encoded by transcript variant 1; hnRNP
                     2H9"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein H3
                     isoform 1"
                     /protein_id="NP_001073293.1"
                     /db_xref="CCDS:CCDS48583.1"
                     /db_xref="GeneID:432467"
                     /db_xref="MGI:MGI:1926462"
                     /translation="MDWVMKHNGPNDASDGTVRLRGLPFGCSKEEIVQFFQGLEIVPN
                     GITLTMDYQGRSTGEAFVQFASKEIAENALGKHKERIGHRYIEIFRSSRSEIKGFYDP
                     PRRLLGQRPGPYDRPIGGRGGYYGAGRGSMYDRMRRGGDGYDGGYGGFDDYGGYNNYG
                     YGNDGFDDRMRDGRGMGGHGYGGAGDASSGFHGGHFVHMRGLPFRATENDIANFFSPL
                     NPIRVHIDIGADGRATGEADVEFVTHEDAVAAMSKDKNNMQHRYIELFLNSTPGGGSG
                     MGGSGMGGYGRDGMDNQGGYGSVGRMGMGNSYSGGYGAPDGLGGYGRGGGGSGGYYGQ
                     GGMSGGGWRGMY"
     exon            266..404
                     /gene="Hnrnph3"
                     /gene_synonym="Hnrph3"
                     /inference="alignment:Splign:2.1.0"
     exon            405..589
                     /gene="Hnrnph3"
                     /gene_synonym="Hnrph3"
                     /inference="alignment:Splign:2.1.0"
     exon            590..676
                     /gene="Hnrnph3"
                     /gene_synonym="Hnrph3"
                     /inference="alignment:Splign:2.1.0"
     exon            677..792
                     /gene="Hnrnph3"
                     /gene_synonym="Hnrph3"
                     /inference="alignment:Splign:2.1.0"
     exon            793..928
                     /gene="Hnrnph3"
                     /gene_synonym="Hnrph3"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1024
                     /gene="Hnrnph3"
                     /gene_synonym="Hnrph3"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1117
                     /gene="Hnrnph3"
                     /gene_synonym="Hnrph3"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..2168
                     /gene="Hnrnph3"
                     /gene_synonym="Hnrph3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagacggt tgaggggagc gagggagccg aaccgttgtg gcgagcgctc agcagcgggc
       61 gagccaggcg tccctgcccg cgaccagacc cgcgcgagcg tcggtgtagg cgttgcttac
      121 gccccacagg catttaaatc aagcagtatt gaaatggatt gggttatgaa acataatggt
      181 ccaaatgacg ctagcgatgg gaccgtgcga cttcgtggac tgccatttgg ttgcagcaaa
      241 gaggaaatag ttcagttctt tcaagggttg gaaatcgtgc caaatgggat aacattgacg
      301 atggactacc aggggagaag cacaggggag gccttcgtgc agtttgcttc aaaggagata
      361 gcagaaaatg ctctggggaa acacaaggaa agaatagggc acaggtatat tgagatcttc
      421 aggagtagca ggagtgaaat caaaggattt tatgatccac caagaagatt gctgggacag
      481 cgaccgggac catatgatag accaatagga ggaagagggg gttattatgg agctgggcgt
      541 ggaagtatgt atgacagaat gcgacgagga ggtgatggat atgatggtgg ctatggaggt
      601 tttgatgact atggtggcta taataattat ggctatggaa acgatggctt tgatgacagg
      661 atgcgagatg gaagaggcat gggaggacat ggctatggtg gagctggtga tgcaagttca
      721 ggtttccatg gtggtcattt tgtgcacatg agagggctgc cttttcgtgc gactgaaaat
      781 gatattgcta atttcttctc accgctcaat ccaatacgtg ttcatattga cattggagcc
      841 gatggcagag caacaggcga ggcagatgta gagtttgtga cacatgaaga tgcagtagct
      901 gccatgtcta aagataaaaa caacatgcaa catcgataca ttgaactctt cttgaattct
      961 actcctggag gtggctctgg aatgggaggt tctggaatgg gaggctatgg cagagatgga
     1021 atggataatc aaggaggata cgggtctgtt gggagaatgg ggatggggaa cagctacagc
     1081 ggaggctacg gtgctcctga tggcttggga ggctatggtc gtggtggtgg aggcagtgga
     1141 ggttactatg ggcaaggtgg aatgagtgga ggtggatggc gtgggatgta ctgacaacac
     1201 caccccaacg tacacgtcct aacacacctg ctctactaga ctttcttaca gatttcattt
     1261 cttttgtatt tcaagaactt tataacgact gaaggaatgt gttatattat ttggtaaagc
     1321 aacagactgc gatgggaaaa tctgttttct gtaggttgtt tcatttgttg catactttga
     1381 cttaaataaa tttttatatt caaaccactg atgttgctac tttttatata taggtactcc
     1441 taaagatgtg ctgccttcat aagatttggg ataatgtatc ttactgttag catagtgcag
     1501 tgatagaggg caagacagcg agtcttaagt aggcatctag ggtagcacta cctttcaccc
     1561 ctggacatac tgtaaataaa aagcctaaag atacgttcag gtggtttcag gaacataagc
     1621 taattctgta ttcttttcgg tctcttttat caagcatagc tctgaataat tcaagacgta
     1681 tctggattct aaatattcac aaattgtatt atgaatgggg gtaggggtat aaaaccctca
     1741 tagcacttga ctaagatacc aaaaatggtt cccaaaactt gagtttgttg gagtagtttg
     1801 aaattcttaa taatgacaga aaaactctgt aaatacacgg gcatttacta taatgggtat
     1861 atgcttactt gtattttcag tttctcaccc aagaaaacag ggtctttata atggtataaa
     1921 tgactacatt taggagacta taaaacaatg ctgtagctgg ttttgcgtct gaaactggct
     1981 ttgagtagtt aagtgccctg tgtagaagga aaacgtgctt tctactaatc tttttattac
     2041 tttgctcaat aagacttttc cccaaattgg ctaatggatc aaaatgaacc tgtcagtgtg
     2101 atctcagtta ttgagttact tgttttttgc tagatatgtt attaatgtaa taaatgtcaa
     2161 catgggaaaa
//
