LOCUS       NM_019868               2489 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus heterogeneous nuclear ribonucleoprotein H2 (Hnrnph2),
            transcript variant 1, mRNA.
ACCESSION   NM_019868
VERSION     NM_019868.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2489)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2489)
  AUTHORS   Korff,A., Yang,X., O'Donovan,K., Gonzalez,A., Teubner,B.J.,
            Nakamura,H., Messing,J., Yang,F., Carisey,A.F., Wang,Y.D.,
            Patni,T., Sheppard,H., Zakharenko,S.S., Chook,Y.M., Taylor,J.P. and
            Kim,H.J.
  TITLE     A murine model of hnRNPH2-related neurodevelopmental disorder
            reveals a mechanism for genetic compensation by Hnrnph1
  JOURNAL   J Clin Invest 133 (14), e160309 (2023)
   PUBMED   37463454
  REMARK    GeneRIF: A murine model of hnRNPH2-related neurodevelopmental
            disorder reveals a mechanism for genetic compensation by Hnrnph1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2489)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2489)
  AUTHORS   Ruan,Q.T., Yazdani,N., Blum,B.C., Beierle,J.A., Lin,W.,
            Coelho,M.A., Fultz,E.K., Healy,A.F., Shahin,J.R., Kandola,A.K.,
            Luttik,K.P., Zheng,K., Smith,N.J., Cheung,J., Mortazavi,F.,
            Apicco,D.J., Ragu Varman,D., Ramamoorthy,S., Ash,P.E.A.,
            Rosene,D.L., Emili,A., Wolozin,B., Szumlinski,K.K. and Bryant,C.D.
  TITLE     A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced
            Reinforcement, Reward, and Dopamine Release and Increases
            Synaptosomal hnRNP H and Mitochondrial Proteins
  JOURNAL   J Neurosci 40 (1), 107-130 (2020)
   PUBMED   31704785
REFERENCE   5  (bases 1 to 2489)
  AUTHORS   Hamada,T., Miyakawa,K., Kushige,H., Shibata,S. and Kurachi,S.
  TITLE     Age-related expression analysis of mouse liver nuclear protein
            binding to 3'-untranslated region of Period2 gene
  JOURNAL   J Physiol Sci 65 (4), 349-357 (2015)
   PUBMED   25846207
  REMARK    GeneRIF: hnRNP C and hnRNP H bind to the 3'-UTR of the circadian
            clock gene Period 2 (mPer2).
REFERENCE   6  (bases 1 to 2489)
  AUTHORS   Maggi,L.B. Jr., Kuchenruether,M., Dadey,D.Y., Schwope,R.M.,
            Grisendi,S., Townsend,R.R., Pandolfi,P.P. and Weber,J.D.
  TITLE     Nucleophosmin serves as a rate-limiting nuclear export chaperone
            for the Mammalian ribosome
  JOURNAL   Mol Cell Biol 28 (23), 7050-7065 (2008)
   PUBMED   18809582
REFERENCE   7  (bases 1 to 2489)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2489)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   9  (bases 1 to 2489)
  AUTHORS   Oeltjen,J.C., Malley,T.M., Muzny,D.M., Miller,W., Gibbs,R.A. and
            Belmont,J.W.
  TITLE     Large-scale comparative sequence analysis of the human and murine
            Bruton's tyrosine kinase loci reveals conserved regulatory domains
  JOURNAL   Genome Res 7 (4), 315-329 (1997)
   PUBMED   9110171
REFERENCE   10 (bases 1 to 2489)
  AUTHORS   Oeltjen,J.C., Liu,X., Lu,J., Allen,R.C., Muzny,D., Belmont,J.W. and
            Gibbs,R.A.
  TITLE     Sixty-nine kilobases of contiguous human genomic sequence
            containing the alpha-galactosidase A and Bruton's tyrosine kinase
            loci
  JOURNAL   Mamm Genome 6 (5), 334-338 (1995)
   PUBMED   7626884
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX004852.5, BY135797.1, AK077716.1 and AI853236.1.
            
            On Aug 27, 2015 this sequence version replaced NM_019868.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077716.1, SRR9219381.167011.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BX004852.5         51792-51848
            58-439              BY135797.1         2-383
            440-2471            AK077716.1         334-2365
            2472-2489           AI853236.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2489
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 56.2 cM"
     gene            1..2489
                     /gene="Hnrnph2"
                     /gene_synonym="DXHXS1271E; Ftp-3; Ftp3; H'; HNRNP; Hnrph2"
                     /note="heterogeneous nuclear ribonucleoprotein H2"
                     /db_xref="GeneID:56258"
                     /db_xref="MGI:MGI:1201779"
     exon            1..155
                     /gene="Hnrnph2"
                     /gene_synonym="DXHXS1271E; Ftp-3; Ftp3; H'; HNRNP; Hnrph2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..226
                     /gene="Hnrnph2"
                     /gene_synonym="DXHXS1271E; Ftp-3; Ftp3; H'; HNRNP; Hnrph2"
                     /inference="alignment:Splign:2.1.0"
     exon            227..271
                     /gene="Hnrnph2"
                     /gene_synonym="DXHXS1271E; Ftp-3; Ftp3; H'; HNRNP; Hnrph2"
                     /inference="alignment:Splign:2.1.0"
     exon            272..2477
                     /gene="Hnrnph2"
                     /gene_synonym="DXHXS1271E; Ftp-3; Ftp3; H'; HNRNP; Hnrph2"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1674
                     /gene="Hnrnph2"
                     /gene_synonym="DXHXS1271E; Ftp-3; Ftp3; H'; HNRNP; Hnrph2"
                     /note="heterogeneous nuclear ribonucleoprotein H'; hnRNP
                     H'; hnRNP H2"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein H2"
                     /protein_id="NP_063921.1"
                     /db_xref="CCDS:CCDS30397.1"
                     /db_xref="GeneID:56258"
                     /db_xref="MGI:MGI:1201779"
                     /translation="MMLSTEGREGFVVKVRGLPWSCSAEEVMRFFSDCKIQNGTSGVR
                     FIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNSVEMDWVLKHTGP
                     NSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGMTLPVDFQGRSTGEAFVQFA
                     SQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMTMQRPGPYDRPGAGRG
                     YNSIGRGAGFERMRRGAYGGGYGGYDDYGGYNDGYGFGSDRFGRDLNYCFSGMSDHRY
                     GDGGSSFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPMRVHIEIGPDGRVTGEADVE
                     FATHEDAVAAMAKDKANMQHRYVELFLNSTAGTSGGAYDHSYVELFLNSTAGASGGAY
                     GSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDYQSNLA"
     polyA_site      2305
                     /gene="Hnrnph2"
                     /gene_synonym="DXHXS1271E; Ftp-3; Ftp3; H'; HNRNP; Hnrph2"
                     /note="major polyA site"
ORIGIN      
        1 aagccgagag ttgctcacgt gaccgagatc tcacatgacg tagatgctca cgtgatcaat
       61 cgcttacgtg agcagaagta gttctggtcg tcgtctatcg tctcgctata gccgtttgag
      121 ggaagaagaa ggaaaatccc ccggtctcgt tggagtcctg cagcaaacat ttttaaagta
      181 tttctgtcga ccagatacct ggaagaaact ctaacagggt caaaggataa ttccttaagg
      241 cacatacctg aagtggattt tctgtcagaa gccacattga atttgcattg agccaagctt
      301 gccaccaaga gtccatcagt caccatgatg ctgagcacag agggcaggga ggggttcgtg
      361 gtgaaggtca ggggcctacc ctggtcctgc tcagccgagg aagtgatgcg cttcttctct
      421 gattgcaaaa tccaaaatgg cacatcaggt gttcgtttca tctacaccag agaaggcaga
      481 ccgagtggtg aagcatttgt cgaacttgaa tctgaagatg aagtgaaatt ggctttaaag
      541 aaagacagag aaaccatggg acacagatat gttgaagtat tcaaatccaa cagtgttgaa
      601 atggattggg tgttaaagca tacaggtcca aatagtcctg atactgccaa tgatggtttt
      661 gtacgactca gaggactccc atttggctgt agcaaggaag aaattgttca gttcttttca
      721 gggttggaaa ttgtgccaaa tgggatgaca ctgccagtgg actttcaggg gcggagcaca
      781 ggggaagctt ttgtgcagtt tgcttcacag gagatagctg agaaggcctt aaagaaacac
      841 aaggaaagaa tagggcatag gtacatcgaa atcttcaaga gtagccgagc tgaagtccga
      901 acccactatg atccacctag aaagctcatg actatgcagc gcccgggtcc ttacgatagg
      961 ccaggggctg gaagagggta taatagcatt ggcagaggag ccgggtttga aagaatgagg
     1021 cggggtgcct atggtggagg gtatggaggc tatgatgact atggaggtta taatgacggg
     1081 tatggttttg ggtctgatag atttggaaga gacctaaact actgtttctc aggaatgtct
     1141 gatcatagat atggagatgg tgggtccagt ttccagagca ccacggggca ctgtgtacat
     1201 atgagggggt taccatacag agccaccgag aatgatattt acaatttttt ctcacctctt
     1261 aatcccatga gagtgcacat tgaaatagga cctgatggaa gagttactgg tgaggcagat
     1321 gttgagtttg ctactcatga agacgctgtg gcagctatgg caaaagataa agcaaatatg
     1381 caacacagat atgtggagct cttcttgaat tctaccgcag ggacaagtgg aggagcttat
     1441 gatcatagct atgtagagct ctttttgaat tctacagcag gggcaagtgg tggtgcttac
     1501 ggtagccaga tgatgggagg gatgggttta tccaaccagt ctagttatgg aggtccggcc
     1561 agccagcagc tgagtggtgg ctatggaggg ggttatggtg gtcagagcag tatgagtgga
     1621 tatgaccaag ttcttcagga aaactcaagt gactatcagt caaaccttgc ttaggaagca
     1681 agggaccatc caataacatc tacatgaata aaagctatct ttataggaac tggatagagt
     1741 agggagggtg tctttatatc cagtatgatt ggtaaatggg aagtacaact gcttctgatc
     1801 actattggtc agcttctttc ttctttttcc tttttttttt tttaaaaaaa agaacaaaaa
     1861 tttaagtttt aacagtttcg cattacaagc ttgtgattca tgcttactgt aaagtgaaag
     1921 ttaagattgt tttcaaactt taagctcagc aattttgaac actgaaaata ttcatctagg
     1981 atgtaataac aagttcagta ttgaccataa ctgtcaactc ccctttgagc tttcctcaag
     2041 ttagttatgt tgtaggagtg tacttaagca gcaagcatat ttaggtttaa agcagtttca
     2101 cttacgttaa atgttgctct tataccacaa tacatcgaaa acttcagatg catgttgaaa
     2161 aacatgcttt tctgtaaaaa aaaatatata taggagctgt gtctatgatt caaagtgaca
     2221 acatttggca tgtttgttaa ttctagcttt ttggtttaat atcctgtaag gcacgtgagt
     2281 gtacactttc actttttttt ttaaagatcc ggaacaattt tgagatgtga taccaataca
     2341 ttaggagttt ggtcatgtta tttgtatgga attctggggc tttgatttaa accttacctt
     2401 gtattgtgaa ttccatttag atgtattgta ctaagtgaaa cttgttaaat aaatcttcct
     2461 tttaaaaact ggaaaaaaaa aaaaaaaaa
//
