LOCUS       NM_001360173            4037 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Mus musculus heterogeneous nuclear ribonucleoprotein C (Hnrnpc),
            transcript variant 7, mRNA.
ACCESSION   NM_001360173 XM_017315849
VERSION     NM_001360173.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4037)
  AUTHORS   Cai Y, Chen T, Wang M, Deng L, Li C, Fu S and Xie K.
  TITLE     N6-methylation of RNA-bound adenosine regulator HNRNPC promotes
            vascular endothelial dysfunction in type 2 diabetes mellitus by
            activating the PSEN1-mediated Notch pathway
  JOURNAL   Diabetes Res Clin Pract 197, 110261 (2023)
   PUBMED   36681355
  REMARK    GeneRIF: N6-methylation of RNA-bound adenosine regulator HNRNPC
            promotes vascular endothelial dysfunction in type 2 diabetes
            mellitus by activating the PSEN1-mediated Notch pathway.
REFERENCE   2  (bases 1 to 4037)
  AUTHORS   Park S, Yang HD, Seo JW, Nam JW and Nam SW.
  TITLE     hnRNPC induces isoform shifts in miR-21-5p leading to cancer
            development
  JOURNAL   Exp Mol Med 54 (6), 812-824 (2022)
   PUBMED   35729324
  REMARK    GeneRIF: hnRNPC induces isoform shifts in miR-21-5p leading to
            cancer development.
REFERENCE   3  (bases 1 to 4037)
  AUTHORS   Balaguer N, Moreno I, Herrero M, Gonzalez M, Simon C and Vilella F.
  TITLE     Heterogeneous nuclear ribonucleoprotein C1 may control miR-30d
            levels in endometrial exosomes affecting early embryo implantation
  JOURNAL   Mol Hum Reprod 24 (8), 411-425 (2018)
   PUBMED   29846695
  REMARK    GeneRIF: The data show that hnRNPC1 may be involved in the
            internalization of miR-30d inside exosomes.
REFERENCE   4  (bases 1 to 4037)
  AUTHORS   Borreca A, Gironi K, Amadoro G and Ammassari-Teule M.
  TITLE     Opposite Dysregulation of Fragile-X Mental Retardation Protein and
            Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced
            APP Translation in Alzheimer Disease
  JOURNAL   Mol Neurobiol 53 (5), 3227-3234 (2016)
   PUBMED   26048669
  REMARK    GeneRIF: APP levels then decrease progressively as a function of
            age in close relationship with the gradual normalization of FMRP
            and hnRNP C levels.
REFERENCE   5  (bases 1 to 4037)
  AUTHORS   Hamada T, Miyakawa K, Kushige H, Shibata S and Kurachi S.
  TITLE     Age-related expression analysis of mouse liver nuclear protein
            binding to 3'-untranslated region of Period2 gene
  JOURNAL   J Physiol Sci 65 (4), 349-357 (2015)
   PUBMED   25846207
  REMARK    GeneRIF: hnRNP C and hnRNP H bind to the 3'-UTR of the circadian
            clock gene Period 2 (mPer2).
REFERENCE   6  (bases 1 to 4037)
  AUTHORS   Ko MS, Threat TA, Wang X, Horton JH, Cui Y, Wang X, Pryor E, Paris
            J, Wells-Smith J, Kitchen JR, Rowe LB, Eppig J, Satoh T, Brant L,
            Fujiwara H, Yotsumoto S and Nakashima H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 4037)
  AUTHORS   Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J
            and Beier DR.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   8  (bases 1 to 4037)
  AUTHORS   Raffalli-Mathieu F, Geneste O and Lang MA.
  TITLE     Characterization of two nuclear proteins that interact with
            cytochrome P-450 1A2 mRNA. Regulation of RNA binding and possible
            role in the expression of the Cyp1a2 gene
  JOURNAL   Eur J Biochem 245 (1), 17-24 (1997)
   PUBMED   9128719
REFERENCE   9  (bases 1 to 4037)
  AUTHORS   Ferreira J and Carmo-Fonseca M.
  TITLE     The biogenesis of the coiled body during early mouse development
  JOURNAL   Development 121 (2), 601-612 (1995)
   PUBMED   7768196
REFERENCE   10 (bases 1 to 4037)
  AUTHORS   von Melchner H, DeGregori JV, Rayburn H, Reddy S, Friedel C and
            Ruley HE.
  TITLE     Selective disruption of genes expressed in totipotent embryonal
            stem cells
  JOURNAL   Genes Dev 6 (6), 919-927 (1992)
   PUBMED   1317320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY227292.1, BQ443834.1, CF748747.1, CN456693.1, EH101141.1,
            AK010845.1, CN714625.1, AV165766.2 and BP767634.1.
            
            [WARNING] On Sep 26, 2023 this sequence was replaced by
            NM_001360173.2.
            
            On Jan 30, 2018 this sequence version replaced XM_017315849.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.150023.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BY227292.1         2-33
            33-794              BQ443834.1         1-762
            795-1376            CF748747.1         23-604
            1377-1861           CN456693.1         129-613
            1862-2378           EH101141.1         80-596
            2379-2961           AK010845.1         1104-1686
            2962-2977           CN714625.1         470-485
            2978-3484           AV165766.2         34-540
            3485-4037           BP767634.1         48-600              c
FEATURES             Location/Qualifiers
     source          1..4037
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.79 cM"
     gene            1..4037
                     /gene="Hnrnpc"
                     /gene_synonym="D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2;
                     Hnrpc; Hnrpc1; Hnrpc2"
                     /note="heterogeneous nuclear ribonucleoprotein C"
                     /db_xref="GeneID:15381"
                     /db_xref="MGI:MGI:107795"
     exon            1..133
                     /gene="Hnrnpc"
                     /gene_synonym="D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2;
                     Hnrpc; Hnrpc1; Hnrpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            134..1356
                     /gene="Hnrnpc"
                     /gene_synonym="D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2;
                     Hnrpc; Hnrpc1; Hnrpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1633
                     /gene="Hnrnpc"
                     /gene_synonym="D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2;
                     Hnrpc; Hnrpc1; Hnrpc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1393..2334
                     /gene="Hnrnpc"
                     /gene_synonym="D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2;
                     Hnrpc; Hnrpc1; Hnrpc2"
                     /note="isoform 1 is encoded by transcript variant 7;
                     heterogeneous nuclear ribonucleoproteins C1/C2;
                     heterogeneous ribonucleoprotein C1/C2; hnRNP C1 / hnRNP
                     C2; hnRNP C1/C2; heterogeneous nuclear ribonucleoprotein
                     C1; heterogeneous nuclear ribonucleoprotein C2; snoRNA
                     MBI-122"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform 1"
                     /protein_id="NP_001347102.1"
                     /db_xref="CCDS:CCDS36917.1"
                     /db_xref="GeneID:15381"
                     /db_xref="MGI:MGI:107795"
                     /translation="MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIV
                     GCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAAEPKVNRGKAGVKRSAA
                     EMYGSVPEHPSPSPLLSSSFDLDYDFQRDYYDRMYSYPARVPPPPPIARAVVPSKRQR
                     VSGNTSRRGKSGFNSKSGQRGSSSKSGKLKGDDLQAIKKELTQIKQKVDSLLESLEKI
                     EKEQSKQADLSFSSPVEMKNEKSEEEQSSASVKKDETNVKMESEAGADDSAEEGDLLD
                     DDDNEDRGDDQLELKDDEKEPEEGEDDRDSANGEDDS"
     exon            1634..1748
                     /gene="Hnrnpc"
                     /gene_synonym="D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2;
                     Hnrpc; Hnrpc1; Hnrpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1796
                     /gene="Hnrnpc"
                     /gene_synonym="D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2;
                     Hnrpc; Hnrpc1; Hnrpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1957
                     /gene="Hnrnpc"
                     /gene_synonym="D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2;
                     Hnrpc; Hnrpc1; Hnrpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2071
                     /gene="Hnrnpc"
                     /gene_synonym="D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2;
                     Hnrpc; Hnrpc1; Hnrpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2253
                     /gene="Hnrnpc"
                     /gene_synonym="D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2;
                     Hnrpc; Hnrpc1; Hnrpc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..4037
                     /gene="Hnrnpc"
                     /gene_synonym="D14Wsu171e; hnrnp-C; hnRNPC1; hnRNPC2;
                     Hnrpc; Hnrpc1; Hnrpc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggagctc gggggccatt ttgtgaggag acggagagcg aacggtcgtg tggttcttcg
       61 ctgttgtagc tccggcgtct cggcgtagac tcgcagtagg agaggcggtc tcttctctct
      121 ctccttcctt ttgggcagca aggcgaaccc catccttact cactggagct cagctttgat
      181 ttttaacttc ccttccccac ctttccagaa cacacacatt cccatttcaa aattgatttt
      241 ataaagacat tttaaatata ctgatgcaac ttggtgtgca ctacggcaaa catacaggtg
      301 tttttttaaa aattatttcc aaaaaacaac aaaacaaaac aaacgggacc tggatttaag
      361 atgtaatttt taaaatttct atttctattt ttttctgcag cagttgggtt agaggaggag
      421 ccttttagcc tcataaactg acctctctac ttcgtgtatt tttaagatta actgatgatg
      481 tggaaagggc tttgcttgtc tgctattgag aacattaccc ttgcggtttt tgtggaaact
      541 gcttttggaa aagaaaagaa ttgaacttta ctgacttgac atttttagac ctcccgtttt
      601 tctaatctgg gctattttta tttttgtttt tttacagtga gatttttttg atcttcagct
      661 acagtaagtt attacaattt tttttttaca tttttcctga ctttcgctgg tttccttttt
      721 attgttgtta cttactagtt attattatta ctatacttat aatggtgatg atgatgatga
      781 taatgatgat ttttaaacgg attaaagtgg agtttttctg aatgttaaga tttcttcagc
      841 ctcctgattg actttggagt tttccatctt gggagagaaa gtgaaggtgt tagcattttt
      901 aagtagcttg atcacataaa ccctttctct cccaacccca cccttgcccc caaccccttc
      961 cccacactgg aaataatttt actggctgtt aagtctttga ccttattttt cctgatcttt
     1021 aacttaactg ttttagagca tctctggacg tctgtatttt taattttttt ttatttttat
     1081 ttttttttct ttttaatctt tcatttgtta gatttttaaa ctgtgctgca ataaaatgtg
     1141 tgtggtacta tttaacacct ataatggtga tggcattttc ccaaaaagcc atcttcctac
     1201 tgtttccctt gaaatcccat cctgcttttc ctgtacacta cccctcacaa accacaagcc
     1261 gcagcaacat ggatgcccag tctggagcag caacagccag gatgacctgg agccaggggg
     1321 gccttcggaa cagatgtata cccttcctgg gtgatgtttt cagctttgtg agaaacctca
     1381 tcatcaaagg agatggctag caatgttacc aacaagacag atcctcggtc catgaattcc
     1441 cgtgtattca ttgggaatct caacactctg gtggtcaaga agtctgatgt ggaggccatc
     1501 ttttcaaagt atggcaaaat tgtgggctgc tctgtgcata aaggctttgc ctttgtccag
     1561 tatgttaatg aaagaaatgc ccgagctgct gtagctggcg aggatggcag aatgattgct
     1621 ggccaggttt tagatattaa cctggctgca gagccaaaag tgaaccgagg aaaagcaggt
     1681 gtgaaacgat ctgcagcgga gatgtacggg tcagtaccag aacacccttc tccgtcccct
     1741 ctactcagtt cctcatttga cttggactat gactttcaac gggattatta tgacaggatg
     1801 tacagttacc cagcgcgggt tcctcctcct cctcctattg ctcgagctgt ggtgccttcc
     1861 aaacgtcagc gtgtttcagg gaacacctca cgaaggggca aaagtggatt caattcgaag
     1921 agtggacaaa ggggatcttc ttccaagtct ggaaaattga aaggtgatga ccttcaggcc
     1981 attaaaaagg agctgactca gataaaacaa aaagtggatt ctcttctgga aagcctggaa
     2041 aaaattgaaa aagaacaaag caagcaagca gacttgtcct tctcatcccc agtagagatg
     2101 aagaatgaaa agtctgaaga agagcagagc agcgcctctg tgaagaaaga tgagactaat
     2161 gtgaagatgg agtctgaggc aggtgcagat gactctgctg aggagggtga cctgctggat
     2221 gatgacgata atgaagatcg gggggatgac cagctggagt tgaaggatga tgaaaaagag
     2281 cctgaggaag gagaagacga cagagacagc gccaatgggg aggatgactc ttaagcacat
     2341 agtggagctt agaaatctta tcccattatt catttaccta ggcgtttgtg ggagatgaaa
     2401 gtaacaccag gtcatctccc ctggggtctt ctgcacattc tcactgttgt cccgccttac
     2461 cctccctgtg ttcattaatt catgattgcc ctgcgcctag ttacagttcc acttcctttg
     2521 atgctccgta gtactttcgt taagtctcac cctgtaagtt ttgctttaat tttgatacct
     2581 ctttgactta acaataaaaa gttgtatggt ttttatcaac tgtctccaaa ataatctctt
     2641 gttatgcagg gagtacagtt cttcccattc atgacttcag tagttgcttc cctaactgca
     2701 gaggcatctc atttacttgt aaccccaaga gcagctttgc attagaggtg tgtgttttcc
     2761 ctcacgtgag tgggactgtt acaacacgaa tgtaaccatg tatttttgtg aatgggagtt
     2821 ggcatgtcaa atgcatctta caggaaaata gtgtaatagt cttaatattt gttttctaaa
     2881 gttataccat gggttatttt tgtgaacagc ctgatgtttg ggatcttttt ctcaaaaata
     2941 aacagttcct tattaaacca ggaatttgaa ggaaagacaa tttttttttt tccgagacag
     3001 gatttttcta tataggcctg gctgtcctgg aacccacttt gtagaccagg ctggcctgga
     3061 actcagagat ctgcctgcct ctgcctcctg agtgctggga ttaaagccgt gcgccaccac
     3121 accctgctgg aaagaaagtt tttcaattac attttttttt taatagcagc ctccacaaat
     3181 cgttaggttg tattaaatat aatcttcatg cataccaata tatatgaata aaagtcattt
     3241 tgagagcatt gttaacttta aatatttttg acacggagtg cttgaatgtt cagttactga
     3301 ttaaaaccca ggtttcttta ttgcattctc aacctgtgcc tcaaaagttt caaaatagga
     3361 aagcatttgt ctttcccgtt ttatatagca tttgccttcc taagaactga gtctataacg
     3421 agagttataa ttacccatgt gaagtactct tacccctttt cttgatttgt ttgagtcagc
     3481 ttggaacatt ttgctgtgta agacctaaca taaggtaaag gtataaacag atttgggggc
     3541 ttgtttgttt atttttgtat agcaggctat tcaaatcttt tatgcacaca gactttctac
     3601 ttctcaaaaa gaccctgttg tgtatatcta gcatacagct gcaagtctat gctttcatgc
     3661 tatgcattgt aggcaaaagt aacccatgat aaaactgagg agaggctgat ctaggggctt
     3721 cccttggctc cagtgtgcaa atataaaaat ggcttttatt gtgacccccc tctgcccctt
     3781 cccctaatct tgatattgtc ttgggttttt gaggaattgg ctagatatca gaggttaaag
     3841 atgctaataa ataaaacctg tttaaatatg ctgttagaag ctggtgtgta caaaatgctg
     3901 gggtgggttc aattagttca gtattgggta ctttctgata ttgggtattg tatttattca
     3961 ggtgactccc ccgccccctc cccccaaaaa aagcagttgg gaaatttgag aataaagact
     4021 gtggttctgt ccctttt
//
