LOCUS       NM_001048061            2545 bp    mRNA    linear   ROD 23-JUL-2024
DEFINITION  Mus musculus heterogeneous nuclear ribonucleoprotein A/B (Hnrnpab),
            transcript variant 1, mRNA.
ACCESSION   NM_001048061
VERSION     NM_001048061.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2545)
  AUTHORS   Lv,L., Yang,X., Zhang,Y., Ren,X., Zeng,S., Zhang,Z., Wang,Q.,
            Lv,J., Gao,P., Dorf,M.E., Li,S., Zhao,L. and Fu,B.
  TITLE     hnRNPAB inhibits Influenza A virus infection by disturbing
            polymerase activity
  JOURNAL   Antiviral Res 228, 105925 (2024)
   PUBMED   38944160
  REMARK    GeneRIF: hnRNPAB inhibits Influenza A virus infection by disturbing
            polymerase activity.
REFERENCE   2  (bases 1 to 2545)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2545)
  AUTHORS   Fukuda,N., Fukuda,T., Percipalle,P., Oda,K., Takei,N.,
            Czaplinski,K., Touhara,K., Yoshihara,Y. and Sasaoka,T.
  TITLE     Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and
            maturation of olfactory sensory neurons
  JOURNAL   Cell Rep 42 (5), 112398 (2023)
   PUBMED   37083330
  REMARK    GeneRIF: Axonal mRNA binding of hnRNP A/B is crucial for axon
            targeting and maturation of olfactory sensory neurons.
REFERENCE   4  (bases 1 to 2545)
  AUTHORS   Lampasona,A.A. and Czaplinski,K.
  TITLE     Hnrnpab regulates neural cell motility through transcription of
            Eps8
  JOURNAL   RNA 25 (1), 45-59 (2019)
   PUBMED   30314980
  REMARK    GeneRIF: Scrutinized the motility of Hnrnpab(-/-) cells and
            confirmed that the decreases in both cell motility and Eps8 are
            restored by ectopically coexpressing both alternatively spliced
            Hnrnpab isoforms, therefore these variants are surprisingly
            nonredundant for cell motility.
REFERENCE   5  (bases 1 to 2545)
  AUTHORS   Herriges,M.J., Tischfield,D.J., Cui,Z., Morley,M.P., Han,Y.,
            Babu,A., Li,S., Lu,M., Cendan,I., Garcia,B.A., Anderson,S.A. and
            Morrisey,E.E.
  TITLE     The NANCI-Nkx2.1 gene duplex buffers Nkx2.1 expression to maintain
            lung development and homeostasis
  JOURNAL   Genes Dev 31 (9), 889-903 (2017)
   PUBMED   28546511
REFERENCE   6  (bases 1 to 2545)
  AUTHORS   Dean,J.L., Sully,G., Wait,R., Rawlinson,L., Clark,A.R. and
            Saklatvala,J.
  TITLE     Identification of a novel AU-rich-element-binding protein which is
            related to AUF1
  JOURNAL   Biochem J 366 (Pt 3), 709-719 (2002)
   PUBMED   12086581
  REMARK    GeneRIF: structure and binding of CBF-A (AUF2)
REFERENCE   7  (bases 1 to 2545)
  AUTHORS   Inoue,A., Omori,A., Ichinose,S., Takahashi,K.P., Kinoshita,Y. and
            Mita,S.
  TITLE     S1 proteins C2 and D2 are novel hnRNPs similar to the
            transcriptional repressor, CArG box motif-binding factor A
  JOURNAL   Eur J Biochem 268 (13), 3654-3663 (2001)
   PUBMED   11432731
REFERENCE   8  (bases 1 to 2545)
  AUTHORS   Blanc,V., Navaratnam,N., Henderson,J.O., Anant,S., Kennedy,S.,
            Jarmuz,A., Scott,J. and Davidson,N.O.
  TITLE     Identification of GRY-RBP as an apolipoprotein B RNA-binding
            protein that interacts with both apobec-1 and apobec-1
            complementation factor to modulate C to U editing
  JOURNAL   J Biol Chem 276 (13), 10272-10283 (2001)
   PUBMED   11134005
REFERENCE   9  (bases 1 to 2545)
  AUTHORS   Kamada,S. and Miwa,T.
  TITLE     A protein binding to CArG box motifs and to single-stranded DNA
            functions as a transcriptional repressor
  JOURNAL   Gene 119 (2), 229-236 (1992)
   PUBMED   1398104
REFERENCE   10 (bases 1 to 2545)
  AUTHORS   Tucker,P.W., Liu,C.P., Mushinski,J.F. and Blattner,F.R.
  TITLE     Mouse immunoglobulin D: messenger RNA and genomic DNA sequences
  JOURNAL   Science 209 (4463), 1353-1360 (1980)
   PUBMED   6968091
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ166869.1, CA325334.1, BQ445737.1, CF751043.1 and AL645602.14.
            
            Summary: This gene encodes a protein with consensus RNA binding
            domains present in a number of other RNA binding proteins and a
            glycine-rich C-terminus. This gene overlaps in a tail-to-tail
            orientation the gene encoding alanine-glyoxylate aminotransferase
            2-like 2. Some of the exons of this gene are interspersed with
            exons of alanine-glyoxylate aminotransferase 2-like 2. Two
            alternatively spliced transcript variants that encode distinct
            proteins have been described for this gene. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) is the longer transcript and
            it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165609.1, SRR11927931.299665.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-407               CJ166869.1         1-407
            408-860             CA325334.1         106-558
            861-1307            BQ445737.1         221-667
            1308-1769           CF751043.1         97-558
            1770-2545           AL645602.14        4295-5070           c
FEATURES             Location/Qualifiers
     source          1..2545
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.11 cM"
     gene            1..2545
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /note="heterogeneous nuclear ribonucleoprotein A/B"
                     /db_xref="GeneID:15384"
                     /db_xref="MGI:MGI:1330294"
     exon            1..215
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     exon            216..462
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..1237
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /note="isoform 1 is encoded by transcript variant 1; S1
                     protein D2; hnRNP A/B; CArG-binding factor-A"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein A/B
                     isoform 1"
                     /protein_id="NP_001041526.1"
                     /db_xref="CCDS:CCDS48787.1"
                     /db_xref="GeneID:15384"
                     /db_xref="MGI:MGI:1330294"
                     /translation="MSDAAEEQPMETTGATENGHEAAPEGEAPVEPSAAAAAPAASAG
                     SGGGTTTAPSGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVV
                     DCTIKMDPNTGRSRGFGFILFKDSSSVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKK
                     IFVGGLNPEATEEKIREYFGQFGEIEAIELPIDPKLNKRRGFVFITFKEEDPVKKVLE
                     KKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGQSQSWNQGYGNYW
                     NQGYGYQQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNNYKPY"
     exon            463..631
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     exon            632..790
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     exon            791..922
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1025
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1166
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..2545
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1750..1755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /note="hexamer: AATAAA"
     regulatory      1756..1761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /note="hexamer: AATGAA"
     polyA_site      1769
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /note="major polyA site"
     polyA_site      1776
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
     regulatory      2525..2530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
                     /note="hexamer: AATAAA"
     polyA_site      2545
                     /gene="Hnrnpab"
                     /gene_synonym="3010025C11Rik; CBF-A; Cgbfa; Hnrpab"
ORIGIN      
        1 ggcattataa agagctccac gagttggcat tgtcaggcgg tggcaccgcg cgggacggag
       61 ttaaggtctt ctttatcggc agtgtacggc ggcggccgag cggagcgata gtcagtggct
      121 gcggacgagc cctcgggggt gcgagcgtga ccgcggccaa gcccgcgcgt cgccttctgc
      181 ggcgagtagg gcctcgcggc gtcatcggcg gcgagtagcc gctgcggcct ggccgaccat
      241 gtcggacgcg gctgaggagc agcccatgga gacgacgggc gccaccgaga acggacacga
      301 ggccgccccc gaaggcgagg ccccggtcga gcccagcgcg gctgccgcgg cccccgcggc
      361 ctcggccggg tctgggggcg ggaccacgac cgcaccgagc gggaaccaga acggcgcgga
      421 gggcgaccag atcaacgcca gcaagaacga ggaggacgcg ggaaaaatgt tcgttggtgg
      481 tctgagctgg gataccagca aaaaagactt aaaggattat tttactaagt ttggagaggt
      541 tgttgactgt acaataaaaa tggatcccaa cactggacga tcaagagggt ttgggtttat
      601 tctcttcaaa gattcttcta gtgtggaaaa ggtcttagat cagaaggagc acaggctgga
      661 tggtcgtgtc attgacccta aaaaggctat ggctatgaag aaggaccctg tgaagaaaat
      721 ctttgtggga ggtctaaacc ctgaagccac agaggaaaag atcagagaat acttcggcca
      781 gtttggggag attgaggcca ttgagcttcc aatagatccc aagttgaaca aaagacgggg
      841 ttttgttttt attacattta aagaggaaga tcctgtgaag aaagttctgg agaagaaatt
      901 tcatactgtc agtggaagca agtgtgaaat caaggttgcc cagcccaaag aggtgtatca
      961 gcaacagcag tatggctctg ggggcagagg aaatcgcaat cgagggaacc gaggcagtgg
     1021 tggaggtcag agtcagagtt ggaatcaggg ctacggcaac tactggaacc agggctacgg
     1081 ctaccagcag ggctacgggc cgggctatgg cggctacgac tactcgccct atggctatta
     1141 cggctacggc cccggctacg actacagtca gggtagtaca aattacggaa agagccagcg
     1201 acgtggtggt catcagaata actacaagcc atactgagag gcagcaggag cggccgagtg
     1261 acgaccgcac acgctttgtt tggacgcgga gtgaacacaa ttatgtacca aatttaactt
     1321 ggcaaacttt tatggcctgt cccatgtgca tcttatttaa aatttccccc agaaatcact
     1381 ctcctgttta ctattccaga gctctagttg taggcagcgt gtggcgtctc agaggccaga
     1441 gcggcactag ggggctgatt ttattaccag gttaccctgt tctagatcag gagggtctat
     1501 ttcctgttgc cgctctgcag cctggacctg tggaccctgg ttgtaaagag taaaactgta
     1561 tcttaggaaa ccagtgtcac ctttttcacc ttttaatttt atattatttg tgtcatacat
     1621 ttccagtaat ggaagtgtta attttactgt actttttggt accttttggg aatctaatgt
     1681 attgtaaggt attttacacg tgtcctgatt ttgccacgac ctggatattg aagctatcca
     1741 agcttttgaa ataaaaatga aaaacaaaac ccccaagcct gggtaaatgt gggatgctct
     1801 gtgagacctt gcccagtgtt ggagatgcca ggtctcctgt agcaaagcag aggtccttta
     1861 gttatcccat ctgatctttt tagctgccct tttgtgccca ttgtctccat agcagagacc
     1921 atcttgccat gtattatata tattccatgt tcttagtttc agtcaagtac aagttgaaat
     1981 gttggggatc tgctgatgga ggtggggcca agtctggctt acctgggggg tgcttgatcc
     2041 tcagggtttc acaacttctt actttttctt ccatgtctgg aaaatgatca cagatcgttt
     2101 ctttttcccc ccaagacagg gtttctctgt agccctggtt aggttatcct ggaactctgt
     2161 agaccaggct ggccttgaac tcagaaatcc acctggctct gcctcccaag tgctgggatt
     2221 aaaggcgtgc gccaccacgc ctggcctacc ctcagtttct aagatgcttg ggatagttta
     2281 gagattggct tatgtctcat catttcccta gcacagatgg tccctttgta agcccagtca
     2341 ccactcactg ttctgtacac atagaaccct ctaagaaatg tatcaattcc aaaacgcagt
     2401 aggggtggct aacaagcagg aataggaagg gatccttggt agcttgtttt ttgtctgttg
     2461 ggatctgagc tttgtataac aaccactttg gtgtatagtc atttctagtt cggtagtttt
     2521 cttaaataaa ttgagggaga ccttg
//
