LOCUS       NM_001374745            2252 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus heterogeneous nuclear ribonucleoprotein A2/B1
            (Hnrnpa2b1), transcript variant 4, mRNA.
ACCESSION   NM_001374745 XM_006506374
VERSION     NM_001374745.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2252)
  AUTHORS   Wang,X., Fan,X., Zhang,J., Wang,F., Chen,J., Wen,Y., Wang,L.,
            Li,T., Li,H., Gu,H., Zhang,Y. and Yuan,S.
  TITLE     hnRNPA2B1 represses the disassembly of arsenite-induced stress
            granules and is essential for male fertility
  JOURNAL   Cell Rep 43 (2), 113769 (2024)
   PUBMED   38363675
REFERENCE   2  (bases 1 to 2252)
  AUTHORS   Hao,W., Chen,Z., Tang,J., Yang,R., Gao,W.Q. and Xu,H.
  TITLE     hnRNPA2B1 promotes the occurrence and progression of hepatocellular
            carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation
            manner
  JOURNAL   J Transl Med 21 (1), 861 (2023)
   PUBMED   38017546
  REMARK    GeneRIF: hnRNPA2B1 promotes the occurrence and progression of
            hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA
            methylation manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2252)
  AUTHORS   Tan,L., Gao,R., Chen,X., Geng,Y., Yin,X., Peng,C., Mu,X., Su,Y.,
            Zhang,Y., Li,F. and He,J.
  TITLE     lincRNA RP24-315D19.10 promotes endometrial decidualization via
            upregulation of hnRNPA2B1
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (7), 166762 (2023)
   PUBMED   37295480
  REMARK    GeneRIF: lincRNA RP24-315D19.10 promotes endometrial
            decidualization via upregulation of hnRNPA2B1.
REFERENCE   4  (bases 1 to 2252)
  AUTHORS   Yao,F., Huang,S., Liu,J., Tan,C., Xu,M., Wang,D., Huang,M., Zhu,Y.,
            Huang,X. and He,S.
  TITLE     Deletion of ARGLU1 causes global defects in alternative splicing in
            vivo and mouse cortical malformations primarily via apoptosis
  JOURNAL   Cell Death Dis 14 (8), 543 (2023)
   PUBMED   37612280
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2252)
  AUTHORS   Chen,W., Wang,Y., Xia,W., Zhang,J. and Zhao,Y.
  TITLE     Neddylation-mediated degradation of hnRNPA2B1 contributes to
            hypertriglyceridemia pancreatitis
  JOURNAL   Cell Death Dis 13 (10), 863 (2022)
   PUBMED   36220838
  REMARK    GeneRIF: Neddylation-mediated degradation of hnRNPA2B1 contributes
            to hypertriglyceridemia pancreatitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2252)
  AUTHORS   Hou,V.C., Lersch,R., Gee,S.L., Ponthier,J.L., Lo,A.J., Wu,M.,
            Turck,C.W., Koury,M., Krainer,A.R., Mayeda,A. and Conboy,J.G.
  TITLE     Decrease in hnRNP A/B expression during erythropoiesis mediates a
            pre-mRNA splicing switch
  JOURNAL   EMBO J 21 (22), 6195-6204 (2002)
   PUBMED   12426391
REFERENCE   7  (bases 1 to 2252)
  AUTHORS   Brumwell,C., Antolik,C., Carson,J.H. and Barbarese,E.
  TITLE     Intracellular trafficking of hnRNP A2 in oligodendrocytes
  JOURNAL   Exp Cell Res 279 (2), 310-320 (2002)
   PUBMED   12243756
REFERENCE   8  (bases 1 to 2252)
  AUTHORS   Hatfield,J.T., Rothnagel,J.A. and Smith,R.
  TITLE     Characterization of the mouse hnRNP A2/B1/B0 gene and
            identification of processed pseudogenes
  JOURNAL   Gene 295 (1), 33-42 (2002)
   PUBMED   12242009
REFERENCE   9  (bases 1 to 2252)
  AUTHORS   Ferreira,J. and Carmo-Fonseca,M.
  TITLE     The biogenesis of the coiled body during early mouse development
  JOURNAL   Development 121 (2), 601-612 (1995)
   PUBMED   7768196
REFERENCE   10 (bases 1 to 2252)
  AUTHORS   Kozu,T., Henrich,B. and Schafer,K.P.
  TITLE     Structure and expression of the gene (HNRPA2B1) encoding the human
            hnRNP protein A2/B1
  JOURNAL   Genomics 25 (2), 365-371 (1995)
   PUBMED   7789969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154011.3.
            
            On Oct 10, 2019 this sequence version replaced XM_006506374.4.
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3835353.10753.1,
                                           SRR13422598.788713.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               AC154011.3         137121-137295       c
            176-211             AC154011.3         134841-134876       c
            212-322             AC154011.3         134635-134745       c
            323-469             AC154011.3         134356-134502       c
            470-680             AC154011.3         133945-134155       c
            681-782             AC154011.3         133753-133854       c
            783-863             AC154011.3         133592-133672       c
            864-926             AC154011.3         132629-132691       c
            927-1046            AC154011.3         131878-131997       c
            1047-1169           AC154011.3         131539-131661       c
            1170-1252           AC154011.3         130861-130943       c
            1253-2252           AC154011.3         127884-128883       c
FEATURES             Location/Qualifiers
     source          1..2252
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 24.87 cM"
     gene            1..2252
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /note="heterogeneous nuclear ribonucleoprotein A2/B1"
                     /db_xref="GeneID:53379"
                     /db_xref="MGI:MGI:104819"
     exon            1..175
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1231
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /note="isoform 3 is encoded by transcript variant 4; hnRNP
                     A2/B1; heterogenous nuclear ribonucleoprotein A2/B1;
                     heterogeneous nuclear ribonucleoproteins A2/B1"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoproteins A2/B1
                     isoform 3"
                     /protein_id="NP_001361674.1"
                     /db_xref="CCDS:CCDS90046.1"
                     /db_xref="GeneID:53379"
                     /db_xref="MGI:MGI:104819"
                     /translation="MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQW
                     GKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREES
                     GKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTF
                     DDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGN
                     FGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGY
                     GNQGGGYGGGYDNYGGGNYGSGSYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGG
                     NYGPGGSGGSGGYGGRSRY"
     exon            176..211
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..322
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..469
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..680
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..782
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..863
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..926
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1046
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1169
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1252
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..2252
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1544..1549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /note="hexamer: AATAAA"
     polyA_site      1565
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /note="major polyA site"
     regulatory      1739..1744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /note="hexamer: AATATA"
     polyA_site      1756
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
     regulatory      1973..1978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /note="hexamer: AATAAA"
     polyA_site      1995
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
     regulatory      2224..2229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
                     /note="hexamer: AATAAA"
     polyA_site      2252
                     /gene="Hnrnpa2b1"
                     /gene_synonym="9130414A06Rik; hnrnp-A; Hnrpa2; Hnrpa2b1"
ORIGIN      
        1 agtagcagcg gcgccggtcc cgtgtgcagg agctcctttg cggcccagtt tcttggccat
       61 cgcctgctct ccccacagcg ccaggacgag tcccgtgcgc gtccgtccgc ggaggtcttt
      121 ctcatctcgc tcggctgcgg gaaatcgggc tgaagcgact gagtccgcga tggagaaaac
      181 tttagaaact gttcctttgg agaggaaaaa gagagaaaag gaacagttcc gaaagctctt
      241 tattggtggc ttaagctttg aaaccacaga agaaagtttg agaaactact atgagcaatg
      301 gggaaagctc acagactgtg tggttatgcg ggatcctgca agcaaaagat caagaggatt
      361 tggctttgta actttctcat ccatggccga ggttgacgct gccatggctg caaggcccca
      421 ttccattgat ggcagggtag ttgagccaaa acgtgctgta gcaagagagg agtctggaaa
      481 accaggagcc catgtgactg tgaagaagct gtttgttggt ggaattaagg aagatactga
      541 ggaacaccac cttagagatt actttgaaga gtatggaaaa attgatacta ttgaaataat
      601 taccgatagg cagtctggaa agaaaagagg ctttggcttt gttacttttg atgaccatga
      661 tcctgtggat aaaattgtct tgcaaaaata tcacaccata aatggtcaca atgcagaagt
      721 tagaaaggca ttgtctagac aagaaatgca ggaagtccaa agttctagga gtggaagagg
      781 aggaaacttt ggttttgggg attctcgtgg tggcggtggc aattttggac caggaccagg
      841 aagcaacttt agggggggat ctgatggata cggaagtgga cgtggatttg gggatggcta
      901 taatgggtat ggaggaggac ctggaggtgg caattttgga ggtagccctg gttatggagg
      961 aggaagagga ggatatggtg gtggaggacc tggatatggc aaccagggtg ggggctacgg
     1021 aggtggttat gacaactatg gaggaggaaa ttatggaagt ggaagttaca atgattttgg
     1081 aaattataac cagcagcctt ctaactatgg tccaatgaag agtggaaact ttgggggtag
     1141 caggaacatg ggaggaccat atggtggagg gaactatggt cctggaggaa gtggaggaag
     1201 tggtggctat ggtggaagga gcagatatta agcttcttcc tacttaccat gggaaggtgt
     1261 cttgctgcag gtaactaatg aagaagtggt caaccacaga gtcttcaaga aataagaaat
     1321 tctgtaccat ctgaaagtag ttcttgttgg tgccttcatt taagaagcac ttttaagaaa
     1381 agggaatgtt ttctgattta aaacttcatt tagtacaggt tcttaataaa attacaaaaa
     1441 tgctgattgt aaagggtaac atcaaattag caaaggataa tgtattgttt taggatttgt
     1501 gagtagacag ataagagctc tattttaaat acaagtttta taaaataaat acttttgtat
     1561 ccaaattact tggtgtaatg cttacacata agtgtgaatc ttgttctatc aacatcagtt
     1621 gtctacaaga tcgacactat aaatgctaga ctagttttgc acagaactat acatttagtt
     1681 ctcattcaat actaatagga gaaaaaagca ttaataggca ttatttactg tctaataaaa
     1741 tataccttac tatgaattgt gcactgctac aacttgatgc tgaacactaa tggtggcatt
     1801 ttgaaaccat ggattttaac cagatagtgt tttgagttac cacttttgca gaacaccaaa
     1861 acactgattt ttattccaat tgtgaatggg tagcagtggt taaggtactg tggtttaaga
     1921 gtaatgggaa attgatttaa aacaaccaga gttaacttca tttgcttacg ccaataaagc
     1981 aatatataca ggtaagtcaa tggctaaaaa atgtgagctc ttaacatctt gtaaagtgta
     2041 tcaacagtca ttctaaatac ttggcttttg gctagaaaag ctagcaaacc cattaggtag
     2101 tgttgtgcat gccctcagtc ccagcacttg ggaagttaaa ggctatgttc cagacaaggc
     2161 tgcatgtgag tctcatacac atacccgtcg ccattaagag tttgtttttg gacttcaaag
     2221 caaaataaag tctcacacaa ttgtttttta aa
//
